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The map label for this gene is enr [C]

Identifier: 153937190

GI number: 153937190

Start: 2239669

End: 2241666

Strand: Reverse

Name: enr [C]

Synonym: CLC_2109

Alternate gene names: 153937190

Gene position: 2241666-2239669 (Counterclockwise)

Preceding gene: 153936058

Following gene: 153936642

Centisome position: 59.61

GC content: 34.98

Gene sequence:

>1998_bases
ATGAAGGATAAGTATAAGGTACTTTATGACCCAATTAAAATTGGAAAATTGGAGATTAAAAATAGATATGTTCTTGCTCC
AATGGGACCAGGAGGAATGTGTAACGCCGATGGTAGTTTTAATAAAAGAGGAATTGAGTTTTATGTAGAACGTGCAAAAG
GCGGAACTGGATTAATTATGACAGGTGTAACAATGGTGGAAAACAATATTGAAAAATGTGCATTGCCATCCATGCCATGT
CCAACAATTAACCCTTTAAACTTTATTACAACAGGTAATGAAATGACAGAAAGAGTCCATGCATATGGATCAAAAATATT
TTTACAATTATCAGCAGGATTTGGTAGAGTAAGTATACCATCTATTGTAGGAAAAGTGGCAGTAGCACCTTCTAAAATTC
CACATAGATTTTTACCAGGAGTAACCTGTCGTGAGTTAACTACAGAAGAAGTAAAAGAATATGTAAAAGCCTTTGGTGAG
TCAGCAGAAATTGCAAAAAAAGCTGGATTTGATGGTGTAGAAATTCACGCAGTACATGAAGGATACTTATTAGATCAATT
TGCTATTTCTTTCTTTAACCATCGTACTGATGAATATGGTGGATCATTAGAAAATCGCTTAAGATTTGCCTGTGAAGTTG
TACAAGAGATTAAGAAACGTTGTGGACAAGACTTCCCAGTTTCACTTAGATACAGTATTAAGAGCTTCATTAAGGATTGG
TGTAAGGGCGGCTTACCGGATGAAGAATTTGAAGAAAAGGGAAGAGATATTCCAGAAGGAATTGAAGCTGCTAAAATACT
TGTTGCAGCAGGATATGATGCGCTAAATGGAGACGTTGGATCTTATGATTCATGGTATTGGAGTCATCCACCAATGTATC
AAAAGAAGGGATTATACCTTCCATACAATGAAATACTTAAAAAGGTAGTAGACGTACCTATTATTACAGCAGGAAGAATG
GAGGATCCTGAACTATCAAGTGATGCAATTTTGTCAGGAAAAACAGATATGATTGCTTTAGGAAGACCACTTCTTGCAGA
TGCAGAAATTCCAAATAAAATCTTTGAAGATAAATATGATAAAGTTAGACCTTGCTTATCTTGTCAGGAAGGATGCATGG
GAAGATTACAGAATTTTGCAACAGTATCCTGTGCAGTAAATCCTGCCTGTGGACGTGAAAAGGAGTATGGACTAAAAAAA
GCAGAACAGATTAAGAAAGTTCTTATTGTAGGTGGCGGTGTTGCAGGAATGGAAGCCGCAAGAGTTGCAGCTATTCGTGG
ACACAAAGTAACATTGATTGAAAAGAATGGTTATCTTGGAGGAAATATTGTACCAGGAGGAGTTCCAGATTTCAAAGATG
ACGATCGTGCACTTGTTAAGTGGTATGAATGCATATTGAAAGATTTAGGTGTTGAAATAAAATTAAATGTGGATGCATCA
AAGGAAAATATCAAAGAATTTGGAGCTGATGAAGTGCTTTTAGCAACAGGTTCTAGTCCAAGAACATTGACTATTGAAGG
AGCTGATAAGGTTTATTCAGCAGAAGATGTGCTAATGGAAAGAAAAAATGTTGGTGAAAAGGTTATTGTAATTGGTGGAG
GACTTGTTGGATGTGAAACAGCTCTTTGGTTAAAACAACAAGGTAAAGAGGTTACAATTGTAGAGATGCAAAATGATATT
CTACAAGTAGGTGGACCTTTATGTCATGCAAACCATGATATGCTTGTTGATTTAATTAAATTCAATAAGATTGATGTTAA
GACAAGCTCCTATATCAGCAAGAAAACAGATGAAGGATTTGTTTTAAATACAAATGGAGAAGAATCAATTATTAATGCTG
ATAGTGCTGTTGTAGCTATTGGATATTTATCTGAAAAAGACTTATATAGTGAAGTTAGATTTGATATCCCAAATGCAAGA
CTTATTGGAGATGCTAATAAAGTTCAAAATATTATGTATGCTATTTGGAGTGCATATGAAGTAGCTAAAAATATTTAA

Upstream 100 bases:

>100_bases
ATAACAATATCCTCTTGAAAGTAAAGCTGCTTTATGCTCTATACTGAAGGTGACAGGAAAATAAAAAAATACAAATGTGA
ATTCAGAAAGGAGAAATAAA

Downstream 100 bases:

>100_bases
ATGAACCTTTGTAAAAACTAGAATGGATTTATATCCATATCTAGTTTTTGCTCTTTACTGAAATTCTATAAGTATATGGG
TGTTTGTTATGTACTATTTG

Product: 2-enoate reductase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 665; Mature: 665

Protein sequence:

>665_residues
MKDKYKVLYDPIKIGKLEIKNRYVLAPMGPGGMCNADGSFNKRGIEFYVERAKGGTGLIMTGVTMVENNIEKCALPSMPC
PTINPLNFITTGNEMTERVHAYGSKIFLQLSAGFGRVSIPSIVGKVAVAPSKIPHRFLPGVTCRELTTEEVKEYVKAFGE
SAEIAKKAGFDGVEIHAVHEGYLLDQFAISFFNHRTDEYGGSLENRLRFACEVVQEIKKRCGQDFPVSLRYSIKSFIKDW
CKGGLPDEEFEEKGRDIPEGIEAAKILVAAGYDALNGDVGSYDSWYWSHPPMYQKKGLYLPYNEILKKVVDVPIITAGRM
EDPELSSDAILSGKTDMIALGRPLLADAEIPNKIFEDKYDKVRPCLSCQEGCMGRLQNFATVSCAVNPACGREKEYGLKK
AEQIKKVLIVGGGVAGMEAARVAAIRGHKVTLIEKNGYLGGNIVPGGVPDFKDDDRALVKWYECILKDLGVEIKLNVDAS
KENIKEFGADEVLLATGSSPRTLTIEGADKVYSAEDVLMERKNVGEKVIVIGGGLVGCETALWLKQQGKEVTIVEMQNDI
LQVGGPLCHANHDMLVDLIKFNKIDVKTSSYISKKTDEGFVLNTNGEESIINADSAVVAIGYLSEKDLYSEVRFDIPNAR
LIGDANKVQNIMYAIWSAYEVAKNI

Sequences:

>Translated_665_residues
MKDKYKVLYDPIKIGKLEIKNRYVLAPMGPGGMCNADGSFNKRGIEFYVERAKGGTGLIMTGVTMVENNIEKCALPSMPC
PTINPLNFITTGNEMTERVHAYGSKIFLQLSAGFGRVSIPSIVGKVAVAPSKIPHRFLPGVTCRELTTEEVKEYVKAFGE
SAEIAKKAGFDGVEIHAVHEGYLLDQFAISFFNHRTDEYGGSLENRLRFACEVVQEIKKRCGQDFPVSLRYSIKSFIKDW
CKGGLPDEEFEEKGRDIPEGIEAAKILVAAGYDALNGDVGSYDSWYWSHPPMYQKKGLYLPYNEILKKVVDVPIITAGRM
EDPELSSDAILSGKTDMIALGRPLLADAEIPNKIFEDKYDKVRPCLSCQEGCMGRLQNFATVSCAVNPACGREKEYGLKK
AEQIKKVLIVGGGVAGMEAARVAAIRGHKVTLIEKNGYLGGNIVPGGVPDFKDDDRALVKWYECILKDLGVEIKLNVDAS
KENIKEFGADEVLLATGSSPRTLTIEGADKVYSAEDVLMERKNVGEKVIVIGGGLVGCETALWLKQQGKEVTIVEMQNDI
LQVGGPLCHANHDMLVDLIKFNKIDVKTSSYISKKTDEGFVLNTNGEESIINADSAVVAIGYLSEKDLYSEVRFDIPNAR
LIGDANKVQNIMYAIWSAYEVAKNI
>Mature_665_residues
MKDKYKVLYDPIKIGKLEIKNRYVLAPMGPGGMCNADGSFNKRGIEFYVERAKGGTGLIMTGVTMVENNIEKCALPSMPC
PTINPLNFITTGNEMTERVHAYGSKIFLQLSAGFGRVSIPSIVGKVAVAPSKIPHRFLPGVTCRELTTEEVKEYVKAFGE
SAEIAKKAGFDGVEIHAVHEGYLLDQFAISFFNHRTDEYGGSLENRLRFACEVVQEIKKRCGQDFPVSLRYSIKSFIKDW
CKGGLPDEEFEEKGRDIPEGIEAAKILVAAGYDALNGDVGSYDSWYWSHPPMYQKKGLYLPYNEILKKVVDVPIITAGRM
EDPELSSDAILSGKTDMIALGRPLLADAEIPNKIFEDKYDKVRPCLSCQEGCMGRLQNFATVSCAVNPACGREKEYGLKK
AEQIKKVLIVGGGVAGMEAARVAAIRGHKVTLIEKNGYLGGNIVPGGVPDFKDDDRALVKWYECILKDLGVEIKLNVDAS
KENIKEFGADEVLLATGSSPRTLTIEGADKVYSAEDVLMERKNVGEKVIVIGGGLVGCETALWLKQQGKEVTIVEMQNDI
LQVGGPLCHANHDMLVDLIKFNKIDVKTSSYISKKTDEGFVLNTNGEESIINADSAVVAIGYLSEKDLYSEVRFDIPNAR
LIGDANKVQNIMYAIWSAYEVAKNI

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=566, Percent_Identity=32.5088339222615, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1787939, Length=257, Percent_Identity=31.5175097276265, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17565138, Length=360, Percent_Identity=28.0555555555556, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17564188, Length=227, Percent_Identity=29.0748898678414, Blast_Score=96, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17559802, Length=217, Percent_Identity=29.9539170506912, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559804, Length=226, Percent_Identity=31.4159292035398, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17540738, Length=214, Percent_Identity=30.3738317757009, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI72001454, Length=300, Percent_Identity=29.3333333333333, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17566914, Length=216, Percent_Identity=24.0740740740741, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321973, Length=248, Percent_Identity=30.6451612903226, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6325086, Length=242, Percent_Identity=30.1652892561983, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28574881, Length=173, Percent_Identity=33.5260115606936, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24665539, Length=173, Percent_Identity=33.5260115606936, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24665547, Length=173, Percent_Identity=33.5260115606936, Blast_Score=66, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24665543, Length=173, Percent_Identity=33.5260115606936, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 73111; Mature: 73111

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKYKVLYDPIKIGKLEIKNRYVLAPMGPGGMCNADGSFNKRGIEFYVERAKGGTGLIM
CCCCCEEEECCEEECEEEECCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
TGVTMVENNIEKCALPSMPCPTINPLNFITTGNEMTERVHAYGSKIFLQLSAGFGRVSIP
ECHHHHHCCHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHCCCEEEEEEECCCCCEEHH
SIVGKVAVAPSKIPHRFLPGVTCRELTTEEVKEYVKAFGESAEIAKKAGFDGVEIHAVHE
HHHHHHHCCCCCCCHHHCCCCCHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEEC
GYLLDQFAISFFNHRTDEYGGSLENRLRFACEVVQEIKKRCGQDFPVSLRYSIKSFIKDW
CHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHH
CKGGLPDEEFEEKGRDIPEGIEAAKILVAAGYDALNGDVGSYDSWYWSHPPMYQKKGLYL
HCCCCCCHHHHHHCCCCCCHHHHHEEEEEECCHHCCCCCCCCCCCCCCCCCCHHCCCCCC
PYNEILKKVVDVPIITAGRMEDPELSSDAILSGKTDMIALGRPLLADAEIPNKIFEDKYD
CHHHHHHHHHCCCEEECCCCCCCCCCCCCEECCCCCEEECCCCCCCCCCCCHHHHHHHHH
KVRPCLSCQEGCMGRLQNFATVSCAVNPACGREKEYGLKKAEQIKKVLIVGGGVAGMEAA
HHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHCCHHHHHHCEEEEECCCHHCHHHH
RVAAIRGHKVTLIEKNGYLGGNIVPGGVPDFKDDDRALVKWYECILKDLGVEIKLNVDAS
HHHEECCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCC
KENIKEFGADEVLLATGSSPRTLTIEGADKVYSAEDVLMERKNVGEKVIVIGGGLVGCET
HHHHHHCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHH
ALWLKQQGKEVTIVEMQNDILQVGGPLCHANHDMLVDLIKFNKIDVKTSSYISKKTDEGF
HHHHHHCCCEEEEEEECHHHHHHCCCEEECCCHHHHHHHHCCEEEECHHHHHHCCCCCCE
VLNTNGEESIINADSAVVAIGYLSEKDLYSEVRFDIPNARLIGDANKVQNIMYAIWSAYE
EEECCCCCCEEECCCEEEEEEECCCHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHH
VAKNI
HHHCC
>Mature Secondary Structure
MKDKYKVLYDPIKIGKLEIKNRYVLAPMGPGGMCNADGSFNKRGIEFYVERAKGGTGLIM
CCCCCEEEECCEEECEEEECCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
TGVTMVENNIEKCALPSMPCPTINPLNFITTGNEMTERVHAYGSKIFLQLSAGFGRVSIP
ECHHHHHCCHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHCCCEEEEEEECCCCCEEHH
SIVGKVAVAPSKIPHRFLPGVTCRELTTEEVKEYVKAFGESAEIAKKAGFDGVEIHAVHE
HHHHHHHCCCCCCCHHHCCCCCHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEEC
GYLLDQFAISFFNHRTDEYGGSLENRLRFACEVVQEIKKRCGQDFPVSLRYSIKSFIKDW
CHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHH
CKGGLPDEEFEEKGRDIPEGIEAAKILVAAGYDALNGDVGSYDSWYWSHPPMYQKKGLYL
HCCCCCCHHHHHHCCCCCCHHHHHEEEEEECCHHCCCCCCCCCCCCCCCCCCHHCCCCCC
PYNEILKKVVDVPIITAGRMEDPELSSDAILSGKTDMIALGRPLLADAEIPNKIFEDKYD
CHHHHHHHHHCCCEEECCCCCCCCCCCCCEECCCCCEEECCCCCCCCCCCCHHHHHHHHH
KVRPCLSCQEGCMGRLQNFATVSCAVNPACGREKEYGLKKAEQIKKVLIVGGGVAGMEAA
HHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHCCHHHHHHCEEEEECCCHHCHHHH
RVAAIRGHKVTLIEKNGYLGGNIVPGGVPDFKDDDRALVKWYECILKDLGVEIKLNVDAS
HHHEECCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCC
KENIKEFGADEVLLATGSSPRTLTIEGADKVYSAEDVLMERKNVGEKVIVIGGGLVGCET
HHHHHHCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHH
ALWLKQQGKEVTIVEMQNDILQVGGPLCHANHDMLVDLIKFNKIDVKTSSYISKKTDEGF
HHHHHHCCCEEEEEEECHHHHHHCCCEEECCCHHHHHHHHCCEEEECHHHHHHCCCCCCE
VLNTNGEESIINADSAVVAIGYLSEKDLYSEVRFDIPNARLIGDANKVQNIMYAIWSAYE
EEECCCCCCEEECCCEEEEEEECCCHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHH
VAKNI
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]