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The map label for this gene is glyA [H]

Identifier: 152977502

GI number: 152977502

Start: 3896556

End: 3897797

Strand: Reverse

Name: glyA [H]

Synonym: Bcer98_3835

Alternate gene names: 152977502

Gene position: 3897797-3896556 (Counterclockwise)

Preceding gene: 152977503

Following gene: 152977501

Centisome position: 95.37

GC content: 38.89

Gene sequence:

>1242_bases
GTGGATCATTTAAAACGTCAAGATGAAAAGGTATTTGCTGCAATTGAAGCGGAATTAGGAAGACAGCGTTCAAAAATTGA
GTTAATTGCTTCGGAAAACTTCGTAAGCGAAGCTGTAATGGAAGCACAAGGTTCTGTTTTAACAAATAAGTATGCGGAAG
GGTATCCTGGTAAACGTTACTATGGCGGTTGTGAGCATGTAGACGTAGTAGAGGATATTGCACGCGATCGTGTGAAAGAG
ATCTTTGGTGCTGAACATGTAAATGTTCAACCGCATTCTGGTGCACAAGCGAACATGGCTGTATACTTCACAATTTTAGA
GCATGGAGATACAGTTCTTGGTATGAATTTATCTCATGGCGGTCATTTGACACACGGAAGTCCTGTTAACTTTAGTGGAG
TGCAATATAATTTTGTAGAATATGGTGTGGATGCTGAAACTCATCGTATTAACTACGACGATGTGTTAGCAAAAGCAAAA
GAACATAAACCAAAACTAATCGTTGCAGGTGCAAGTGCATATCCTCGTGTGATCGATTTCAAAAGATTTCGTGAAATTGC
AGATGAAGTAGGGGCATATTTAATGGTGGATATGGCTCATATTGCAGGTTTAGTTGCAGCGGGCTTACATCCGAATCCAG
TGCCACATGCACATTTTGTTACGACAACAACACATAAAACATTACGCGGTCCACGCGGTGGTATGATTTTATGTGAAGAG
AAATTTGCAAAGCAAATTGATAAATCAATCTTCCCTGGTATTCAAGGCGGTCCACTTATGCATGTCATCGCTGCAAAAGC
TGTTGCATTTGGGGAAGCACTTCAAGATGACTTTAAAACATATGCGCAAAATATTATTCATAATGCACAGCGTTTAGCAG
AAGGACTTCAAAAAGAAGGACTTACACTCGTTTCTGGTGGAACGGATAACCACCTGATTTTAATTGATGTTCGCAACTTA
AATATTACAGGAAAAGTGGCAGAACATGTATTAGATGAAGTAGGTATTACAGTAAACAAAAATACAATTCCATTTGAAAC
AGCAAGTCCATTTGTAACAAGTGGTGTACGTATCGGTACAGCGGCTGTAACATCTCGTGGCTTTGGCTTAGAAGAAATGG
ATGAAATCGCATCAATTATTGCACATACATTAAAAAATCACGAAGACGAAACTGCATTAGAAGAAGCTCGTAAACGTGTA
GCTGTATTAACAAGTAAGTTTCCAATGTACACTGATTTATAA

Upstream 100 bases:

>100_bases
AAGATTTAAAAGAATTACAACTTGAATTTTCGTTTTTTCTGAATAAATAGGAAAAAACTATTGGGAATTAATGTAATTCG
TTCAGAAAAGGGGGATTTTG

Downstream 100 bases:

>100_bases
TAGATGAAAGAAAACCACTGTAACATCATGTTGCAGTGGTTTTCTTTCGGTTGCATAATGCTTGAATATAGAGAAAGAAC
TTCATGAGAACAGATGAAGC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MDHLKRQDEKVFAAIEAELGRQRSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRVKE
IFGAEHVNVQPHSGAQANMAVYFTILEHGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDAETHRINYDDVLAKAK
EHKPKLIVAGASAYPRVIDFKRFREIADEVGAYLMVDMAHIAGLVAAGLHPNPVPHAHFVTTTTHKTLRGPRGGMILCEE
KFAKQIDKSIFPGIQGGPLMHVIAAKAVAFGEALQDDFKTYAQNIIHNAQRLAEGLQKEGLTLVSGGTDNHLILIDVRNL
NITGKVAEHVLDEVGITVNKNTIPFETASPFVTSGVRIGTAAVTSRGFGLEEMDEIASIIAHTLKNHEDETALEEARKRV
AVLTSKFPMYTDL

Sequences:

>Translated_413_residues
MDHLKRQDEKVFAAIEAELGRQRSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRVKE
IFGAEHVNVQPHSGAQANMAVYFTILEHGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDAETHRINYDDVLAKAK
EHKPKLIVAGASAYPRVIDFKRFREIADEVGAYLMVDMAHIAGLVAAGLHPNPVPHAHFVTTTTHKTLRGPRGGMILCEE
KFAKQIDKSIFPGIQGGPLMHVIAAKAVAFGEALQDDFKTYAQNIIHNAQRLAEGLQKEGLTLVSGGTDNHLILIDVRNL
NITGKVAEHVLDEVGITVNKNTIPFETASPFVTSGVRIGTAAVTSRGFGLEEMDEIASIIAHTLKNHEDETALEEARKRV
AVLTSKFPMYTDL
>Mature_413_residues
MDHLKRQDEKVFAAIEAELGRQRSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRVKE
IFGAEHVNVQPHSGAQANMAVYFTILEHGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDAETHRINYDDVLAKAK
EHKPKLIVAGASAYPRVIDFKRFREIADEVGAYLMVDMAHIAGLVAAGLHPNPVPHAHFVTTTTHKTLRGPRGGMILCEE
KFAKQIDKSIFPGIQGGPLMHVIAAKAVAFGEALQDDFKTYAQNIIHNAQRLAEGLQKEGLTLVSGGTDNHLILIDVRNL
NITGKVAEHVLDEVGITVNKNTIPFETASPFVTSGVRIGTAAVTSRGFGLEEMDEIASIIAHTLKNHEDETALEEARKRV
AVLTSKFPMYTDL

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=453, Percent_Identity=41.5011037527594, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI261862352, Length=453, Percent_Identity=41.5011037527594, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI261862350, Length=453, Percent_Identity=41.5011037527594, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI261862348, Length=453, Percent_Identity=41.5011037527594, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI261862346, Length=448, Percent_Identity=41.2946428571429, Blast_Score=328, Evalue=8e-90,
Organism=Homo sapiens, GI22547186, Length=429, Percent_Identity=44.0559440559441, Blast_Score=321, Evalue=7e-88,
Organism=Homo sapiens, GI22547189, Length=414, Percent_Identity=42.7536231884058, Blast_Score=293, Evalue=2e-79,
Organism=Escherichia coli, GI1788902, Length=417, Percent_Identity=58.273381294964, Blast_Score=481, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI25144732, Length=403, Percent_Identity=45.6575682382134, Blast_Score=352, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI25144729, Length=403, Percent_Identity=45.6575682382134, Blast_Score=352, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6319739, Length=422, Percent_Identity=45.9715639810426, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=402, Percent_Identity=44.5273631840796, Blast_Score=320, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24640005, Length=452, Percent_Identity=42.0353982300885, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221329721, Length=452, Percent_Identity=42.0353982300885, Blast_Score=363, Evalue=1e-100,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45199; Mature: 45199

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHLKRQDEKVFAAIEAELGRQRSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRY
CCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
YGGCEHVDVVEDIARDRVKEIFGAEHVNVQPHSGAQANMAVYFTILEHGDTVLGMNLSHG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEECCC
GHLTHGSPVNFSGVQYNFVEYGVDAETHRINYDDVLAKAKEHKPKLIVAGASAYPRVIDF
CCCCCCCCCCCCCEEEEHEEECCCCCCEECCHHHHHHHHHHCCCCEEEECCCCCCHHHHH
KRFREIADEVGAYLMVDMAHIAGLVAAGLHPNPVPHAHFVTTTTHKTLRGPRGGMILCEE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHCCCCCCEEEEHH
KFAKQIDKSIFPGIQGGPLMHVIAAKAVAFGEALQDDFKTYAQNIIHNAQRLAEGLQKEG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTLVSGGTDNHLILIDVRNLNITGKVAEHVLDEVGITVNKNTIPFETASPFVTSGVRIGT
CEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCHHHCCEEECH
AAVTSRGFGLEEMDEIASIIAHTLKNHEDETALEEARKRVAVLTSKFPMYTDL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDHLKRQDEKVFAAIEAELGRQRSKIELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRY
CCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHCCCCCCCC
YGGCEHVDVVEDIARDRVKEIFGAEHVNVQPHSGAQANMAVYFTILEHGDTVLGMNLSHG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEECCC
GHLTHGSPVNFSGVQYNFVEYGVDAETHRINYDDVLAKAKEHKPKLIVAGASAYPRVIDF
CCCCCCCCCCCCCEEEEHEEECCCCCCEECCHHHHHHHHHHCCCCEEEECCCCCCHHHHH
KRFREIADEVGAYLMVDMAHIAGLVAAGLHPNPVPHAHFVTTTTHKTLRGPRGGMILCEE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHCCCCCCEEEEHH
KFAKQIDKSIFPGIQGGPLMHVIAAKAVAFGEALQDDFKTYAQNIIHNAQRLAEGLQKEG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LTLVSGGTDNHLILIDVRNLNITGKVAEHVLDEVGITVNKNTIPFETASPFVTSGVRIGT
CEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCHHHCCEEECH
AAVTSRGFGLEEMDEIASIIAHTLKNHEDETALEEARKRVAVLTSKFPMYTDL
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA