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The map label for this gene is mutL

Identifier: 152976134

GI number: 152976134

Start: 2508232

End: 2510181

Strand: Reverse

Name: mutL

Synonym: Bcer98_2420

Alternate gene names: 152976134

Gene position: 2510181-2508232 (Counterclockwise)

Preceding gene: 152976135

Following gene: 152976133

Centisome position: 61.42

GC content: 38.62

Gene sequence:

>1950_bases
ATGGGGAAAATTCGCAAACTCGATGAACAACTCTCCAACTTAATTGCAGCTGGGGAAGTAGTAGAGCGTCCTGCTTCTGT
CGTGAAAGAACTTGTGGAAAATTCCATCGATGCGAATAGTACATCTATTGAAATCCACTTGGAAGAAGCTGGGTTATCAA
AAATTCGCATTATTGATAATGGAGACGGTATTGCTGAAGAAGACTGCATTGTCGCATTTGAACGCCATGCGACAAGTAAA
ATAAAAGATGAAAATGATTTGTTTCGCATAAGAACGCTCGGTTTCCGAGGAGAGGCATTACCGAGTATTGCATCTGTTAG
TGAATTAGAGTTAGTTACAAGCACAGGAGACGCACCGGGTACACATCTTATTATTAAAGGTGGAGAGATTATAAAACAGG
AGAAAACCGCGAGCCGTAAAGGAACGGATATTACGGTTCAAAACTTGTTTTTTAACACACCAGCACGTCTTAAATATATG
AAAACTATTCATACAGAGCTCGGAAATATTACAGATATTGTGTATCGCATTGCCATGTCTCATCCAGAAGTGTCATTGAA
ATTATTCCATAATACGAAAAAATTACTTCACACATCTGGAAATGGTGATGTGAGACAAGTACTAGCAGCGATTTACAGTA
TTCAAGTTGCGAAAAAATTGATTCCAATTGAAGCGGAGTCGTTAGATTTTACCATTCGCGGATATGTAACATTGCCAGAG
GTAACGAGAGCTTCTCGCAATTATATGTCAACAATTGTTAATGGCCGTTACGTGCGAAACTATGTATTAATGAAAGCGAT
CCAGCAAGGATATCATACATTGCTTCCAGTTGGTCGCTATCCGATTGGTTTCTTATCCATTGAGATGGATCCAATGTTAG
TGGATGTTAACGTTCATCCGGCAAAACTGGAAGTGCGTTTTAGTAAAGAACAAGAACTTCTGCAATTCATTGAACAAACA
TTACAAGATGCCTTTAAAAAAGTCCAGCTTATTCCAGATGCCGGCGTAACAACGAAGAAAAAAACAAAAGATGAGAGTGT
TCAAGAACAATTTCATTTTGAACATACAAAACCAAAAGAACCATCTATGCCTAATATCGTTTTACCGACTGGAATGGATG
AAGCGCAAGAAGAGGAAAGCGCAGAAAAACCATCAGTAGCGCCGCAATTATGGCAACAGCCAAAACAAGAATGGCAACCG
CCACAATCCCTTGTAAGAGAAGAAGAGAGTTGGCAATCAACTTCGAAACCGCTCATTGAAGAAAAGGCGGCTCATAACGA
ACAAGAATGGGATCATCATGAAGAAGAATTTGAATTAGAAGAATTGGATGAATTGCAGAATATCGAAGAAATTGAAATGA
ACGGGAATGATTTACCGCCTCTTTATCCAATTGGACAGATGCATGGAACGTACATCTTTGCTCAAAACGATAAAGGGCTA
TATATGATTGACCAACATGCGGCACAAGAACGAATTAACTATGAATATTTCCGCGATAAAGTAGGACAAGTGACACAAGA
AGTTCAAGAATTGCTTGTCCCATATCGTATTGATTTATCATTAAACGAATTTTTACGTGTCGAAGAACAACTAGAAGAAT
TGAAAAAGGTAGGATTATTCCTAGAGCAATTCGGCCATCAATCTTTTATCGTTCGCTCGCACCCAATATGGTTTCCAAAA
GGGAAAGAAACGGAAATCATTGATGAAATGATGCAACAAGTTGTGAAACTGAAAAAAGTAGACATAAAAAAATTGCGTGA
AGAAGCAGCCATTATGATGAGCTGTAAAGCATCCATTAAAGCAAATCAATATTTAACAAACGATCAAATCTTCGCACTTT
TAGAAGAACTACGCACAACAAGCAACCCTTACACATGCCCGCACGGTAGACCGATTATTATACATCATTCGACCTATGAA
CTGGAGAAAATGTTTAAGCGGGTGATGTAG

Upstream 100 bases:

>100_bases
CACAAATTAAAAAAATTGATTTACTTGATATGACGCCTTTAGAAGCATTAAATGAACTGTATCGCTTACAGAAGAAATTA
AAGAAAGGATGAGTAAGTAG

Downstream 100 bases:

>100_bases
GTAGATTGTGTAGGAATAAAAATTAACTTTACTGAGTTAAAAATGAATGTTGTATAATATAACATTAGATTGTTATTTTG
ATAAAATATTAGATTCAACT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MGKIRKLDEQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDNGDGIAEEDCIVAFERHATSK
IKDENDLFRIRTLGFRGEALPSIASVSELELVTSTGDAPGTHLIIKGGEIIKQEKTASRKGTDITVQNLFFNTPARLKYM
KTIHTELGNITDIVYRIAMSHPEVSLKLFHNTKKLLHTSGNGDVRQVLAAIYSIQVAKKLIPIEAESLDFTIRGYVTLPE
VTRASRNYMSTIVNGRYVRNYVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHPAKLEVRFSKEQELLQFIEQT
LQDAFKKVQLIPDAGVTTKKKTKDESVQEQFHFEHTKPKEPSMPNIVLPTGMDEAQEEESAEKPSVAPQLWQQPKQEWQP
PQSLVREEESWQSTSKPLIEEKAAHNEQEWDHHEEEFELEELDELQNIEEIEMNGNDLPPLYPIGQMHGTYIFAQNDKGL
YMIDQHAAQERINYEYFRDKVGQVTQEVQELLVPYRIDLSLNEFLRVEEQLEELKKVGLFLEQFGHQSFIVRSHPIWFPK
GKETEIIDEMMQQVVKLKKVDIKKLREEAAIMMSCKASIKANQYLTNDQIFALLEELRTTSNPYTCPHGRPIIIHHSTYE
LEKMFKRVM

Sequences:

>Translated_649_residues
MGKIRKLDEQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDNGDGIAEEDCIVAFERHATSK
IKDENDLFRIRTLGFRGEALPSIASVSELELVTSTGDAPGTHLIIKGGEIIKQEKTASRKGTDITVQNLFFNTPARLKYM
KTIHTELGNITDIVYRIAMSHPEVSLKLFHNTKKLLHTSGNGDVRQVLAAIYSIQVAKKLIPIEAESLDFTIRGYVTLPE
VTRASRNYMSTIVNGRYVRNYVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHPAKLEVRFSKEQELLQFIEQT
LQDAFKKVQLIPDAGVTTKKKTKDESVQEQFHFEHTKPKEPSMPNIVLPTGMDEAQEEESAEKPSVAPQLWQQPKQEWQP
PQSLVREEESWQSTSKPLIEEKAAHNEQEWDHHEEEFELEELDELQNIEEIEMNGNDLPPLYPIGQMHGTYIFAQNDKGL
YMIDQHAAQERINYEYFRDKVGQVTQEVQELLVPYRIDLSLNEFLRVEEQLEELKKVGLFLEQFGHQSFIVRSHPIWFPK
GKETEIIDEMMQQVVKLKKVDIKKLREEAAIMMSCKASIKANQYLTNDQIFALLEELRTTSNPYTCPHGRPIIIHHSTYE
LEKMFKRVM
>Mature_648_residues
GKIRKLDEQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDNGDGIAEEDCIVAFERHATSKI
KDENDLFRIRTLGFRGEALPSIASVSELELVTSTGDAPGTHLIIKGGEIIKQEKTASRKGTDITVQNLFFNTPARLKYMK
TIHTELGNITDIVYRIAMSHPEVSLKLFHNTKKLLHTSGNGDVRQVLAAIYSIQVAKKLIPIEAESLDFTIRGYVTLPEV
TRASRNYMSTIVNGRYVRNYVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHPAKLEVRFSKEQELLQFIEQTL
QDAFKKVQLIPDAGVTTKKKTKDESVQEQFHFEHTKPKEPSMPNIVLPTGMDEAQEEESAEKPSVAPQLWQQPKQEWQPP
QSLVREEESWQSTSKPLIEEKAAHNEQEWDHHEEEFELEELDELQNIEEIEMNGNDLPPLYPIGQMHGTYIFAQNDKGLY
MIDQHAAQERINYEYFRDKVGQVTQEVQELLVPYRIDLSLNEFLRVEEQLEELKKVGLFLEQFGHQSFIVRSHPIWFPKG
KETEIIDEMMQQVVKLKKVDIKKLREEAAIMMSCKASIKANQYLTNDQIFALLEELRTTSNPYTCPHGRPIIIHHSTYEL
EKMFKRVM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=327, Percent_Identity=36.697247706422, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI4505911, Length=329, Percent_Identity=28.8753799392097, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI189458898, Length=329, Percent_Identity=28.8753799392097, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI310128478, Length=350, Percent_Identity=28.8571428571429, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI4505913, Length=350, Percent_Identity=27.4285714285714, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI189458896, Length=320, Percent_Identity=30, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI263191589, Length=231, Percent_Identity=29.8701298701299, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI310128480, Length=307, Percent_Identity=27.0358306188925, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI91992162, Length=271, Percent_Identity=27.3062730627306, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI91992160, Length=271, Percent_Identity=27.3062730627306, Blast_Score=91, Evalue=5e-18,
Organism=Escherichia coli, GI1790612, Length=373, Percent_Identity=39.6782841823056, Blast_Score=225, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI71991825, Length=425, Percent_Identity=31.5294117647059, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17562796, Length=456, Percent_Identity=26.3157894736842, Blast_Score=138, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=329, Percent_Identity=35.5623100303951, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=362, Percent_Identity=29.0055248618785, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6325093, Length=212, Percent_Identity=27.8301886792453, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136968, Length=326, Percent_Identity=34.3558282208589, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17136970, Length=358, Percent_Identity=27.6536312849162, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_BACCN (A7GR98)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001375651.1
- ProteinModelPortal:   A7GR98
- SMR:   A7GR98
- STRING:   A7GR98
- EnsemblBacteria:   EBBACT00000036437
- GeneID:   5343735
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_2420
- eggNOG:   COG0323
- GeneTree:   EBGT00050000002475
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   PRK00095
- BioCyc:   BCER315749:BCER98_2420-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 74340; Mature: 74209

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKIRKLDEQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEC
GDGIAEEDCIVAFERHATSKIKDENDLFRIRTLGFRGEALPSIASVSELELVTSTGDAPG
CCCCCCCHHHEEEHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHCHHHHEEEECCCCCCC
THLIIKGGEIIKQEKTASRKGTDITVQNLFFNTPARLKYMKTIHTELGNITDIVYRIAMS
CEEEEECCHHHHHHHHCCCCCCCEEEEHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HPEVSLKLFHNTKKLLHTSGNGDVRQVLAAIYSIQVAKKLIPIEAESLDFTIRGYVTLPE
CCCEEEEEECCCHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECHH
VTRASRNYMSTIVNGRYVRNYVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHCCCCCCCEEEEEEEECCEEEEEECCC
AKLEVRFSKEQELLQFIEQTLQDAFKKVQLIPDAGVTTKKKTKDESVQEQFHFEHTKPKE
EEEEEEECCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
PSMPNIVLPTGMDEAQEEESAEKPSVAPQLWQQPKQEWQPPQSLVREEESWQSTSKPLIE
CCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHCCHHHCCCHHHHHCCHHHHHHCCCCHHH
EKAAHNEQEWDHHEEEFELEELDELQNIEEIEMNGNDLPPLYPIGQMHGTYIFAQNDKGL
HHHCCCCHHCCCCHHHCCHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCE
YMIDQHAAQERINYEYFRDKVGQVTQEVQELLVPYRIDLSLNEFLRVEEQLEELKKVGLF
EEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHH
LEQFGHQSFIVRSHPIWFPKGKETEIIDEMMQQVVKLKKVDIKKLREEAAIMMSCKASIK
HHHHCCCEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ANQYLTNDQIFALLEELRTTSNPYTCPHGRPIIIHHSTYELEKMFKRVM
CCCEECCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHCC
>Mature Secondary Structure 
GKIRKLDEQLSNLIAAGEVVERPASVVKELVENSIDANSTSIEIHLEEAGLSKIRIIDN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEC
GDGIAEEDCIVAFERHATSKIKDENDLFRIRTLGFRGEALPSIASVSELELVTSTGDAPG
CCCCCCCHHHEEEHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHCHHHHEEEECCCCCCC
THLIIKGGEIIKQEKTASRKGTDITVQNLFFNTPARLKYMKTIHTELGNITDIVYRIAMS
CEEEEECCHHHHHHHHCCCCCCCEEEEHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHC
HPEVSLKLFHNTKKLLHTSGNGDVRQVLAAIYSIQVAKKLIPIEAESLDFTIRGYVTLPE
CCCEEEEEECCCHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECHH
VTRASRNYMSTIVNGRYVRNYVLMKAIQQGYHTLLPVGRYPIGFLSIEMDPMLVDVNVHP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHCCCCCCCEEEEEEEECCEEEEEECCC
AKLEVRFSKEQELLQFIEQTLQDAFKKVQLIPDAGVTTKKKTKDESVQEQFHFEHTKPKE
EEEEEEECCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
PSMPNIVLPTGMDEAQEEESAEKPSVAPQLWQQPKQEWQPPQSLVREEESWQSTSKPLIE
CCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHCCHHHCCCHHHHHCCHHHHHHCCCCHHH
EKAAHNEQEWDHHEEEFELEELDELQNIEEIEMNGNDLPPLYPIGQMHGTYIFAQNDKGL
HHHCCCCHHCCCCHHHCCHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCE
YMIDQHAAQERINYEYFRDKVGQVTQEVQELLVPYRIDLSLNEFLRVEEQLEELKKVGLF
EEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHH
LEQFGHQSFIVRSHPIWFPKGKETEIIDEMMQQVVKLKKVDIKKLREEAAIMMSCKASIK
HHHHCCCEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ANQYLTNDQIFALLEELRTTSNPYTCPHGRPIIIHHSTYELEKMFKRVM
CCCEECCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA