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The map label for this gene is ytkD [H]

Identifier: 152977147

GI number: 152977147

Start: 3522618

End: 3523097

Strand: Reverse

Name: ytkD [H]

Synonym: Bcer98_3459

Alternate gene names: 152977147

Gene position: 3523097-3522618 (Counterclockwise)

Preceding gene: 152977148

Following gene: 152977146

Centisome position: 86.2

GC content: 36.25

Gene sequence:

>480_bases
ATGTACACATTTAAAGATTATTACCACAACACTGTACAATTATCGTTTGAACGTTATCCATTTTCTCCTGAGCCAAAGCA
TGTTTGGGTTGTATGCCGGTACAGGGATCAATGGTTATTAACGCATCATTTGCGCCGTGGTCTTGAATTTCCAGGTGGAA
AAGTAGAAATGGGAGAGACACCGGAAGAAGCGGCAGTTAGGGAAGTTCATGAAGAAACCGGCGGGATTGTTTCTGATTTA
ACTTACTTAGGGCAATACAAAGTGTCAGGAAAAGATAAAATTATTATTAAAAATATTTATTTCGCAACCATTAGTGCGGT
GGAAGAACATACGCATTATGAAGAAACAAAAGGATCTGTGTTATTAAAAGAAATTCCTGATAACATTAAACATGATAGAA
AATTTAGTTTTATTATGCGCGATGATGTATTAGCGCGTACGATGAAGCATATAGAAGAACTCGGCTGTTTTATAAAGTAA

Upstream 100 bases:

>100_bases
AATCAATGGATTATAGTTGGATAACATTATGCAGGAAAGCGAGAATATGCTACAATTTGTGGTAGGAAAAACTTGTAACC
ATCAATAGGGGAGTAATGGC

Downstream 100 bases:

>100_bases
AGTGGCCGAGTTCTTTTATCATACGGGATTGTTCAAACTCACCTCAAAATAAATCTCTCTTTCTTTAAAAATAAGTATCG
CATATTTTAGAAAGAATGCG

Product: nucleoside triphosphatase YtkD

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MYTFKDYYHNTVQLSFERYPFSPEPKHVWVVCRYRDQWLLTHHLRRGLEFPGGKVEMGETPEEAAVREVHEETGGIVSDL
TYLGQYKVSGKDKIIIKNIYFATISAVEEHTHYEETKGSVLLKEIPDNIKHDRKFSFIMRDDVLARTMKHIEELGCFIK

Sequences:

>Translated_159_residues
MYTFKDYYHNTVQLSFERYPFSPEPKHVWVVCRYRDQWLLTHHLRRGLEFPGGKVEMGETPEEAAVREVHEETGGIVSDL
TYLGQYKVSGKDKIIIKNIYFATISAVEEHTHYEETKGSVLLKEIPDNIKHDRKFSFIMRDDVLARTMKHIEELGCFIK
>Mature_159_residues
MYTFKDYYHNTVQLSFERYPFSPEPKHVWVVCRYRDQWLLTHHLRRGLEFPGGKVEMGETPEEAAVREVHEETGGIVSDL
TYLGQYKVSGKDKIIIKNIYFATISAVEEHTHYEETKGSVLLKEIPDNIKHDRKFSFIMRDDVLARTMKHIEELGCFIK

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR014078 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18725; Mature: 18725

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTFKDYYHNTVQLSFERYPFSPEPKHVWVVCRYRDQWLLTHHLRRGLEFPGGKVEMGET
CCCCHHHCCCEEEEEEEECCCCCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCEEECCCC
PEEAAVREVHEETGGIVSDLTYLGQYKVSGKDKIIIKNIYFATISAVEEHTHYEETKGSV
CHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCE
LLKEIPDNIKHDRKFSFIMRDDVLARTMKHIEELGCFIK
EHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MYTFKDYYHNTVQLSFERYPFSPEPKHVWVVCRYRDQWLLTHHLRRGLEFPGGKVEMGET
CCCCHHHCCCEEEEEEEECCCCCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCEEECCCC
PEEAAVREVHEETGGIVSDLTYLGQYKVSGKDKIIIKNIYFATISAVEEHTHYEETKGSV
CHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCE
LLKEIPDNIKHDRKFSFIMRDDVLARTMKHIEELGCFIK
EHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]