BacMap

Definition	Bacillus cereus subsp. cytotoxis NVH 391-98, complete genome.
Accession	NC_009674
Length	4,087,024

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The map label for this gene is fabG [H]

Identifier: 152976996

GI number: 152976996

Start: 3370856

End: 3371653

Strand: Reverse

Name: fabG [H]

Synonym: Bcer98_3300

Alternate gene names: 152976996

Gene position: 3371653-3370856 (Counterclockwise)

Preceding gene: 152976998

Following gene: 152976995

Centisome position: 82.5

GC content: 37.09

Gene sequence:

>798_bases
ATGGAGTATAGTAATTTAAAAGGAGGCATGTTTGTGAGACACGCGCTCATTACAGCCGGTACAAAAGGTTTAGGAAAGCA
AGTAACAGAGAAATTATTAGCGAATGGACATTCTGTAACAGTCACATACCATAGCGACAGAAGCGCTGTAGAGGAAATGA
AAGAAAAGTATAATCATATAGAAGAACGTCTACAGTTTATACAAGCGGATGTCACGAAGAAAGAAGATTTACATAAAATA
GTAGAAGAAGCGACAAAGCGTTTTGGTAAGATCGATTTTTTAATTAATAATGCGGGTCCTTATGTGTTTGAACGAAAAAA
ATTAGTGGATTATGAAGAACAGGAATGGAATGAGATGATTCAAGGAAATTTAACGGCGGTATTTCATCTGTTAAAACTCG
TTGTTCCAATTATGAGAAGGAATCAATTTGGTCGCATTATTAATTATGGATTTCAAGGGGCCGATAGTGCACCGGGATGG
ATATATCGTTCAGCTTTTGCAGCAGCAAAAGTAGGGCTTGTTTCATTAACGAAGACAGTTGCTTATGAAGAAGCAGAATA
TGGTATTACAGCAAATATGGTTTGCCCAGGTGATATTATTGGTGAGATGAAAGAAGCAACAATTCAAGAAGCGCGCATAT
TGAAAGATAAGCGTACGCCAATTGGTAGATCAGGAACAGGTGAAGATATCGCACGTACCATCTCATTTTTATGCGAAGAA
GATTCTGATATGATTACGGGTACAATTATTGAAATAACAGGGGCAGTTGATGTAATTCATCGATATCGACAAAAGTAA

Upstream 100 bases:

>100_bases
TAAAACAAATTCTGGTAATATACGTAAAAAAACGTTACAGAATTTTGAAAAGTTTGTTTTGATTCTTTTTAGTTGTAATT
GCAGCAAGAACTTGTTACAT

Downstream 100 bases:

>100_bases
ATAAAGTGAAACTTTAATCAGTGGAGGTTCTTCATCCCCACTGATTATGAGCTCTCACCAATCGGGCTGTTACGGGCAGC
CCTACTCCCACCTATCTTCC

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MEYSNLKGGMFVRHALITAGTKGLGKQVTEKLLANGHSVTVTYHSDRSAVEEMKEKYNHIEERLQFIQADVTKKEDLHKI
VEEATKRFGKIDFLINNAGPYVFERKKLVDYEEQEWNEMIQGNLTAVFHLLKLVVPIMRRNQFGRIINYGFQGADSAPGW
IYRSAFAAAKVGLVSLTKTVAYEEAEYGITANMVCPGDIIGEMKEATIQEARILKDKRTPIGRSGTGEDIARTISFLCEE
DSDMITGTIIEITGAVDVIHRYRQK

Sequences:

>Translated_265_residues
MEYSNLKGGMFVRHALITAGTKGLGKQVTEKLLANGHSVTVTYHSDRSAVEEMKEKYNHIEERLQFIQADVTKKEDLHKI
VEEATKRFGKIDFLINNAGPYVFERKKLVDYEEQEWNEMIQGNLTAVFHLLKLVVPIMRRNQFGRIINYGFQGADSAPGW
IYRSAFAAAKVGLVSLTKTVAYEEAEYGITANMVCPGDIIGEMKEATIQEARILKDKRTPIGRSGTGEDIARTISFLCEE
DSDMITGTIIEITGAVDVIHRYRQK
>Mature_265_residues
MEYSNLKGGMFVRHALITAGTKGLGKQVTEKLLANGHSVTVTYHSDRSAVEEMKEKYNHIEERLQFIQADVTKKEDLHKI
VEEATKRFGKIDFLINNAGPYVFERKKLVDYEEQEWNEMIQGNLTAVFHLLKLVVPIMRRNQFGRIINYGFQGADSAPGW
IYRSAFAAAKVGLVSLTKTVAYEEAEYGITANMVCPGDIIGEMKEATIQEARILKDKRTPIGRSGTGEDIARTISFLCEE
DSDMITGTIIEITGAVDVIHRYRQK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=265, Percent_Identity=25.6603773584906, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI15277342, Length=259, Percent_Identity=28.957528957529, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI59889578, Length=202, Percent_Identity=28.2178217821782, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI32483357, Length=260, Percent_Identity=28.8461538461538, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI66933014, Length=215, Percent_Identity=30.6976744186047, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI5031737, Length=252, Percent_Identity=26.984126984127, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI40254992, Length=248, Percent_Identity=26.6129032258064, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4758504, Length=193, Percent_Identity=28.4974093264249, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI126723750, Length=268, Percent_Identity=27.2388059701493, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI83715985, Length=185, Percent_Identity=28.1081081081081, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=24.8979591836735, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=31.404958677686, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI87082160, Length=263, Percent_Identity=28.5171102661597, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI1788459, Length=241, Percent_Identity=26.9709543568465, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=29.2490118577075, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=27.843137254902, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1789208, Length=249, Percent_Identity=26.1044176706827, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=26.2948207171315, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=25.3061224489796, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789057, Length=257, Percent_Identity=25.6809338521401, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1789378, Length=245, Percent_Identity=21.6326530612245, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI2367365, Length=240, Percent_Identity=24.1666666666667, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=30, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=29.2490118577075, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=28.5171102661597, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=251, Percent_Identity=28.6852589641434, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=25.78125, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=259, Percent_Identity=23.5521235521236, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=26.4822134387352, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=239, Percent_Identity=27.6150627615063, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=265, Percent_Identity=27.9245283018868, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17551412, Length=243, Percent_Identity=26.3374485596708, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=242, Percent_Identity=25.6198347107438, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=263, Percent_Identity=25.4752851711027, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=25.0950570342205, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17568967, Length=191, Percent_Identity=27.2251308900524, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=266, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=275, Percent_Identity=28, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=187, Percent_Identity=25.1336898395722, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=242, Percent_Identity=25.2066115702479, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=262, Percent_Identity=25.1908396946565, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=240, Percent_Identity=25.4166666666667, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=246, Percent_Identity=23.1707317073171, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=126, Percent_Identity=35.7142857142857, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322227, Length=217, Percent_Identity=23.0414746543779, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=191, Percent_Identity=25.130890052356, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI21355319, Length=253, Percent_Identity=27.6679841897233, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24644339, Length=246, Percent_Identity=25.2032520325203, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI23397609, Length=256, Percent_Identity=26.5625, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI18859837, Length=262, Percent_Identity=27.4809160305344, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=26.0869565217391, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=25.5060728744939, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21357041, Length=195, Percent_Identity=28.2051282051282, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=25.296442687747, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24665243, Length=198, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI221331218, Length=198, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24665247, Length=197, Percent_Identity=25.8883248730964, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221331216, Length=197, Percent_Identity=25.8883248730964, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 29868; Mature: 29868

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYSNLKGGMFVRHALITAGTKGLGKQVTEKLLANGHSVTVTYHSDRSAVEEMKEKYNHI
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHH
EERLQFIQADVTKKEDLHKIVEEATKRFGKIDFLINNAGPYVFERKKLVDYEEQEWNEMI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHCCCHHHHHHHHH
QGNLTAVFHLLKLVVPIMRRNQFGRIINYGFQGADSAPGWIYRSAFAAAKVGLVSLTKTV
HCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AYEEAEYGITANMVCPGDIIGEMKEATIQEARILKDKRTPIGRSGTGEDIARTISFLCEE
HHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
DSDMITGTIIEITGAVDVIHRYRQK
CCCEEEEHHEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MEYSNLKGGMFVRHALITAGTKGLGKQVTEKLLANGHSVTVTYHSDRSAVEEMKEKYNHI
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHH
EERLQFIQADVTKKEDLHKIVEEATKRFGKIDFLINNAGPYVFERKKLVDYEEQEWNEMI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHCCCHHHHHHHHH
QGNLTAVFHLLKLVVPIMRRNQFGRIINYGFQGADSAPGWIYRSAFAAAKVGLVSLTKTV
HCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AYEEAEYGITANMVCPGDIIGEMKEATIQEARILKDKRTPIGRSGTGEDIARTISFLCEE
HHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
DSDMITGTIIEITGAVDVIHRYRQK
CCCEEEEHHEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]