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The map label for this gene is ndhS [H]

Identifier: 153934497

GI number: 153934497

Start: 301718

End: 302191

Strand: Direct

Name: ndhS [H]

Synonym: CLC_0319

Alternate gene names: 153934497

Gene position: 301718-302191 (Clockwise)

Preceding gene: 153937386

Following gene: 153936251

Centisome position: 8.02

GC content: 35.02

Gene sequence:

>474_bases
ATGATATCATATATAGAAGAGACAAAAATAGAACTAGACATAAATGGCGAAAAGAGAAGCGTGATTGTAAGACCGGCAGA
TACACTTCTTAGAGTACTTAGAGAAAAATTGGGATTAACCGGAGGAAAGCCTGGTTGTGAAAATGGAGATTGCGGTGCGT
GTACTGTACTTTTAGATGGAATACCAATTAAATCATGTATTATATTGGCGGTTGAGGCCGTTGGACATAAATTAATCACC
ATTGAGGGGTTGAAGGAAGAACCTATTCAAAAAGCTTTTATTGAAAAAATGGGCTTTCAATGTGGGTATTGCACTCCCGG
TTTCATAATGAACTGCTATGGACTTATAAAAAACAACCCTTATGCAGATGATGAAACTATTGAAAAATGGCTACAGTCTA
ATATTTGTAGATGTACCGGATATGAAGAAATCAGAGATGCTGTAAAATCAGTATTATTTTCAAACAAAAAATAA

Upstream 100 bases:

>100_bases
CTCCTATACTTGGTAATATCCAAGGCTCTTCTGAATATAAAAGGTTTGTATTAAGAAATTTACTTGAGTATACTTTGGAA
ATACTGGATGGTGAGAGAAG

Downstream 100 bases:

>100_bases
GGGGGATACCTTTATGATGAACTTGATTATTTAGAGATGCAATTTAACTTGCTATATTAAGTGGTTTTGAGTCTGTAAAG
GAATGTTTCCTCGCGGATGA

Product: xanthine dehydrogenase family protein, iron-sulfur-binding subunit

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MISYIEETKIELDINGEKRSVIVRPADTLLRVLREKLGLTGGKPGCENGDCGACTVLLDGIPIKSCIILAVEAVGHKLIT
IEGLKEEPIQKAFIEKMGFQCGYCTPGFIMNCYGLIKNNPYADDETIEKWLQSNICRCTGYEEIRDAVKSVLFSNKK

Sequences:

>Translated_157_residues
MISYIEETKIELDINGEKRSVIVRPADTLLRVLREKLGLTGGKPGCENGDCGACTVLLDGIPIKSCIILAVEAVGHKLIT
IEGLKEEPIQKAFIEKMGFQCGYCTPGFIMNCYGLIKNNPYADDETIEKWLQSNICRCTGYEEIRDAVKSVLFSNKK
>Mature_157_residues
MISYIEETKIELDINGEKRSVIVRPADTLLRVLREKLGLTGGKPGCENGDCGACTVLLDGIPIKSCIILAVEAVGHKLIT
IEGLKEEPIQKAFIEKMGFQCGYCTPGFIMNCYGLIKNNPYADDETIEKWLQSNICRCTGYEEIRDAVKSVLFSNKK

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=160, Percent_Identity=36.875, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI71773480, Length=155, Percent_Identity=38.7096774193548, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1786480, Length=159, Percent_Identity=38.3647798742138, Blast_Score=107, Evalue=4e-25,
Organism=Escherichia coli, GI1789232, Length=154, Percent_Identity=39.6103896103896, Blast_Score=100, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17540638, Length=164, Percent_Identity=37.8048780487805, Blast_Score=109, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17539860, Length=158, Percent_Identity=37.9746835443038, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32566215, Length=158, Percent_Identity=36.7088607594937, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17737937, Length=153, Percent_Identity=35.9477124183007, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24647193, Length=158, Percent_Identity=39.2405063291139, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24647197, Length=160, Percent_Identity=36.875, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24647195, Length=160, Percent_Identity=36.875, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24647199, Length=153, Percent_Identity=39.8692810457516, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24647201, Length=152, Percent_Identity=39.4736842105263, Blast_Score=90, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 17407; Mature: 17407

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
5.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISYIEETKIELDINGEKRSVIVRPADTLLRVLREKLGLTGGKPGCENGDCGACTVLLDG
CCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
IPIKSCIILAVEAVGHKLITIEGLKEEPIQKAFIEKMGFQCGYCTPGFIMNCYGLIKNNP
CCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
YADDETIEKWLQSNICRCTGYEEIRDAVKSVLFSNKK
CCCHHHHHHHHHCCCEECCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MISYIEETKIELDINGEKRSVIVRPADTLLRVLREKLGLTGGKPGCENGDCGACTVLLDG
CCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
IPIKSCIILAVEAVGHKLITIEGLKEEPIQKAFIEKMGFQCGYCTPGFIMNCYGLIKNNP
CCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
YADDETIEKWLQSNICRCTGYEEIRDAVKSVLFSNKK
CCCHHHHHHHHHCCCEECCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA