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The map label for this gene is moeA [C]

Identifier: 153935520

GI number: 153935520

Start: 1997985

End: 1999211

Strand: Reverse

Name: moeA [C]

Synonym: CLC_1887

Alternate gene names: 153935520

Gene position: 1999211-1997985 (Counterclockwise)

Preceding gene: 153934484

Following gene: 153935632

Centisome position: 53.16

GC content: 31.7

Gene sequence:

>1227_bases
GTGGACTTATTTAATGTTGTATCTATTAAAGAGGCCAAAAGTCTTATAGAAAAAAATTTTAATGTAAAACCGATAAAGGA
AGAAGTGGAACTTTTAAGTAGTATGGATAGGGTTATATATGAGGATATAGTTTCTCATATAAATGTACCTAATTTTAGAA
GATCTACAGTAGATGGATATGCTGTAAATTCTAAGGATGTGGCAGGTGCTAGTGAAAGTATGCCCGCTATGATGAACTAT
AGGGGAGAAGTTTTCATGGGGAAAATTCCTGAAGTTAATATCGATTTTCCTGGGGATTGTGTGTATGTTCCAACGGGAGG
TATGATTCCAGAAGGATCAGATTCTGTAATTATGGTGGAATATACAGAAAGGGTTCATGAGGATACAGTACTTATAAATA
AAGCTACAGCCTATGGTGAAAAGGTAGTAGAAATAGGTGAAGATATAGCTAAAGAGGAAGTAATAATAAAAAAAGGTGAA
AGATTAAGACCCTATGAAATAGGGGTATTATCTAGTCTTGGAATAACTAAAGTGCCTGTATGTAGGAACCCTAAGGTAGC
TATAATATCTACAGGAGATGAGATAGTAGATCCTAATAAAGAGCCAAATCTAGGTGAGGTTAGAGATATAAATTCTTATC
TTTTACAGGCTTCCATTATTGAAGATGGAGGTATTCCTATAAATTATGGAATTATAAGAGATGATTTTAATCTTCTAAAA
AATACAGTAGAAAAAGCTATAGAAGATACGGATATTGTACTTATATCCGGGGGGAGTTCTGTAGGAAAAAAAGATGTTAC
TATAGATGTTATAAATAGTTTAGGAGATCCTGGAGTTTTTGTTCATGGCATAGCAATAAAACCTGGTAAACCAACTATTA
TAGGAAATGTTAAGGATAAAATAGTTTTTGGATTACCAGGACATCCTCTATCTGCAGCTGTTGTATATAAGGTTATAGTT
AAATATTATATAGATAAAATTGCAGGTGTTAAAGAAAAGGTTTTTCCTATAGTTTGTAAGTTTAATATAAATTATCATAG
TGCAAAGGGAAGAGAAGAGTATTTACCAGTAACATTAAATTGGCAAGAGAATGAAATAATTGCATCACCTATATTTTCTA
AATCTGGACTTATAAGTGGTTTTTCTAAGGCTTATGGTTTTATAAAGATGGATAAGAATCTTGAGGGAATAAAAAAGAAT
GAGAAAGTATTTGTATATAGATTTTAG

Upstream 100 bases:

>100_bases
ATTTACAGGCAGTATTAGGTGCTATACCTCATGGAATAGAGATTCTATTAGGTGAGGCATCAGAATGTGCTAGATAGAAT
GGTTTAAGGAGGTAATATTA

Downstream 100 bases:

>100_bases
GAGGTTTTAATATGGGGCAAAATATTTATCTTTCAAATTATGAAATTGAAGAGGCATTAAAATTTTATTTTAGTAAGATA
AGCATAGAAAGACAAAATGA

Product: molybdopterin biosynthesis enzyme MoeA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MDLFNVVSIKEAKSLIEKNFNVKPIKEEVELLSSMDRVIYEDIVSHINVPNFRRSTVDGYAVNSKDVAGASESMPAMMNY
RGEVFMGKIPEVNIDFPGDCVYVPTGGMIPEGSDSVIMVEYTERVHEDTVLINKATAYGEKVVEIGEDIAKEEVIIKKGE
RLRPYEIGVLSSLGITKVPVCRNPKVAIISTGDEIVDPNKEPNLGEVRDINSYLLQASIIEDGGIPINYGIIRDDFNLLK
NTVEKAIEDTDIVLISGGSSVGKKDVTIDVINSLGDPGVFVHGIAIKPGKPTIIGNVKDKIVFGLPGHPLSAAVVYKVIV
KYYIDKIAGVKEKVFPIVCKFNINYHSAKGREEYLPVTLNWQENEIIASPIFSKSGLISGFSKAYGFIKMDKNLEGIKKN
EKVFVYRF

Sequences:

>Translated_408_residues
MDLFNVVSIKEAKSLIEKNFNVKPIKEEVELLSSMDRVIYEDIVSHINVPNFRRSTVDGYAVNSKDVAGASESMPAMMNY
RGEVFMGKIPEVNIDFPGDCVYVPTGGMIPEGSDSVIMVEYTERVHEDTVLINKATAYGEKVVEIGEDIAKEEVIIKKGE
RLRPYEIGVLSSLGITKVPVCRNPKVAIISTGDEIVDPNKEPNLGEVRDINSYLLQASIIEDGGIPINYGIIRDDFNLLK
NTVEKAIEDTDIVLISGGSSVGKKDVTIDVINSLGDPGVFVHGIAIKPGKPTIIGNVKDKIVFGLPGHPLSAAVVYKVIV
KYYIDKIAGVKEKVFPIVCKFNINYHSAKGREEYLPVTLNWQENEIIASPIFSKSGLISGFSKAYGFIKMDKNLEGIKKN
EKVFVYRF
>Mature_408_residues
MDLFNVVSIKEAKSLIEKNFNVKPIKEEVELLSSMDRVIYEDIVSHINVPNFRRSTVDGYAVNSKDVAGASESMPAMMNY
RGEVFMGKIPEVNIDFPGDCVYVPTGGMIPEGSDSVIMVEYTERVHEDTVLINKATAYGEKVVEIGEDIAKEEVIIKKGE
RLRPYEIGVLSSLGITKVPVCRNPKVAIISTGDEIVDPNKEPNLGEVRDINSYLLQASIIEDGGIPINYGIIRDDFNLLK
NTVEKAIEDTDIVLISGGSSVGKKDVTIDVINSLGDPGVFVHGIAIKPGKPTIIGNVKDKIVFGLPGHPLSAAVVYKVIV
KYYIDKIAGVKEKVFPIVCKFNINYHSAKGREEYLPVTLNWQENEIIASPIFSKSGLISGFSKAYGFIKMDKNLEGIKKN
EKVFVYRF

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=343, Percent_Identity=32.9446064139942, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI10880983, Length=343, Percent_Identity=32.9446064139942, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1787049, Length=325, Percent_Identity=33.8461538461538, Blast_Score=183, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25147659, Length=339, Percent_Identity=31.2684365781711, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=186, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136978, Length=356, Percent_Identity=27.5280898876405, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24638841, Length=356, Percent_Identity=27.5280898876405, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45025; Mature: 45025

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLFNVVSIKEAKSLIEKNFNVKPIKEEVELLSSMDRVIYEDIVSHINVPNFRRSTVDGY
CCCHHHEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
AVNSKDVAGASESMPAMMNYRGEVFMGKIPEVNIDFPGDCVYVPTGGMIPEGSDSVIMVE
EECCCCCCCCCCCCCHHHCCCCCEEECCCCEEEECCCCCEEEECCCCCCCCCCCCEEEEE
YTERVHEDTVLINKATAYGEKVVEIGEDIAKEEVIIKKGERLRPYEIGVLSSLGITKVPV
EHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEECCC
CRNPKVAIISTGDEIVDPNKEPNLGEVRDINSYLLQASIIEDGGIPINYGIIRDDFNLLK
CCCCCEEEEECCCHHCCCCCCCCCCCHHHHHHHHEEEEEECCCCCEEEEEEEECCHHHHH
NTVEKAIEDTDIVLISGGSSVGKKDVTIDVINSLGDPGVFVHGIAIKPGKPTIIGNVKDK
HHHHHHCCCCCEEEEECCCCCCCCCEEEEEHHCCCCCCEEEEEEEECCCCCEEEECCCCE
IVFGLPGHPLSAAVVYKVIVKYYIDKIAGVKEKVFPIVCKFNINYHSAKGREEYLPVTLN
EEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEECCCCCCCEEEEEEE
WQENEIIASPIFSKSGLISGFSKAYGFIKMDKNLEGIKKNEKVFVYRF
CCCCCEEECCCCCCCCCHHHHHHHCEEEEECCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MDLFNVVSIKEAKSLIEKNFNVKPIKEEVELLSSMDRVIYEDIVSHINVPNFRRSTVDGY
CCCHHHEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
AVNSKDVAGASESMPAMMNYRGEVFMGKIPEVNIDFPGDCVYVPTGGMIPEGSDSVIMVE
EECCCCCCCCCCCCCHHHCCCCCEEECCCCEEEECCCCCEEEECCCCCCCCCCCCEEEEE
YTERVHEDTVLINKATAYGEKVVEIGEDIAKEEVIIKKGERLRPYEIGVLSSLGITKVPV
EHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEECCC
CRNPKVAIISTGDEIVDPNKEPNLGEVRDINSYLLQASIIEDGGIPINYGIIRDDFNLLK
CCCCCEEEEECCCHHCCCCCCCCCCCHHHHHHHHEEEEEECCCCCEEEEEEEECCHHHHH
NTVEKAIEDTDIVLISGGSSVGKKDVTIDVINSLGDPGVFVHGIAIKPGKPTIIGNVKDK
HHHHHHCCCCCEEEEECCCCCCCCCEEEEEHHCCCCCCEEEEEEEECCCCCEEEECCCCE
IVFGLPGHPLSAAVVYKVIVKYYIDKIAGVKEKVFPIVCKFNINYHSAKGREEYLPVTLN
EEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEECCCCCCCEEEEEEE
WQENEIIASPIFSKSGLISGFSKAYGFIKMDKNLEGIKKNEKVFVYRF
CCCCCEEECCCCCCCCCHHHHHHHCEEEEECCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]