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The map label for this gene is pyrE [H]

Identifier: 152976243

GI number: 152976243

Start: 2630558

End: 2631190

Strand: Reverse

Name: pyrE [H]

Synonym: Bcer98_2531

Alternate gene names: 152976243

Gene position: 2631190-2630558 (Counterclockwise)

Preceding gene: 152976244

Following gene: 152976240

Centisome position: 64.38

GC content: 39.81

Gene sequence:

>633_bases
ATGAAAAAAGAAATCGCATCGCATTTATTAGAAATTGGAGCAGTATTTTTACAACCAAATGATCCATTCACTTGGTCTTC
TGGTATGAAATCGCCAATTTATTGTGATAATCGCCTAACTTTATCGTACCCAAAAGTACGTCAAGCAATTGCGGCGGGAT
TAGAGGAATTAATTAAAGAACACTTCCCAACTGTAGAAGTTATTGCAGGAACAGCAACTGCTGGTATTGCCCATGCTGCA
TGGGTAAGCGATCGTATGAATTTACCAATGTGCTACGTACGTAGTAAAGCAAAAGGTCACGGTAAAGGAAACCAAATTGA
AGGAAAAGCGGAAAAAGGTCAAAAAGTAGTTGTAGTAGAAGATCTTATTTCAACTGGTGGTAGTGCGATTACTTGCGTAG
AAGCGCTTCGTGAGGCAGGTTGTGAAGTATTAGGAATCGTATCAATCTTCACATATGAGCTTGAAGCAGGAAAAGAAAAA
CTAGCGGCAGCTAATGTAGCGTCATATTCTTTAAGCGACTATAGCACATTAACTCAAGTGGCGGAAGAAAAAGGTATGAT
TGGACAAGCTGAAATGAAAAAACTGCAAGAATGGCGCAAAAATCCAGCTGACGAGGCTTGGATTACAGCGTAA

Upstream 100 bases:

>100_bases
TTGGTTCAAGTTACATTGTGGTTGGACGTAGTATTACAAAAGCAGAAAATCCGCTTGAAGCATATCAAACAGTAAAACAA
CAGTGGGAAGGTGTAACAGT

Downstream 100 bases:

>100_bases
CACGAAAAGAACGACTGCGGGGAACGCGGTCGTTTTTTATCATCGTTAAAACTTCATGTAAAGAAGATATAGTAGGAGCA
TCGCACTTGAGTTGCGAGTT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKEHFPTVEVIAGTATAGIAHAA
WVSDRMNLPMCYVRSKAKGHGKGNQIEGKAEKGQKVVVVEDLISTGGSAITCVEALREAGCEVLGIVSIFTYELEAGKEK
LAAANVASYSLSDYSTLTQVAEEKGMIGQAEMKKLQEWRKNPADEAWITA

Sequences:

>Translated_210_residues
MKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKEHFPTVEVIAGTATAGIAHAA
WVSDRMNLPMCYVRSKAKGHGKGNQIEGKAEKGQKVVVVEDLISTGGSAITCVEALREAGCEVLGIVSIFTYELEAGKEK
LAAANVASYSLSDYSTLTQVAEEKGMIGQAEMKKLQEWRKNPADEAWITA
>Mature_210_residues
MKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKEHFPTVEVIAGTATAGIAHAA
WVSDRMNLPMCYVRSKAKGHGKGNQIEGKAEKGQKVVVVEDLISTGGSAITCVEALREAGCEVLGIVSIFTYELEAGKEK
LAAANVASYSLSDYSTLTQVAEEKGMIGQAEMKKLQEWRKNPADEAWITA

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=176, Percent_Identity=23.2954545454545, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508631, Length=180, Percent_Identity=31.6666666666667, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17554964, Length=170, Percent_Identity=26.4705882352941, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17933654, Length=196, Percent_Identity=28.0612244897959, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 22760; Mature: 22760

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKE
CHHHHHHHHHHHCEEEECCCCCCCCCCCCCCCEEECCEEEECCHHHHHHHHHHHHHHHHH
HFPTVEVIAGTATAGIAHAAWVSDRMNLPMCYVRSKAKGHGKGNQIEGKAEKGQKVVVVE
HCCCEEEEECCHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCCCCCCCHHCCCCEEEEEH
DLISTGGSAITCVEALREAGCEVLGIVSIFTYELEAGKEKLAAANVASYSLSDYSTLTQV
HHHHCCCCHHHHHHHHHHCCCHHEEHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHH
AEEKGMIGQAEMKKLQEWRKNPADEAWITA
HHHCCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKKEIASHLLEIGAVFLQPNDPFTWSSGMKSPIYCDNRLTLSYPKVRQAIAAGLEELIKE
CHHHHHHHHHHHCEEEECCCCCCCCCCCCCCCEEECCEEEECCHHHHHHHHHHHHHHHHH
HFPTVEVIAGTATAGIAHAAWVSDRMNLPMCYVRSKAKGHGKGNQIEGKAEKGQKVVVVE
HCCCEEEEECCHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCCCCCCCHHCCCCEEEEEH
DLISTGGSAITCVEALREAGCEVLGIVSIFTYELEAGKEKLAAANVASYSLSDYSTLTQV
HHHHCCCCHHHHHHHHHHCCCHHEEHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHH
AEEKGMIGQAEMKKLQEWRKNPADEAWITA
HHHCCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA