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The map label for this gene is lytC [H]

Identifier: 153934473

GI number: 153934473

Start: 2286166

End: 2287782

Strand: Reverse

Name: lytC [H]

Synonym: CLC_2151

Alternate gene names: 153934473

Gene position: 2287782-2286166 (Counterclockwise)

Preceding gene: 153935909

Following gene: 153936340

Centisome position: 60.84

GC content: 27.03

Gene sequence:

>1617_bases
ATGAAAAGGATAATTACACTAGTTACTTCTATAGCATTAGTTTTGGGAGTATCGACAATAGCTCAGGGAAAAAATAATTA
CAGTGTAAGTAGAATAGAGGGTGCAAATAGATATAAGACATCTTTAAACATATCAAAACAATTTAATAATGATAAAGTAG
ATAATGTAATAATAGCAAGTGGAAGTGATTTTCCAGATGCATTAGCGGGAAGTAGTCTTTCTAAAAAATTAAAAGCTCCA
ATATTATTGGTAGATAAAGATATAAAAGGCAGCTTAGATTCAATAGATTACATAAAGAATCATCTAAATGTAAATGAAAA
TGTATACATATTAGGCGGTAATGCTTCTGTAAGTGAAGATTATGTAAATTACATAAAATCATTAGGATATAAAAATATTA
TAAGATTAGGTGGAAAAAATAGATTTGATACCAATAGAACAATAATAAATTCTATGAATATAGAAAAGGGAACTCCAATA
GTTATAACTAATGGATATGGATTTGCAGATGCATTAAGTGTGTCTAGTGCTGCAACCTCAAAAGGATATCCTATTTTAAT
GAGTGATTCTAAAACTTTGCCTAATGAAATTAAAGATAAAATTAGAGAAATCCAACCTTCTAAATTATATTTAATAGGTG
GACAAGGTTCTTTAAGTAATAATATAATTACAGAAGTAAGAAATATAGTACCTTCATTAAATTATAGCAATATAACAAGA
ATTTGGGGAAATACCAGATATGATACTTCATTAGAGATATGTAAATACTTTAACTTAGATTCAGATACAGCAGTAATTGC
TAATGGAGAAAATTTTCCAGATGCTTTATCTGGCAGCGCATTAGCAGCAAAACAAAATGCTCCAATAGTACTTACAAACG
GTAAAGATATGTCAAATCAGAAAAAATATTTAAATACGACAAACTATAAAAATTTAATTTTACTTGGTGGTTCAGGAGCA
ATAAGTTCTAATTTAGAAAATATCTTAAATGGAACAATAAATGAACTAGATATAATAAAAAGTAAAAGTGTCTATAACTC
TAATATGAAAGATAACAATGGAGACATTTATTCAGCATACCTATATAGTGATGACAAAAAAATAGAAATAGCAGAGTATA
GCTGGGCTGGAGCACAAAAAGGAGATATATTAAGTACTGGTCATTATAAAATAGCTATAGTAAAGCAAGGAGAGAGTGAA
CCAAAGATATATGATGCATATGATAATAAACCAATAAAATTAAACTTAAACAGAAATTCAGTTAAAGTATATAAAAATAA
ACAATCAAATGGTTCGGATTTTCTTATGATTGGTATGCCAGTATCCAGTAATATTTCAGAAATAAAGCTTTATTATATAA
AAGATGGAGAAGTGAAAAAAACATATTTTAAAGATAAAAAAAGTATGGAAAGTGAGGCATATACTTTTAATTCACTATTC
TTTAATCAAAGAGAGGCTGATATTTTTGAAACATCAACTTATGACAATATGCAGACTTTTTTATTCTATGTACATTCATG
GAAATTCAATTTAGAGGATGGTGTCTTCTATAATTTAGGATTTAGTACTATGAATCAAGATACTTATTTTAATTACGAAA
AAAAGGTTCAACAATAA

Upstream 100 bases:

>100_bases
TATATAATATGACTTATTTATTATTTTATATAAATTGAATTTTGTTTTTAAATCTTAAAAAATAGTAGTATTAGTAACAA
TTAGGAAAGAGAGACATTCA

Downstream 100 bases:

>100_bases
TTAAATTATAACTTGTATACAAATATTTAATATTATAAAATACATTAAATATTTGTTATGAAATCAGGAGATTGATGAAT
ACGGATATTAATTATATTTT

Product: amidase domain-containing protein

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MKRIITLVTSIALVLGVSTIAQGKNNYSVSRIEGANRYKTSLNISKQFNNDKVDNVIIASGSDFPDALAGSSLSKKLKAP
ILLVDKDIKGSLDSIDYIKNHLNVNENVYILGGNASVSEDYVNYIKSLGYKNIIRLGGKNRFDTNRTIINSMNIEKGTPI
VITNGYGFADALSVSSAATSKGYPILMSDSKTLPNEIKDKIREIQPSKLYLIGGQGSLSNNIITEVRNIVPSLNYSNITR
IWGNTRYDTSLEICKYFNLDSDTAVIANGENFPDALSGSALAAKQNAPIVLTNGKDMSNQKKYLNTTNYKNLILLGGSGA
ISSNLENILNGTINELDIIKSKSVYNSNMKDNNGDIYSAYLYSDDKKIEIAEYSWAGAQKGDILSTGHYKIAIVKQGESE
PKIYDAYDNKPIKLNLNRNSVKVYKNKQSNGSDFLMIGMPVSSNISEIKLYYIKDGEVKKTYFKDKKSMESEAYTFNSLF
FNQREADIFETSTYDNMQTFLFYVHSWKFNLEDGVFYNLGFSTMNQDTYFNYEKKVQQ

Sequences:

>Translated_538_residues
MKRIITLVTSIALVLGVSTIAQGKNNYSVSRIEGANRYKTSLNISKQFNNDKVDNVIIASGSDFPDALAGSSLSKKLKAP
ILLVDKDIKGSLDSIDYIKNHLNVNENVYILGGNASVSEDYVNYIKSLGYKNIIRLGGKNRFDTNRTIINSMNIEKGTPI
VITNGYGFADALSVSSAATSKGYPILMSDSKTLPNEIKDKIREIQPSKLYLIGGQGSLSNNIITEVRNIVPSLNYSNITR
IWGNTRYDTSLEICKYFNLDSDTAVIANGENFPDALSGSALAAKQNAPIVLTNGKDMSNQKKYLNTTNYKNLILLGGSGA
ISSNLENILNGTINELDIIKSKSVYNSNMKDNNGDIYSAYLYSDDKKIEIAEYSWAGAQKGDILSTGHYKIAIVKQGESE
PKIYDAYDNKPIKLNLNRNSVKVYKNKQSNGSDFLMIGMPVSSNISEIKLYYIKDGEVKKTYFKDKKSMESEAYTFNSLF
FNQREADIFETSTYDNMQTFLFYVHSWKFNLEDGVFYNLGFSTMNQDTYFNYEKKVQQ
>Mature_538_residues
MKRIITLVTSIALVLGVSTIAQGKNNYSVSRIEGANRYKTSLNISKQFNNDKVDNVIIASGSDFPDALAGSSLSKKLKAP
ILLVDKDIKGSLDSIDYIKNHLNVNENVYILGGNASVSEDYVNYIKSLGYKNIIRLGGKNRFDTNRTIINSMNIEKGTPI
VITNGYGFADALSVSSAATSKGYPILMSDSKTLPNEIKDKIREIQPSKLYLIGGQGSLSNNIITEVRNIVPSLNYSNITR
IWGNTRYDTSLEICKYFNLDSDTAVIANGENFPDALSGSALAAKQNAPIVLTNGKDMSNQKKYLNTTNYKNLILLGGSGA
ISSNLENILNGTINELDIIKSKSVYNSNMKDNNGDIYSAYLYSDDKKIEIAEYSWAGAQKGDILSTGHYKIAIVKQGESE
PKIYDAYDNKPIKLNLNRNSVKVYKNKQSNGSDFLMIGMPVSSNISEIKLYYIKDGEVKKTYFKDKKSMESEAYTFNSLF
FNQREADIFETSTYDNMQTFLFYVHSWKFNLEDGVFYNLGFSTMNQDTYFNYEKKVQQ

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 60042; Mature: 60042

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIITLVTSIALVLGVSTIAQGKNNYSVSRIEGANRYKTSLNISKQFNNDKVDNVIIAS
CHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCEEEEEC
GSDFPDALAGSSLSKKLKAPILLVDKDIKGSLDSIDYIKNHLNVNENVYILGGNASVSED
CCCCCHHHCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHH
YVNYIKSLGYKNIIRLGGKNRFDTNRTIINSMNIEKGTPIVITNGYGFADALSVSSAATS
HHHHHHHCCCHHEEEECCCCCCCCCCEEEEECCCCCCCCEEEECCCCCHHHHHHCCCCCC
KGYPILMSDSKTLPNEIKDKIREIQPSKLYLIGGQGSLSNNIITEVRNIVPSLNYSNITR
CCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEE
IWGNTRYDTSLEICKYFNLDSDTAVIANGENFPDALSGSALAAKQNAPIVLTNGKDMSNQ
ECCCCCCCCCHHHHEEECCCCCCEEEECCCCCCCCCCCCEEEECCCCCEEEECCCCCCCC
KKYLNTTNYKNLILLGGSGAISSNLENILNGTINELDIIKSKSVYNSNMKDNNGDIYSAY
HHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHHEEECCCHHCCCCCCCCCCEEEEE
LYSDDKKIEIAEYSWAGAQKGDILSTGHYKIAIVKQGESEPKIYDAYDNKPIKLNLNRNS
EECCCCEEEEEEEECCCCCCCCEEECCCEEEEEEECCCCCCCEEECCCCCCEEEEECCCE
VKVYKNKQSNGSDFLMIGMPVSSNISEIKLYYIKDGEVKKTYFKDKKSMESEAYTFNSLF
EEEEECCCCCCCCEEEEEECCCCCCCEEEEEEEECCCEEHHHHHHHHHCCHHCEEEEHHE
FNQREADIFETSTYDNMQTFLFYVHSWKFNLEDGVFYNLGFSTMNQDTYFNYEKKVQQ
ECCCCCCEEECCCCCCCEEEEEEEEEEEEECCCCEEEEECCCCCCCCCEECHHHHHCC
>Mature Secondary Structure
MKRIITLVTSIALVLGVSTIAQGKNNYSVSRIEGANRYKTSLNISKQFNNDKVDNVIIAS
CHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCEEEEEC
GSDFPDALAGSSLSKKLKAPILLVDKDIKGSLDSIDYIKNHLNVNENVYILGGNASVSED
CCCCCHHHCCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHH
YVNYIKSLGYKNIIRLGGKNRFDTNRTIINSMNIEKGTPIVITNGYGFADALSVSSAATS
HHHHHHHCCCHHEEEECCCCCCCCCCEEEEECCCCCCCCEEEECCCCCHHHHHHCCCCCC
KGYPILMSDSKTLPNEIKDKIREIQPSKLYLIGGQGSLSNNIITEVRNIVPSLNYSNITR
CCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEE
IWGNTRYDTSLEICKYFNLDSDTAVIANGENFPDALSGSALAAKQNAPIVLTNGKDMSNQ
ECCCCCCCCCHHHHEEECCCCCCEEEECCCCCCCCCCCCEEEECCCCCEEEECCCCCCCC
KKYLNTTNYKNLILLGGSGAISSNLENILNGTINELDIIKSKSVYNSNMKDNNGDIYSAY
HHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHHEEECCCHHCCCCCCCCCCEEEEE
LYSDDKKIEIAEYSWAGAQKGDILSTGHYKIAIVKQGESEPKIYDAYDNKPIKLNLNRNS
EECCCCEEEEEEEECCCCCCCCEEECCCEEEEEEECCCCCCCEEECCCCCCEEEEECCCE
VKVYKNKQSNGSDFLMIGMPVSSNISEIKLYYIKDGEVKKTYFKDKKSMESEAYTFNSLF
EEEEECCCCCCCCEEEEEECCCCCCCEEEEEEEECCCEEHHHHHHHHHCCHHCEEEEHHE
FNQREADIFETSTYDNMQTFLFYVHSWKFNLEDGVFYNLGFSTMNQDTYFNYEKKVQQ
ECCCCCCEEECCCCCCCEEEEEEEEEEEEECCCCEEEEECCCCCCCCCEECHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]