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The map label for this gene is ycbL [H]

Identifier: 153936748

GI number: 153936748

Start: 2343020

End: 2343727

Strand: Reverse

Name: ycbL [H]

Synonym: CLC_2212

Alternate gene names: 153936748

Gene position: 2343727-2343020 (Counterclockwise)

Preceding gene: 153936527

Following gene: 153934849

Centisome position: 62.32

GC content: 31.5

Gene sequence:

>708_bases
ATGGAAAGGTTAAAGATATTAATTGTAGAAGATGATGTTAATATAAATAATATGATAAAGGAATCCTTGATAAAAGAAGG
ATACGATATCGGGCAAGCTTTTCATGGACTTGAAGCTATGGAAAAATTTCAAGGTGAAAATTATCATATGGTAATTATGG
ATATTATGATGCCTGTTATGGATGGCATCGAGTCAATGAGAAGAATCAGGGAAAAAAGTAAAGTTCCAATTATAATACTT
TCTGCAAAGGGAGAAGACAGTGACAAAATAATAGGACTTGGTATGGGAGCGGATGATTACATTGTAAAACCATTTTCAGT
GCCAGAGCTTATAGCAAGAGTTAAATGTAATATAAGAAGAGCTATTTATTATAATGAAACCAAAAGTATTAAAGAAAATA
AGATACATGAGTATGGTGATGTGAAATTTGATATAAATAATTACACAGTTACCAAGGGAGGAAAGGAACTTACTCTTACT
GCAAAGGAAATGAAAATTCTTAAGCTTTTCTTTGAAAATCCAAACAGAGTATTTACTAAAGTGCAGATATATGACAGTGT
ATGGGGAGAAGAATTTTTATCAGATTATAATACGGTAACAGTGCATATGAGAAGACTTAGAAGTAAAATCGAGGATGATC
CCAATAACCCTAAACTTATAGAAACTGTTTGGGGAATAGGATACAAATTAACAGGTGATAGACAATGA

Upstream 100 bases:

>100_bases
TTTGTATATATAGGTAGGTTATATAAATAATCATAAAAATATTATGAAAGGGAAAAGTATAATAAATTTTTATTATATAT
TTAGTATATAAGGTGATATT

Downstream 100 bases:

>100_bases
ATTGGATATTAATAATTATTATAATAATACTATTTATACTATTATTAAATGATAAAATAAAAACTAAAAGGATTACTGCA
AAATTAAAAGAGATTCTTAA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MERLKILIVEDDVNINNMIKESLIKEGYDIGQAFHGLEAMEKFQGENYHMVIMDIMMPVMDGIESMRRIREKSKVPIIIL
SAKGEDSDKIIGLGMGADDYIVKPFSVPELIARVKCNIRRAIYYNETKSIKENKIHEYGDVKFDINNYTVTKGGKELTLT
AKEMKILKLFFENPNRVFTKVQIYDSVWGEEFLSDYNTVTVHMRRLRSKIEDDPNNPKLIETVWGIGYKLTGDRQ

Sequences:

>Translated_235_residues
MERLKILIVEDDVNINNMIKESLIKEGYDIGQAFHGLEAMEKFQGENYHMVIMDIMMPVMDGIESMRRIREKSKVPIIIL
SAKGEDSDKIIGLGMGADDYIVKPFSVPELIARVKCNIRRAIYYNETKSIKENKIHEYGDVKFDINNYTVTKGGKELTLT
AKEMKILKLFFENPNRVFTKVQIYDSVWGEEFLSDYNTVTVHMRRLRSKIEDDPNNPKLIETVWGIGYKLTGDRQ
>Mature_235_residues
MERLKILIVEDDVNINNMIKESLIKEGYDIGQAFHGLEAMEKFQGENYHMVIMDIMMPVMDGIESMRRIREKSKVPIIIL
SAKGEDSDKIIGLGMGADDYIVKPFSVPELIARVKCNIRRAIYYNETKSIKENKIHEYGDVKFDINNYTVTKGGKELTLT
AKEMKILKLFFENPNRVFTKVQIYDSVWGEEFLSDYNTVTVHMRRLRSKIEDDPNNPKLIETVWGIGYKLTGDRQ

Specific function: Member of the two-component regulatory system ycbM/ycbL [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=32.0512820512821, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=34.4978165938865, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=36.4035087719298, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=32.8888888888889, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=32.3529411764706, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=31.304347826087, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789402, Length=230, Percent_Identity=35.6521739130435, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=30.1310043668122, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=31.7596566523605, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1790860, Length=235, Percent_Identity=30.6382978723404, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=28.82096069869, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=27.7533039647577, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI145693140, Length=228, Percent_Identity=28.9473684210526, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=34.5794392523364, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788713, Length=107, Percent_Identity=34.5794392523364, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788191, Length=111, Percent_Identity=32.4324324324324, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790299, Length=133, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790437, Length=111, Percent_Identity=28.8288288288288, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=115, Percent_Identity=37.3913043478261, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27222; Mature: 27222

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLKILIVEDDVNINNMIKESLIKEGYDIGQAFHGLEAMEKFQGENYHMVIMDIMMPVM
CCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHH
DGIESMRRIREKSKVPIIILSAKGEDSDKIIGLGMGADDYIVKPFSVPELIARVKCNIRR
HHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCCCHHHHHHHHHHHHEE
AIYYNETKSIKENKIHEYGDVKFDINNYTVTKGGKELTLTAKEMKILKLFFENPNRVFTK
EEEECCCCCHHHHCCHHCCCEEEEECCEEEECCCCEEEEEHHHHHHHHHHHCCCCEEEEE
VQIYDSVWGEEFLSDYNTVTVHMRRLRSKIEDDPNNPKLIETVWGIGYKLTGDRQ
EEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEECCCCC
>Mature Secondary Structure
MERLKILIVEDDVNINNMIKESLIKEGYDIGQAFHGLEAMEKFQGENYHMVIMDIMMPVM
CCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHH
DGIESMRRIREKSKVPIIILSAKGEDSDKIIGLGMGADDYIVKPFSVPELIARVKCNIRR
HHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCCCEECCCCHHHHHHHHHHHHEE
AIYYNETKSIKENKIHEYGDVKFDINNYTVTKGGKELTLTAKEMKILKLFFENPNRVFTK
EEEECCCCCHHHHCCHHCCCEEEEECCEEEECCCCEEEEEHHHHHHHHHHHCCCCEEEEE
VQIYDSVWGEEFLSDYNTVTVHMRRLRSKIEDDPNNPKLIETVWGIGYKLTGDRQ
EEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]