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The map label for this gene is murC

Identifier: 153934724

GI number: 153934724

Start: 3667225

End: 3668601

Strand: Direct

Name: murC

Synonym: CLC_3526

Alternate gene names: 153934724

Gene position: 3667225-3668601 (Clockwise)

Preceding gene: 153934529

Following gene: 153937220

Centisome position: 97.52

GC content: 28.03

Gene sequence:

>1377_bases
GTGTCATTTGATTTTATAAAAGATAAAAATAAACATATACATTTTATAGGTATAGGTGGAATAAGTATGAGTGGGTTAGC
GGAAATACTACTTTATAATAACTTTTCCATATCTGGCTCAGATATGAATTCATCACCTATAACTGAAAAATTAAAAGATA
AAGGTGCAAAAATATATATTGGTCATAAAAAAGAAAATGTAAAAGATGCTGATTTAATAGTATATACTGCTGCCATTGCT
TCTGATAACCCTGAAATAACAAAAGCCAAAGAAAAAAATATTAAATTAATGGATAGAGCAGACTTTTTAGGTAACTTAAT
GAAAGGCTACAAATATAATATTGCCATATCTGGAACTCATGGTAAAACAACTACAACTTCCATGTTATCTCATGTAGCAT
TAAAGGCTAATGTTGATCCAACTATTTTAGTAGGTGGTAATTTAGATATAATAAATGGTAATGTAAGAGTAGGTGAAAGT
GACTTCTTTATAACAGAAGCTTGTGAGTATAAATCCTCATTCCTTAAATTTTTCCCATATATCGGGGTAATTTTAAACAT
AGATGCAGATCATTTAGATTATTATAAAGATTTAGATGATATAAAAAATGCTTTTTCAAAATTTATTAAATTAATTCCTA
AAGATGGCTATCTTGTAGCTTATGGAGAAGATAAAAATATACAAAGCATTATAAAGGAGGCTAGCTGTAACGTTATAACC
TATGGTATAAACTCAGGAGATATACAAGCTCATAATATAGAATATGATGAAAAAGCTTGCGGAAATTTTGATGTAGTTAA
AGATAACCAAAAATTATTTTCAGTAAAACTAAATGTTCCTGGAAAACACAACATACTAAATTCTCTAGCTAGTATATGTA
TTGGATTGGCTTCAAATATGAAAGATAAAGATATAATTGAAGGTATTGAAAGCTTTTTTGGAACCCATAGAAGATTTGAA
CTAAAAGGCTGTAAGAATAATATTACTGTAATAGATGATTATGCTCATCATCCTACAGAAATATCTGCTACATTAGATGC
AGCTAAAAAATATCCTCACAATAAATTGTTCTGTGTTTTTCAACCACACACTTATTCCAGAACATTAACCTTATTTGATG
ACTTTACTAAATGCTTTGACAATGCAGACGAAATTATTTTAGCTGATATATATGCTGCTAGGGAAAAGGACACTGGTATT
ATAAGTTCAGATATGCTGGGAGATAAACTAAGAGATCGAGGATTAAAATGTACTAATTTTCATAAATTTGATGATATAAA
AAATTATCTTATAGAAAATACTAAAGATGGTGACTTAATATTAACTGTTGGAGCTGGAGATATATATAAAGTAGGAGAAA
TGTATATTAATTTATAA

Upstream 100 bases:

>100_bases
AATTAAAATTTAAAATAAAACATTCTACTTTAATGTGTTTTTTTGTTTTGTTTTTGTATATAATTATCTAATATAACTAA
TATTTGAGGAGTTGATCTGG

Downstream 100 bases:

>100_bases
AATTATGCTTAAAACATCTTCCTTTGGGAAATACTATTTTTAAAATCCATCGGGAGGTGTTTTTATGAGAAACTTTTTAA
TATCTTCTATAGTAAATTTA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSFDFIKDKNKHIHFIGIGGISMSGLAEILLYNNFSISGSDMNSSPITEKLKDKGAKIYIGHKKENVKDADLIVYTAAIA
SDNPEITKAKEKNIKLMDRADFLGNLMKGYKYNIAISGTHGKTTTTSMLSHVALKANVDPTILVGGNLDIINGNVRVGES
DFFITEACEYKSSFLKFFPYIGVILNIDADHLDYYKDLDDIKNAFSKFIKLIPKDGYLVAYGEDKNIQSIIKEASCNVIT
YGINSGDIQAHNIEYDEKACGNFDVVKDNQKLFSVKLNVPGKHNILNSLASICIGLASNMKDKDIIEGIESFFGTHRRFE
LKGCKNNITVIDDYAHHPTEISATLDAAKKYPHNKLFCVFQPHTYSRTLTLFDDFTKCFDNADEIILADIYAAREKDTGI
ISSDMLGDKLRDRGLKCTNFHKFDDIKNYLIENTKDGDLILTVGAGDIYKVGEMYINL

Sequences:

>Translated_458_residues
MSFDFIKDKNKHIHFIGIGGISMSGLAEILLYNNFSISGSDMNSSPITEKLKDKGAKIYIGHKKENVKDADLIVYTAAIA
SDNPEITKAKEKNIKLMDRADFLGNLMKGYKYNIAISGTHGKTTTTSMLSHVALKANVDPTILVGGNLDIINGNVRVGES
DFFITEACEYKSSFLKFFPYIGVILNIDADHLDYYKDLDDIKNAFSKFIKLIPKDGYLVAYGEDKNIQSIIKEASCNVIT
YGINSGDIQAHNIEYDEKACGNFDVVKDNQKLFSVKLNVPGKHNILNSLASICIGLASNMKDKDIIEGIESFFGTHRRFE
LKGCKNNITVIDDYAHHPTEISATLDAAKKYPHNKLFCVFQPHTYSRTLTLFDDFTKCFDNADEIILADIYAAREKDTGI
ISSDMLGDKLRDRGLKCTNFHKFDDIKNYLIENTKDGDLILTVGAGDIYKVGEMYINL
>Mature_457_residues
SFDFIKDKNKHIHFIGIGGISMSGLAEILLYNNFSISGSDMNSSPITEKLKDKGAKIYIGHKKENVKDADLIVYTAAIAS
DNPEITKAKEKNIKLMDRADFLGNLMKGYKYNIAISGTHGKTTTTSMLSHVALKANVDPTILVGGNLDIINGNVRVGESD
FFITEACEYKSSFLKFFPYIGVILNIDADHLDYYKDLDDIKNAFSKFIKLIPKDGYLVAYGEDKNIQSIIKEASCNVITY
GINSGDIQAHNIEYDEKACGNFDVVKDNQKLFSVKLNVPGKHNILNSLASICIGLASNMKDKDIIEGIESFFGTHRRFEL
KGCKNNITVIDDYAHHPTEISATLDAAKKYPHNKLFCVFQPHTYSRTLTLFDDFTKCFDNADEIILADIYAAREKDTGII
SSDMLGDKLRDRGLKCTNFHKFDDIKNYLIENTKDGDLILTVGAGDIYKVGEMYINL

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=458, Percent_Identity=36.0262008733624, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1790680, Length=387, Percent_Identity=29.1989664082687, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1786276, Length=331, Percent_Identity=22.0543806646526, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_CLOB1 (A7FPH5)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001385863.1
- ProteinModelPortal:   A7FPH5
- SMR:   A7FPH5
- STRING:   A7FPH5
- GeneID:   5397565
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_3629
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   CBOT441770:CLB_3629-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51147; Mature: 51016

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDFIKDKNKHIHFIGIGGISMSGLAEILLYNNFSISGSDMNSSPITEKLKDKGAKIYI
CCCCCCCCCCCEEEEEEECCCCHHHHEEEEEEECCEECCCCCCCCCCHHHHHCCCCEEEE
GHKKENVKDADLIVYTAAIASDNPEITKAKEKNIKLMDRADFLGNLMKGYKYNIAISGTH
ECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHCCEEEEEEEECCC
GKTTTTSMLSHVALKANVDPTILVGGNLDIINGNVRVGESDFFITEACEYKSSFLKFFPY
CCCHHHHHHHHHEEEECCCCEEEECCCEEEEECCEEECCCCEEEEHHHHHHHHHHHHHCC
IGVILNIDADHLDYYKDLDDIKNAFSKFIKLIPKDGYLVAYGEDKNIQSIIKEASCNVIT
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCEEE
YGINSGDIQAHNIEYDEKACGNFDVVKDNQKLFSVKLNVPGKHNILNSLASICIGLASNM
EECCCCCEEEECCCCCHHCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCC
KDKDIIEGIESFFGTHRRFELKGCKNNITVIDDYAHHPTEISATLDAAKKYPHNKLFCVF
CHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEE
QPHTYSRTLTLFDDFTKCFDNADEIILADIYAAREKDTGIISSDMLGDKLRDRGLKCTNF
CCCCCCEEEHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCEEHHHHHHHHHHCCCCCCCC
HKFDDIKNYLIENTKDGDLILTVGAGDIYKVGEMYINL
CCHHHHHHHHHCCCCCCCEEEEECCCCCEEECEEEECC
>Mature Secondary Structure 
SFDFIKDKNKHIHFIGIGGISMSGLAEILLYNNFSISGSDMNSSPITEKLKDKGAKIYI
CCCCCCCCCCEEEEEEECCCCHHHHEEEEEEECCEECCCCCCCCCCHHHHHCCCCEEEE
GHKKENVKDADLIVYTAAIASDNPEITKAKEKNIKLMDRADFLGNLMKGYKYNIAISGTH
ECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHCCEEEEEEEECCC
GKTTTTSMLSHVALKANVDPTILVGGNLDIINGNVRVGESDFFITEACEYKSSFLKFFPY
CCCHHHHHHHHHEEEECCCCEEEECCCEEEEECCEEECCCCEEEEHHHHHHHHHHHHHCC
IGVILNIDADHLDYYKDLDDIKNAFSKFIKLIPKDGYLVAYGEDKNIQSIIKEASCNVIT
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCEEE
YGINSGDIQAHNIEYDEKACGNFDVVKDNQKLFSVKLNVPGKHNILNSLASICIGLASNM
EECCCCCEEEECCCCCHHCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCC
KDKDIIEGIESFFGTHRRFELKGCKNNITVIDDYAHHPTEISATLDAAKKYPHNKLFCVF
CHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEE
QPHTYSRTLTLFDDFTKCFDNADEIILADIYAAREKDTGIISSDMLGDKLRDRGLKCTNF
CCCCCCEEEHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCEEHHHHHHHHHHCCCCCCCC
HKFDDIKNYLIENTKDGDLILTVGAGDIYKVGEMYINL
CCHHHHHHHHHCCCCCCCEEEEECCCCCEEECEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA