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The map label for this gene is ilvA [H]

Identifier: 153934948

GI number: 153934948

Start: 3603138

End: 3604355

Strand: Reverse

Name: ilvA [H]

Synonym: CLC_3451

Alternate gene names: 153934948

Gene position: 3604355-3603138 (Counterclockwise)

Preceding gene: 153935851

Following gene: 153937063

Centisome position: 95.85

GC content: 32.43

Gene sequence:

>1218_bases
ATGGAGTTAAACTTAGATACAATAAAAAAAGCTCAAAATAACATAAAAACAGTAGTTAGAAAAACACCTTTGTTTTATTC
AAGCACTTTTTCTAGAAAAACAGGATATGAAGTATATTTAAAATGTGAAAATAAACAAAAGACTGGAGCTTTTAAATTAA
GAGGCGCATATAACAAGATAGTTTCATTAACTGAGGAAGAAAGAAAAAAGGGGGTCATTGCATCTTCAGCAGGAAACCAT
GCTCAAGGTGTTGCTTATGCAGCTACCGCCTTTGGAATAAAATCTACTATAGCTATGCCTAAAACTGCTCCTCAAGCTAA
GGTTATGGCAACAAAAGGATATGGAGCAGAAGTTGTTCAGCACGGGGAAGTTTATGATGAATGTTATGAAAAAGCATTAG
AAATACAAAAGGCTACAGGAGCTACTTTTGTACATCCTTTTAATGATATACACGTTATGGCGGGTCAAGGCACAATAGCA
TTAGAAATATTAGAAGAAATAGAAGATATAGATGCTATAATAGTTCCAATAGGAGGAGGAGGGCTAATATCAGGAATAGC
TGTAGCAGCTAAATCCATAAAGCGAGATATAAAAATTATAGGAGTTCAATCAGCTATTATAGCCTCTACAAAGGCGTCAT
TAGAAAAAAATGAAATTGTAACTTTGCCAGGAGCTAAGTCTTTAGCAGATGGTATTTCAGTAAAGACTCCAGGGGATATT
GCTTTTAAATATATTAGAGAATATGTAGATGAAGTAGTTACAGTTACAGAAGATGAAATAGCTTATGGAATTTTCGAACT
TATTGAGAAGACGAAAGTTATTGCAGAAGGTGCGGGAGCATCAACTGTTGCAGCTTTATTAGCTAATAAGATTAATATTA
AAGGTAAAAAGGTTGTAGCTCTAATAAGTGGCGGTAATATAGATATAGCTATGATATCTAAAATAATAGATAGACAGCTT
ATAATGCTTAAGAGAAGAATAAGATTTAAAGTAGAATTACAGGATAAAATAGGAGAATTCGAAGATGTTATTTCGAATAT
TGTTTCTACAGGAGCTAATATAGTTAAGGCTAGACAGGACACTAATTGGAGTGAAAAAGGACTAGAATATGCAAATGTAA
TATTTGAAGTAGAAGTTCAAAGTAAAGAACAAGGAGATAAGTTATTGAAACAACTTAGCGAAAAAGGGTATAATATACAA
ACAAATATATGTATGTAA

Upstream 100 bases:

>100_bases
GTATTAAAAGTTTATTGGGTATAGGTTAATAGATTGAATAAAAATATTATATGGTTTATTATAAAAATATAATTTAGAAT
GGGATGGGAGATAGATGATT

Downstream 100 bases:

>100_bases
TAAATTTAGTAAAATAGGAGGTAAATAGATGAAGGTTTACAATACTTTAACTAATAAAAAAGAAGAGTTTCTTACGTTAG
TACCAGGAGAAGTTAAAATG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYNKIVSLTEEERKKGVIASSAGNH
AQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEVVQHGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGTIA
LEILEEIEDIDAIIVPIGGGGLISGIAVAAKSIKRDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPGDI
AFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKVVALISGGNIDIAMISKIIDRQL
IMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKARQDTNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYNIQ
TNICM

Sequences:

>Translated_405_residues
MELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYNKIVSLTEEERKKGVIASSAGNH
AQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEVVQHGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGTIA
LEILEEIEDIDAIIVPIGGGGLISGIAVAAKSIKRDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPGDI
AFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKVVALISGGNIDIAMISKIIDRQL
IMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKARQDTNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYNIQ
TNICM
>Mature_405_residues
MELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYNKIVSLTEEERKKGVIASSAGNH
AQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEVVQHGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGTIA
LEILEEIEDIDAIIVPIGGGGLISGIAVAAKSIKRDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPGDI
AFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKVVALISGGNIDIAMISKIIDRQL
IMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKARQDTNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYNIQ
TNICM

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=310, Percent_Identity=36.7741935483871, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI33469958, Length=321, Percent_Identity=30.2180685358255, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI19923959, Length=327, Percent_Identity=27.5229357798165, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1789505, Length=317, Percent_Identity=47.3186119873817, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI1790207, Length=383, Percent_Identity=33.9425587467363, Blast_Score=206, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71991565, Length=384, Percent_Identity=37.7604166666667, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17537387, Length=393, Percent_Identity=34.8600508905852, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17508781, Length=311, Percent_Identity=30.5466237942122, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322631, Length=306, Percent_Identity=39.2156862745098, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320930, Length=399, Percent_Identity=33.0827067669173, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319788, Length=305, Percent_Identity=24.2622950819672, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21355833, Length=350, Percent_Identity=39.7142857142857, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24645328, Length=266, Percent_Identity=38.3458646616541, Blast_Score=141, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43996; Mature: 43996

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYNKI
CCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHHHH
VSLTEEERKKGVIASSAGNHAQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEVVQ
HHCCHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHH
HGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGTIALEILEEIEDIDAIIVPIGGG
CCHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCC
GLISGIAVAAKSIKRDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPGDI
HHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHCCCCCCEEECCCCHHHHCCCCCCCCHHH
AFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKVVA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEE
LISGGNIDIAMISKIIDRQLIMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKARQD
EEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCHHHHHHHHHHHCCCCEEEECCC
TNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYNIQTNICM
CCHHHHCCEEEEEEEEEEECCHHHHHHHHHHHHHCCCEEEEECCC
>Mature Secondary Structure
MELNLDTIKKAQNNIKTVVRKTPLFYSSTFSRKTGYEVYLKCENKQKTGAFKLRGAYNKI
CCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCCCCEEECCHHHHH
VSLTEEERKKGVIASSAGNHAQGVAYAATAFGIKSTIAMPKTAPQAKVMATKGYGAEVVQ
HHCCHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHH
HGEVYDECYEKALEIQKATGATFVHPFNDIHVMAGQGTIALEILEEIEDIDAIIVPIGGG
CCHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCC
GLISGIAVAAKSIKRDIKIIGVQSAIIASTKASLEKNEIVTLPGAKSLADGISVKTPGDI
HHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHCCCCCCEEECCCCHHHHCCCCCCCCHHH
AFKYIREYVDEVVTVTEDEIAYGIFELIEKTKVIAEGAGASTVAALLANKINIKGKKVVA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEE
LISGGNIDIAMISKIIDRQLIMLKRRIRFKVELQDKIGEFEDVISNIVSTGANIVKARQD
EEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCHHHHHHHHHHHCCCCEEEECCC
TNWSEKGLEYANVIFEVEVQSKEQGDKLLKQLSEKGYNIQTNICM
CCHHHHCCEEEEEEEEEEECCHHHHHHHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA