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The map label for this gene is opuE [H]

Identifier: 152976032

GI number: 152976032

Start: 2400961

End: 2402439

Strand: Reverse

Name: opuE [H]

Synonym: Bcer98_2308

Alternate gene names: 152976032

Gene position: 2402439-2400961 (Counterclockwise)

Preceding gene: 152976033

Following gene: 152976030

Centisome position: 58.78

GC content: 38.67

Gene sequence:

>1479_bases
GTGAAGGTTGAAATTATAATTTCGCTTGCTATTTATATGGCAGGTATGTTGTATATCGGATATTGGTCTTATAAAAAGAC
GTCCGATTTATCAGATTACATGTTGGGGGGACGAGGACTTGGTCCAGCAGTTACGGCCTTATCGGCTGGTGCCTCTGATA
TGAGTGGTTGGATGCTAATGGGATTGCCTGGTGCAATGTATGCAACAGGATTGTCCAGTATGTGGATCGCTATTGGTCTC
TTGCTTGGTGCATATGCGAACTATTTATTATTAGCACCGCGCTTACGTACGTATACGGAAGTAGCAAATGATTCTATTAC
TATACCAGACTTTTTAGAAAATCGATTTCAAGATCGTACAAAAATACTTCGTTTTGTCTCCGCCATTGTTATTTTAGTCT
TTTTTACATTTTATGCGTCAGCTGGTTTAGTTTCAGGTGGCCGTCTATTTGAAAGTTCATTTAACTTAGATTATAAAATT
GGTTTATTTGTAACAGTCGGTGTTGTTGTCGCATATACACTATTTGGTGGATTTTTAGCAGTTAGTTGGACGGACTTTGT
TCAAGGGTGCATTATGTTTATAGCTCTTGTTTTAGTTCCAATTGTTGCTTTTACAGATATTGGTGGGGTAGCAGAAACGT
TCAATGGGATCAAGGCTGTTGACCCGGCTCGTCTAGATTTATTTAAAGGAACTACGATACTAGGGATTATTTCATTTTTA
GCTTGGGGACTTGGATATTTTGGTCAACCTCATATTATTGTCCGCTTTATGGCAATTACCTCTATTCAAGATTTAAAAAC
TTCGCGAAGAATTGGTATCGGGTGGATGAGTATTTCTATACTCGGTGCGATGCTTACAGGACTCGTTGGTATTGCTTACT
ATTCTCAAAGTGATAGTACATTAGCAGACCCAGAGATGGTCTTTGTAGCATTCTCGAATATTTTATTCCACCCGTATATT
ACAGGCTTCTTGCTCTCAGCTATTTTAGCTTCTATTATGAGTAGTATTTCCTCACAATTACTTGTTATCTCTAGTGCGGT
AACGGAAGATTTCTATAAAACATTTTTCCGTCGTAACGCATCAGATAAAGAACTTGTATGTATCGGAAGGCTTGCTGTTT
TAGTCGTCGCAATGATTGCTGTTGTTTTAGCGTATCATCCAAGTGATACGATTTTAACCCTTGTTGGTTATGCATGGGCA
GGATTTGGTTCAGCGTTTGGACCAGCTATTTTGCTTAGTCTTTATTGGAAACGAACGACAAAATGGGGCGTGCTCGCGGG
TATGATTGTTGGTGCTGTTACAGTCATTGCATGGGTACAGATTCCGTTTTTAAAGGAAATGCTATATGAAATGGTACCAG
GCTTTACTTTCAGTTTATTAGCTGTTATTATTGTTAGTATTTTAACAAAAGAACCTTCAAAAGCTGTACATCGAGAGTTT
CATGAGATGGAAACAGTTTTGGGACAAGCGACAGAGTAG

Upstream 100 bases:

>100_bases
AAATCTTTGTTAAGGTAGGAAACCATAAGCGAAAACAAAATAGAAAAAGTCATTTTTCGAAATGTTAAGTGGCTTATGGA
AACGAAAAAGGAGAGATTTG

Downstream 100 bases:

>100_bases
AGGTTGTAGTAGTTTGAAAGAAATAGATTCAGAGAAAAAGGTAAATGTTTTTTCATTTACCTTTTTTGATGGCAATTTTA
TTTTGTAGATGTCGAAGTAG

Product: sodium/proline symporter

Products: NA

Alternate protein names: Sodium/proline symporter [H]

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MKVEIIISLAIYMAGMLYIGYWSYKKTSDLSDYMLGGRGLGPAVTALSAGASDMSGWMLMGLPGAMYATGLSSMWIAIGL
LLGAYANYLLLAPRLRTYTEVANDSITIPDFLENRFQDRTKILRFVSAIVILVFFTFYASAGLVSGGRLFESSFNLDYKI
GLFVTVGVVVAYTLFGGFLAVSWTDFVQGCIMFIALVLVPIVAFTDIGGVAETFNGIKAVDPARLDLFKGTTILGIISFL
AWGLGYFGQPHIIVRFMAITSIQDLKTSRRIGIGWMSISILGAMLTGLVGIAYYSQSDSTLADPEMVFVAFSNILFHPYI
TGFLLSAILASIMSSISSQLLVISSAVTEDFYKTFFRRNASDKELVCIGRLAVLVVAMIAVVLAYHPSDTILTLVGYAWA
GFGSAFGPAILLSLYWKRTTKWGVLAGMIVGAVTVIAWVQIPFLKEMLYEMVPGFTFSLLAVIIVSILTKEPSKAVHREF
HEMETVLGQATE

Sequences:

>Translated_492_residues
MKVEIIISLAIYMAGMLYIGYWSYKKTSDLSDYMLGGRGLGPAVTALSAGASDMSGWMLMGLPGAMYATGLSSMWIAIGL
LLGAYANYLLLAPRLRTYTEVANDSITIPDFLENRFQDRTKILRFVSAIVILVFFTFYASAGLVSGGRLFESSFNLDYKI
GLFVTVGVVVAYTLFGGFLAVSWTDFVQGCIMFIALVLVPIVAFTDIGGVAETFNGIKAVDPARLDLFKGTTILGIISFL
AWGLGYFGQPHIIVRFMAITSIQDLKTSRRIGIGWMSISILGAMLTGLVGIAYYSQSDSTLADPEMVFVAFSNILFHPYI
TGFLLSAILASIMSSISSQLLVISSAVTEDFYKTFFRRNASDKELVCIGRLAVLVVAMIAVVLAYHPSDTILTLVGYAWA
GFGSAFGPAILLSLYWKRTTKWGVLAGMIVGAVTVIAWVQIPFLKEMLYEMVPGFTFSLLAVIIVSILTKEPSKAVHREF
HEMETVLGQATE
>Mature_492_residues
MKVEIIISLAIYMAGMLYIGYWSYKKTSDLSDYMLGGRGLGPAVTALSAGASDMSGWMLMGLPGAMYATGLSSMWIAIGL
LLGAYANYLLLAPRLRTYTEVANDSITIPDFLENRFQDRTKILRFVSAIVILVFFTFYASAGLVSGGRLFESSFNLDYKI
GLFVTVGVVVAYTLFGGFLAVSWTDFVQGCIMFIALVLVPIVAFTDIGGVAETFNGIKAVDPARLDLFKGTTILGIISFL
AWGLGYFGQPHIIVRFMAITSIQDLKTSRRIGIGWMSISILGAMLTGLVGIAYYSQSDSTLADPEMVFVAFSNILFHPYI
TGFLLSAILASIMSSISSQLLVISSAVTEDFYKTFFRRNASDKELVCIGRLAVLVVAMIAVVLAYHPSDTILTLVGYAWA
GFGSAFGPAILLSLYWKRTTKWGVLAGMIVGAVTVIAWVQIPFLKEMLYEMVPGFTFSLLAVIIVSILTKEPSKAVHREF
HEMETVLGQATE

Specific function: Catalyzes the sodium-dependent uptake of extracellular proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=496, Percent_Identity=55.4435483870968, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI11141885, Length=465, Percent_Identity=25.8064516129032, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI110835708, Length=546, Percent_Identity=23.992673992674, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI109659836, Length=385, Percent_Identity=22.5974025974026, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI4507031, Length=544, Percent_Identity=23.1617647058824, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI157671931, Length=377, Percent_Identity=22.5464190981432, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787251, Length=488, Percent_Identity=49.1803278688525, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI1790503, Length=517, Percent_Identity=26.3056092843327, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI87082237, Length=481, Percent_Identity=29.3139293139293, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI1790113, Length=392, Percent_Identity=24.7448979591837, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17539284, Length=471, Percent_Identity=23.5668789808917, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640370, Length=358, Percent_Identity=26.2569832402235, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24648033, Length=399, Percent_Identity=23.0576441102757, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21356865, Length=399, Percent_Identity=23.0576441102757, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24645928, Length=379, Percent_Identity=26.6490765171504, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24651739, Length=468, Percent_Identity=24.1452991452991, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI281362918, Length=389, Percent_Identity=26.2210796915167, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221459584, Length=374, Percent_Identity=23.5294117647059, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24651741, Length=460, Percent_Identity=25.2173913043478, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI221459588, Length=380, Percent_Identity=22.6315789473684, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573698, Length=452, Percent_Identity=23.8938053097345, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221459586, Length=382, Percent_Identity=21.2041884816754, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53602; Mature: 53602

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCCC
>Mature Secondary Structure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HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377 [H]