Click here to switch to the map view.

The map label for this gene is pdp [H]

Identifier: 152976495

GI number: 152976495

Start: 2864223

End: 2865527

Strand: Reverse

Name: pdp [H]

Synonym: Bcer98_2784

Alternate gene names: 152976495

Gene position: 2865527-2864223 (Counterclockwise)

Preceding gene: 152976496

Following gene: 152976494

Centisome position: 70.11

GC content: 38.01

Gene sequence:

>1305_bases
ATGAGAATGGTGGACCTAATTGCCAAAAAACGTGATGGACATGCGCTAACAACAGAAGAAATTAATTTTATTGTTGAAGG
ATTTACAAACGGTGATATTCCTGATTATCAAATGAGCTCTTTTGCAATGGCGATTTTCTTTCAAGATATGAATGAACAAG
AGCGTGCTGATTTAACAATGGCAATGGTAAATAGCGGTGATACAATTGATCTCTCAGCAATTGAAGGGATAAAGGTAGAT
AAGCATTCTACAGGTGGCGTTGGGGATACAACTACGCTTGTACTAGGTCCGTTAGTAGCTGCTTTAGGTGTACCAGTTGC
AAAAATGTCTGGACGTGGTTTAGGACATACTGGTGGTACAATTGATAAATTAGAAGCTGTGCCAGGATTCCATGTGGAAA
TTGAAAATGAAGAGTTTATTCGCCTTGTAAATGAAAATAAAATTGCTGTTATTGGACAAAGTGGGAACTTAACACCTGCT
GATAAGAAGTTATACGCACTTCGTGATGTAACAGCGACGGTAAACTCTATACCACTTATCGCAAGTTCTATTATGAGTAA
AAAAATTGCTGCAGGTGCAGATGCGATCGTTCTAGATGTAAAAACTGGTGCGGGTGCATTTATGAAAACGGATGAAGATG
CAAAACGTCTTGCAGAAGCAATGGTGCGTATTGGAAATAATGTAGGCCGTAAGACAATGGCAGTTATTTCGGATATGAGT
CAACCGCTTGGTGAAGCAATCGGTAACGCGTTGGAAGTACAAGAAGCAATTGATACATTGCAAGGTAAAGGTCCAAAAGA
TTTAGAAGAGCTATGTTTAACACTTGGAAGTCAAATGGTATACCTTGCTGGTAAAGCATCTTCTTTAGAAGATGCACGTA
ATAAACTTATTGAAGTAATGAATAATGGAAAAGCGTTAGACACATTTAAATTATTTTTAGCAGCGCAAGGCGGAGATGCT
TCAGTTATTGATGACCCTTCTAAATTGCCACAAGCTAAATATAAAATTGAAGTTGAAGCAAAAGAAGACGGATATGTGTC
TGAGATTGTGGCAGATGAAATCGGGACAGCAGCAATGCTTTTAGGTGCTGGACGTGCAACGAAAGAATCTGAGATTGATT
TAGCGGTTGGCCTTATGCTTCGGAAAAAAGTTGGCGATAGCGTAAAACAAGGTGAATCGCTTGTAACAATTTATGCAAAC
CGTGAAAATGTAGAAGATGTGAAGACGAAGATTTATGAGAATATAAAAATTACAAAAAATCATGTCAAAGCACCTACATT
AGTACATGGTATTGTAACGAAATAA

Upstream 100 bases:

>100_bases
CTTCATCATGATGAAGTGATTGAAACAACAGAACGTGTGAAAGCAAACTTCTTAGCATTGGTAAAAGCGATTGTAAAACA
AATGAAGGGGTGAGCTCACT

Downstream 100 bases:

>100_bases
TAAGCGAAAAGCTGAGGAGAGTTCTCCTTGGCTTTTTTTATTACTTTTTGTTTATAATAGTAATGGGTGAAATTATGATT
AGAATTTGTGCAATAACGAA

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRMVDLIAKKRDGHALTTEEINFIVEGFTNGDIPDYQMSSFAMAIFFQDMNEQERADLTMAMVNSGDTIDLSAIEGIKVD
KHSTGGVGDTTTLVLGPLVAALGVPVAKMSGRGLGHTGGTIDKLEAVPGFHVEIENEEFIRLVNENKIAVIGQSGNLTPA
DKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAKRLAEAMVRIGNNVGRKTMAVISDMS
QPLGEAIGNALEVQEAIDTLQGKGPKDLEELCLTLGSQMVYLAGKASSLEDARNKLIEVMNNGKALDTFKLFLAAQGGDA
SVIDDPSKLPQAKYKIEVEAKEDGYVSEIVADEIGTAAMLLGAGRATKESEIDLAVGLMLRKKVGDSVKQGESLVTIYAN
RENVEDVKTKIYENIKITKNHVKAPTLVHGIVTK

Sequences:

>Translated_434_residues
MRMVDLIAKKRDGHALTTEEINFIVEGFTNGDIPDYQMSSFAMAIFFQDMNEQERADLTMAMVNSGDTIDLSAIEGIKVD
KHSTGGVGDTTTLVLGPLVAALGVPVAKMSGRGLGHTGGTIDKLEAVPGFHVEIENEEFIRLVNENKIAVIGQSGNLTPA
DKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAKRLAEAMVRIGNNVGRKTMAVISDMS
QPLGEAIGNALEVQEAIDTLQGKGPKDLEELCLTLGSQMVYLAGKASSLEDARNKLIEVMNNGKALDTFKLFLAAQGGDA
SVIDDPSKLPQAKYKIEVEAKEDGYVSEIVADEIGTAAMLLGAGRATKESEIDLAVGLMLRKKVGDSVKQGESLVTIYAN
RENVEDVKTKIYENIKITKNHVKAPTLVHGIVTK
>Mature_434_residues
MRMVDLIAKKRDGHALTTEEINFIVEGFTNGDIPDYQMSSFAMAIFFQDMNEQERADLTMAMVNSGDTIDLSAIEGIKVD
KHSTGGVGDTTTLVLGPLVAALGVPVAKMSGRGLGHTGGTIDKLEAVPGFHVEIENEEFIRLVNENKIAVIGQSGNLTPA
DKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAKRLAEAMVRIGNNVGRKTMAVISDMS
QPLGEAIGNALEVQEAIDTLQGKGPKDLEELCLTLGSQMVYLAGKASSLEDARNKLIEVMNNGKALDTFKLFLAAQGGDA
SVIDDPSKLPQAKYKIEVEAKEDGYVSEIVADEIGTAAMLLGAGRATKESEIDLAVGLMLRKKVGDSVKQGESLVTIYAN
RENVEDVKTKIYENIKITKNHVKAPTLVHGIVTK

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=434, Percent_Identity=37.5576036866359, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI4503445, Length=434, Percent_Identity=37.5576036866359, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI166158922, Length=434, Percent_Identity=37.5576036866359, Blast_Score=279, Evalue=4e-75,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=45.049504950495, Blast_Score=336, Evalue=2e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46336; Mature: 46336

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMVDLIAKKRDGHALTTEEINFIVEGFTNGDIPDYQMSSFAMAIFFQDMNEQERADLTM
CCHHHHHHHCCCCCEEEHHHHEEEEEECCCCCCCCCHHHHHEEEHHHHCCCCHHHHCEEE
AMVNSGDTIDLSAIEGIKVDKHSTGGVGDTTTLVLGPLVAALGVPVAKMSGRGLGHTGGT
EEECCCCEEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAVPGFHVEIENEEFIRLVNENKIAVIGQSGNLTPADKKLYALRDVTATVNSIPLI
HHHHHCCCCEEEEECCHHHEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAKRLAEAMVRIGNNVGRKTMAVISDMS
HHHHHHHHHHCCCCEEEEEEECCCCCCEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QPLGEAIGNALEVQEAIDTLQGKGPKDLEELCLTLGSQMVYLAGKASSLEDARNKLIEVM
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
NNGKALDTFKLFLAAQGGDASVIDDPSKLPQAKYKIEVEAKEDGYVSEIVADEIGTAAML
CCCCCCEEEEEEEEECCCCCCCCCCHHHCCCCEEEEEEEECCCCHHHHHHHHHHCHHHHH
LGAGRATKESEIDLAVGLMLRKKVGDSVKQGESLVTIYANRENVEDVKTKIYENIKITKN
HCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEECC
HVKAPTLVHGIVTK
CCCCCHHHHHCCCC
>Mature Secondary Structure
MRMVDLIAKKRDGHALTTEEINFIVEGFTNGDIPDYQMSSFAMAIFFQDMNEQERADLTM
CCHHHHHHHCCCCCEEEHHHHEEEEEECCCCCCCCCHHHHHEEEHHHHCCCCHHHHCEEE
AMVNSGDTIDLSAIEGIKVDKHSTGGVGDTTTLVLGPLVAALGVPVAKMSGRGLGHTGGT
EEECCCCEEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAVPGFHVEIENEEFIRLVNENKIAVIGQSGNLTPADKKLYALRDVTATVNSIPLI
HHHHHCCCCEEEEECCHHHEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTDEDAKRLAEAMVRIGNNVGRKTMAVISDMS
HHHHHHHHHHCCCCEEEEEEECCCCCCEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QPLGEAIGNALEVQEAIDTLQGKGPKDLEELCLTLGSQMVYLAGKASSLEDARNKLIEVM
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
NNGKALDTFKLFLAAQGGDASVIDDPSKLPQAKYKIEVEAKEDGYVSEIVADEIGTAAML
CCCCCCEEEEEEEEECCCCCCCCCCHHHCCCCEEEEEEEECCCCHHHHHHHHHHCHHHHH
LGAGRATKESEIDLAVGLMLRKKVGDSVKQGESLVTIYANRENVEDVKTKIYENIKITKN
HCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCEEEEEECCCCHHHHHHHHHHCCEEECC
HVKAPTLVHGIVTK
CCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]