| Definition | Clostridium botulinum A str. Hall, complete genome. |
|---|---|
| Accession | NC_009698 |
| Length | 3,760,560 |
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The map label for this gene is gyrA [H]
Identifier: 153935617
GI number: 153935617
Start: 6342
End: 8867
Strand: Direct
Name: gyrA [H]
Synonym: CLC_0007
Alternate gene names: 153935617
Gene position: 6342-8867 (Clockwise)
Preceding gene: 153936801
Following gene: 153934873
Centisome position: 0.17
GC content: 28.7
Gene sequence:
>2526_bases ATGCTAAACGAAGGAAAGATTTTGCCTGTAGATGTAAGTAAAGAAATGAAGAAATGTTATATAGACTATGCCATGAGTGT AATAGCTGGCCGTGCATTACCAGATGTAAGGGATGGGTTAAAGCCAGTACATAGAAGAATAATATATTCAATGCAGGGAT TAGGATTAGCTCCAGAAAAAGGTTATAGAAAATGTGCAAGAATTGTAGGAGATGTACTGGGTAAGTATCATCCTCATGGA GATACAGCAGTTTATGAAGCTTTAGTAAGAATGGCTCAGAATTTTTCAATAAGATATACATTAGTAGATGGTCATGGAAA TTTTGGTTCTGTAGATGGTGATGGAGCAGCAGCAATGAGATATACAGAAGCTAAGATGAGTAAAATATCTATGGAACTTA TAAAAGACATAAATAAAAATACAGTTGATTTTATTCCTAACTTTGATGGAGAAGAAGAAGAACCATCTGTATTACCATCA AGGTTTCCTAATCTTTTAGTTAATGGTTCTTCAGGTATAGCAGTAGGTATGGCTACTAATATTCCACCTCATAATTTAAC AGAGGTTATAGATGGAATAATAATGCTAATAGAAAATGAAGATGTAAATATACTTGATTTAATGACTAAAATAAAAGGAC CAGATTTCCCTACTTCTGGATTAATCGTAGGTACAAGAGGAATAAGGGAAGCTTATGAAACGGGTAGGGGAAAAGTTATA ATTAGAGCTAAAGCTGAGATTGAAGAGGAAAAAGGGAAAAATAAGATAATAGTTACAGAAATACCTTATCAAGTTAATAA AGCTAGACTTATAGAAAATATGGCTAACCTTGTAAAGGATAAAAAAATAAATGGAATTTCAGATTTAAGAGATGAATCAG ATAGAGATGGTATGAGAATTGTTATAGAATTAAAAAGGGATGCAAATCCTAATATAGTTTTAAACCAATTATATAAGCAT ACAAAACTTCAAGATACCTTTGGAATAATTATGTTAGCTTTAGTTAATAACCAACCTCAAATTTTAAATTTAAAAGAAAT ATTAGTTAATTATGTGGAATTCCAAAAGGAAGTAATAAGAAGAAGAACTAGATTTGACTTAGATAAAGCATTAGCAAGGG CTCATATATTAGAAGGTTTAAGAATAGCCTTAGATCATATTGATGAAGTTATAAAGCTTATAAGAGCATCTAAAAATACA GCTGAAGCTAAAGAGGGATTAATGAATAACTTTAATCTTTCAGAAAAACAAGCTCAAGCTATATTAGATATGAAGTTACA AAGGCTTACAGGTTTAGAAAGAGAAAAAATAGAAGAAGAATATAAAGAACTTATGGAAAAGATAAGTTATTTTAGAGAAA TATTGGATAAAGAAGAGTTAGTACTAAGTATAATAAAAGAAGAATTAATAGAGATAAAAAATAAATATGGTGATGAAAGA AAAACAGAAATAGTAAAAGGTGAACATGATATAGATATAGAGGACTTAATTGAAGATAAAAAGGTAATAATAACTTTAAC TCATGGTGGATACATAAAAAGATTAGATATGGATACATACTCTTCACAAAAAAGAGGAGGAAAGGGTATTCAAGCCACAT CTACAAAACAGGATGATTTTATAGAAAATATGTTTGTAACATCTACTCATAGTACTATATTATTCTTTACAAATAGGGGT AAGGTATATAAACTTAAAGCTTATGAAATACCAGAAGCAGGAAGAACAGCTAAAGGTACAAATATAGTAAATATTATACC TATAGAAAATAATGAAAAAATACAAACAGTAATAGGATTAAAAGACATAGATGATATGAAACATTTTGTAATGTGTACTA GAAATGGAATAATTAAAAAGACAGAAATAAAGAAATATTCTTCTATAAGAAAAGGTGGATTAAATGCCATAAATTTAAGA GAAGATGATGAACTAATAGATGTAAAAATGACTAAAGGAAATAATGAAATAATAATAGTCACACAAAATGGGTACTGCAT AAGATTTAATGAAGAAGATGTAAGGCCTATGGGAAGAGTTGCAACAGGAGTTAAAGGTATAACATTAAGAGAAGATGATA AAGCTGTATCTATGGAGGTAGTGTTAGAAGATGAAGCACTACTATCAATAAGTGAAAATGGATTTGGAAAAAGAACAGAT ATAGAAGAATATCCTATCCATAGAAGAGGTGGAAAAGGTGTTATAACTTATAAAATAACAGATAAAACAGGACCTATAGT TGGAGCAAGGTTTATAAAAGAAGATGATGAACTTATGCTTGTAAATAGTGGTGATGTTGCAATAAGAATAAATGTTTCGG AAATATCTAAAACTAGTAGAAATGCTATGGGTGTAAAACTAATGAGAACTAGTGAAGAAGAAAAAATAGTAGCTATAGCT AAAATAAAGAGTGAAGACATAATAGAAGAAGAAATTTTAAATGAAGAAAATTTAAATGAAGAAAATTTAAATGAAGAAAA TTTAAATGAAGAAAATTTAAATGAAGAAAATTTAAATGAAGAATAA
Upstream 100 bases:
>100_bases ATGGGAACAAAAGTAGAACCAAGAAGAGACTTTATAGAAAGTAATGCTGATAAAGTAGTTAACTTGGATATATAAGATAA GATTGTAAAGAGGTGTAATC
Downstream 100 bases:
>100_bases ATAATAAGAAAAATCAGCATTAATGCTGATTTTTCTTATTATAAATTTTAATTATAAAAAACAACTTTTCCAGACGTATC AATATAAGAAATATAAATAA
Product: DNA gyrase subunit A
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 841; Mature: 841
Protein sequence:
>841_residues MLNEGKILPVDVSKEMKKCYIDYAMSVIAGRALPDVRDGLKPVHRRIIYSMQGLGLAPEKGYRKCARIVGDVLGKYHPHG DTAVYEALVRMAQNFSIRYTLVDGHGNFGSVDGDGAAAMRYTEAKMSKISMELIKDINKNTVDFIPNFDGEEEEPSVLPS RFPNLLVNGSSGIAVGMATNIPPHNLTEVIDGIIMLIENEDVNILDLMTKIKGPDFPTSGLIVGTRGIREAYETGRGKVI IRAKAEIEEEKGKNKIIVTEIPYQVNKARLIENMANLVKDKKINGISDLRDESDRDGMRIVIELKRDANPNIVLNQLYKH TKLQDTFGIIMLALVNNQPQILNLKEILVNYVEFQKEVIRRRTRFDLDKALARAHILEGLRIALDHIDEVIKLIRASKNT AEAKEGLMNNFNLSEKQAQAILDMKLQRLTGLEREKIEEEYKELMEKISYFREILDKEELVLSIIKEELIEIKNKYGDER KTEIVKGEHDIDIEDLIEDKKVIITLTHGGYIKRLDMDTYSSQKRGGKGIQATSTKQDDFIENMFVTSTHSTILFFTNRG KVYKLKAYEIPEAGRTAKGTNIVNIIPIENNEKIQTVIGLKDIDDMKHFVMCTRNGIIKKTEIKKYSSIRKGGLNAINLR EDDELIDVKMTKGNNEIIIVTQNGYCIRFNEEDVRPMGRVATGVKGITLREDDKAVSMEVVLEDEALLSISENGFGKRTD IEEYPIHRRGGKGVITYKITDKTGPIVGARFIKEDDELMLVNSGDVAIRINVSEISKTSRNAMGVKLMRTSEEEKIVAIA KIKSEDIIEEEILNEENLNEENLNEENLNEENLNEENLNEE
Sequences:
>Translated_841_residues MLNEGKILPVDVSKEMKKCYIDYAMSVIAGRALPDVRDGLKPVHRRIIYSMQGLGLAPEKGYRKCARIVGDVLGKYHPHG DTAVYEALVRMAQNFSIRYTLVDGHGNFGSVDGDGAAAMRYTEAKMSKISMELIKDINKNTVDFIPNFDGEEEEPSVLPS RFPNLLVNGSSGIAVGMATNIPPHNLTEVIDGIIMLIENEDVNILDLMTKIKGPDFPTSGLIVGTRGIREAYETGRGKVI IRAKAEIEEEKGKNKIIVTEIPYQVNKARLIENMANLVKDKKINGISDLRDESDRDGMRIVIELKRDANPNIVLNQLYKH TKLQDTFGIIMLALVNNQPQILNLKEILVNYVEFQKEVIRRRTRFDLDKALARAHILEGLRIALDHIDEVIKLIRASKNT AEAKEGLMNNFNLSEKQAQAILDMKLQRLTGLEREKIEEEYKELMEKISYFREILDKEELVLSIIKEELIEIKNKYGDER KTEIVKGEHDIDIEDLIEDKKVIITLTHGGYIKRLDMDTYSSQKRGGKGIQATSTKQDDFIENMFVTSTHSTILFFTNRG KVYKLKAYEIPEAGRTAKGTNIVNIIPIENNEKIQTVIGLKDIDDMKHFVMCTRNGIIKKTEIKKYSSIRKGGLNAINLR EDDELIDVKMTKGNNEIIIVTQNGYCIRFNEEDVRPMGRVATGVKGITLREDDKAVSMEVVLEDEALLSISENGFGKRTD IEEYPIHRRGGKGVITYKITDKTGPIVGARFIKEDDELMLVNSGDVAIRINVSEISKTSRNAMGVKLMRTSEEEKIVAIA KIKSEDIIEEEILNEENLNEENLNEENLNEENLNEENLNEE >Mature_841_residues MLNEGKILPVDVSKEMKKCYIDYAMSVIAGRALPDVRDGLKPVHRRIIYSMQGLGLAPEKGYRKCARIVGDVLGKYHPHG DTAVYEALVRMAQNFSIRYTLVDGHGNFGSVDGDGAAAMRYTEAKMSKISMELIKDINKNTVDFIPNFDGEEEEPSVLPS RFPNLLVNGSSGIAVGMATNIPPHNLTEVIDGIIMLIENEDVNILDLMTKIKGPDFPTSGLIVGTRGIREAYETGRGKVI IRAKAEIEEEKGKNKIIVTEIPYQVNKARLIENMANLVKDKKINGISDLRDESDRDGMRIVIELKRDANPNIVLNQLYKH TKLQDTFGIIMLALVNNQPQILNLKEILVNYVEFQKEVIRRRTRFDLDKALARAHILEGLRIALDHIDEVIKLIRASKNT AEAKEGLMNNFNLSEKQAQAILDMKLQRLTGLEREKIEEEYKELMEKISYFREILDKEELVLSIIKEELIEIKNKYGDER KTEIVKGEHDIDIEDLIEDKKVIITLTHGGYIKRLDMDTYSSQKRGGKGIQATSTKQDDFIENMFVTSTHSTILFFTNRG KVYKLKAYEIPEAGRTAKGTNIVNIIPIENNEKIQTVIGLKDIDDMKHFVMCTRNGIIKKTEIKKYSSIRKGGLNAINLR EDDELIDVKMTKGNNEIIIVTQNGYCIRFNEEDVRPMGRVATGVKGITLREDDKAVSMEVVLEDEALLSISENGFGKRTD IEEYPIHRRGGKGVITYKITDKTGPIVGARFIKEDDELMLVNSGDVAIRINVSEISKTSRNAMGVKLMRTSEEEKIVAIA KIKSEDIIEEEILNEENLNEENLNEENLNEENLNEENLNEE
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=317, Percent_Identity=24.9211356466877, Blast_Score=84, Evalue=5e-16, Organism=Homo sapiens, GI19913406, Length=177, Percent_Identity=28.2485875706215, Blast_Score=75, Evalue=2e-13, Organism=Escherichia coli, GI1788562, Length=843, Percent_Identity=50.6524317912218, Blast_Score=863, Evalue=0.0, Organism=Escherichia coli, GI1789396, Length=673, Percent_Identity=35.9583952451709, Blast_Score=418, Evalue=1e-118, Organism=Caenorhabditis elegans, GI17535065, Length=176, Percent_Identity=29.5454545454545, Blast_Score=74, Evalue=4e-13, Organism=Caenorhabditis elegans, GI212645845, Length=476, Percent_Identity=23.9495798319328, Blast_Score=73, Evalue=6e-13, Organism=Saccharomyces cerevisiae, GI6324241, Length=378, Percent_Identity=24.8677248677249, Blast_Score=91, Evalue=6e-19, Organism=Drosophila melanogaster, GI17136538, Length=363, Percent_Identity=23.1404958677686, Blast_Score=74, Evalue=5e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR005743 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013757 - InterPro: IPR013760 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 95128; Mature: 95128
Theoretical pI: Translated: 5.28; Mature: 5.28
Prosite motif: PS00572 GLYCOSYL_HYDROL_F1_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 3.7 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 3.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLNEGKILPVDVSKEMKKCYIDYAMSVIAGRALPDVRDGLKPVHRRIIYSMQGLGLAPEK CCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH GYRKCARIVGDVLGKYHPHGDTAVYEALVRMAQNFSIRYTLVDGHGNFGSVDGDGAAAMR HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCHHEE YTEAKMSKISMELIKDINKNTVDFIPNFDGEEEEPSVLPSRFPNLLVNGSSGIAVGMATN HHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHCCCCEEEECCCCEEEEEECC IPPHNLTEVIDGIIMLIENEDVNILDLMTKIKGPDFPTSGLIVGTRGIREAYETGRGKVI CCCCHHHHHHCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHCCCCEEE IRAKAEIEEEKGKNKIIVTEIPYQVNKARLIENMANLVKDKKINGISDLRDESDRDGMRI EEEECHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCEE VIELKRDANPNIVLNQLYKHTKLQDTFGIIMLALVNNQPQILNLKEILVNYVEFQKEVIR EEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCEECHHHHHHHHHHHHHHHHH RRTRFDLDKALARAHILEGLRIALDHIDEVIKLIRASKNTAEAKEGLMNNFNLSEKQAQA HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHH ILDMKLQRLTGLEREKIEEEYKELMEKISYFREILDKEELVLSIIKEELIEIKNKYGDER HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCH KTEIVKGEHDIDIEDLIEDKKVIITLTHGGYIKRLDMDTYSSQKRGGKGIQATSTKQDDF HHHHCCCCCCCCHHHHHCCCEEEEEEECCCEEEEEECCCCCCHHCCCCCCEECCCCCHHH IENMFVTSTHSTILFFTNRGKVYKLKAYEIPEAGRTAKGTNIVNIIPIENNEKIQTVIGL HHHHEEEECCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEECC KDIDDMKHFVMCTRNGIIKKTEIKKYSSIRKGGLNAINLREDDELIDVKMTKGNNEIIIV CCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCCEEEEE TQNGYCIRFNEEDVRPMGRVATGVKGITLREDDKAVSMEVVLEDEALLSISENGFGKRTD ECCCEEEEECCHHCCHHHHHHCCCCCEEEECCCCEEEEEEEEECCEEEEECCCCCCCCCC IEEYPIHRRGGKGVITYKITDKTGPIVGARFIKEDDELMLVNSGDVAIRINVSEISKTSR CHHCCCCCCCCCEEEEEEEECCCCCEEEHHHCCCCCCEEEEECCCEEEEEEHHHHHHCCC NAMGVKLMRTSEEEKIVAIAKIKSEDIIEEEILNEENLNEENLNEENLNEENLNEENLNE CCCCEEEEECCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC E C >Mature Secondary Structure MLNEGKILPVDVSKEMKKCYIDYAMSVIAGRALPDVRDGLKPVHRRIIYSMQGLGLAPEK CCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH GYRKCARIVGDVLGKYHPHGDTAVYEALVRMAQNFSIRYTLVDGHGNFGSVDGDGAAAMR HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCHHEE YTEAKMSKISMELIKDINKNTVDFIPNFDGEEEEPSVLPSRFPNLLVNGSSGIAVGMATN HHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHCCCCEEEECCCCEEEEEECC IPPHNLTEVIDGIIMLIENEDVNILDLMTKIKGPDFPTSGLIVGTRGIREAYETGRGKVI CCCCHHHHHHCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHCCCCEEE IRAKAEIEEEKGKNKIIVTEIPYQVNKARLIENMANLVKDKKINGISDLRDESDRDGMRI EEEECHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCEE VIELKRDANPNIVLNQLYKHTKLQDTFGIIMLALVNNQPQILNLKEILVNYVEFQKEVIR EEEEECCCCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCEECHHHHHHHHHHHHHHHHH RRTRFDLDKALARAHILEGLRIALDHIDEVIKLIRASKNTAEAKEGLMNNFNLSEKQAQA HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHH ILDMKLQRLTGLEREKIEEEYKELMEKISYFREILDKEELVLSIIKEELIEIKNKYGDER HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCH KTEIVKGEHDIDIEDLIEDKKVIITLTHGGYIKRLDMDTYSSQKRGGKGIQATSTKQDDF HHHHCCCCCCCCHHHHHCCCEEEEEEECCCEEEEEECCCCCCHHCCCCCCEECCCCCHHH IENMFVTSTHSTILFFTNRGKVYKLKAYEIPEAGRTAKGTNIVNIIPIENNEKIQTVIGL HHHHEEEECCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEECC KDIDDMKHFVMCTRNGIIKKTEIKKYSSIRKGGLNAINLREDDELIDVKMTKGNNEIIIV CCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCCEEEEE TQNGYCIRFNEEDVRPMGRVATGVKGITLREDDKAVSMEVVLEDEALLSISENGFGKRTD ECCCEEEEECCHHCCHHHHHHCCCCCEEEECCCCEEEEEEEEECCEEEEECCCCCCCCCC IEEYPIHRRGGKGVITYKITDKTGPIVGARFIKEDDELMLVNSGDVAIRINVSEISKTSR CHHCCCCCCCCCEEEEEEEECCCCCEEEHHHCCCCCCEEEEECCCEEEEEEHHHHHHCCC NAMGVKLMRTSEEEKIVAIAKIKSEDIIEEEILNEENLNEENLNEENLNEENLNEENLNE CCCCEEEEECCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC E C
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11466286 [H]