BacMap

Definition	Clostridium botulinum A str. Hall, complete genome.
Accession	NC_009698
Length	3,760,560

Click here to switch to the map view.

The map label for this gene is yvgN [H]

Identifier: 153936954

GI number: 153936954

Start: 1054407

End: 1055252

Strand: Direct

Name: yvgN [H]

Synonym: CLC_1037

Alternate gene names: 153936954

Gene position: 1054407-1055252 (Clockwise)

Preceding gene: 153935525

Following gene: 153937747

Centisome position: 28.04

GC content: 32.03

Gene sequence:

>846_bases
ATGCAAGATATAAAGAGTTATACAATTTTAAATAACGGAGTAAAGATGCCTTGGCTTGGATTTGGTACTTATAAGGTGGA
AAATGGGGACACGGTTATTCAATCAGTAAAGGAAGCCCTTAAAATTGGATATGGTCATATAGATACTGCTTCTTATTATG
GAAACGAAGAAGGAGTTGGCACTGCAATAAAAGAAAGCAGAATTCCTAGAAAAGATATATTTTTAGTAAGCAAAGTTTGG
AATTCAGAGCAGGGTTATGATAAAACTTTAAAATCCTTTGAAGATTCTATAAAAAAACTTGGCACAGATTATCTTGATTT
ATATTTAATTCATTGGCCTCAACCTTTAAGCAAAGAAACGTGGAAGGCCTTAGAAAAACTTTATAAAGAAGGACGTGTAA
AAGCTATTGGAGTAAGCAATTTTTTAGTTGATCACTTAAAGTGGTTATTAGAAGATGCCGAAATCATGCCAATAGTAAAT
CAGGTGGAATTTCATCCTCAACTTATTCAAAAGGACTTAATAGAGTTCTGCAGCAAAAATAATATACAATTAGAAGCATG
GTCTCCATTAATGAGAGGTAAAGTATTCGAAATCGAACTTTTACAGGATATTGCTCGAAAATACGGAAAAACAATATCTC
AAATCGTTTTAAGATGGGATCTACAAATGGGTGTGGTTACTATTCCTAAATCAATAAACCCATCAAGAATAAAAGAAAAT
GCAGATATATTCGACTTTGAAATAAGTAAAGAAGATATGGATAAAATTCAGCAACTAGATAAAGGTTTAAGGGTGGGCTC
AGACCCTAATAAAGTTTATCCATGTCAAAGTATATCTAATAAATAG

Upstream 100 bases:

>100_bases
TAGAGTTGTAGTGTACAAACTAACTTATACAAGCCGCTAAGTTGTGTTAAGTAATTATGAAAAGATAGCTTTAAAAATCA
TACTTATAAGGAGTGATTTA

Downstream 100 bases:

>100_bases
TATTATTAAGATTAATGTTCCTATTTTATATAGTGAACAGAAGGTATTTTATAAAAGGGTTTTAAATAATGACAAGTATT
CATATAATGAGGGAATTAAT

Product: aldo/keto reductase family oxidoreductase

Products: NA

Alternate protein names: GR; Methylglyoxal reductase [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MQDIKSYTILNNGVKMPWLGFGTYKVENGDTVIQSVKEALKIGYGHIDTASYYGNEEGVGTAIKESRIPRKDIFLVSKVW
NSEQGYDKTLKSFEDSIKKLGTDYLDLYLIHWPQPLSKETWKALEKLYKEGRVKAIGVSNFLVDHLKWLLEDAEIMPIVN
QVEFHPQLIQKDLIEFCSKNNIQLEAWSPLMRGKVFEIELLQDIARKYGKTISQIVLRWDLQMGVVTIPKSINPSRIKEN
ADIFDFEISKEDMDKIQQLDKGLRVGSDPNKVYPCQSISNK

Sequences:

>Translated_281_residues
MQDIKSYTILNNGVKMPWLGFGTYKVENGDTVIQSVKEALKIGYGHIDTASYYGNEEGVGTAIKESRIPRKDIFLVSKVW
NSEQGYDKTLKSFEDSIKKLGTDYLDLYLIHWPQPLSKETWKALEKLYKEGRVKAIGVSNFLVDHLKWLLEDAEIMPIVN
QVEFHPQLIQKDLIEFCSKNNIQLEAWSPLMRGKVFEIELLQDIARKYGKTISQIVLRWDLQMGVVTIPKSINPSRIKEN
ADIFDFEISKEDMDKIQQLDKGLRVGSDPNKVYPCQSISNK
>Mature_281_residues
MQDIKSYTILNNGVKMPWLGFGTYKVENGDTVIQSVKEALKIGYGHIDTASYYGNEEGVGTAIKESRIPRKDIFLVSKVW
NSEQGYDKTLKSFEDSIKKLGTDYLDLYLIHWPQPLSKETWKALEKLYKEGRVKAIGVSNFLVDHLKWLLEDAEIMPIVN
QVEFHPQLIQKDLIEFCSKNNIQLEAWSPLMRGKVFEIELLQDIARKYGKTISQIVLRWDLQMGVVTIPKSINPSRIKEN
ADIFDFEISKEDMDKIQQLDKGLRVGSDPNKVYPCQSISNK

Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI24497577, Length=295, Percent_Identity=38.3050847457627, Blast_Score=204, Evalue=5e-53,
Organism=Homo sapiens, GI5174391, Length=295, Percent_Identity=38.3050847457627, Blast_Score=204, Evalue=5e-53,
Organism=Homo sapiens, GI223468663, Length=299, Percent_Identity=37.4581939799331, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI93277124, Length=314, Percent_Identity=35.3503184713376, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI310109922, Length=274, Percent_Identity=37.2262773722628, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI45446745, Length=295, Percent_Identity=35.2542372881356, Blast_Score=174, Evalue=6e-44,
Organism=Homo sapiens, GI4503285, Length=295, Percent_Identity=35.2542372881356, Blast_Score=174, Evalue=6e-44,
Organism=Homo sapiens, GI5174695, Length=296, Percent_Identity=35.472972972973, Blast_Score=174, Evalue=6e-44,
Organism=Homo sapiens, GI24497583, Length=310, Percent_Identity=35.8064516129032, Blast_Score=174, Evalue=8e-44,
Organism=Homo sapiens, GI4502049, Length=301, Percent_Identity=38.5382059800665, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI5453543, Length=295, Percent_Identity=34.9152542372881, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI310109920, Length=295, Percent_Identity=34.9152542372881, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI24497585, Length=295, Percent_Identity=36.9491525423729, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI291291012, Length=276, Percent_Identity=36.9565217391304, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI300116273, Length=275, Percent_Identity=34.5454545454545, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI300116271, Length=273, Percent_Identity=34.0659340659341, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI310109924, Length=154, Percent_Identity=35.0649350649351, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI207028673, Length=123, Percent_Identity=40.650406504065, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI310109926, Length=123, Percent_Identity=39.8373983739837, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI87082198, Length=267, Percent_Identity=44.1947565543071, Blast_Score=247, Evalue=8e-67,
Organism=Escherichia coli, GI1786400, Length=266, Percent_Identity=33.4586466165414, Blast_Score=157, Evalue=8e-40,
Organism=Escherichia coli, GI1788081, Length=258, Percent_Identity=31.3953488372093, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788070, Length=317, Percent_Identity=24.6056782334385, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI48994888, Length=258, Percent_Identity=25.5813953488372, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87081735, Length=199, Percent_Identity=26.6331658291457, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787674, Length=250, Percent_Identity=24, Blast_Score=71, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71998625, Length=285, Percent_Identity=41.4035087719298, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17561298, Length=272, Percent_Identity=35.6617647058824, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17564128, Length=296, Percent_Identity=34.7972972972973, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=37.1323529411765, Blast_Score=178, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17552492, Length=277, Percent_Identity=34.6570397111913, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17537077, Length=292, Percent_Identity=34.9315068493151, Blast_Score=176, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17537075, Length=297, Percent_Identity=35.016835016835, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17550248, Length=300, Percent_Identity=35.6666666666667, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17566692, Length=290, Percent_Identity=34.8275862068965, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17562292, Length=275, Percent_Identity=33.4545454545455, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17537079, Length=303, Percent_Identity=29.3729372937294, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17561300, Length=270, Percent_Identity=32.2222222222222, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17550246, Length=84, Percent_Identity=47.6190476190476, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320576, Length=286, Percent_Identity=38.4615384615385, Blast_Score=195, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6324694, Length=294, Percent_Identity=37.0748299319728, Blast_Score=189, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6319625, Length=294, Percent_Identity=36.734693877551, Blast_Score=169, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6321896, Length=317, Percent_Identity=32.807570977918, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6320079, Length=283, Percent_Identity=37.1024734982332, Blast_Score=163, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322556, Length=269, Percent_Identity=33.8289962825279, Blast_Score=161, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24663317, Length=291, Percent_Identity=41.5807560137457, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI24657054, Length=309, Percent_Identity=37.2168284789644, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24644950, Length=302, Percent_Identity=35.0993377483444, Blast_Score=190, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24662789, Length=294, Percent_Identity=37.4149659863946, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI221378297, Length=322, Percent_Identity=33.2298136645963, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI20129731, Length=307, Percent_Identity=35.1791530944625, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21356425, Length=293, Percent_Identity=36.1774744027304, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI45553081, Length=289, Percent_Identity=35.6401384083045, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24662781, Length=275, Percent_Identity=39.2727272727273, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI281366140, Length=257, Percent_Identity=34.6303501945525, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24662785, Length=273, Percent_Identity=38.8278388278388, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24646155, Length=135, Percent_Identity=39.2592592592593, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.283 [H]

Molecular weight: Translated: 32307; Mature: 32307

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDIKSYTILNNGVKMPWLGFGTYKVENGDTVIQSVKEALKIGYGHIDTASYYGNEEGVG
CCCCCCEEEECCCCCCCEECCCEEEECCCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCC
TAIKESRIPRKDIFLVSKVWNSEQGYDKTLKSFEDSIKKLGTDYLDLYLIHWPQPLSKET
HHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHH
WKALEKLYKEGRVKAIGVSNFLVDHLKWLLEDAEIMPIVNQVEFHPQLIQKDLIEFCSKN
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHCCC
NIQLEAWSPLMRGKVFEIELLQDIARKYGKTISQIVLRWDLQMGVVTIPKSINPSRIKEN
CEEEEECCHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHCC
ADIFDFEISKEDMDKIQQLDKGLRVGSDPNKVYPCQSISNK
CCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQDIKSYTILNNGVKMPWLGFGTYKVENGDTVIQSVKEALKIGYGHIDTASYYGNEEGVG
CCCCCCEEEECCCCCCCEECCCEEEECCCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCC
TAIKESRIPRKDIFLVSKVWNSEQGYDKTLKSFEDSIKKLGTDYLDLYLIHWPQPLSKET
HHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHH
WKALEKLYKEGRVKAIGVSNFLVDHLKWLLEDAEIMPIVNQVEFHPQLIQKDLIEFCSKN
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHCCC
NIQLEAWSPLMRGKVFEIELLQDIARKYGKTISQIVLRWDLQMGVVTIPKSINPSRIKEN
CEEEEECCHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHCC
ADIFDFEISKEDMDKIQQLDKGLRVGSDPNKVYPCQSISNK
CCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]