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The map label for this gene is ytcI [H]

Identifier: 152977012

GI number: 152977012

Start: 3386806

End: 3388392

Strand: Reverse

Name: ytcI [H]

Synonym: Bcer98_3317

Alternate gene names: 152977012

Gene position: 3388392-3386806 (Counterclockwise)

Preceding gene: 152977013

Following gene: 152977011

Centisome position: 82.91

GC content: 37.74

Gene sequence:

>1587_bases
ATGAAGAGAGAAGAATTATTAGCGCCACCGTCGTATAATTTAGTTACAGAGATAGAGAAATATATGAATGAAAAAGACAA
GTTAGCATTAATTTGGCAGGATGAGAAGGGAGCAAGAAGAGAGGTTACATACTTTGAATTAATAAAAGGAGCAAATAAAA
TTGGAAACGCTTTTATAAAAAGTGGTTTGCAAAAAGGGGACAAGCTTCTTATTATGATGCCGCGTTTAATCGAAGCGTAT
ATGACATATATAGGAGCAATTAAAGCAGGATTTGTTGTAATTCCAAGTTCTGAAATGCTTCGCAAAAAAGATATTGAATA
TCGTATTCAACATGGAGAAGTAAAAGCTATTATAAGTTATGAACCATATATTTCACAATTTGAAGGAATAGAGGGAATGG
ATTCTCTTCAAAAATTTGTGTTAAGTGAAAAAGAAGTAGATGGATGGGCGAATTTAAATACTGCATTAGAAACAGAAAGT
GATGTATTAGATATTGTCAAGACGGATAAGGAAGATATGGTCTTTTTATCTTATACATCAGGAACGACAGGAAACCCAAA
AGGTGTTGTTCATACACATGCTTGGGGGTATGCACATTTGCGGACGAGCGCTCCGAATTGGCTTGGAATTGAAGAGAATG
ATATTGTATGGGCAACGGCTAGTCCAGGATGGCAAAAGTGGATTTGGAGTCCGTTTTTAGCAACTCTCGGTTCAGGTGCA
ACTGGATTTGTATATCACGGTAAATTTGAGCCGAAAACATACTTACAGCTATTAGATGAGAACCAAGTAAATGTGCTTTG
CTGTACGCCGACAGAATATCGTTTAATGGCCAAGGTGGAAAACTTGCAGCAATATAATTTAAAGGCATTGCACAGTGCTG
TATCCGCAGGAGAGCCGTTAAATCGTGAGGTCATTGAAACGTTCCAAAAGCACTTTCAGGTTACTGTTAGAGATGGATAT
GGTCAAACAGAAAATACATTGCTCATTGGTGTTATGAAAGGGATGGAAATAAGACCGGGATCGATGGGAAAACCAACGCC
GGGGAATCAAGTAGAAATTATCAATGAAGAAGGACACCCTGTATCTGTTGGAGAAGTGGGAGATATTGCTGTTCATATTG
ATACACCGGCACTCTTTAAACAATATTATAAAGATGATGAACGTACAGCAATGCAATTCCGTGGTGATTACTATATTACA
GGGGATAAAGCGAAAAAAGATGAAGACGGCTATTTTTGGTTTGAAGGCCGCGGTGATGATATTATTATTAGTTCTGGCTA
CACAATTGGCCCATTTGAGGTGGAAGATGCACTTGTGAAGCATCCATATGTAAGAGAATGCGCAGTAGTAGCGAGCCCAG
ATGAGATTCGCGGAAGTGTCGTAAAGGCATTTATCGTATTAAGAGACAATGTACAGGAAAAAGAAGATACATTGATCCCT
TTACTCCAAGAACATGTTAAAACATTAACAGCACCTTATAAATATCCTCGTAAGATTGAATTTGTAGACGAACTACCAAA
AACGATTTCCGGAAAAATTAGACGTGTTGAACTTAGAAAACAGGAAATGGAATTGCGGTTAAAGTAA

Upstream 100 bases:

>100_bases
CTTTCGACATCGATGAAAAATTTTTCAAAAGAAGAGGGTTCAAAATTTACAGAAAATTCTTTATTATAAAAGGGAGGCAT
AGTGACAAAGGAGGATATTG

Downstream 100 bases:

>100_bases
AAGATATATTGAATATAGAATGGTAAGTGTCAACAATCTTAGCGAATCAAAATGAATATTGGAACAGCACCATATGATGT
GAAATGGTGCTTTTTTTCTA

Product: AMP-dependent synthetase and ligase

Products: AMP; diphosphate; acetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MKREELLAPPSYNLVTEIEKYMNEKDKLALIWQDEKGARREVTYFELIKGANKIGNAFIKSGLQKGDKLLIMMPRLIEAY
MTYIGAIKAGFVVIPSSEMLRKKDIEYRIQHGEVKAIISYEPYISQFEGIEGMDSLQKFVLSEKEVDGWANLNTALETES
DVLDIVKTDKEDMVFLSYTSGTTGNPKGVVHTHAWGYAHLRTSAPNWLGIEENDIVWATASPGWQKWIWSPFLATLGSGA
TGFVYHGKFEPKTYLQLLDENQVNVLCCTPTEYRLMAKVENLQQYNLKALHSAVSAGEPLNREVIETFQKHFQVTVRDGY
GQTENTLLIGVMKGMEIRPGSMGKPTPGNQVEIINEEGHPVSVGEVGDIAVHIDTPALFKQYYKDDERTAMQFRGDYYIT
GDKAKKDEDGYFWFEGRGDDIIISSGYTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRDNVQEKEDTLIP
LLQEHVKTLTAPYKYPRKIEFVDELPKTISGKIRRVELRKQEMELRLK

Sequences:

>Translated_528_residues
MKREELLAPPSYNLVTEIEKYMNEKDKLALIWQDEKGARREVTYFELIKGANKIGNAFIKSGLQKGDKLLIMMPRLIEAY
MTYIGAIKAGFVVIPSSEMLRKKDIEYRIQHGEVKAIISYEPYISQFEGIEGMDSLQKFVLSEKEVDGWANLNTALETES
DVLDIVKTDKEDMVFLSYTSGTTGNPKGVVHTHAWGYAHLRTSAPNWLGIEENDIVWATASPGWQKWIWSPFLATLGSGA
TGFVYHGKFEPKTYLQLLDENQVNVLCCTPTEYRLMAKVENLQQYNLKALHSAVSAGEPLNREVIETFQKHFQVTVRDGY
GQTENTLLIGVMKGMEIRPGSMGKPTPGNQVEIINEEGHPVSVGEVGDIAVHIDTPALFKQYYKDDERTAMQFRGDYYIT
GDKAKKDEDGYFWFEGRGDDIIISSGYTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRDNVQEKEDTLIP
LLQEHVKTLTAPYKYPRKIEFVDELPKTISGKIRRVELRKQEMELRLK
>Mature_528_residues
MKREELLAPPSYNLVTEIEKYMNEKDKLALIWQDEKGARREVTYFELIKGANKIGNAFIKSGLQKGDKLLIMMPRLIEAY
MTYIGAIKAGFVVIPSSEMLRKKDIEYRIQHGEVKAIISYEPYISQFEGIEGMDSLQKFVLSEKEVDGWANLNTALETES
DVLDIVKTDKEDMVFLSYTSGTTGNPKGVVHTHAWGYAHLRTSAPNWLGIEENDIVWATASPGWQKWIWSPFLATLGSGA
TGFVYHGKFEPKTYLQLLDENQVNVLCCTPTEYRLMAKVENLQQYNLKALHSAVSAGEPLNREVIETFQKHFQVTVRDGY
GQTENTLLIGVMKGMEIRPGSMGKPTPGNQVEIINEEGHPVSVGEVGDIAVHIDTPALFKQYYKDDERTAMQFRGDYYIT
GDKAKKDEDGYFWFEGRGDDIIISSGYTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRDNVQEKEDTLIP
LLQEHVKTLTAPYKYPRKIEFVDELPKTISGKIRRVELRKQEMELRLK

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=538, Percent_Identity=39.7769516728625, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI38505220, Length=515, Percent_Identity=40, Blast_Score=374, Evalue=1e-103,
Organism=Homo sapiens, GI122937307, Length=533, Percent_Identity=38.2739212007505, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI157311624, Length=538, Percent_Identity=36.2453531598513, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI157311622, Length=538, Percent_Identity=36.2453531598513, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI58082049, Length=538, Percent_Identity=36.2453531598513, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI115511026, Length=530, Percent_Identity=36.0377358490566, Blast_Score=324, Evalue=2e-88,
Organism=Homo sapiens, GI42544134, Length=368, Percent_Identity=31.7934782608696, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI28416953, Length=528, Percent_Identity=28.7878787878788, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI195947378, Length=417, Percent_Identity=28.0575539568345, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI13375727, Length=536, Percent_Identity=27.7985074626866, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI8923896, Length=574, Percent_Identity=27.8745644599303, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI253970489, Length=588, Percent_Identity=27.5510204081633, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI156151445, Length=553, Percent_Identity=24.5931283905967, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI187761345, Length=538, Percent_Identity=25.092936802974, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI187761343, Length=538, Percent_Identity=25.092936802974, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI31982927, Length=542, Percent_Identity=21.5867158671587, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790505, Length=542, Percent_Identity=28.4132841328413, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI221142682, Length=507, Percent_Identity=25.4437869822485, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1788107, Length=513, Percent_Identity=25.5360623781676, Blast_Score=162, Evalue=7e-41,
Organism=Escherichia coli, GI1786529, Length=552, Percent_Identity=26.8115942028986, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI145693145, Length=518, Percent_Identity=26.0617760617761, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1786810, Length=531, Percent_Identity=24.4821092278719, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1789201, Length=373, Percent_Identity=24.3967828418231, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=537, Percent_Identity=26.2569832402235, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71982997, Length=366, Percent_Identity=32.2404371584699, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71983001, Length=366, Percent_Identity=32.2404371584699, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17557194, Length=521, Percent_Identity=25.1439539347409, Blast_Score=145, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI32563687, Length=517, Percent_Identity=24.3713733075435, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17558820, Length=490, Percent_Identity=24.6938775510204, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17538037, Length=519, Percent_Identity=24.0847784200385, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71994694, Length=548, Percent_Identity=26.4598540145985, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI71994703, Length=547, Percent_Identity=26.3254113345521, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI71994690, Length=547, Percent_Identity=26.3254113345521, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560308, Length=382, Percent_Identity=28.0104712041885, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=536, Percent_Identity=23.134328358209, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71985884, Length=381, Percent_Identity=27.2965879265092, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17560140, Length=522, Percent_Identity=23.3716475095785, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71996755, Length=490, Percent_Identity=24.0816326530612, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115534440, Length=532, Percent_Identity=23.4962406015038, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319264, Length=564, Percent_Identity=28.9007092198582, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6323182, Length=566, Percent_Identity=27.9151943462898, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6319699, Length=348, Percent_Identity=25.5747126436782, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24667955, Length=545, Percent_Identity=28.0733944954128, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI62472339, Length=529, Percent_Identity=28.3553875236295, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21355225, Length=521, Percent_Identity=27.063339731286, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24667959, Length=365, Percent_Identity=32.3287671232877, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24581924, Length=529, Percent_Identity=27.7882797731569, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI21355181, Length=474, Percent_Identity=25.9493670886076, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI18859661, Length=492, Percent_Identity=27.6422764227642, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI19922652, Length=515, Percent_Identity=23.8834951456311, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24656500, Length=506, Percent_Identity=23.1225296442688, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24653035, Length=478, Percent_Identity=22.5941422594142, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI21356947, Length=354, Percent_Identity=25.7062146892655, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24648260, Length=358, Percent_Identity=25.1396648044693, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI161076582, Length=474, Percent_Identity=21.9409282700422, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648257, Length=515, Percent_Identity=22.3300970873786, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20130353, Length=586, Percent_Identity=22.1843003412969, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573631, Length=586, Percent_Identity=22.1843003412969, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356441, Length=378, Percent_Identity=22.7513227513227, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI20130357, Length=359, Percent_Identity=24.2339832869081, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI281365686, Length=318, Percent_Identity=21.0691823899371, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648253, Length=360, Percent_Identity=22.5, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21358303, Length=323, Percent_Identity=21.0526315789474, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648255, Length=360, Percent_Identity=22.5, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.1

Molecular weight: Translated: 59929; Mature: 59929

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKREELLAPPSYNLVTEIEKYMNEKDKLALIWQDEKGARREVTYFELIKGANKIGNAFIK
CCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCHHHHHHHHH
SGLQKGDKLLIMMPRLIEAYMTYIGAIKAGFVVIPSSEMLRKKDIEYRIQHGEVKAIISY
HHHCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEECCHHHHHHCCCEEEEECCCEEEEEEE
EPYISQFEGIEGMDSLQKFVLSEKEVDGWANLNTALETESDVLDIVKTDKEDMVFLSYTS
CHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHCCCHHHHHHHHCCCCCEEEEEECC
GTTGNPKGVVHTHAWGYAHLRTSAPNWLGIEENDIVWATASPGWQKWIWSPFLATLGSGA
CCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCC
TGFVYHGKFEPKTYLQLLDENQVNVLCCTPTEYRLMAKVENLQQYNLKALHSAVSAGEPL
CEEEEECCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NREVIETFQKHFQVTVRDGYGQTENTLLIGVMKGMEIRPGSMGKPTPGNQVEIINEEGHP
CHHHHHHHHHHEEEEEECCCCCCCCEEEEEEECCCEECCCCCCCCCCCCEEEEECCCCCE
VSVGEVGDIAVHIDTPALFKQYYKDDERTAMQFRGDYYITGDKAKKDEDGYFWFEGRGDD
EECCCCCCEEEEECCHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCCCCEEEEECCCCE
IIISSGYTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRDNVQEKEDTLIP
EEEECCCEECCCCHHHHHHCCCCHHHEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
LLQEHVKTLTAPYKYPRKIEFVDELPKTISGKIRRVELRKQEMELRLK
HHHHHHHHHCCCCCCCCEEHHHHHCCHHHCCCEEEEEEEHHHHHEECC
>Mature Secondary Structure
MKREELLAPPSYNLVTEIEKYMNEKDKLALIWQDEKGARREVTYFELIKGANKIGNAFIK
CCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCHHHHHHHHH
SGLQKGDKLLIMMPRLIEAYMTYIGAIKAGFVVIPSSEMLRKKDIEYRIQHGEVKAIISY
HHHCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEECCHHHHHHCCCEEEEECCCEEEEEEE
EPYISQFEGIEGMDSLQKFVLSEKEVDGWANLNTALETESDVLDIVKTDKEDMVFLSYTS
CHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHCCCHHHHHHHHCCCCCEEEEEECC
GTTGNPKGVVHTHAWGYAHLRTSAPNWLGIEENDIVWATASPGWQKWIWSPFLATLGSGA
CCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCC
TGFVYHGKFEPKTYLQLLDENQVNVLCCTPTEYRLMAKVENLQQYNLKALHSAVSAGEPL
CEEEEECCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NREVIETFQKHFQVTVRDGYGQTENTLLIGVMKGMEIRPGSMGKPTPGNQVEIINEEGHP
CHHHHHHHHHHEEEEEECCCCCCCCEEEEEEECCCEECCCCCCCCCCCCEEEEECCCCCE
VSVGEVGDIAVHIDTPALFKQYYKDDERTAMQFRGDYYITGDKAKKDEDGYFWFEGRGDD
EECCCCCCEEEEECCHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCCCCEEEEECCCCE
IIISSGYTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRDNVQEKEDTLIP
EEEECCCEECCCCHHHHHHCCCCHHHEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
LLQEHVKTLTAPYKYPRKIEFVDELPKTISGKIRRVELRKQEMELRLK
HHHHHHHHHCCCCCCCCEEHHHHHCCHHHCCCEEEEEEEHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetate; CoA

Specific reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

General reaction: Acid-thiol ligation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]