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The map label for this gene is comEC [H]

Identifier: 153936510

GI number: 153936510

Start: 454273

End: 455145

Strand: Direct

Name: comEC [H]

Synonym: CLC_0455

Alternate gene names: 153936510

Gene position: 454273-455145 (Clockwise)

Preceding gene: 153934915

Following gene: 153936976

Centisome position: 12.08

GC content: 26.69

Gene sequence:

>873_bases
ATGAAAATAAAAACACCTAGAACTTTCTTAGTGTTTATTGTTGTAGTAAGTTTTTTTTGCATAAAAGCTTTTGCAAAGGA
TAGAAATCCAGAAGTACATTTTATAGATACAGGTCAAAGCGACTGTATATTAATTAAAACAGGAAAAGAAAATTATTTAA
TAGATACTGGATGGGAATATTATAGTGGAAAAGTATTAAGTTATTTAAATTCTAATAATGTAGATAAAATAGATGGAGTT
ATATTAACTCACTATCATGATGATCATTATGGTGGGTTAGAGATGCTTTTAAAAACATCTAAAGTAAGAAAGATTTTTTT
ACCTAAGCATGATAGCGATGACAAGAAAAAAGTAATTAGTACGATAAAAAAACACAAAGTTAATTATGCATGGATAGAAG
ATGGGTGGGAAGTTAAGGGAAGAAAATTAAATTTAAAGGCTATAGTGCCTATTAATGTAGATAGTAAGAATGAAAATAAT
AATTCTATAGTACTATTTGGTAAAATAGATGGAGTTAAATATTTATTTTTGGGGGATTGTGAAAAGAGGGAGGAAATGGA
TATGATATCTAATAAAAAGATAAAAGAATGCGATGTTTTAAAAGTCTCTCATCACGGATTTAAGACTAGTAACAGTGATG
AACTCCTAGATATAGCAAAACCTAAAATTGCTATTGTTACTTGTGATGGAATATATAGTCCAGATAGAATTATAATAGAT
AGATTAAAAAACAAAGGTATAGAAGTCTTTACAACAAGCAACAAAGGAAATTTAATAATTAGGGAGCAAGAAATAATTTG
GAATAGGTATTCTTACTATATAAACAAAGGGAAAAATTTTATGGGAAATACTTATTTAAAATTCATATCTTAA

Upstream 100 bases:

>100_bases
TAAAAGAGTCAGCAGAGGATTATTTAACCTTAAATAAAAATTTTAATAGAGAATAAAATATAACTTACTACAAAAAATAA
ACATAGTGAGGAGGTGTATT

Downstream 100 bases:

>100_bases
AATTAGGGATTTATAAAAGTATATTGAATTCTAATACACAAATATAAAAAAATGTACTTCATAAACATATGAATTAGTTT
ATCCGATGACTACCCGCTCT

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKIKTPRTFLVFIVVVSFFCIKAFAKDRNPEVHFIDTGQSDCILIKTGKENYLIDTGWEYYSGKVLSYLNSNNVDKIDGV
ILTHYHDDHYGGLEMLLKTSKVRKIFLPKHDSDDKKKVISTIKKHKVNYAWIEDGWEVKGRKLNLKAIVPINVDSKNENN
NSIVLFGKIDGVKYLFLGDCEKREEMDMISNKKIKECDVLKVSHHGFKTSNSDELLDIAKPKIAIVTCDGIYSPDRIIID
RLKNKGIEVFTTSNKGNLIIREQEIIWNRYSYYINKGKNFMGNTYLKFIS

Sequences:

>Translated_290_residues
MKIKTPRTFLVFIVVVSFFCIKAFAKDRNPEVHFIDTGQSDCILIKTGKENYLIDTGWEYYSGKVLSYLNSNNVDKIDGV
ILTHYHDDHYGGLEMLLKTSKVRKIFLPKHDSDDKKKVISTIKKHKVNYAWIEDGWEVKGRKLNLKAIVPINVDSKNENN
NSIVLFGKIDGVKYLFLGDCEKREEMDMISNKKIKECDVLKVSHHGFKTSNSDELLDIAKPKIAIVTCDGIYSPDRIIID
RLKNKGIEVFTTSNKGNLIIREQEIIWNRYSYYINKGKNFMGNTYLKFIS
>Mature_290_residues
MKIKTPRTFLVFIVVVSFFCIKAFAKDRNPEVHFIDTGQSDCILIKTGKENYLIDTGWEYYSGKVLSYLNSNNVDKIDGV
ILTHYHDDHYGGLEMLLKTSKVRKIFLPKHDSDDKKKVISTIKKHKVNYAWIEDGWEVKGRKLNLKAIVPINVDSKNENN
NSIVLFGKIDGVKYLFLGDCEKREEMDMISNKKIKECDVLKVSHHGFKTSNSDELLDIAKPKIAIVTCDGIYSPDRIIID
RLKNKGIEVFTTSNKGNLIIREQEIIWNRYSYYINKGKNFMGNTYLKFIS

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 33475; Mature: 33475

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00743 BETA_LACTAMASE_B_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKTPRTFLVFIVVVSFFCIKAFAKDRNPEVHFIDTGQSDCILIKTGKENYLIDTGWEY
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCCCEEEECCCCH
YSGKVLSYLNSNNVDKIDGVILTHYHDDHYGGLEMLLKTSKVRKIFLPKHDSDDKKKVIS
HCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCEEEEECCCCCCCHHHHHHH
TIKKHKVNYAWIEDGWEVKGRKLNLKAIVPINVDSKNENNNSIVLFGKIDGVKYLFLGDC
HHHHHCCEEEEEECCEEECCEEEEEEEEEEEECCCCCCCCCEEEEEEEECCEEEEEECCC
EKREEMDMISNKKIKECDVLKVSHHGFKTSNSDELLDIAKPKIAIVTCDGIYSPDRIIID
CCHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCEEEEEEECCCCCCCHHHHH
RLKNKGIEVFTTSNKGNLIIREQEIIWNRYSYYINKGKNFMGNTYLKFIS
HHHCCCEEEEEECCCCCEEEEEHHHHHHHEEEEEECCCCCCCCEEEEEEC
>Mature Secondary Structure
MKIKTPRTFLVFIVVVSFFCIKAFAKDRNPEVHFIDTGQSDCILIKTGKENYLIDTGWEY
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEECCCCEEEECCCCH
YSGKVLSYLNSNNVDKIDGVILTHYHDDHYGGLEMLLKTSKVRKIFLPKHDSDDKKKVIS
HCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCEEEEECCCCCCCHHHHHHH
TIKKHKVNYAWIEDGWEVKGRKLNLKAIVPINVDSKNENNNSIVLFGKIDGVKYLFLGDC
HHHHHCCEEEEEECCEEECCEEEEEEEEEEEECCCCCCCCCEEEEEEEECCEEEEEECCC
EKREEMDMISNKKIKECDVLKVSHHGFKTSNSDELLDIAKPKIAIVTCDGIYSPDRIIID
CCHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCEEEEEEECCCCCCCHHHHH
RLKNKGIEVFTTSNKGNLIIREQEIIWNRYSYYINKGKNFMGNTYLKFIS
HHHCCCEEEEEECCCCCEEEEEHHHHHHHEEEEEECCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]