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The map label for this gene is norM [H]

Identifier: 153003129

GI number: 153003129

Start: 290307

End: 291689

Strand: Reverse

Name: norM [H]

Synonym: Anae109_0252

Alternate gene names: 153003129

Gene position: 291689-290307 (Counterclockwise)

Preceding gene: 153003138

Following gene: 153003116

Centisome position: 5.53

GC content: 74.69

Gene sequence:

>1383_bases
ATGGACGCCCCTCACCCGTCCGAGCGCACGCGCGCCTCCGGGCGCAGCGCGATCCTGCGCCCCCTCCTCGCGCTCGCCTG
GCCCATGGTGGTCTCCCGCGCCACCCAGGTCGTGGTGGGCATCGCGGACGCCGTGATGGTCGCCCACCTCGGCGAGGCGG
CGCTCGCGGCGACGACCACGGGAGCGACGAACGCCTTCTCGATCGTCATCCTGCCGATGGGGATCGTGTTCGTCGTCCAG
AGCTTCGCGTCCCAGCTCTTCGGGCGCGGCGACCTCGCCGGGGCGCGGCGCTTCGGCTGGTACGGGCTCGCCGTCGCCGC
GGGCGCGCAGGTGCTCGGCGTGCTGGGCACGCTCGCGACGCCGCGCGCCCTCGAGGCCTTCGCCTACGCGCCGGACGTGC
GCGCGCTCATGAGCGGCTACCTCCAGATCCGGCTCCTCTCGGCCGGCGCGGTGGTGGGGCTGGAGGCGCTCTCGAACTAC
TACGGCGGCCTGGGCGACACGCGGCTGCCGATGCGCGCGAACCTCGCGGCGATGGTGCTGAACGTGGCAGGCAACTGGCT
CCTCATCGACGGGCGGCTGGGGCTGCCCGCGCTCGGCGTCACGGGCGCCGCCGTCGCGAGCACCCTCTCGACCGCGCTCG
CGTTCGCCGGGCTCCTGGCGGTGTTCGTGCGCGAGGGACGCCGGACCGGGACCGGGACGCTCCGCGCCCGGGAGCTCGGG
CGGCTGCTCCGCTTCGGCGTGCCGTCCGGCGTCAACTGGTTCTTCGAGGTCCTGGCCTTCGTCTTCTTCGTGAACGTGGT
GTTCGTCGAGCTCGGGACGACGTCGCTCGCGGCCCTCATGGCGATCCTCCAGGTGAACACGGTCGCGTTCATGCCCGCGT
GGGCGCTCGCGAGCGCGGGCGCCATCCTGGTGGGTCAGGCGATCGGCGCGTCCCACGCCGACCGCGTCCCGCGCCTCGTG
GCGGTCACGTTCGCGGTGAGCGCCGCCTGGCAGCTCTTCGTCGGCGCCCTGTACGTCCTCGCGCCGGAGGCGATCCTCGC
GCCGTTCGCGACCGGCGCCGGACCGGGGAGCGCCTTCGTCGCGATCGGCCGGCGCGTGCTGCTCCTCGCGGCGGCCTGGC
AGCTCTTCGACGCCGCCGCGATGTCGCTCGGAGAGGCGCTGAGGGCGGCGGGCGACACCGCGTTCGTCATGTGGATGCGG
GTCACCCTCGGCTGGGCGGTCTTCGTCCCGGGGACCTGGATCTCGGTGCGCGAGCTCGGCGCGGGCGAGGTGGTCGCCGT
GGGATGGCTGGTGCTGTGGCTGGCGCTGCTCGCCCTGGCGCTCCTGCTGCGCTTCCGCTCCGGCGCCTGGCGGCGGATCG
AGCTCGTGCCCGAGGCGCCCTGA

Upstream 100 bases:

>100_bases
ATCTAGCGCAGCGGCGAGACCGAGCCGCGGGCCCGGCGGGGACCCGCCCGGGCGCCCGCGCTTCCGGGCGCGGCGAGGTC
CGGGGTACCCTGCGCGGCCG

Downstream 100 bases:

>100_bases
AGCGGCCGGTGAACCATCCGCGGCGCCATCGCGACGGCCGGGGACTCTTCACGACGCGCGGGGAGTCAGCGCTCGCAGCG
GGGTGGCGCGTCGGCGCCGG

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MDAPHPSERTRASGRSAILRPLLALAWPMVVSRATQVVVGIADAVMVAHLGEAALAATTTGATNAFSIVILPMGIVFVVQ
SFASQLFGRGDLAGARRFGWYGLAVAAGAQVLGVLGTLATPRALEAFAYAPDVRALMSGYLQIRLLSAGAVVGLEALSNY
YGGLGDTRLPMRANLAAMVLNVAGNWLLIDGRLGLPALGVTGAAVASTLSTALAFAGLLAVFVREGRRTGTGTLRARELG
RLLRFGVPSGVNWFFEVLAFVFFVNVVFVELGTTSLAALMAILQVNTVAFMPAWALASAGAILVGQAIGASHADRVPRLV
AVTFAVSAAWQLFVGALYVLAPEAILAPFATGAGPGSAFVAIGRRVLLLAAAWQLFDAAAMSLGEALRAAGDTAFVMWMR
VTLGWAVFVPGTWISVRELGAGEVVAVGWLVLWLALLALALLLRFRSGAWRRIELVPEAP

Sequences:

>Translated_460_residues
MDAPHPSERTRASGRSAILRPLLALAWPMVVSRATQVVVGIADAVMVAHLGEAALAATTTGATNAFSIVILPMGIVFVVQ
SFASQLFGRGDLAGARRFGWYGLAVAAGAQVLGVLGTLATPRALEAFAYAPDVRALMSGYLQIRLLSAGAVVGLEALSNY
YGGLGDTRLPMRANLAAMVLNVAGNWLLIDGRLGLPALGVTGAAVASTLSTALAFAGLLAVFVREGRRTGTGTLRARELG
RLLRFGVPSGVNWFFEVLAFVFFVNVVFVELGTTSLAALMAILQVNTVAFMPAWALASAGAILVGQAIGASHADRVPRLV
AVTFAVSAAWQLFVGALYVLAPEAILAPFATGAGPGSAFVAIGRRVLLLAAAWQLFDAAAMSLGEALRAAGDTAFVMWMR
VTLGWAVFVPGTWISVRELGAGEVVAVGWLVLWLALLALALLLRFRSGAWRRIELVPEAP
>Mature_460_residues
MDAPHPSERTRASGRSAILRPLLALAWPMVVSRATQVVVGIADAVMVAHLGEAALAATTTGATNAFSIVILPMGIVFVVQ
SFASQLFGRGDLAGARRFGWYGLAVAAGAQVLGVLGTLATPRALEAFAYAPDVRALMSGYLQIRLLSAGAVVGLEALSNY
YGGLGDTRLPMRANLAAMVLNVAGNWLLIDGRLGLPALGVTGAAVASTLSTALAFAGLLAVFVREGRRTGTGTLRARELG
RLLRFGVPSGVNWFFEVLAFVFFVNVVFVELGTTSLAALMAILQVNTVAFMPAWALASAGAILVGQAIGASHADRVPRLV
AVTFAVSAAWQLFVGALYVLAPEAILAPFATGAGPGSAFVAIGRRVLLLAAAWQLFDAAAMSLGEALRAAGDTAFVMWMR
VTLGWAVFVPGTWISVRELGAGEVVAVGWLVLWLALLALALLLRFRSGAWRRIELVPEAP

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI48994890, Length=418, Percent_Identity=24.8803827751196, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47989; Mature: 47989

Theoretical pI: Translated: 11.39; Mature: 11.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAPHPSERTRASGRSAILRPLLALAWPMVVSRATQVVVGIADAVMVAHLGEAALAATTT
CCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECC
GATNAFSIVILPMGIVFVVQSFASQLFGRGDLAGARRFGWYGLAVAAGAQVLGVLGTLAT
CCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCC
PRALEAFAYAPDVRALMSGYLQIRLLSAGAVVGLEALSNYYGGLGDTRLPMRANLAAMVL
CHHHHHHHCCCCHHHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
NVAGNWLLIDGRLGLPALGVTGAAVASTLSTALAFAGLLAVFVREGRRTGTGTLRARELG
HHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
RLLRFGVPSGVNWFFEVLAFVFFVNVVFVELGTTSLAALMAILQVNTVAFMPAWALASAG
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AILVGQAIGASHADRVPRLVAVTFAVSAAWQLFVGALYVLAPEAILAPFATGAGPGSAFV
HHEEEHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHH
AIGRRVLLLAAAWQLFDAAAMSLGEALRAAGDTAFVMWMRVTLGWAVFVPGTWISVRELG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCEEEECCCCEEEHHHCC
AGEVVAVGWLVLWLALLALALLLRFRSGAWRRIELVPEAP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
>Mature Secondary Structure
MDAPHPSERTRASGRSAILRPLLALAWPMVVSRATQVVVGIADAVMVAHLGEAALAATTT
CCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECC
GATNAFSIVILPMGIVFVVQSFASQLFGRGDLAGARRFGWYGLAVAAGAQVLGVLGTLAT
CCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCC
PRALEAFAYAPDVRALMSGYLQIRLLSAGAVVGLEALSNYYGGLGDTRLPMRANLAAMVL
CHHHHHHHCCCCHHHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
NVAGNWLLIDGRLGLPALGVTGAAVASTLSTALAFAGLLAVFVREGRRTGTGTLRARELG
HHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
RLLRFGVPSGVNWFFEVLAFVFFVNVVFVELGTTSLAALMAILQVNTVAFMPAWALASAG
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AILVGQAIGASHADRVPRLVAVTFAVSAAWQLFVGALYVLAPEAILAPFATGAGPGSAFV
HHEEEHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHH
AIGRRVLLLAAAWQLFDAAAMSLGEALRAAGDTAFVMWMRVTLGWAVFVPGTWISVRELG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCEEEECCCCEEEHHHCC
AGEVVAVGWLVLWLALLALALLLRFRSGAWRRIELVPEAP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]