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The map label for this gene is panF [H]

Identifier: 152975955

GI number: 152975955

Start: 2323369

End: 2324802

Strand: Reverse

Name: panF [H]

Synonym: Bcer98_2227

Alternate gene names: 152975955

Gene position: 2324802-2323369 (Counterclockwise)

Preceding gene: 152975956

Following gene: 152975954

Centisome position: 56.88

GC content: 36.68

Gene sequence:

>1434_bases
ATGAATTGGTATGTAATAATTCCAATGATAATTTCTTTTATCATTGTATTTTTAATTGGTGTATATGCATCACGGCGCGT
ACAAGCGACAGCGCATCATAAATTTTTGCAAGAATACTTTCTTGGTGGACGTGAACTTGGTGGATTATTATTAGCAATGA
CAATGATTGCGACATATGGTAGTGCAAGCAGTTTTATTGGAGGGCCAGGTATTGCTTACAATATGGGACTTGGATGGGTA
CTACTATCTGCTATTCAAATCGTCACCGGCTATATTGTATTAACGGTTCTTGGTAAAAAATTTGCCATTATTGCACGCAA
AATGGAAGCCATTACACTTATCGATTATTTAAAAGGGCGCTATAATCATAAAGGTGTTGTCATTTTATCGGCATTATGCA
TTATTATCTTTTTATTTTCTGCAACTGTAGCCCAGTGGGTTGGTGGCGGACGGTTAATAGAATCGTTAACGGGGCTTTCC
TATACAACATCTTTATTTTTGTTTACATTTTCTGTTCTTGTGTATGTTTTAATCGGTGGATTTCGAGCAGTTGCATTATC
TGATACATTACTAGGAATCATTATGTTAGTGGGCACAACAATTATTTTAATTGCAACAGTAATCGCTGGGGGCGGAATTG
AAAATATTATGCATGACCTTGTGCAAATCAATCCGAAGCTAATTACACCATTTGGAGCAGACGGCAGTTTAACGAAAACA
TATGTGACATCATTTTGGATTTTAATAGGGATTGGAGTAGTTGGATTACCGCAAATTAGCGTGCGTGCCATGTCTTATAA
AAATTCAAAAGCGATGCATCAAGCATTAATCATTGGTACTGTTGTCGTAGGAACGATTATGATTGGCATGCATTTAACAG
GTGTATTTGCTCGTGTTGTACTTCCAGGCATAGATGTGCCTGATAAGGTGATGCCTCTTTTAGCAATGGAAGTATTACCA
CCTTGGCTTGCAGGAATTTTTTTAGCAGCACCGATGGCGGCGATTATGTCTACAGTGAATTCGCTCTTATTGCTTGTGAG
TTCGTCTATCATGAAAGATATATACGTAAATTACATAAGTGAAAAAGCTACAGATCAAGCAATTAAAACAGGAAGTTTAT
GGATTACAGGGATCATTGGCTTACTTGTTTATGCAGCAGCGATTAAGCCACCAGACTTCTTAATTTGGTTAAATTTATTT
TCTTTTGGTGGTTTAGAAGCAGCGTTTATTTGGCCGATTGTTTTAGGATTATATTGGAGAAAAGGAAATGCGATTGGTGC
TTTTACATCTATAATTGTTGGGGTAGGATCTTATATCATCATTCACCTTTGGTTCCCCAATCCATTTCAAATTCATACGG
TAGTATTTCCAATTTGTTTTGCGCTAATAGCTTACATACTTGGCAGCATTATGACAACGAAAAAAGAATCATAA

Upstream 100 bases:

>100_bases
CGTTGGATTTCTTATCATGGTTGTCTTGCTAAGTTTAGTTGTACGCTTTGTATTTCAAGATATTCCACTCGATGAGGAAG
AAAAAAGTGAGGAATGATAG

Downstream 100 bases:

>100_bases
AAAAACGCAGTGTTTACAAAAAACACTGCGTTTTTTATGAGAAAATAAATTTTTTCATTCTGTAATTTTTTCCTGTTCAT
AAATTAATAACAACTGTTAG

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNWYVIIPMIISFIIVFLIGVYASRRVQATAHHKFLQEYFLGGRELGGLLLAMTMIATYGSASSFIGGPGIAYNMGLGWV
LLSAIQIVTGYIVLTVLGKKFAIIARKMEAITLIDYLKGRYNHKGVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLS
YTTSLFLFTFSVLVYVLIGGFRAVALSDTLLGIIMLVGTTIILIATVIAGGGIENIMHDLVQINPKLITPFGADGSLTKT
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTVVVGTIMIGMHLTGVFARVVLPGIDVPDKVMPLLAMEVLP
PWLAGIFLAAPMAAIMSTVNSLLLLVSSSIMKDIYVNYISEKATDQAIKTGSLWITGIIGLLVYAAAIKPPDFLIWLNLF
SFGGLEAAFIWPIVLGLYWRKGNAIGAFTSIIVGVGSYIIIHLWFPNPFQIHTVVFPICFALIAYILGSIMTTKKES

Sequences:

>Translated_477_residues
MNWYVIIPMIISFIIVFLIGVYASRRVQATAHHKFLQEYFLGGRELGGLLLAMTMIATYGSASSFIGGPGIAYNMGLGWV
LLSAIQIVTGYIVLTVLGKKFAIIARKMEAITLIDYLKGRYNHKGVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLS
YTTSLFLFTFSVLVYVLIGGFRAVALSDTLLGIIMLVGTTIILIATVIAGGGIENIMHDLVQINPKLITPFGADGSLTKT
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTVVVGTIMIGMHLTGVFARVVLPGIDVPDKVMPLLAMEVLP
PWLAGIFLAAPMAAIMSTVNSLLLLVSSSIMKDIYVNYISEKATDQAIKTGSLWITGIIGLLVYAAAIKPPDFLIWLNLF
SFGGLEAAFIWPIVLGLYWRKGNAIGAFTSIIVGVGSYIIIHLWFPNPFQIHTVVFPICFALIAYILGSIMTTKKES
>Mature_477_residues
MNWYVIIPMIISFIIVFLIGVYASRRVQATAHHKFLQEYFLGGRELGGLLLAMTMIATYGSASSFIGGPGIAYNMGLGWV
LLSAIQIVTGYIVLTVLGKKFAIIARKMEAITLIDYLKGRYNHKGVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLS
YTTSLFLFTFSVLVYVLIGGFRAVALSDTLLGIIMLVGTTIILIATVIAGGGIENIMHDLVQINPKLITPFGADGSLTKT
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTVVVGTIMIGMHLTGVFARVVLPGIDVPDKVMPLLAMEVLP
PWLAGIFLAAPMAAIMSTVNSLLLLVSSSIMKDIYVNYISEKATDQAIKTGSLWITGIIGLLVYAAAIKPPDFLIWLNLF
SFGGLEAAFIWPIVLGLYWRKGNAIGAFTSIIVGVGSYIIIHLWFPNPFQIHTVVFPICFALIAYILGSIMTTKKES

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=497, Percent_Identity=27.9678068410463, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI157671931, Length=389, Percent_Identity=22.6221079691517, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI14140236, Length=478, Percent_Identity=22.3849372384937, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4507035, Length=344, Percent_Identity=24.1279069767442, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI167466278, Length=349, Percent_Identity=22.0630372492837, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87082237, Length=435, Percent_Identity=50.3448275862069, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1787251, Length=447, Percent_Identity=27.9642058165548, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1790503, Length=386, Percent_Identity=24.8704663212435, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1790113, Length=434, Percent_Identity=24.4239631336406, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17539284, Length=395, Percent_Identity=25.0632911392405, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573698, Length=363, Percent_Identity=23.6914600550964, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51612; Mature: 51612

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWYVIIPMIISFIIVFLIGVYASRRVQATAHHKFLQEYFLGGRELGGLLLAMTMIATYG
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
SASSFIGGPGIAYNMGLGWVLLSAIQIVTGYIVLTVLGKKFAIIARKMEAITLIDYLKGR
CCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YNHKGVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLSYTTSLFLFTFSVLVYVLIGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FRAVALSDTLLGIIMLVGTTIILIATVIAGGGIENIMHDLVQINPKLITPFGADGSLTKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHH
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTVVVGTIMIGMHLTGVFARVV
HHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPGIDVPDKVMPLLAMEVLPPWLAGIFLAAPMAAIMSTVNSLLLLVSSSIMKDIYVNYIS
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKATDQAIKTGSLWITGIIGLLVYAAAIKPPDFLIWLNLFSFGGLEAAFIWPIVLGLYWR
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHC
KGNAIGAFTSIIVGVGSYIIIHLWFPNPFQIHTVVFPICFALIAYILGSIMTTKKES
CCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNWYVIIPMIISFIIVFLIGVYASRRVQATAHHKFLQEYFLGGRELGGLLLAMTMIATYG
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
SASSFIGGPGIAYNMGLGWVLLSAIQIVTGYIVLTVLGKKFAIIARKMEAITLIDYLKGR
CCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YNHKGVVILSALCIIIFLFSATVAQWVGGGRLIESLTGLSYTTSLFLFTFSVLVYVLIGG
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FRAVALSDTLLGIIMLVGTTIILIATVIAGGGIENIMHDLVQINPKLITPFGADGSLTKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHH
YVTSFWILIGIGVVGLPQISVRAMSYKNSKAMHQALIIGTVVVGTIMIGMHLTGVFARVV
HHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPGIDVPDKVMPLLAMEVLPPWLAGIFLAAPMAAIMSTVNSLLLLVSSSIMKDIYVNYIS
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKATDQAIKTGSLWITGIIGLLVYAAAIKPPDFLIWLNLFSFGGLEAAFIWPIVLGLYWR
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHC
KGNAIGAFTSIIVGVGSYIIIHLWFPNPFQIHTVVFPICFALIAYILGSIMTTKKES
CCCCHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]