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The map label for this gene is npr-4 [H]

Identifier: 153932555

GI number: 153932555

Start: 1543309

End: 1545093

Strand: Reverse

Name: npr-4 [H]

Synonym: CLB_1469

Alternate gene names: 153932555

Gene position: 1545093-1543309 (Counterclockwise)

Preceding gene: 153932249

Following gene: 153933732

Centisome position: 39.99

GC content: 30.81

Gene sequence:

>1785_bases
ATGAAAAGTAAAAAATTATTAGCTACAGTGTTAAGTGCTGTAATCACTTTTTCAGCAGTTTCAGCAGTTTCAGCTGCACC
TGTAGGAAAAGAAAGTAAAAGTGACCCAAAGACCACAACAATATCTTGGGACAAAAGTGAACAAAATGCTAAAAAGGCTA
CTACAGACATAAAGCAAAAGAAATTTGACAACGCTCAAGAAATAACTAAATTCTTTGAGAAAAACATATCTAAATTCGGG
GTAAAAAAAGGTACTCTTAACAGTACTAAAACTTTAAAAGATGACAAAGGTAAAACTCACTATCATACAATTTATGAAGT
AGAAGGTATACCTGTATACTATGGAAGAATTGTCTTTACAACTGAAAAAGACTCAACTATGGATTCTATAAATGGTAGAG
TTGATACTGTTTTTGAAAATGGAAATTGGAAAAACAAAATCAAACTATCAAAAGAAGATGCCATAGCAAAAGCTAAAGCT
GATATTAAAAATGAAAAATCCAACAAGGAAAAGGCTGAGTTATATCTGTATAATTTCGAGGGCAAACCTTATGTAGTTTA
TTTAGTAAATTCAATTACAAATAGCGGTAATTGGGATATTTTTGTTAATGCTGAAGATGGTTCTATAGTAAATAAATTTA
ATAATACCCCTACTCTACTTGATACTAAAGCTGAGAAATTACCCAATGCTAAAAAAATTAAAGATGAAGCTGAAAAAAAT
GAAGCTAAAAAGGCTAATAATATGAATAATATAATTGATGTACAAGGTCAAAGCGTTAAAGGATTAGGAAGAACTAGCTT
AGATGGACTAGTAAATATTAATCTAACTTATGACAATGGAAGATATTATTTAAAAGATAATAATAGAAAAATTTATCTAT
ATGATTTAAAAAATCAAGTTGATCTGGATGACTTAAACGATTTTTATGACTCTCCAAAGGGTGGCCATAATGAAGAGCTT
ATGCGTAGATCTGAATTAGTATCTAATTCTAATAATAATTTTGTAGATGATAATCAAGTTAACTCTGTAGATGCTTATGC
AAATATGGCTAAGTCTTATGATTATTATAAAAATAAACTATCTAGAAATAGTCTTGATAATAAAGGTATGAATATTAAGG
GATTTGTTCATTTTGACAAAAATTTAGGTAACGCCTTTTGGGTTGGAGAATACGATAGTATGTTCTTTGGCGATGGTGAT
GGAGTGCGCTTATCTCCTCTTGCTAAAGCTTTAGATATTGTAGGCCACGAACTAAGTCATGGTGTTACTAATAAAGCATC
AAATCTTAAATATGAAAAGGAATCTGGTGCTTTAAATGAATCCTTCTCAGATATTATGGGAACAGCTATTGAGGGTAAAA
ACTTTGAAATAGGTGAAGACTGCTGGATACCTACTTGGTTCTATGGAGAGGTAATGAGAGATATGAAAGATCCATCTAGA
GGAAGACAACCCGCTCACATGAAAAATTTTAGAAAGCTTCCTGTTGATAGAGATAATGATTGGGGTGGAGTTCATATAAA
TTCAGGTATAATAAACCATGCTGCTTATTTAATTGCAAATGGATTTGAAAAAATGGGTGCAAAAGATAGTAAAGATATTA
TGGGAAAACTATTTTATATAGCTAATTGCTATTACTGGGATGAAACAACAGATTTTGCTAAATGCAGAAACGATGTAGTT
AAAGTTGCTAAAGATCTTTATGGTGACAATAGTAAAGAAGTTGAAATTGTAAAAAATGCTTTTGACCAAGTTGGAATAAC
TGCTACGCCTCAATTGCCATTATAG

Upstream 100 bases:

>100_bases
ATAAATATATCTATATAAAATTATAAACCTATTGATATTTTGCTATATAAATATCAATAGGTTTATAAGTAAAAATATAT
TAAATGGGGGTTATTTATTC

Downstream 100 bases:

>100_bases
TCAAATATACTTTGATTATAAAATATATTTATAAAACTATATAATTTTAGTATTTTACTTTATAAACATTAAAAAGTTTA
TAAGTAAAAATATATTAAAA

Product: thermolysin metallopeptidase

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MKSKKLLATVLSAVITFSAVSAVSAAPVGKESKSDPKTTTISWDKSEQNAKKATTDIKQKKFDNAQEITKFFEKNISKFG
VKKGTLNSTKTLKDDKGKTHYHTIYEVEGIPVYYGRIVFTTEKDSTMDSINGRVDTVFENGNWKNKIKLSKEDAIAKAKA
DIKNEKSNKEKAELYLYNFEGKPYVVYLVNSITNSGNWDIFVNAEDGSIVNKFNNTPTLLDTKAEKLPNAKKIKDEAEKN
EAKKANNMNNIIDVQGQSVKGLGRTSLDGLVNINLTYDNGRYYLKDNNRKIYLYDLKNQVDLDDLNDFYDSPKGGHNEEL
MRRSELVSNSNNNFVDDNQVNSVDAYANMAKSYDYYKNKLSRNSLDNKGMNIKGFVHFDKNLGNAFWVGEYDSMFFGDGD
GVRLSPLAKALDIVGHELSHGVTNKASNLKYEKESGALNESFSDIMGTAIEGKNFEIGEDCWIPTWFYGEVMRDMKDPSR
GRQPAHMKNFRKLPVDRDNDWGGVHINSGIINHAAYLIANGFEKMGAKDSKDIMGKLFYIANCYYWDETTDFAKCRNDVV
KVAKDLYGDNSKEVEIVKNAFDQVGITATPQLPL

Sequences:

>Translated_594_residues
MKSKKLLATVLSAVITFSAVSAVSAAPVGKESKSDPKTTTISWDKSEQNAKKATTDIKQKKFDNAQEITKFFEKNISKFG
VKKGTLNSTKTLKDDKGKTHYHTIYEVEGIPVYYGRIVFTTEKDSTMDSINGRVDTVFENGNWKNKIKLSKEDAIAKAKA
DIKNEKSNKEKAELYLYNFEGKPYVVYLVNSITNSGNWDIFVNAEDGSIVNKFNNTPTLLDTKAEKLPNAKKIKDEAEKN
EAKKANNMNNIIDVQGQSVKGLGRTSLDGLVNINLTYDNGRYYLKDNNRKIYLYDLKNQVDLDDLNDFYDSPKGGHNEEL
MRRSELVSNSNNNFVDDNQVNSVDAYANMAKSYDYYKNKLSRNSLDNKGMNIKGFVHFDKNLGNAFWVGEYDSMFFGDGD
GVRLSPLAKALDIVGHELSHGVTNKASNLKYEKESGALNESFSDIMGTAIEGKNFEIGEDCWIPTWFYGEVMRDMKDPSR
GRQPAHMKNFRKLPVDRDNDWGGVHINSGIINHAAYLIANGFEKMGAKDSKDIMGKLFYIANCYYWDETTDFAKCRNDVV
KVAKDLYGDNSKEVEIVKNAFDQVGITATPQLPL
>Mature_594_residues
MKSKKLLATVLSAVITFSAVSAVSAAPVGKESKSDPKTTTISWDKSEQNAKKATTDIKQKKFDNAQEITKFFEKNISKFG
VKKGTLNSTKTLKDDKGKTHYHTIYEVEGIPVYYGRIVFTTEKDSTMDSINGRVDTVFENGNWKNKIKLSKEDAIAKAKA
DIKNEKSNKEKAELYLYNFEGKPYVVYLVNSITNSGNWDIFVNAEDGSIVNKFNNTPTLLDTKAEKLPNAKKIKDEAEKN
EAKKANNMNNIIDVQGQSVKGLGRTSLDGLVNINLTYDNGRYYLKDNNRKIYLYDLKNQVDLDDLNDFYDSPKGGHNEEL
MRRSELVSNSNNNFVDDNQVNSVDAYANMAKSYDYYKNKLSRNSLDNKGMNIKGFVHFDKNLGNAFWVGEYDSMFFGDGD
GVRLSPLAKALDIVGHELSHGVTNKASNLKYEKESGALNESFSDIMGTAIEGKNFEIGEDCWIPTWFYGEVMRDMKDPSR
GRQPAHMKNFRKLPVDRDNDWGGVHINSGIINHAAYLIANGFEKMGAKDSKDIMGKLFYIANCYYWDETTDFAKCRNDVV
KVAKDLYGDNSKEVEIVKNAFDQVGITATPQLPL

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 66853; Mature: 66853

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKKLLATVLSAVITFSAVSAVSAAPVGKESKSDPKTTTISWDKSEQNAKKATTDIKQK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHH
KFDNAQEITKFFEKNISKFGVKKGTLNSTKTLKDDKGKTHYHTIYEVEGIPVYYGRIVFT
HCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEEEEE
TEKDSTMDSINGRVDTVFENGNWKNKIKLSKEDAIAKAKADIKNEKSNKEKAELYLYNFE
ECCCCCHHHCCCEEEEEEECCCCCCEEEECHHHHHHHHHHHHCCCCCCCCEEEEEEEEEC
GKPYVVYLVNSITNSGNWDIFVNAEDGSIVNKFNNTPTLLDTKAEKLPNAKKIKDEAEKN
CCEEEEEEEECCCCCCCEEEEEECCCCCHHHHCCCCCCEECCHHHHCCCHHHHHHHHHHH
EAKKANNMNNIIDVQGQSVKGLGRTSLDGLVNINLTYDNGRYYLKDNNRKIYLYDLKNQV
HHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEECCEEEEEECCCEEEEEECCCCC
DLDDLNDFYDSPKGGHNEELMRRSELVSNSNNNFVDDNQVNSVDAYANMAKSYDYYKNKL
CHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SRNSLDNKGMNIKGFVHFDKNLGNAFWVGEYDSMFFGDGDGVRLSPLAKALDIVGHELSH
HHCCCCCCCCEEEEEEEECCCCCCEEEEECCCCEEECCCCCEEHHHHHHHHHHHHHHHHC
GVTNKASNLKYEKESGALNESFSDIMGTAIEGKNFEIGEDCWIPTWFYGEVMRDMKDPSR
CCCCCHHCCEECHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
GRQPAHMKNFRKLPVDRDNDWGGVHINSGIINHAAYLIANGFEKMGAKDSKDIMGKLFYI
CCCCHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHCCHHHHCCCCCHHHHHHEEEE
ANCYYWDETTDFAKCRNDVVKVAKDLYGDNSKEVEIVKNAFDQVGITATPQLPL
EEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKSKKLLATVLSAVITFSAVSAVSAAPVGKESKSDPKTTTISWDKSEQNAKKATTDIKQK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHH
KFDNAQEITKFFEKNISKFGVKKGTLNSTKTLKDDKGKTHYHTIYEVEGIPVYYGRIVFT
HCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEEEEE
TEKDSTMDSINGRVDTVFENGNWKNKIKLSKEDAIAKAKADIKNEKSNKEKAELYLYNFE
ECCCCCHHHCCCEEEEEEECCCCCCEEEECHHHHHHHHHHHHCCCCCCCCEEEEEEEEEC
GKPYVVYLVNSITNSGNWDIFVNAEDGSIVNKFNNTPTLLDTKAEKLPNAKKIKDEAEKN
CCEEEEEEEECCCCCCCEEEEEECCCCCHHHHCCCCCCEECCHHHHCCCHHHHHHHHHHH
EAKKANNMNNIIDVQGQSVKGLGRTSLDGLVNINLTYDNGRYYLKDNNRKIYLYDLKNQV
HHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEECCEEEEEECCCEEEEEECCCCC
DLDDLNDFYDSPKGGHNEELMRRSELVSNSNNNFVDDNQVNSVDAYANMAKSYDYYKNKL
CHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
SRNSLDNKGMNIKGFVHFDKNLGNAFWVGEYDSMFFGDGDGVRLSPLAKALDIVGHELSH
HHCCCCCCCCEEEEEEEECCCCCCEEEEECCCCEEECCCCCEEHHHHHHHHHHHHHHHHC
GVTNKASNLKYEKESGALNESFSDIMGTAIEGKNFEIGEDCWIPTWFYGEVMRDMKDPSR
CCCCCHHCCEECHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
GRQPAHMKNFRKLPVDRDNDWGGVHINSGIINHAAYLIANGFEKMGAKDSKDIMGKLFYI
CCCCHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHCCHHHHCCCCCHHHHHHEEEE
ANCYYWDETTDFAKCRNDVVKVAKDLYGDNSKEVEIVKNAFDQVGITATPQLPL
EEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]