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The map label for this gene is acdA [H]

Identifier: 152977527

GI number: 152977527

Start: 3920152

End: 3921291

Strand: Reverse

Name: acdA [H]

Synonym: Bcer98_3862

Alternate gene names: 152977527

Gene position: 3921291-3920152 (Counterclockwise)

Preceding gene: 152977528

Following gene: 152977526

Centisome position: 95.94

GC content: 44.3

Gene sequence:

>1140_bases
ATGCATTTCAATCTATCTGCAGAACATGAAATGATCCGAAAAATGGTGCGCGACTTTGCGAGGAATGAAGTTGCTCCCAC
AGCGGCAAAGCGAGACGAAGAAGAAAGTTTTGATCGCGCTTTATTTGATCAAATGGCAGCCCTTGGATTAACAGGAATTC
CGTGGCCTGAAGAATATGGCGGAATTGGAAGTGATTACTTAGCATATGTAATCGCAGTAGAGGAATTATCGCGTGCTTGC
GCTTCGACAGGTGTAACGTTATCTGCACATACTTCTTTGGCAGGATGGCCTATTTTTACATTTGGCACAGAAGCGCAAAA
ACAACAGTTTTTACGCCCGATGGCAGAAGGCAAGAAAATCGGTGCATATGGTTTAACGGAGCCAGGTTCAGGATCAGATG
CAGGCGGGATGAAAACGACAGCAAGGCGCGAGGGAAATCACTATATTTTAAATGGTTCTAAGATTTTTATTACAAACGGT
GGTATTGCGGACATTTACGTTGTTTTTGCGCTGACTGACCTAGAAGCGAAGCAGCGCGGCACAAGCGCTTTTATTGTAGA
AAGTGATGCGCCGGGATTCTTGATTGGTAAGAAGGAAAGTAAGCTTGGCATTCGTTCTTCGCCAACGACAGAAATTATAT
TTGAAGATTGCCGCATTCCTGTTGAAAACTTACTTGGCGAAGAAGGGCAAGGATTTAAAATTGCCATGCAGACGCTAGAC
GGCGGTCGCAATGGCATTGCCGCGCAGGCAGTAGGGATTGCCCAAGCTGCTTTAGATGTTTCTGTGGCATATGCGAGGGA
GCGACATCAGTTTGGAAAACCAATCGCTGCGCAGCAAGGTATTAGTTTTAAATTGGCGGATATGGCAACGAATGTAGAAG
CAGCGAGGTTACTCACTTATCAAGCGGCTTGGCTTGAATCTGAAGGGCTTCCTTACGGAAAAGAATCCGCGATGTCAAAG
TTATTTGCTGGAGATATAGCGATGAAAGTAGCAACGGAAGCAGTTCAAATATTTGGTGGTTACGGATATACAAAGGATTA
TCCAGTAGAGCGCTTTATGCGCGATGCAAAGATTACACAAATTTATGAAGGAACGCAAGAGATTCAAAGGCTTGTCATTT
CTCGTATGTTAACAAAATAA

Upstream 100 bases:

>100_bases
GCGATGCGAAAATTTGTGAAATTTATGAGGGAACGAGTGAAATACAAAGACTTGTAATTAGTAGAGCACTGTAATAGAAG
AGCATGGGGAGGAAAGGGTT

Downstream 100 bases:

>100_bases
GAGGAAAAAGCGTAGGGAGTCTCCTGTGCTTTTTCTGCAAATGAAAGAGGGGTGAAGGGGATGGTTAAGCATAACGTGCA
GGCATCAGTAAAAGATGAGA

Product: acyl-CoA dehydrogenase domain-containing protein

Products: 2-butenoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MHFNLSAEHEMIRKMVRDFARNEVAPTAAKRDEEESFDRALFDQMAALGLTGIPWPEEYGGIGSDYLAYVIAVEELSRAC
ASTGVTLSAHTSLAGWPIFTFGTEAQKQQFLRPMAEGKKIGAYGLTEPGSGSDAGGMKTTARREGNHYILNGSKIFITNG
GIADIYVVFALTDLEAKQRGTSAFIVESDAPGFLIGKKESKLGIRSSPTTEIIFEDCRIPVENLLGEEGQGFKIAMQTLD
GGRNGIAAQAVGIAQAALDVSVAYARERHQFGKPIAAQQGISFKLADMATNVEAARLLTYQAAWLESEGLPYGKESAMSK
LFAGDIAMKVATEAVQIFGGYGYTKDYPVERFMRDAKITQIYEGTQEIQRLVISRMLTK

Sequences:

>Translated_379_residues
MHFNLSAEHEMIRKMVRDFARNEVAPTAAKRDEEESFDRALFDQMAALGLTGIPWPEEYGGIGSDYLAYVIAVEELSRAC
ASTGVTLSAHTSLAGWPIFTFGTEAQKQQFLRPMAEGKKIGAYGLTEPGSGSDAGGMKTTARREGNHYILNGSKIFITNG
GIADIYVVFALTDLEAKQRGTSAFIVESDAPGFLIGKKESKLGIRSSPTTEIIFEDCRIPVENLLGEEGQGFKIAMQTLD
GGRNGIAAQAVGIAQAALDVSVAYARERHQFGKPIAAQQGISFKLADMATNVEAARLLTYQAAWLESEGLPYGKESAMSK
LFAGDIAMKVATEAVQIFGGYGYTKDYPVERFMRDAKITQIYEGTQEIQRLVISRMLTK
>Mature_379_residues
MHFNLSAEHEMIRKMVRDFARNEVAPTAAKRDEEESFDRALFDQMAALGLTGIPWPEEYGGIGSDYLAYVIAVEELSRAC
ASTGVTLSAHTSLAGWPIFTFGTEAQKQQFLRPMAEGKKIGAYGLTEPGSGSDAGGMKTTARREGNHYILNGSKIFITNG
GIADIYVVFALTDLEAKQRGTSAFIVESDAPGFLIGKKESKLGIRSSPTTEIIFEDCRIPVENLLGEEGQGFKIAMQTLD
GGRNGIAAQAVGIAQAALDVSVAYARERHQFGKPIAAQQGISFKLADMATNVEAARLLTYQAAWLESEGLPYGKESAMSK
LFAGDIAMKVATEAVQIFGGYGYTKDYPVERFMRDAKITQIYEGTQEIQRLVISRMLTK

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=53.8666666666667, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI4501859, Length=381, Percent_Identity=40.6824146981627, Blast_Score=303, Evalue=1e-82,
Organism=Homo sapiens, GI7656849, Length=376, Percent_Identity=42.2872340425532, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=44.0318302387268, Blast_Score=301, Evalue=7e-82,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=44.0318302387268, Blast_Score=301, Evalue=7e-82,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=42.4, Blast_Score=298, Evalue=7e-81,
Organism=Homo sapiens, GI226958414, Length=337, Percent_Identity=43.9169139465875, Blast_Score=282, Evalue=3e-76,
Organism=Homo sapiens, GI21361497, Length=353, Percent_Identity=42.2096317280453, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=35.8288770053476, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI76496475, Length=373, Percent_Identity=38.0697050938338, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI4557235, Length=373, Percent_Identity=38.0697050938338, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI4503943, Length=377, Percent_Identity=31.5649867374005, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI7669494, Length=365, Percent_Identity=31.2328767123288, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI48976061, Length=295, Percent_Identity=32.5423728813559, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI211971008, Length=295, Percent_Identity=32.5423728813559, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI38505218, Length=291, Percent_Identity=28.5223367697594, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI218563752, Length=289, Percent_Identity=25.9515570934256, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=30.5483028720627, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=31.1855670103093, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI87082384, Length=271, Percent_Identity=28.4132841328413, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87081702, Length=315, Percent_Identity=27.3015873015873, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=45.4068241469816, Blast_Score=313, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI17534899, Length=383, Percent_Identity=46.2140992167102, Blast_Score=313, Evalue=9e-86,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=42.8947368421053, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=39.8395721925134, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17506239, Length=375, Percent_Identity=38.9333333333333, Blast_Score=291, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=39.0501319261214, Blast_Score=280, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=39.1534391534392, Blast_Score=271, Evalue=5e-73,
Organism=Caenorhabditis elegans, GI71985184, Length=352, Percent_Identity=38.9204545454545, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71990804, Length=275, Percent_Identity=42.9090909090909, Blast_Score=235, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17534353, Length=364, Percent_Identity=32.967032967033, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI71985192, Length=301, Percent_Identity=39.202657807309, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17505929, Length=379, Percent_Identity=32.1899736147757, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17551932, Length=383, Percent_Identity=30.2872062663185, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=35.4243542435424, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=39.5652173913043, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=33.6099585062241, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17562446, Length=291, Percent_Identity=29.553264604811, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17531913, Length=179, Percent_Identity=29.608938547486, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=310, Percent_Identity=26.7741935483871, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=310, Percent_Identity=26.7741935483871, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=52.2666666666667, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=47.2, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=42.5925925925926, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI24666513, Length=375, Percent_Identity=39.4666666666667, Blast_Score=304, Evalue=6e-83,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=38.3202099737533, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI281363737, Length=386, Percent_Identity=37.5647668393782, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI19920834, Length=382, Percent_Identity=33.5078534031414, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.2

Molecular weight: Translated: 41230; Mature: 41230

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFNLSAEHEMIRKMVRDFARNEVAPTAAKRDEEESFDRALFDQMAALGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHC
GIGSDYLAYVIAVEELSRACASTGVTLSAHTSLAGWPIFTFGTEAQKQQFLRPMAEGKKI
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCHHHHHHHHHHHHCCCEE
GAYGLTEPGSGSDAGGMKTTARREGNHYILNGSKIFITNGGIADIYVVFALTDLEAKQRG
CCCCCCCCCCCCCCCCCCHHHHCCCCEEEEECCEEEEECCCCEEEEEEEEEECCHHHHCC
TSAFIVESDAPGFLIGKKESKLGIRSSPTTEIIFEDCRIPVENLLGEEGQGFKIAMQTLD
CEEEEEECCCCCEEEECCCCCCCCCCCCCHHEEHHHCCCCHHHHCCCCCCCEEEEEEECC
GGRNGIAAQAVGIAQAALDVSVAYARERHQFGKPIAAQQGISFKLADMATNVEAARLLTY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEHHHHCCHHHHHHHHH
QAAWLESEGLPYGKESAMSKLFAGDIAMKVATEAVQIFGGYGYTKDYPVERFMRDAKITQ
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTQEIQRLVISRMLTK
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHFNLSAEHEMIRKMVRDFARNEVAPTAAKRDEEESFDRALFDQMAALGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHC
GIGSDYLAYVIAVEELSRACASTGVTLSAHTSLAGWPIFTFGTEAQKQQFLRPMAEGKKI
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCHHHHHHHHHHHHCCCEE
GAYGLTEPGSGSDAGGMKTTARREGNHYILNGSKIFITNGGIADIYVVFALTDLEAKQRG
CCCCCCCCCCCCCCCCCCHHHHCCCCEEEEECCEEEEECCCCEEEEEEEEEECCHHHHCC
TSAFIVESDAPGFLIGKKESKLGIRSSPTTEIIFEDCRIPVENLLGEEGQGFKIAMQTLD
CEEEEEECCCCCEEEECCCCCCCCCCCCCHHEEHHHCCCCHHHHCCCCCCCEEEEEEECC
GGRNGIAAQAVGIAQAALDVSVAYARERHQFGKPIAAQQGISFKLADMATNVEAARLLTY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEHHHHCCHHHHHHHHH
QAAWLESEGLPYGKESAMSKLFAGDIAMKVATEAVQIFGGYGYTKDYPVERFMRDAKITQ
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTQEIQRLVISRMLTK
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: butanoyl-CoA; acceptor

Specific reaction: butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]