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The map label for this gene is uppS [H]

Identifier: 152976189

GI number: 152976189

Start: 2573694

End: 2574470

Strand: Reverse

Name: uppS [H]

Synonym: Bcer98_2475

Alternate gene names: 152976189

Gene position: 2574470-2573694 (Counterclockwise)

Preceding gene: 152976190

Following gene: 152976188

Centisome position: 62.99

GC content: 38.61

Gene sequence:

>777_bases
ATGATGTTAAAAAAGTTTCCTTTTTTTAAAGGTAAAAAGGTCACATCGTTTGACCATCTCATAGAAGAAGCAAAAAAGGG
ACACATCCCAGAGCATATTGCAATCATTATGGATGGTAATGGAAGGTGGGCAAAAAAAAGAGCGATGCCTCGTATTGCTG
GACATCATGAAGGGATGCAAGTCGTAAAGAAGATTACGAAATTTGCTAGTAAACTTGATGTGAAAGTGTTGACTCTTTAT
GCTTTTTCTACTGAGAATTGGAAAAGACCGAAAAAGGAAGTTGAGTATTTAATGAAGCTTCCAGAAGAATTTCTAGGTAC
ATTTTTGCCAGAACTAATTGAAGAAAATGTACAAGTTCGAGTAATTGGACAAAAAGATCGCCTTCCTATGCATACGCGCA
GAGCGATGGAAAAAGCTATGGAAGATACAAAAGAGAATACGGGATTAATTCTTAATTTTGCGTTAAACTATGGAAGTCGC
GATGAAATCGTTTCGGCTGTGCAACATATGATGAAAGATAGCGAAGAAGGAAAAGTGCGTTCAGAAGATATCAATGAGGA
AATGATTTCTTCCTACTTAATGACAAGTGCTTTACCTGACCCAGACTTGCTTATTCGTACAAGTGGGGAAGTGCGTATCA
GTAATTTCATGTTATGGCAAATTGCGTATACAGAGCTTTGGTTTACAAATGTGTACTGGCCGGATTTTACCGAGGAACAT
TTGCTGCATGCGATTACTGACTTTCAACAGAGAGGGCGCAGATTCGGAGGCGTTTAG

Upstream 100 bases:

>100_bases
ATCATGGAAGTGTAATAGCGGTACCTTCGCAAATATGACCCTCTTCTTAAGGGGGTCTTTTTACACTTTTTGGCATACGT
CTGCTTGTTGGAGGGTATGA

Downstream 100 bases:

>100_bases
AAAGAGAGGGTTTGGTAGTGAAACAGAGAATTATTACTGGAGTGATTGCTGCCGCACTATTCATTCCCATCGTATTTTAC
GGAGGGTTGCCTTTTACAGT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MMLKKFPFFKGKKVTSFDHLIEEAKKGHIPEHIAIIMDGNGRWAKKRAMPRIAGHHEGMQVVKKITKFASKLDVKVLTLY
AFSTENWKRPKKEVEYLMKLPEEFLGTFLPELIEENVQVRVIGQKDRLPMHTRRAMEKAMEDTKENTGLILNFALNYGSR
DEIVSAVQHMMKDSEEGKVRSEDINEEMISSYLMTSALPDPDLLIRTSGEVRISNFMLWQIAYTELWFTNVYWPDFTEEH
LLHAITDFQQRGRRFGGV

Sequences:

>Translated_258_residues
MMLKKFPFFKGKKVTSFDHLIEEAKKGHIPEHIAIIMDGNGRWAKKRAMPRIAGHHEGMQVVKKITKFASKLDVKVLTLY
AFSTENWKRPKKEVEYLMKLPEEFLGTFLPELIEENVQVRVIGQKDRLPMHTRRAMEKAMEDTKENTGLILNFALNYGSR
DEIVSAVQHMMKDSEEGKVRSEDINEEMISSYLMTSALPDPDLLIRTSGEVRISNFMLWQIAYTELWFTNVYWPDFTEEH
LLHAITDFQQRGRRFGGV
>Mature_258_residues
MMLKKFPFFKGKKVTSFDHLIEEAKKGHIPEHIAIIMDGNGRWAKKRAMPRIAGHHEGMQVVKKITKFASKLDVKVLTLY
AFSTENWKRPKKEVEYLMKLPEEFLGTFLPELIEENVQVRVIGQKDRLPMHTRRAMEKAMEDTKENTGLILNFALNYGSR
DEIVSAVQHMMKDSEEGKVRSEDINEEMISSYLMTSALPDPDLLIRTSGEVRISNFMLWQIAYTELWFTNVYWPDFTEEH
LLHAITDFQQRGRRFGGV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=228, Percent_Identity=39.9122807017544, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI45580742, Length=228, Percent_Identity=39.9122807017544, Blast_Score=170, Evalue=1e-42,
Organism=Escherichia coli, GI1786371, Length=238, Percent_Identity=44.5378151260504, Blast_Score=213, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI71993029, Length=228, Percent_Identity=37.280701754386, Blast_Score=154, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=34.2723004694836, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=225, Percent_Identity=32.4444444444444, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI18857969, Length=227, Percent_Identity=38.7665198237885, Blast_Score=172, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30066; Mature: 30066

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLKKFPFFKGKKVTSFDHLIEEAKKGHIPEHIAIIMDGNGRWAKKRAMPRIAGHHEGMQ
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHCCCHHHCCHHHHH
VVKKITKFASKLDVKVLTLYAFSTENWKRPKKEVEYLMKLPEEFLGTFLPELIEENVQVR
HHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCEEE
VIGQKDRLPMHTRRAMEKAMEDTKENTGLILNFALNYGSRDEIVSAVQHMMKDSEEGKVR
EECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCC
SEDINEEMISSYLMTSALPDPDLLIRTSGEVRISNFMLWQIAYTELWFTNVYWPDFTEEH
HHHCCHHHHHHHHHHHCCCCCCEEEECCCCEEEHHEEEHHHHHHHHHHHCCCCCCCCHHH
LLHAITDFQQRGRRFGGV
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMLKKFPFFKGKKVTSFDHLIEEAKKGHIPEHIAIIMDGNGRWAKKRAMPRIAGHHEGMQ
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHCCCHHHCCHHHHH
VVKKITKFASKLDVKVLTLYAFSTENWKRPKKEVEYLMKLPEEFLGTFLPELIEENVQVR
HHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCEEE
VIGQKDRLPMHTRRAMEKAMEDTKENTGLILNFALNYGSRDEIVSAVQHMMKDSEEGKVR
EECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCC
SEDINEEMISSYLMTSALPDPDLLIRTSGEVRISNFMLWQIAYTELWFTNVYWPDFTEEH
HHHCCHHHHHHHHHHHCCCCCCEEEECCCCEEEHHEEEHHHHHHHHHHHCCCCCCCCHHH
LLHAITDFQQRGRRFGGV
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]