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The map label for this gene is serA [H]

Identifier: 153935586

GI number: 153935586

Start: 1209918

End: 1210862

Strand: Direct

Name: serA [H]

Synonym: CLC_1176

Alternate gene names: 153935586

Gene position: 1209918-1210862 (Clockwise)

Preceding gene: 153936752

Following gene: 153934844

Centisome position: 32.17

GC content: 29.74

Gene sequence:

>945_bases
ATGATAAAAATATTAGTTTCTGATGGAATGGAGCAGAATGCTTTAAATAAATTAAACGAGCAAGGATTTGTAGTATTAGA
TAAACATTTTGAAAAAGAGGAGCTTAAAGATAAAATAAAAGATTTTGATGCTATTATAATAAGATCAGCTACTAAGGTAG
ATAAGGAAATAATAGATGCAGGTATAAAAGGAAATTTAAAATTAGTTGTAAGAGCAGGAGTTGGACTTGATAATGTGGAT
TTAGAATATGCGAAAGAAAAAGAAGTTAAGGTTTTTAATACACCTAAAGCTAGTAGTGTATCTGTGGCAGAGTTAACTTT
AGGACACATGCTTTGTATAAGTAGATTTATAAATACGGCAAATGTTACTATGCTTCAAGGAAAATGGGAAAAGAAAAAGT
ATAACGGAACAGAAATATATGGCAAAACATTGGGCCTAATAGGATTTGGAAGAATAGCTAGAGAGGTAGCTAAAAGAGCT
AATGCTTTAGGTATGAATGTAATTTATTATGATATAGCAGGTAAATGTGAAGAATATGAAGAATTTAAATGCTGTACCTT
AGATTATTTATTAAATAATTCAGATTTTATATCTGTCCATATACCTTTCAGTAAAGATAGAGGAGCTTTGTTAAAGGAAG
AAGAATTTAATAAAATGAAAGATGGAGTTTATATAATAAATTGTGCTAGAGGTGGAGTAATAGAAGAAGAAGCTCTTTTA
AAAGCTCTTAATAACGGAAAAGTAACAGCAGCAGCCTTAGATGTATTTGAAAATGAGCCAAAACCAAAGAAAGAACTTAT
AAATCATGAAAGAGTAAGTATAACACCTCATATAGGGGCATCTACTAAAGAAGCGCAGATGAGAATAGGAGAAGAAATAG
TAGATATATTAGATAATTTTTTCAATATAGGAGGAGAAGAACATGACCATATTAAAGTCATTTAG

Upstream 100 bases:

>100_bases
CCGAATTGTAATTGGAAATAAGAATAATTAAAAATAGATTAATTATATTTACAAAGAAAATTAATGGGATTACCCATATA
TATTTGAAAGGGTGAAATTT

Downstream 100 bases:

>100_bases
AGCAATAAGACCTAATAAAGGATTTGAATGTAAAATAGCAGCCTTACCTTATGATGTAGTAAATACTGATGAAGCTAGAG
AAATAGGGGGCAAAAACCCC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MIKILVSDGMEQNALNKLNEQGFVVLDKHFEKEELKDKIKDFDAIIIRSATKVDKEIIDAGIKGNLKLVVRAGVGLDNVD
LEYAKEKEVKVFNTPKASSVSVAELTLGHMLCISRFINTANVTMLQGKWEKKKYNGTEIYGKTLGLIGFGRIAREVAKRA
NALGMNVIYYDIAGKCEEYEEFKCCTLDYLLNNSDFISVHIPFSKDRGALLKEEEFNKMKDGVYIINCARGGVIEEEALL
KALNNGKVTAAALDVFENEPKPKKELINHERVSITPHIGASTKEAQMRIGEEIVDILDNFFNIGGEEHDHIKVI

Sequences:

>Translated_314_residues
MIKILVSDGMEQNALNKLNEQGFVVLDKHFEKEELKDKIKDFDAIIIRSATKVDKEIIDAGIKGNLKLVVRAGVGLDNVD
LEYAKEKEVKVFNTPKASSVSVAELTLGHMLCISRFINTANVTMLQGKWEKKKYNGTEIYGKTLGLIGFGRIAREVAKRA
NALGMNVIYYDIAGKCEEYEEFKCCTLDYLLNNSDFISVHIPFSKDRGALLKEEEFNKMKDGVYIINCARGGVIEEEALL
KALNNGKVTAAALDVFENEPKPKKELINHERVSITPHIGASTKEAQMRIGEEIVDILDNFFNIGGEEHDHIKVI
>Mature_314_residues
MIKILVSDGMEQNALNKLNEQGFVVLDKHFEKEELKDKIKDFDAIIIRSATKVDKEIIDAGIKGNLKLVVRAGVGLDNVD
LEYAKEKEVKVFNTPKASSVSVAELTLGHMLCISRFINTANVTMLQGKWEKKKYNGTEIYGKTLGLIGFGRIAREVAKRA
NALGMNVIYYDIAGKCEEYEEFKCCTLDYLLNNSDFISVHIPFSKDRGALLKEEEFNKMKDGVYIINCARGGVIEEEALL
KALNNGKVTAAALDVFENEPKPKKELINHERVSITPHIGASTKEAQMRIGEEIVDILDNFFNIGGEEHDHIKVI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=294, Percent_Identity=46.2585034013605, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI61743967, Length=242, Percent_Identity=32.6446280991736, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI4557497, Length=242, Percent_Identity=32.6446280991736, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=34.2857142857143, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI145580578, Length=245, Percent_Identity=34.2857142857143, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI4557499, Length=245, Percent_Identity=34.2857142857143, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI6912396, Length=267, Percent_Identity=30.7116104868914, Blast_Score=119, Evalue=2e-27,
Organism=Escherichia coli, GI1789279, Length=311, Percent_Identity=35.048231511254, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI87082289, Length=240, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787645, Length=198, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788660, Length=276, Percent_Identity=28.6231884057971, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081824, Length=242, Percent_Identity=26.4462809917355, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=296, Percent_Identity=42.5675675675676, Blast_Score=240, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI25147481, Length=255, Percent_Identity=29.4117647058824, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=318, Percent_Identity=35.5345911949685, Blast_Score=206, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6322116, Length=318, Percent_Identity=35.2201257861635, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6324055, Length=265, Percent_Identity=31.6981132075472, Blast_Score=139, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324964, Length=322, Percent_Identity=28.2608695652174, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324980, Length=197, Percent_Identity=25.8883248730964, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=181, Percent_Identity=29.2817679558011, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=263, Percent_Identity=26.2357414448669, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921140, Length=315, Percent_Identity=40.9523809523809, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI45551003, Length=263, Percent_Identity=30.7984790874525, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574284, Length=263, Percent_Identity=30.7984790874525, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24585514, Length=263, Percent_Identity=30.7984790874525, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574282, Length=263, Percent_Identity=30.7984790874525, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI45552429, Length=263, Percent_Identity=30.7984790874525, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574286, Length=264, Percent_Identity=30.3030303030303, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24585516, Length=298, Percent_Identity=28.1879194630872, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI62472511, Length=210, Percent_Identity=37.6190476190476, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24646446, Length=229, Percent_Identity=36.2445414847162, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24646448, Length=229, Percent_Identity=36.2445414847162, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24646452, Length=229, Percent_Identity=36.2445414847162, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24646450, Length=229, Percent_Identity=36.2445414847162, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28571528, Length=263, Percent_Identity=32.319391634981, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 35139; Mature: 35139

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKILVSDGMEQNALNKLNEQGFVVLDKHFEKEELKDKIKDFDAIIIRSATKVDKEIIDA
CEEEEECCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHEEEEECHHHHHHHHHHC
GIKGNLKLVVRAGVGLDNVDLEYAKEKEVKVFNTPKASSVSVAELTLGHMLCISRFINTA
CCCCCEEEEEEECCCCCCCCHHHCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCC
NVTMLQGKWEKKKYNGTEIYGKTLGLIGFGRIAREVAKRANALGMNVIYYDIAGKCEEYE
CEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
EFKCCTLDYLLNNSDFISVHIPFSKDRGALLKEEEFNKMKDGVYIINCARGGVIEEEALL
HCCEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHHH
KALNNGKVTAAALDVFENEPKPKKELINHERVSITPHIGASTKEAQMRIGEEIVDILDNF
HHHCCCCEEEEEHHHHCCCCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FNIGGEEHDHIKVI
HHCCCCCCCCEEEC
>Mature Secondary Structure
MIKILVSDGMEQNALNKLNEQGFVVLDKHFEKEELKDKIKDFDAIIIRSATKVDKEIIDA
CEEEEECCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHEEEEECHHHHHHHHHHC
GIKGNLKLVVRAGVGLDNVDLEYAKEKEVKVFNTPKASSVSVAELTLGHMLCISRFINTA
CCCCCEEEEEEECCCCCCCCHHHCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCC
NVTMLQGKWEKKKYNGTEIYGKTLGLIGFGRIAREVAKRANALGMNVIYYDIAGKCEEYE
CEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
EFKCCTLDYLLNNSDFISVHIPFSKDRGALLKEEEFNKMKDGVYIINCARGGVIEEEALL
HCCEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHHH
KALNNGKVTAAALDVFENEPKPKKELINHERVSITPHIGASTKEAQMRIGEEIVDILDNF
HHHCCCCEEEEEHHHHCCCCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FNIGGEEHDHIKVI
HHCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]