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The map label for this gene is map-2 [H]

Identifier: 153935178

GI number: 153935178

Start: 3692955

End: 3693830

Strand: Direct

Name: map-2 [H]

Synonym: CLC_3555

Alternate gene names: 153935178

Gene position: 3692955-3693830 (Clockwise)

Preceding gene: 153937720

Following gene: 153937481

Centisome position: 98.2

GC content: 33.11

Gene sequence:

>876_bases
ATGCTTAATAAATTAGGTAGAAATGATTTATGTTGGTGTGGTAGTCAAAAAAAATATAAAAAATGCCATTCTGCATTTGA
TAAAAGAATTGAACTTTATAAAACACATGGTCACATAGTTCCTCCTAGGGAAATTATAAAAAAACCAGAACAGATAGTCG
GAATACGTAAAAGTGGGAAAATTAATACCGCAGTTTTAGACTATATTGCAGACCATATCCAAGCTGGTATAACAGCAGAG
GATATTAACCAGCTTATTTATAAAAAAACTATAGAATTAGGAGGTATACCAGCACAACTTGGATTTGAAGGATTTCCCAA
GAGCGTATGTACTTCTATTAATGACCAGGTATGCCATGGAATCCCATCAGAAAACATAGTCTTAAATGATGGAGATATTA
TAAATGTTGACGTTTCAACTATTTATGAAGGATATTTTTCTGATTCTTCTAGAATGTTCTGCATTGGCCATGTAGATGAA
GATAAGAAAAACTTAGTTAATGTGGTGAAGGAATGTGTAAATTTAGGAATAAAACAAGTAAAGCCATGGGGATTTCTCGG
AGATATAGGGCAAGCAATCTATGATCATGCTTTAAAAAATGGATACTCTGTAGTAAAGGAAATTGGTGGTCATGGAATTG
GGCTAGAATTCCATGAAGAGCCTTGGGTAGGTTATACCTCAAAAAAAAATACAGGTATGCTAATGGTGCCAGGTATGATA
TTTACAATAGAACCAATGATTAATATGGGTACTGATGAAATTTTTTTAGATAAGAAAAATGGGTGGACTTATTATACAAC
TGATGGTAAGCCTTCAGCCCAATGGGAAATCATGATATTAGTAACAAATAACGGTTACGAAATATTGGCATACTAA

Upstream 100 bases:

>100_bases
ACTAATATTCAATTATATATGAAACCTAATGTATTTCCAGTACCCCAAAATGAAACTCTTAGTGATTAATAATATTATTC
AATAATGGAAGGAAAGTGAA

Downstream 100 bases:

>100_bases
CTTCATTATATAAATTTTAATGTTGCAATTAAAAATATTAATCACTATAATTTTTAATTGCAGCATTAAATTTAATATAA
ATATATTCTTTACCACTGTT

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MLNKLGRNDLCWCGSQKKYKKCHSAFDKRIELYKTHGHIVPPREIIKKPEQIVGIRKSGKINTAVLDYIADHIQAGITAE
DINQLIYKKTIELGGIPAQLGFEGFPKSVCTSINDQVCHGIPSENIVLNDGDIINVDVSTIYEGYFSDSSRMFCIGHVDE
DKKNLVNVVKECVNLGIKQVKPWGFLGDIGQAIYDHALKNGYSVVKEIGGHGIGLEFHEEPWVGYTSKKNTGMLMVPGMI
FTIEPMINMGTDEIFLDKKNGWTYYTTDGKPSAQWEIMILVTNNGYEILAY

Sequences:

>Translated_291_residues
MLNKLGRNDLCWCGSQKKYKKCHSAFDKRIELYKTHGHIVPPREIIKKPEQIVGIRKSGKINTAVLDYIADHIQAGITAE
DINQLIYKKTIELGGIPAQLGFEGFPKSVCTSINDQVCHGIPSENIVLNDGDIINVDVSTIYEGYFSDSSRMFCIGHVDE
DKKNLVNVVKECVNLGIKQVKPWGFLGDIGQAIYDHALKNGYSVVKEIGGHGIGLEFHEEPWVGYTSKKNTGMLMVPGMI
FTIEPMINMGTDEIFLDKKNGWTYYTTDGKPSAQWEIMILVTNNGYEILAY
>Mature_291_residues
MLNKLGRNDLCWCGSQKKYKKCHSAFDKRIELYKTHGHIVPPREIIKKPEQIVGIRKSGKINTAVLDYIADHIQAGITAE
DINQLIYKKTIELGGIPAQLGFEGFPKSVCTSINDQVCHGIPSENIVLNDGDIINVDVSTIYEGYFSDSSRMFCIGHVDE
DKKNLVNVVKECVNLGIKQVKPWGFLGDIGQAIYDHALKNGYSVVKEIGGHGIGLEFHEEPWVGYTSKKNTGMLMVPGMI
FTIEPMINMGTDEIFLDKKNGWTYYTTDGKPSAQWEIMILVTNNGYEILAY

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=242, Percent_Identity=41.3223140495868, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI40385867, Length=244, Percent_Identity=37.7049180327869, Blast_Score=171, Evalue=7e-43,
Organism=Escherichia coli, GI1786364, Length=246, Percent_Identity=42.2764227642276, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1788728, Length=260, Percent_Identity=28.0769230769231, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=244, Percent_Identity=41.3934426229508, Blast_Score=176, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6323273, Length=248, Percent_Identity=41.9354838709677, Blast_Score=197, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21355531, Length=242, Percent_Identity=39.2561983471074, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24583427, Length=255, Percent_Identity=37.2549019607843, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467
- InterPro:   IPR004027 [H]

Pfam domain/function: PF00557 Peptidase_M24; PF02810 SEC-C [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 32581; Mature: 32581

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKLGRNDLCWCGSQKKYKKCHSAFDKRIELYKTHGHIVPPREIIKKPEQIVGIRKSGK
CCCCCCCCCEEEECCCHHHHHHHHHHHHHEEEECCCCCCCCCHHHHCCHHHHEEECCCCC
INTAVLDYIADHIQAGITAEDINQLIYKKTIELGGIPAQLGFEGFPKSVCTSINDQVCHG
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHCCCHHHHCC
IPSENIVLNDGDIINVDVSTIYEGYFSDSSRMFCIGHVDEDKKNLVNVVKECVNLGIKQV
CCCCCEEECCCCEEEEEHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHC
KPWGFLGDIGQAIYDHALKNGYSVVKEIGGHGIGLEFHEEPWVGYTSKKNTGMLMVPGMI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCEEEECCEE
FTIEPMINMGTDEIFLDKKNGWTYYTTDGKPSAQWEIMILVTNNGYEILAY
EEEEHHHCCCCCEEEEECCCCEEEEECCCCCCCEEEEEEEEECCCEEEEEC
>Mature Secondary Structure
MLNKLGRNDLCWCGSQKKYKKCHSAFDKRIELYKTHGHIVPPREIIKKPEQIVGIRKSGK
CCCCCCCCCEEEECCCHHHHHHHHHHHHHEEEECCCCCCCCCHHHHCCHHHHEEECCCCC
INTAVLDYIADHIQAGITAEDINQLIYKKTIELGGIPAQLGFEGFPKSVCTSINDQVCHG
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHCCCHHHHCC
IPSENIVLNDGDIINVDVSTIYEGYFSDSSRMFCIGHVDEDKKNLVNVVKECVNLGIKQV
CCCCCEEECCCCEEEEEHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHC
KPWGFLGDIGQAIYDHALKNGYSVVKEIGGHGIGLEFHEEPWVGYTSKKNTGMLMVPGMI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCEEEECCEE
FTIEPMINMGTDEIFLDKKNGWTYYTTDGKPSAQWEIMILVTNNGYEILAY
EEEEHHHCCCCCEEEEECCCCEEEEECCCCCCCEEEEEEEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]