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The map label for this gene is panC

Identifier: 153934894

GI number: 153934894

Start: 490798

End: 491643

Strand: Reverse

Name: panC

Synonym: CLC_0490

Alternate gene names: 153934894

Gene position: 491643-490798 (Counterclockwise)

Preceding gene: 153937429

Following gene: 153935836

Centisome position: 13.07

GC content: 26.95

Gene sequence:

>846_bases
ATGAATATAGTTAATACAATAAAAGATGTTAGATTAATCATAAAAAAATGGAAAGATGAAAATTTATCTATAGGCTATGT
ACCTACTATGGGATATTTGCATGAAGGTCATACCTCTCTTATAAAAAAAGCTAGAGAAGAAAATGATAAAGTTATAGTTT
CAATTTTTGTAAATCCAATTCAATTTGGACCAAAGGAAGACTACTCTACTTACCCTAGAGATTTAGTTAAAGATTCATCA
TTATGTGAAAAATTTGGAGTAGATTTAATCTTTAATCCTGAAACCTCAGAAATGTATCCTAATAAAATATATAGTCATAT
AAATGTGGACATACTTACAGAAAATTTATGTGGAGAAAAAAGACCTGGTCATTTTCAGGGGGTATGCACAGTTTTAACAA
AATTTTTTAATATACTAAACCCTACAAAGGCTTATTTGGGTGAAAAAGATGCTCAACAATTAGCTGTAGTAAAAAAGATG
GTAGAGGATTTAAATTTTCCTATAGAAATAATAGGTTGTCCTATAATTAGAGAAGAAGATGGTTTAGCTAAAAGCTCAAG
AAATGCTTATTTAAATAAGCAGGAAAGAAAATCTGCCTTAATATTAAATAAAAGTTTAAAAGAAGCTCTAAAGGCACTAG
AATCTGGAGAAAAAAATTTAAATAATATAAAAGATATTATAGTAAGTAAGCTAAATAAAGAGCCTCTAGCTAAAATAGAT
TATGTAAGTATAGTAGATAGCATCACTTTACAATCTGTGGAAAAAATACAATCTTCAATATTAGTAGCTATAGCAGTTTA
TATAGGTAAAACAAGACTTATAGACAATTTTACTTTTAAACTATAA

Upstream 100 bases:

>100_bases
ACATGCTTTTAAAATAGATGATGATGTAATAAATAAATTATATTAGTTTTTAAATAACCAGCAGAGGGAGGGTAAAGGCT
GATTTTCTCAGCTGAACAAT

Downstream 100 bases:

>100_bases
CTACTCTTTACTCCCTCTTTTAAGGTGATGCAAATATTAGAGCGAGTAGTCATCGGATAAATATTTTTTGAACGCTAATC
TATTATTAATAATAAATACG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MNIVNTIKDVRLIIKKWKDENLSIGYVPTMGYLHEGHTSLIKKAREENDKVIVSIFVNPIQFGPKEDYSTYPRDLVKDSS
LCEKFGVDLIFNPETSEMYPNKIYSHINVDILTENLCGEKRPGHFQGVCTVLTKFFNILNPTKAYLGEKDAQQLAVVKKM
VEDLNFPIEIIGCPIIREEDGLAKSSRNAYLNKQERKSALILNKSLKEALKALESGEKNLNNIKDIIVSKLNKEPLAKID
YVSIVDSITLQSVEKIQSSILVAIAVYIGKTRLIDNFTFKL

Sequences:

>Translated_281_residues
MNIVNTIKDVRLIIKKWKDENLSIGYVPTMGYLHEGHTSLIKKAREENDKVIVSIFVNPIQFGPKEDYSTYPRDLVKDSS
LCEKFGVDLIFNPETSEMYPNKIYSHINVDILTENLCGEKRPGHFQGVCTVLTKFFNILNPTKAYLGEKDAQQLAVVKKM
VEDLNFPIEIIGCPIIREEDGLAKSSRNAYLNKQERKSALILNKSLKEALKALESGEKNLNNIKDIIVSKLNKEPLAKID
YVSIVDSITLQSVEKIQSSILVAIAVYIGKTRLIDNFTFKL
>Mature_281_residues
MNIVNTIKDVRLIIKKWKDENLSIGYVPTMGYLHEGHTSLIKKAREENDKVIVSIFVNPIQFGPKEDYSTYPRDLVKDSS
LCEKFGVDLIFNPETSEMYPNKIYSHINVDILTENLCGEKRPGHFQGVCTVLTKFFNILNPTKAYLGEKDAQQLAVVKKM
VEDLNFPIEIIGCPIIREEDGLAKSSRNAYLNKQERKSALILNKSLKEALKALESGEKNLNNIKDIIVSKLNKEPLAKID
YVSIVDSITLQSVEKIQSSILVAIAVYIGKTRLIDNFTFKL

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=283, Percent_Identity=43.1095406360424, Blast_Score=234, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6322046, Length=311, Percent_Identity=37.2990353697749, Blast_Score=178, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_CLOB1 (A7FR59)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001382808.1
- ProteinModelPortal:   A7FR59
- SMR:   A7FR59
- STRING:   A7FR59
- GeneID:   5398079
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_0457
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   CBOT441770:CLB_0457-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31823; Mature: 31823

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVNTIKDVRLIIKKWKDENLSIGYVPTMGYLHEGHTSLIKKAREENDKVIVSIFVNPI
CCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCHHHHHHHHHHCCCCEEEEEEECHH
QFGPKEDYSTYPRDLVKDSSLCEKFGVDLIFNPETSEMYPNKIYSHINVDILTENLCGEK
CCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCEEEEHHHCCCC
RPGHFQGVCTVLTKFFNILNPTKAYLGEKDAQQLAVVKKMVEDLNFPIEIIGCPIIREED
CCCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCEEECCC
GLAKSSRNAYLNKQERKSALILNKSLKEALKALESGEKNLNNIKDIIVSKLNKEPLAKID
CCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
YVSIVDSITLQSVEKIQSSILVAIAVYIGKTRLIDNFTFKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC
>Mature Secondary Structure
MNIVNTIKDVRLIIKKWKDENLSIGYVPTMGYLHEGHTSLIKKAREENDKVIVSIFVNPI
CCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHCCHHHHHHHHHHCCCCEEEEEEECHH
QFGPKEDYSTYPRDLVKDSSLCEKFGVDLIFNPETSEMYPNKIYSHINVDILTENLCGEK
CCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCEEEEHHHCCCC
RPGHFQGVCTVLTKFFNILNPTKAYLGEKDAQQLAVVKKMVEDLNFPIEIIGCPIIREED
CCCHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCEEECCC
GLAKSSRNAYLNKQERKSALILNKSLKEALKALESGEKNLNNIKDIIVSKLNKEPLAKID
CCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
YVSIVDSITLQSVEKIQSSILVAIAVYIGKTRLIDNFTFKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA