Click here to switch to the map view.

The map label for this gene is hgdC-2 [H]

Identifier: 153934974

GI number: 153934974

Start: 2270092

End: 2270865

Strand: Reverse

Name: hgdC-2 [H]

Synonym: CLC_2135

Alternate gene names: 153934974

Gene position: 2270865-2270092 (Counterclockwise)

Preceding gene: 153937678

Following gene: 153936179

Centisome position: 60.39

GC content: 34.37

Gene sequence:

>774_bases
ATGTACACAATGGGATTAGACATAGGATCTACTACTTCTAAGGGTGTTATTATAAAAGATGGAAAGGAAATAGTTGCTAG
TGTTTTAGTACCTGTTGGAACTGGAACCAGTGGACCTCTAAAACTAATAAAAGAATTAAAAGAAAAATCCAATTTAACAG
AAAAGGATATAGAAAAAACCGTAGTTACAGGCTATGGTAGAATCCAATATAAAGATGCTGACAAACAAATAAGTGAATTA
AGTTGCCATGCTAAAGGAGTAGCATTTTTAATACCAGGTGCAAGGACTATAATAGATATTGGTGGACAAGATGCTAAGGC
TATGAAGTTGAACGCTAAGGGTAAACTTATAAATTTTATAATGAATGATAAATGTGCCGCTGGTACAGGAAGATTTTTAG
ATGTTATGGCAGGGGTTCTTGAAACGGATGTTTCTAAGTTAGGAGAAATATCAAAAAAATCTACAAAGGAAGTTTCAATT
AGTAGTACCTGTACTGTGTTTGCTGAATCAGAGGTAATTTCTCATCTATCAGCAAATGCAAAAAAAGAAGATATTGTAGC
AGGAATTCATACCTCTGTAGTAAGACGTGTATCAACTCTTGCTATGAGAGTAGGTATTGAAGATCAAGTAGTTATGGTAG
GTGGAGTAGCTAGAAATAAAGGAATAGTTAAAGCTATGGAAAAGGAACTAGGGCATGATATAAAAGTGCCAGAATTAGCA
CAATTAACAGGAGCATTAGGTGCAGCTATATATGCCTTTGAGGAAACAAAATAG

Upstream 100 bases:

>100_bases
GTAGAAGATCAAGATAATATATAAAAAAAGATGGTATATCAATTGTAGAGTCTGAATAACAATTACTATACTAAAATATT
TTAAAAAGGGGGATACACAT

Downstream 100 bases:

>100_bases
ATTTAATTGAGAGCGCAAAGATAAAAAGTACATTCATAAACTAATTCATTTCACTAAGAAGTTCTAAATATGACTACATT
AAAAATTTTCTACTTAGGAG

Product: 2-hydroxyglutaryl-CoA dehydratase component A

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MYTMGLDIGSTTSKGVIIKDGKEIVASVLVPVGTGTSGPLKLIKELKEKSNLTEKDIEKTVVTGYGRIQYKDADKQISEL
SCHAKGVAFLIPGARTIIDIGGQDAKAMKLNAKGKLINFIMNDKCAAGTGRFLDVMAGVLETDVSKLGEISKKSTKEVSI
SSTCTVFAESEVISHLSANAKKEDIVAGIHTSVVRRVSTLAMRVGIEDQVVMVGGVARNKGIVKAMEKELGHDIKVPELA
QLTGALGAAIYAFEETK

Sequences:

>Translated_257_residues
MYTMGLDIGSTTSKGVIIKDGKEIVASVLVPVGTGTSGPLKLIKELKEKSNLTEKDIEKTVVTGYGRIQYKDADKQISEL
SCHAKGVAFLIPGARTIIDIGGQDAKAMKLNAKGKLINFIMNDKCAAGTGRFLDVMAGVLETDVSKLGEISKKSTKEVSI
SSTCTVFAESEVISHLSANAKKEDIVAGIHTSVVRRVSTLAMRVGIEDQVVMVGGVARNKGIVKAMEKELGHDIKVPELA
QLTGALGAAIYAFEETK
>Mature_257_residues
MYTMGLDIGSTTSKGVIIKDGKEIVASVLVPVGTGTSGPLKLIKELKEKSNLTEKDIEKTVVTGYGRIQYKDADKQISEL
SCHAKGVAFLIPGARTIIDIGGQDAKAMKLNAKGKLINFIMNDKCAAGTGRFLDVMAGVLETDVSKLGEISKKSTKEVSI
SSTCTVFAESEVISHLSANAKKEDIVAGIHTSVVRRVSTLAMRVGIEDQVVMVGGVARNKGIVKAMEKELGHDIKVPELA
QLTGALGAAIYAFEETK

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=252, Percent_Identity=40.4761904761905, Blast_Score=189, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 27267; Mature: 27267

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTMGLDIGSTTSKGVIIKDGKEIVASVLVPVGTGTSGPLKLIKELKEKSNLTEKDIEKT
CEEEEECCCCCCCCCEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
VVTGYGRIQYKDADKQISELSCHAKGVAFLIPGARTIIDIGGQDAKAMKLNAKGKLINFI
HHCCCCEEEEECHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCEEEEECCCCCEEEEE
MNDKCAAGTGRFLDVMAGVLETDVSKLGEISKKSTKEVSISSTCTVFAESEVISHLSANA
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEHHHHHHHHHCCC
KKEDIVAGIHTSVVRRVSTLAMRVGIEDQVVMVGGVARNKGIVKAMEKELGHDIKVPELA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHH
QLTGALGAAIYAFEETK
HHHHHHHHHHEEEECCC
>Mature Secondary Structure
MYTMGLDIGSTTSKGVIIKDGKEIVASVLVPVGTGTSGPLKLIKELKEKSNLTEKDIEKT
CEEEEECCCCCCCCCEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
VVTGYGRIQYKDADKQISELSCHAKGVAFLIPGARTIIDIGGQDAKAMKLNAKGKLINFI
HHCCCCEEEEECHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCEEEEECCCCCEEEEE
MNDKCAAGTGRFLDVMAGVLETDVSKLGEISKKSTKEVSISSTCTVFAESEVISHLSANA
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEHHHHHHHHHCCC
KKEDIVAGIHTSVVRRVSTLAMRVGIEDQVVMVGGVARNKGIVKAMEKELGHDIKVPELA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHH
QLTGALGAAIYAFEETK
HHHHHHHHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]