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The map label for this gene is vanR [H]

Identifier: 153931133

GI number: 153931133

Start: 3556511

End: 3557203

Strand: Reverse

Name: vanR [H]

Synonym: CLB_3407

Alternate gene names: 153931133

Gene position: 3557203-3556511 (Counterclockwise)

Preceding gene: 153931872

Following gene: 153933939

Centisome position: 92.07

GC content: 27.85

Gene sequence:

>693_bases
TTGAGTTATAAAATATTAATAGTAGATGATGATAAGACCATAGTAGAATTTTTACAAATATTTTTAATTAAAGAAGGATA
TGATGTAAGGATTTCTTATAATGGAGAAGAGGCTTTAGATAAAATAAGAAGTGAACAATTTAATTTAATTCTAATGGATA
TAATGATGCCTAAATTAGATGGATTCGAAGCTATTAAAAGAATAAGAAGACTTACCAATATTCCTATTATATTTTTAACT
ACAAAAGATAGTCAGCAAGATAAAATTAAAGGCTTTATTTCTGGATGTGACGACTACATAACAAAGCCCTTTGATTTAGT
GGAGCTTTCTTTAAGAGTGTCCGCTATACTTAAAAGAGTTAGCACAAGTGTAGCTGAAGAAAATAAGGATATTATAAAAG
TAAAGGATTTAGAACTAAATTTAAAAGAGCACACATTATATAAAGAAAAAAATGAAATAAAGCTTACTCCAAAGGAATTT
GACATTTTATTTTTGCTTGCTAGAAATAAGGGAAGAATTTTTCCATCGAGTGAGATATATGAAAGGGTATGGGGACAAGA
ATTTTTAGAAAATGACAATAGCTTGTTGACCCATATTAGAAATTTAAGAGAAAAGCTAAGTGATACTGTAAAAAACTCAA
AATACATTAAAACTGTTTGGGGAGTGGGTTATAAGATTGAAAAGGAAGCTTAG

Upstream 100 bases:

>100_bases
GATGCATTTTAAATAACTTATTTGGCACAGGGATATATTTCTTTTTAGTACAAAGTGTTATTTGGTATAATTACATGGGA
TATGTAAGGGGGAGTGCTAA

Downstream 100 bases:

>100_bases
AATTGCATTAACAACAGAACTGATGCTACTTTTTGTTATATCTTTAATAATTACAATTTTTGGAATGATGATGGTTTTAG
GGAGTCTAAATATTTCATCG

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MSYKILIVDDDKTIVEFLQIFLIKEGYDVRISYNGEEALDKIRSEQFNLILMDIMMPKLDGFEAIKRIRRLTNIPIIFLT
TKDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRVSTSVAEENKDIIKVKDLELNLKEHTLYKEKNEIKLTPKEF
DILFLLARNKGRIFPSSEIYERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA

Sequences:

>Translated_230_residues
MSYKILIVDDDKTIVEFLQIFLIKEGYDVRISYNGEEALDKIRSEQFNLILMDIMMPKLDGFEAIKRIRRLTNIPIIFLT
TKDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRVSTSVAEENKDIIKVKDLELNLKEHTLYKEKNEIKLTPKEF
DILFLLARNKGRIFPSSEIYERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA
>Mature_229_residues
SYKILIVDDDKTIVEFLQIFLIKEGYDVRISYNGEEALDKIRSEQFNLILMDIMMPKLDGFEAIKRIRRLTNIPIIFLTT
KDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRVSTSVAEENKDIIKVKDLELNLKEHTLYKEKNEIKLTPKEFD
ILFLLARNKGRIFPSSEIYERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.15859030837, Blast_Score=136, Evalue=9e-34,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=32.4324324324324, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=29.8642533936652, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=29.3859649122807, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=35.1111111111111, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=32.4444444444444, Blast_Score=128, Evalue=2e-31,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=30.3964757709251, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=31.858407079646, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=28.3185840707965, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=31.6964285714286, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=29.1479820627803, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=30.5676855895196, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=26.6666666666667, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1790437, Length=102, Percent_Identity=35.2941176470588, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=34.4827586206897, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790299, Length=137, Percent_Identity=28.4671532846715, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788191, Length=122, Percent_Identity=26.2295081967213, Blast_Score=61, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323034, Length=139, Percent_Identity=32.3741007194245, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322000, Length=157, Percent_Identity=29.2993630573248, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26932; Mature: 26800

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYKILIVDDDKTIVEFLQIFLIKEGYDVRISYNGEEALDKIRSEQFNLILMDIMMPKLD
CCEEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCEEEEEHHCCCCC
GFEAIKRIRRLTNIPIIFLTTKDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRV
CHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHH
STSVAEENKDIIKVKDLELNLKEHTLYKEKNEIKLTPKEFDILFLLARNKGRIFPSSEIY
HHHHHHCCCCEEEEEEEEECHHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCCCCHHHH
ERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCEEEECCC
>Mature Secondary Structure 
SYKILIVDDDKTIVEFLQIFLIKEGYDVRISYNGEEALDKIRSEQFNLILMDIMMPKLD
CEEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCEEEEEHHCCCCC
GFEAIKRIRRLTNIPIIFLTTKDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRV
CHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHH
STSVAEENKDIIKVKDLELNLKEHTLYKEKNEIKLTPKEFDILFLLARNKGRIFPSSEIY
HHHHHHCCCCEEEEEEEEECHHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCCCCHHHH
ERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]