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The map label for this gene is hsp90

Identifier: 153936722

GI number: 153936722

Start: 2048003

End: 2049883

Strand: Reverse

Name: hsp90

Synonym: CLC_1931

Alternate gene names: 153936722

Gene position: 2049883-2048003 (Counterclockwise)

Preceding gene: 153936834

Following gene: 153937544

Centisome position: 54.51

GC content: 28.44

Gene sequence:

>1881_bases
ATGGAAACTAAACAATTCAAGGCCGAATCTAAGAGACTTTTAGATCTTATGATTAACTCAATTTATACTCATAAGGAGAT
TTTTTTAAGGGAACTTATCTCCAATTCTAGTGATGCTATTGATAAAATTTATTACAAAACTTTAACAGATGATTCCTTAA
AATTCGAGAGAGATAATTACTATATTAGAGTAGTTTCTGATAAGGAAAATAGGATATTAAAAATTGCTGATACTGGTATT
GGTATGACAAAGGAAGAGCTTGAAAATAACCTTGGAGTTATAGCTAAGAGCGGATCATTACAATTTAAAAAAGAAAATGA
AGTAAAAGAAGGCTATGACATAATAGGCCAATTTGGTGTAGGATTTTATTCAGCCTTTTTAGTATCTGATGATGTTACAG
TTATAAGTAAAGCCTTTGGAAGTAATGAGGCTTACAAATGGAATTCAAAGGGAGCAGAGGGGTACACTATAGAACCTTGT
GAAAAGGAAACTTATGGTACAGAGATTATACTTAAAATTAAAGATAATACAGAGGAAGAAAACTATGATGAATTTTTAGA
GGAATATACATTAAAATCTATAATCAAAAAATACTCTGATTTTATTAGATATCCAATAAAAATGGATTTAACAAAGACAA
AACCTAAAGAGGACAATAAAGAAGAGTTTGAAGAATATAAAGAAGAAGAAACTATAAATAGTATGGTTCCTATCTGGAGA
AAAAATAAGAATGAGCTAAAAGCAGAGGATTATGAGAACTTCTATGCTGAAAAGCACTATGGATTTGATAAACCAATAAA
ATATATTCATACTAGTGTTGATGGTGTGGTAAGTTACAATGCTATTTTATTTATTCCAGAAACAACCCCTTATGATTTTT
ATACAAAAGAATATGAAAAAGGTCTAGAGTTATATTCAAGTGGCGTTTTAATTATGAATAAGTGCGGAGATTTATTACCA
GACTATTTTGGATTTGTTAAAGGTATAGTAGACTCTGAGGATTTATCTCTTAACATATCTAGAGAGATACTACAACATGA
TAGACAATTAAAGCTTATTGCTAAAAACATAAAAACTAAAATTAAGAATGAGTTAGAAAGCTTATTAAAAAAGGAAAGAG
ATAAATATGAAAAATTCTATGAATCCTTTGGAAGACAATTAAAATATGGTGTTTATAGTGATTTTGGAAGTAACAAAGAC
ATACTACAGGATTTATTAATGTTTTATTCCTCTAAAGAGAAAAAGATGGTTACTTTAGCTGAATATGTTTCTAGAATGCC
AGAGGATCAAAAATATATTTATTATGCTGTAGGTGAATCTAATGAAAGAATTGAAAAACTTCCGCAAATAGAAGGAGTAC
TAGATAAGGGATATGAAGTACTATACTTTACAGATGATATAGATGAATTTGCTATTAAAATGCTTATGAGTTACAAAGAG
AAAGAATTTAAATCTGTATCAAGTGGTGATTTGGGTATAGAAGGTGAGGAAAAAGAAAATACATCTAATTCAGATGACAA
AGAAAACAAAGAGTTGTTTGAATCTATGAAAGATATGTTATCAGGAAAAGTTAAAGATGTTAGAGCCTCAAAAAGATTAA
AAAATCATCCAGTATGCTTAGCAAATGAGGGTGAGCTTTCAATTGAAATGGAGAAAGTACTAAATGCTATGCCTAACAAT
CAAAACATAAAAGCAGATAAAGTCTTAGAAATAAATATAAATCACGACGTATTTAAGTCACTAAAAGAAGCTTATGAAGG
AGATAAGGAAAAACTTAAATTATATACAGATTTATTATACAACCAAGCTTTACTTATAGAAGGATTAGCAATAAATGATC
CAGTAGAATTTACAAATAACATTTGTAAAATAATGAAGTAG

Upstream 100 bases:

>100_bases
GCACTCACTAGCTTAAAGTGCTAACAATTAAATTATATTATATTTAGAGTAAATACATAAAAATGTATTTGTAGTTTTTA
ATCTGAAGGGAGAGACTAAT

Downstream 100 bases:

>100_bases
GTGCAAAAGTTTCATAATAATATGAACTTAAAAATTTGCAATATAAATAGCATGTAAAAATTAAAATAGTTTATTATGTT
TAATTTAATTTTGATATAAA

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
METKQFKAESKRLLDLMINSIYTHKEIFLRELISNSSDAIDKIYYKTLTDDSLKFERDNYYIRVVSDKENRILKIADTGI
GMTKEELENNLGVIAKSGSLQFKKENEVKEGYDIIGQFGVGFYSAFLVSDDVTVISKAFGSNEAYKWNSKGAEGYTIEPC
EKETYGTEIILKIKDNTEEENYDEFLEEYTLKSIIKKYSDFIRYPIKMDLTKTKPKEDNKEEFEEYKEEETINSMVPIWR
KNKNELKAEDYENFYAEKHYGFDKPIKYIHTSVDGVVSYNAILFIPETTPYDFYTKEYEKGLELYSSGVLIMNKCGDLLP
DYFGFVKGIVDSEDLSLNISREILQHDRQLKLIAKNIKTKIKNELESLLKKERDKYEKFYESFGRQLKYGVYSDFGSNKD
ILQDLLMFYSSKEKKMVTLAEYVSRMPEDQKYIYYAVGESNERIEKLPQIEGVLDKGYEVLYFTDDIDEFAIKMLMSYKE
KEFKSVSSGDLGIEGEEKENTSNSDDKENKELFESMKDMLSGKVKDVRASKRLKNHPVCLANEGELSIEMEKVLNAMPNN
QNIKADKVLEININHDVFKSLKEAYEGDKEKLKLYTDLLYNQALLIEGLAINDPVEFTNNICKIMK

Sequences:

>Translated_626_residues
METKQFKAESKRLLDLMINSIYTHKEIFLRELISNSSDAIDKIYYKTLTDDSLKFERDNYYIRVVSDKENRILKIADTGI
GMTKEELENNLGVIAKSGSLQFKKENEVKEGYDIIGQFGVGFYSAFLVSDDVTVISKAFGSNEAYKWNSKGAEGYTIEPC
EKETYGTEIILKIKDNTEEENYDEFLEEYTLKSIIKKYSDFIRYPIKMDLTKTKPKEDNKEEFEEYKEEETINSMVPIWR
KNKNELKAEDYENFYAEKHYGFDKPIKYIHTSVDGVVSYNAILFIPETTPYDFYTKEYEKGLELYSSGVLIMNKCGDLLP
DYFGFVKGIVDSEDLSLNISREILQHDRQLKLIAKNIKTKIKNELESLLKKERDKYEKFYESFGRQLKYGVYSDFGSNKD
ILQDLLMFYSSKEKKMVTLAEYVSRMPEDQKYIYYAVGESNERIEKLPQIEGVLDKGYEVLYFTDDIDEFAIKMLMSYKE
KEFKSVSSGDLGIEGEEKENTSNSDDKENKELFESMKDMLSGKVKDVRASKRLKNHPVCLANEGELSIEMEKVLNAMPNN
QNIKADKVLEININHDVFKSLKEAYEGDKEKLKLYTDLLYNQALLIEGLAINDPVEFTNNICKIMK
>Mature_626_residues
METKQFKAESKRLLDLMINSIYTHKEIFLRELISNSSDAIDKIYYKTLTDDSLKFERDNYYIRVVSDKENRILKIADTGI
GMTKEELENNLGVIAKSGSLQFKKENEVKEGYDIIGQFGVGFYSAFLVSDDVTVISKAFGSNEAYKWNSKGAEGYTIEPC
EKETYGTEIILKIKDNTEEENYDEFLEEYTLKSIIKKYSDFIRYPIKMDLTKTKPKEDNKEEFEEYKEEETINSMVPIWR
KNKNELKAEDYENFYAEKHYGFDKPIKYIHTSVDGVVSYNAILFIPETTPYDFYTKEYEKGLELYSSGVLIMNKCGDLLP
DYFGFVKGIVDSEDLSLNISREILQHDRQLKLIAKNIKTKIKNELESLLKKERDKYEKFYESFGRQLKYGVYSDFGSNKD
ILQDLLMFYSSKEKKMVTLAEYVSRMPEDQKYIYYAVGESNERIEKLPQIEGVLDKGYEVLYFTDDIDEFAIKMLMSYKE
KEFKSVSSGDLGIEGEEKENTSNSDDKENKELFESMKDMLSGKVKDVRASKRLKNHPVCLANEGELSIEMEKVLNAMPNN
QNIKADKVLEININHDVFKSLKEAYEGDKEKLKLYTDLLYNQALLIEGLAINDPVEFTNNICKIMK

Specific function: Molecular chaperone. Has ATPase activity

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family

Homologues:

Organism=Homo sapiens, GI20149594, Length=680, Percent_Identity=37.0588235294118, Blast_Score=388, Evalue=1e-107,
Organism=Homo sapiens, GI4507677, Length=681, Percent_Identity=36.1233480176211, Blast_Score=337, Evalue=3e-92,
Organism=Homo sapiens, GI155722983, Length=641, Percent_Identity=30.2652106084243, Blast_Score=302, Evalue=8e-82,
Organism=Homo sapiens, GI154146191, Length=412, Percent_Identity=34.4660194174757, Blast_Score=232, Evalue=8e-61,
Organism=Homo sapiens, GI153792590, Length=412, Percent_Identity=34.4660194174757, Blast_Score=231, Evalue=2e-60,
Organism=Escherichia coli, GI1786679, Length=636, Percent_Identity=36.9496855345912, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17559162, Length=666, Percent_Identity=37.987987987988, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17542208, Length=672, Percent_Identity=35.5654761904762, Blast_Score=342, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI115535205, Length=657, Percent_Identity=32.7245053272451, Blast_Score=299, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI115535167, Length=441, Percent_Identity=36.281179138322, Blast_Score=243, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6325016, Length=680, Percent_Identity=35.5882352941176, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6323840, Length=676, Percent_Identity=35.5029585798817, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI17647529, Length=681, Percent_Identity=36.8575624082232, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI21357739, Length=687, Percent_Identity=34.4978165938865, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI24586016, Length=647, Percent_Identity=33.0757341576507, Blast_Score=308, Evalue=9e-84,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): HTPG_CLOB1 (A7FV42)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001384245.1
- ProteinModelPortal:   A7FV42
- STRING:   A7FV42
- GeneID:   5396727
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_1925
- eggNOG:   COG0326
- HOGENOM:   HBG631012
- OMA:   AIYYITA
- ProtClustDB:   PRK05218
- BioCyc:   CBOT441770:CLB_1925-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00505
- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568
- Gene3D:   G3DSA:3.30.565.10
- PANTHER:   PTHR11528
- PIRSF:   PIRSF002583
- PRINTS:   PR00775
- SMART:   SM00387

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 72853; Mature: 72853

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00298 HSP90

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKQFKAESKRLLDLMINSIYTHKEIFLRELISNSSDAIDKIYYKTLTDDSLKFERDNY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCCE
YIRVVSDKENRILKIADTGIGMTKEELENNLGVIAKSGSLQFKKENEVKEGYDIIGQFGV
EEEEEECCCCCEEEEECCCCCCCHHHHHCCCCEEEECCCEEECCCCCHHHHHHHHHHHHH
GFYSAFLVSDDVTVISKAFGSNEAYKWNSKGAEGYTIEPCEKETYGTEIILKIKDNTEEE
HHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
NYDEFLEEYTLKSIIKKYSDFIRYPIKMDLTKTKPKEDNKEEFEEYKEEETINSMVPIWR
CHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHC
KNKNELKAEDYENFYAEKHYGFDKPIKYIHTSVDGVVSYNAILFIPETTPYDFYTKEYEK
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEECCEEEEEECCCCCCHHHHHHHH
GLELYSSGVLIMNKCGDLLPDYFGFVKGIVDSEDLSLNISREILQHDRQLKLIAKNIKTK
HHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHHH
IKNELESLLKKERDKYEKFYESFGRQLKYGVYSDFGSNKDILQDLLMFYSSKEKKMVTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHCCCCCHHHHHHHHHHHCCCCCHHHHHH
EYVSRMPEDQKYIYYAVGESNERIEKLPQIEGVLDKGYEVLYFTDDIDEFAIKMLMSYKE
HHHHHCCCCCCEEEEEECCCCHHHHHCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHH
KEFKSVSSGDLGIEGEEKENTSNSDDKENKELFESMKDMLSGKVKDVRASKRLKNHPVCL
HHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEE
ANEGELSIEMEKVLNAMPNNQNIKADKVLEININHDVFKSLKEAYEGDKEKLKLYTDLLY
ECCCCCEEEHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHH
NQALLIEGLAINDPVEFTNNICKIMK
CCHHHEECCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
METKQFKAESKRLLDLMINSIYTHKEIFLRELISNSSDAIDKIYYKTLTDDSLKFERDNY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCCE
YIRVVSDKENRILKIADTGIGMTKEELENNLGVIAKSGSLQFKKENEVKEGYDIIGQFGV
EEEEEECCCCCEEEEECCCCCCCHHHHHCCCCEEEECCCEEECCCCCHHHHHHHHHHHHH
GFYSAFLVSDDVTVISKAFGSNEAYKWNSKGAEGYTIEPCEKETYGTEIILKIKDNTEEE
HHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
NYDEFLEEYTLKSIIKKYSDFIRYPIKMDLTKTKPKEDNKEEFEEYKEEETINSMVPIWR
CHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHC
KNKNELKAEDYENFYAEKHYGFDKPIKYIHTSVDGVVSYNAILFIPETTPYDFYTKEYEK
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEECCEEEEEECCCCCCHHHHHHHH
GLELYSSGVLIMNKCGDLLPDYFGFVKGIVDSEDLSLNISREILQHDRQLKLIAKNIKTK
HHHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHCCHHHHHHHHHHHHH
IKNELESLLKKERDKYEKFYESFGRQLKYGVYSDFGSNKDILQDLLMFYSSKEKKMVTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHCCCCCHHHHHHHHHHHCCCCCHHHHHH
EYVSRMPEDQKYIYYAVGESNERIEKLPQIEGVLDKGYEVLYFTDDIDEFAIKMLMSYKE
HHHHHCCCCCCEEEEEECCCCHHHHHCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHH
KEFKSVSSGDLGIEGEEKENTSNSDDKENKELFESMKDMLSGKVKDVRASKRLKNHPVCL
HHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEE
ANEGELSIEMEKVLNAMPNNQNIKADKVLEININHDVFKSLKEAYEGDKEKLKLYTDLLY
ECCCCCEEEHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHH
NQALLIEGLAINDPVEFTNNICKIMK
CCHHHEECCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA