Click here to switch to the map view.

The map label for this gene is sqhC [H]

Identifier: 152975959

GI number: 152975959

Start: 2327405

End: 2329264

Strand: Reverse

Name: sqhC [H]

Synonym: Bcer98_2232

Alternate gene names: 152975959

Gene position: 2329264-2327405 (Counterclockwise)

Preceding gene: 152975960

Following gene: 152975956

Centisome position: 56.99

GC content: 39.03

Gene sequence:

>1860_bases
GTGGTATTATACGGAAGAGTGTGTGCAGAAATAGAGCGGACAATCACTGCACTTCATACAATGCAACAGCAAGATGGTGC
ATGGCGCTTTTGTTTTGAAGGATCGCCATTAACAGATTGTCATATGATTTTTTTACTTCGATTATTAGAAAAGGAAGAAG
AAATAGAGCCGTTTGTAGCAAGGTTAACGTCCATACAAACAAATGAAGGAACTTGGAAGCTATACGAAGATGAACGTGCT
GGCAACGTATCTACTACGATTCAAGCATATGCGGCGTTACTTGCATCTGGCATGTATACGAAAGAGGATGTCAATATGAA
GCGTGCGGAAGCTTTTATTCAAGAAAGAGGAGGAATTGCACGTTCTCATTTTATGACGAAGTTTTTATTAGCACTGCATG
GAGGATATGAATATCCTAGAATGTTTTATTTTCCAACTCCTATTTTATTCTTGCCTGAAGATTCTCCACTTAGCATATTT
GAACTTAGTAGTTCTGCGCGTATTCATCTTATTCCAATGATGATTTGTATGAACAAAAGATTTACTGTATCAAAAACTAT
ACTTCCGAATTTAGATCATATTTCAGGAAGCAGTAAGTCCGAATGGTTTCGTGAGGACCGCTCCTCATTATTTGAAACGA
TTCTTGGAGAAGTGAAAAAGTTTGTAACGTATCCTTTATCTCTTCATCATAAAGGGGACAAAGAAGCAGAGCGCTTTATG
ATAGAGAGGATTGACAGAAATGGTACATTATATAGCTATGCGAGCGCTACATTTTATATGATTTATGCACTTCTGGCGCT
AGGGCATCATATTCAATCACCTCTTATTCAACAAGCAGTCGCAGGGCTCCGAACATACAAATGGCATATGGAAGCGGGCA
TTCATTTACAAAACTCTCCATCTACCGTATGGGATACGGCTTTACTCAGCTATGCATTACAAGAAGCGAATGTAAATGAG
AGCACACCTATGATTCAAACAGCAACAGAATATATATGGCAAAGACAACATCATGAAAAGAAAGACTGGAGCTTGCATGC
ACCTACACTTTCTCCTGGAGGATGGGGGTTCTCAGATGTGAATACAACAATTCCAGACGTTGATGATACAACTGCTGCTT
TAAGAGCGTTAGCACGAAGCAGAAAAAGGAATAGAAGAATAGAGGAGGCTTGGAAAAAAGGGGTGAACTGGGTGAAAGGA
TTACAAAATAAAGACGGAGGATGGGCTGCTTTTGAAAAGGGGGTAACAAATCGGTTTCTGACACATTTACCATTAGAAAA
TTCTGGTGATATGATGACGGATCCTTCTACTGCAGATATTACAGGACGGGTTTTGGAGTTTTTTGGGACGTATGCTCCTA
ATGAATTACAAGATCATCAAAAGAATCGCGCGATTACATGGCTAATGGATGTTCAAGAGAACAATGGATCATGGTACGGA
AAATGGGGGGTCAGTTATATATATGGTACGTGGGCTGCTCTTACAGGATTGCGAGCTGTTGGAGTTGCGAATACACATCC
AGCTTTAAAAAAGGCAGTTATGTGGTTAGAACGTATACAACATCGCGATGGAGGCTGGGGAGAATCTTGCCGAAGTAGTA
TAGAAAAAAGATTTGTTCCGCTATCCTTTAGTACTCCTTCCCAAACTGCATGGGCGATTGATGCTCTTATTTCTTATTAT
GATGAAGAAACACCAGTCATTCGAAAAGGAATTTCTTATTTATTAGAGCACGCTGCGAGTCATCAAGAATATCCTACAGG
AACAGGATTACCAAATGGATTTTATATTCGTTATCATAGTTATTCTTATATGTATCCATTACTTACATTTGCACATTATA
TAAACAAATACCGAAAATAA

Upstream 100 bases:

>100_bases
AGCAGAATGTGTATGTTACATGTTCTGCTTTTTTGTTTTATACATAATTGTTATAAATTGTGAATATCGTGTATGGATTT
CGAAAAGGTAGGTGAAGAGG

Downstream 100 bases:

>100_bases
ACCGAGAGCATTTCTCGGTTTATTTTTCGTGGGTAGTAGGTCCCAATTGAAAAGAGTGAAAGATAGGATTTATTTTTTTT
TCGATTGGCGTTTTTGGCGT

Product: squalene/oxidosqualene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MVLYGRVCAEIERTITALHTMQQQDGAWRFCFEGSPLTDCHMIFLLRLLEKEEEIEPFVARLTSIQTNEGTWKLYEDERA
GNVSTTIQAYAALLASGMYTKEDVNMKRAEAFIQERGGIARSHFMTKFLLALHGGYEYPRMFYFPTPILFLPEDSPLSIF
ELSSSARIHLIPMMICMNKRFTVSKTILPNLDHISGSSKSEWFREDRSSLFETILGEVKKFVTYPLSLHHKGDKEAERFM
IERIDRNGTLYSYASATFYMIYALLALGHHIQSPLIQQAVAGLRTYKWHMEAGIHLQNSPSTVWDTALLSYALQEANVNE
STPMIQTATEYIWQRQHHEKKDWSLHAPTLSPGGWGFSDVNTTIPDVDDTTAALRALARSRKRNRRIEEAWKKGVNWVKG
LQNKDGGWAAFEKGVTNRFLTHLPLENSGDMMTDPSTADITGRVLEFFGTYAPNELQDHQKNRAITWLMDVQENNGSWYG
KWGVSYIYGTWAALTGLRAVGVANTHPALKKAVMWLERIQHRDGGWGESCRSSIEKRFVPLSFSTPSQTAWAIDALISYY
DEETPVIRKGISYLLEHAASHQEYPTGTGLPNGFYIRYHSYSYMYPLLTFAHYINKYRK

Sequences:

>Translated_619_residues
MVLYGRVCAEIERTITALHTMQQQDGAWRFCFEGSPLTDCHMIFLLRLLEKEEEIEPFVARLTSIQTNEGTWKLYEDERA
GNVSTTIQAYAALLASGMYTKEDVNMKRAEAFIQERGGIARSHFMTKFLLALHGGYEYPRMFYFPTPILFLPEDSPLSIF
ELSSSARIHLIPMMICMNKRFTVSKTILPNLDHISGSSKSEWFREDRSSLFETILGEVKKFVTYPLSLHHKGDKEAERFM
IERIDRNGTLYSYASATFYMIYALLALGHHIQSPLIQQAVAGLRTYKWHMEAGIHLQNSPSTVWDTALLSYALQEANVNE
STPMIQTATEYIWQRQHHEKKDWSLHAPTLSPGGWGFSDVNTTIPDVDDTTAALRALARSRKRNRRIEEAWKKGVNWVKG
LQNKDGGWAAFEKGVTNRFLTHLPLENSGDMMTDPSTADITGRVLEFFGTYAPNELQDHQKNRAITWLMDVQENNGSWYG
KWGVSYIYGTWAALTGLRAVGVANTHPALKKAVMWLERIQHRDGGWGESCRSSIEKRFVPLSFSTPSQTAWAIDALISYY
DEETPVIRKGISYLLEHAASHQEYPTGTGLPNGFYIRYHSYSYMYPLLTFAHYINKYRK
>Mature_619_residues
MVLYGRVCAEIERTITALHTMQQQDGAWRFCFEGSPLTDCHMIFLLRLLEKEEEIEPFVARLTSIQTNEGTWKLYEDERA
GNVSTTIQAYAALLASGMYTKEDVNMKRAEAFIQERGGIARSHFMTKFLLALHGGYEYPRMFYFPTPILFLPEDSPLSIF
ELSSSARIHLIPMMICMNKRFTVSKTILPNLDHISGSSKSEWFREDRSSLFETILGEVKKFVTYPLSLHHKGDKEAERFM
IERIDRNGTLYSYASATFYMIYALLALGHHIQSPLIQQAVAGLRTYKWHMEAGIHLQNSPSTVWDTALLSYALQEANVNE
STPMIQTATEYIWQRQHHEKKDWSLHAPTLSPGGWGFSDVNTTIPDVDDTTAALRALARSRKRNRRIEEAWKKGVNWVKG
LQNKDGGWAAFEKGVTNRFLTHLPLENSGDMMTDPSTADITGRVLEFFGTYAPNELQDHQKNRAITWLMDVQENNGSWYG
KWGVSYIYGTWAALTGLRAVGVANTHPALKKAVMWLERIQHRDGGWGESCRSSIEKRFVPLSFSTPSQTAWAIDALISYY
DEETPVIRKGISYLLEHAASHQEYPTGTGLPNGFYIRYHSYSYMYPLLTFAHYINKYRK

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=611, Percent_Identity=24.7135842880524, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI47933397, Length=611, Percent_Identity=24.7135842880524, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI224177558, Length=611, Percent_Identity=24.7135842880524, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI224177556, Length=589, Percent_Identity=24.6179966044143, Blast_Score=114, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6321863, Length=291, Percent_Identity=28.5223367697594, Blast_Score=87, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 70854; Mature: 70854

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLYGRVCAEIERTITALHTMQQQDGAWRFCFEGSPLTDCHMIFLLRLLEKEEEIEPFVA
CEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
RLTSIQTNEGTWKLYEDERAGNVSTTIQAYAALLASGMYTKEDVNMKRAEAFIQERGGIA
HHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCHH
RSHFMTKFLLALHGGYEYPRMFYFPTPILFLPEDSPLSIFELSSSARIHLIPMMICMNKR
HHHHHHHHHHHHHCCCCCCEEEECCCCEEECCCCCCCEEEEECCCCEEEEEHHHHHCCCC
FTVSKTILPNLDHISGSSKSEWFREDRSSLFETILGEVKKFVTYPLSLHHKGDKEAERFM
CEEHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHH
IERIDRNGTLYSYASATFYMIYALLALGHHIQSPLIQQAVAGLRTYKWHMEAGIHLQNSP
HHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEECCCC
STVWDTALLSYALQEANVNESTPMIQTATEYIWQRQHHEKKDWSLHAPTLSPGGWGFSDV
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCC
NTTIPDVDDTTAALRALARSRKRNRRIEEAWKKGVNWVKGLQNKDGGWAAFEKGVTNRFL
CCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
THLPLENSGDMMTDPSTADITGRVLEFFGTYAPNELQDHQKNRAITWLMDVQENNGSWYG
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEEEEEECCCCEEE
KWGVSYIYGTWAALTGLRAVGVANTHPALKKAVMWLERIQHRDGGWGESCRSSIEKRFVP
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEC
LSFSTPSQTAWAIDALISYYDEETPVIRKGISYLLEHAASHQEYPTGTGLPNGFYIRYHS
EECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
YSYMYPLLTFAHYINKYRK
CHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLYGRVCAEIERTITALHTMQQQDGAWRFCFEGSPLTDCHMIFLLRLLEKEEEIEPFVA
CEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
RLTSIQTNEGTWKLYEDERAGNVSTTIQAYAALLASGMYTKEDVNMKRAEAFIQERGGIA
HHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCHH
RSHFMTKFLLALHGGYEYPRMFYFPTPILFLPEDSPLSIFELSSSARIHLIPMMICMNKR
HHHHHHHHHHHHHCCCCCCEEEECCCCEEECCCCCCCEEEEECCCCEEEEEHHHHHCCCC
FTVSKTILPNLDHISGSSKSEWFREDRSSLFETILGEVKKFVTYPLSLHHKGDKEAERFM
CEEHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHH
IERIDRNGTLYSYASATFYMIYALLALGHHIQSPLIQQAVAGLRTYKWHMEAGIHLQNSP
HHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEECCCC
STVWDTALLSYALQEANVNESTPMIQTATEYIWQRQHHEKKDWSLHAPTLSPGGWGFSDV
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCC
NTTIPDVDDTTAALRALARSRKRNRRIEEAWKKGVNWVKGLQNKDGGWAAFEKGVTNRFL
CCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
THLPLENSGDMMTDPSTADITGRVLEFFGTYAPNELQDHQKNRAITWLMDVQENNGSWYG
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEEEEEECCCCEEE
KWGVSYIYGTWAALTGLRAVGVANTHPALKKAVMWLERIQHRDGGWGESCRSSIEKRFVP
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEC
LSFSTPSQTAWAIDALISYYDEETPVIRKGISYLLEHAASHQEYPTGTGLPNGFYIRYHS
EECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEC
YSYMYPLLTFAHYINKYRK
CHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]