Click here to switch to the map view.

The map label for this gene is ung

Identifier: 152977581

GI number: 152977581

Start: 3972185

End: 3972862

Strand: Reverse

Name: ung

Synonym: Bcer98_3919

Alternate gene names: 152977581

Gene position: 3972862-3972185 (Counterclockwise)

Preceding gene: 152977582

Following gene: 152977577

Centisome position: 97.21

GC content: 37.02

Gene sequence:

>678_bases
ATGAAAAAAATTTTAAAGAATGATTGGGAACCAATACTTGGACCAGAGTTTGAGAAGCCATATTATCAAAACTTAAGACA
ATTTTTGAAAGAAGAGTATAGTATGCGGGTCATATATCCAAATGCAAATGATATTTTTAACGCACTACATTATACGAGTT
ATGAGGATACAAAGGTTGTGATTTTAGGGCAGGATCCGTATCATGGACCAAACCAAGCACACGGATTAAGTTTTTCTGTA
CAACCAGGAGTAAGGGTACCACCATCTTTACAAAATATGTATAAGGAACTAAAAGCAGACATTGGATGTGAAATTCCGAA
TCATGGTTATTTAGTAAAATGGGCAGAGCAAGGCGTATTATTGCTTAATACTGTTTTAACAGTTCGCCAAGGAGAGGCGA
ATTCTCATAAAGGAAAAGGATGGGAACAGTTCACAGACCGTGTTATTGAGTTATTAAATGAGCGGGAAAAACCAGTCATC
TTCATATTATGGGGGCGTCACGCACAAGCAAAGAAAAAACGAATTACGAATCCGAATCACTATATCATTGAGTCTGTACA
TCCAAGTCCGCTTTCAGCAAGCCGCGGCTTTTTTGGCAGCAAGCCCTTTTCGAAAGTAAATCGCTTTTTATCTAGCATTG
GTGAAAAAGAAATTGATTGGCAAATTCCAAATTTATAA

Upstream 100 bases:

>100_bases
TAATGAATTTAACAATTTGGGCAGTGGTCTCTCTCGTTGTTTCCTTTGTAGTGTTTACGAAGCAAGATATGGTTAATTAA
ATGAATCAGGAGTGAGGGTA

Downstream 100 bases:

>100_bases
TGTAACAATAAAAGGTAGCTTGTGTGAGCTACCTTTTATTGTTCATTTTTTAATTTTGCATCTAGTACGAATGTGCCAAA
CGGAATAACGGATGCAAGAA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKKILKNDWEPILGPEFEKPYYQNLRQFLKEEYSMRVIYPNANDIFNALHYTSYEDTKVVILGQDPYHGPNQAHGLSFSV
QPGVRVPPSLQNMYKELKADIGCEIPNHGYLVKWAEQGVLLLNTVLTVRQGEANSHKGKGWEQFTDRVIELLNEREKPVI
FILWGRHAQAKKKRITNPNHYIIESVHPSPLSASRGFFGSKPFSKVNRFLSSIGEKEIDWQIPNL

Sequences:

>Translated_225_residues
MKKILKNDWEPILGPEFEKPYYQNLRQFLKEEYSMRVIYPNANDIFNALHYTSYEDTKVVILGQDPYHGPNQAHGLSFSV
QPGVRVPPSLQNMYKELKADIGCEIPNHGYLVKWAEQGVLLLNTVLTVRQGEANSHKGKGWEQFTDRVIELLNEREKPVI
FILWGRHAQAKKKRITNPNHYIIESVHPSPLSASRGFFGSKPFSKVNRFLSSIGEKEIDWQIPNL
>Mature_225_residues
MKKILKNDWEPILGPEFEKPYYQNLRQFLKEEYSMRVIYPNANDIFNALHYTSYEDTKVVILGQDPYHGPNQAHGLSFSV
QPGVRVPPSLQNMYKELKADIGCEIPNHGYLVKWAEQGVLLLNTVLTVRQGEANSHKGKGWEQFTDRVIELLNEREKPVI
FILWGRHAQAKKKRITNPNHYIIESVHPSPLSASRGFFGSKPFSKVNRFLSSIGEKEIDWQIPNL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=52.5581395348837, Blast_Score=228, Evalue=4e-60,
Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=52.5581395348837, Blast_Score=227, Evalue=5e-60,
Organism=Escherichia coli, GI1788934, Length=214, Percent_Identity=55.607476635514, Blast_Score=243, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17556304, Length=224, Percent_Identity=46.4285714285714, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=46.4135021097046, Blast_Score=204, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_BACCN (A7GVE5)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001377098.1
- ProteinModelPortal:   A7GVE5
- SMR:   A7GVE5
- STRING:   A7GVE5
- EnsemblBacteria:   EBBACT00000039672
- GeneID:   5345546
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_3919
- eggNOG:   COG0692
- GeneTree:   EBGT00050000000847
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- BioCyc:   BCER315749:BCER98_3919-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25974; Mature: 25974

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILKNDWEPILGPEFEKPYYQNLRQFLKEEYSMRVIYPNANDIFNALHYTSYEDTKVV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCCCCEEE
ILGQDPYHGPNQAHGLSFSVQPGVRVPPSLQNMYKELKADIGCEIPNHGYLVKWAEQGVL
EECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEE
LLNTVLTVRQGEANSHKGKGWEQFTDRVIELLNEREKPVIFILWGRHAQAKKKRITNPNH
EEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHCCCCCE
YIIESVHPSPLSASRGFFGSKPFSKVNRFLSSIGEKEIDWQIPNL
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCC
>Mature Secondary Structure
MKKILKNDWEPILGPEFEKPYYQNLRQFLKEEYSMRVIYPNANDIFNALHYTSYEDTKVV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCCCCCEEE
ILGQDPYHGPNQAHGLSFSVQPGVRVPPSLQNMYKELKADIGCEIPNHGYLVKWAEQGVL
EECCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEE
LLNTVLTVRQGEANSHKGKGWEQFTDRVIELLNEREKPVIFILWGRHAQAKKKRITNPNH
EEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHCCCCCE
YIIESVHPSPLSASRGFFGSKPFSKVNRFLSSIGEKEIDWQIPNL
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA