Click here to switch to the map view.

The map label for this gene is aroK

Identifier: 153934761

GI number: 153934761

Start: 1951427

End: 1951939

Strand: Reverse

Name: aroK

Synonym: CLC_1843

Alternate gene names: 153934761

Gene position: 1951939-1951427 (Counterclockwise)

Preceding gene: 153935723

Following gene: 153937207

Centisome position: 51.91

GC content: 25.54

Gene sequence:

>513_bases
TTGGAGAATATTGTTTTAATAGGCATGCCTTTAAGTGGAAAAAGCACTTTAGGTAGAGAGCTTAGTAAGATTTTAAAATA
TGATCTTATAGATACGGATACACTTATAGAAGAGATGGAAGATAAAAGTATAAAGGAAATATTTAAAATATATGGGGAAG
ATTACTTTAGAGAAAAGGAATTAAAAATTATAAATAAATTAAAAAAAGAAAGTAATAAAGTTATATCTACAGGTGGAGGC
CTTCCCATATATAATAAAAATATATATGAACTAAAAAAGATTGGTTTTACAGTATATCTTAAGGTACCATTGGAAGAGTT
AATTAAAAGAATGGTAAAGAAGGAATATGATACAAGACCTCTTTTAAAAAACAATGATACAAAATTTTTAGAGGAAATGT
ATAAAAATAGGATAGAGATTTATGAAAAGGCTCATACTATAATATGCAATACTAACTACAAAGAAAGCTTAATTACAATT
GTAAGAGCCTATAAAAAATGGAAGGGTATATAA

Upstream 100 bases:

>100_bases
TAAATCTGAGATTTGTTTAATATCATATAATTATAATAAACTATTGTTACATAAGTATTTTGATTAAAAATATAATTTTT
TAGTAAAGATGGTGGTGAGT

Downstream 100 bases:

>100_bases
AAGAAAAAAATAACAATATATGTATTTTATGAAAAAATATTTGCAAATAACCATAATATTATTTGCAAATAAAGTGAAGT
TTTGATAAAATATCATTGTT

Product: shikimate kinase

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MENIVLIGMPLSGKSTLGRELSKILKYDLIDTDTLIEEMEDKSIKEIFKIYGEDYFREKELKIINKLKKESNKVISTGGG
LPIYNKNIYELKKIGFTVYLKVPLEELIKRMVKKEYDTRPLLKNNDTKFLEEMYKNRIEIYEKAHTIICNTNYKESLITI
VRAYKKWKGI

Sequences:

>Translated_170_residues
MENIVLIGMPLSGKSTLGRELSKILKYDLIDTDTLIEEMEDKSIKEIFKIYGEDYFREKELKIINKLKKESNKVISTGGG
LPIYNKNIYELKKIGFTVYLKVPLEELIKRMVKKEYDTRPLLKNNDTKFLEEMYKNRIEIYEKAHTIICNTNYKESLITI
VRAYKKWKGI
>Mature_170_residues
MENIVLIGMPLSGKSTLGRELSKILKYDLIDTDTLIEEMEDKSIKEIFKIYGEDYFREKELKIINKLKKESNKVISTGGG
LPIYNKNIYELKKIGFTVYLKVPLEELIKRMVKKEYDTRPLLKNNDTKFLEEMYKNRIEIYEKAHTIICNTNYKESLITI
VRAYKKWKGI

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family

Homologues:

Organism=Homo sapiens, GI153792148, Length=143, Percent_Identity=33.5664335664336, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI87082255, Length=157, Percent_Identity=31.2101910828025, Blast_Score=78, Evalue=3e-16,
Organism=Escherichia coli, GI1786587, Length=165, Percent_Identity=29.6969696969697, Blast_Score=70, Evalue=7e-14,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): AROK_CLOB1 (A7FUV4)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001384157.1
- ProteinModelPortal:   A7FUV4
- SMR:   A7FUV4
- STRING:   A7FUV4
- GeneID:   5394770
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_1836
- eggNOG:   COG0703
- HOGENOM:   HBG335815
- OMA:   MIISERV
- ProtClustDB:   CLSK912193
- BioCyc:   CBOT441770:CLB_1836-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00109
- InterPro:   IPR000623
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 20068; Mature: 20068

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 33-33 BINDING 57-57 BINDING 79-79 BINDING 119-119 BINDING 137-137

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENIVLIGMPLSGKSTLGRELSKILKYDLIDTDTLIEEMEDKSIKEIFKIYGEDYFREKE
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCHHHHHHHH
LKIINKLKKESNKVISTGGGLPIYNKNIYELKKIGFTVYLKVPLEELIKRMVKKEYDTRP
HHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCCC
LLKNNDTKFLEEMYKNRIEIYEKAHTIICNTNYKESLITIVRAYKKWKGI
CCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MENIVLIGMPLSGKSTLGRELSKILKYDLIDTDTLIEEMEDKSIKEIFKIYGEDYFREKE
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCHHHHHHHH
LKIINKLKKESNKVISTGGGLPIYNKNIYELKKIGFTVYLKVPLEELIKRMVKKEYDTRP
HHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCCC
LLKNNDTKFLEEMYKNRIEIYEKAHTIICNTNYKESLITIVRAYKKWKGI
CCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA