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The map label for this gene is mutS2 [H]

Identifier: 152975927

GI number: 152975927

Start: 2281612

End: 2283513

Strand: Reverse

Name: mutS2 [H]

Synonym: Bcer98_2199

Alternate gene names: 152975927

Gene position: 2283513-2281612 (Counterclockwise)

Preceding gene: 152975930

Following gene: 152975926

Centisome position: 55.87

GC content: 34.75

Gene sequence:

>1902_bases
GTGAATCAAATGACTTTTGAAAAGTTGCAGTACAATGAATTGAAGGACATTGTTAAATCTTACTGTGTAAGTGGGTTAGG
AAAGCGATTATTGGATCAATTAGAGCCAAGTACAAATATAAAGGTAGTACGAAATCGATTGAATGAAACGACGGAAGCGC
GAGCGATATTAGATGCAGAAGGACATGTACCTTTTTTAGGTATTTCTAATATTGATAACATCATGCAAAAACTAGAAAAA
GGAATGATTCTAGAGCCAAGCGAGTTCGTGAGTGTTTCAGATTTTTTACGGGGCTGTCGCAAGATTAAAAAGTTTATGTT
AGATAAGGAATTTTTTGCACCAATGCTCGCAGCGTATGCAAATTCTATGTCCGAGTTTAAAAGCATAGAGGAAGAAATAC
AATTTTGTATAAAAGGAAACCGTGTTGATTCTGCTGCAAGTAAAGAATTAAAACGAATTCGAAATCAAATGGATTCGGTA
GAGGGAAAAATAAAGGAACGGTTAAATAAATTTTTAAACAGTAGTGCAAATAAGAAGTATATACAAGAATTCTTCATTAG
TAAAAAGGACGACCGATATACGATTCCGGTGAAAGCATCTTATAAAAATCAAGTTGCAGGAACAATTGTTGCAGTTTCTT
CTAAAGGTTCTACTGTTTTTATAGAACCAAATACTGTTACAACATTAAACGTGGAACTGGCAAGCTTACGAGCGGAAGAA
GCGATGGAAGAATATCAAATATTAGCAACTCTCTCAGGAATGATATTAGAAAACATATATCAAATCAAAATAAATATAGA
GCTAGTGAGTCAATATGATTTAGTATTTGCCAAAGCAAAATTTAGTAAGCAAATTGGCGGAATAGAACCCAAGTTAAATG
ATTACGGGTATATAAAGCTCGTTCATTGCAAGCATCCGCTTTTATCAGGAGAAGTGATACCGCTAAATTTTGAAATTGGT
CAAAAATATCGAAGTTTAATTATTACAGGACCAAATGCTGGGGGGAAAACGATTGTTCTGAAAACAATCGGATTATTAAC
ATTAGCGGCAATGTCGGGGTTTCATATTGCAGGAGAGCGAGAAACGGAGATTGCTGTTTTTGAACATATCTTTGTAGATA
TCGGTGATAATCAAAGTATCGAAAATGCACTAAGTACATTTTCATCTCATATGAAAAATCTTTCGGAAATTATGGAAGTA
TCAAATAATAATACGCTGTTATTATTTGATGAAATAGGCAGCGGTACGGAACCGAATGAGGGAGCTGCGCTAGCGATTTC
TATTTTAGAAGAGTTTTATCATATGGGCTGTATCACTGTCGCGACGACGCATTATGGTGAGATTAAGCGATTCTCAGAAA
TGCATAGTGACTTTATGAATGCAGCGATGCAATTTCATAGTGAAACATTGGAACCGATGTATCAATTATTAATTGGAAAA
TCGGGAGAAAGTAATGCACTTTGGATTTCTCGAAAAATGAATGTACGAGAACATGTATTGCAAAGAGCAAAAGAGTACAT
GGAAAACAAAGAATATCGTTTAGAAAAGCTACATGAAGGAAAAGTAAGAAAGCCTAAAATTGTAAAGCAAGCGGTAGAAG
AGGCATATGCATATAAAAAAGGAGATCGCGTGAGATTATTAGATGATGATGAATTTGGAATTATATACCGAGAGAAAGAT
AACTTCTCCAACGTTGTCGTGTTTTCCAAAGAGCGGTTTATAGAAGTAAATAGTAAACGGATTGCTTTAGAGGTCGAGGC
GAAGGAATTATATCCAGAAGGTTACGATTTAGATACGTTGTTTGTAGATTATAAAGAACGAAAAATGCAGCATGATATAG
AGCGTGGATCAAAAAAAGCGCTGCGTAACATTCAAAAAGAAATAAGAAAGAATAAAGGATAA

Upstream 100 bases:

>100_bases
CCCATTTGAATAAACCAAAATATATGACCAGCTCATTAAAATGTAATGAGTAGGTATCTTCGTTTATGATGTAAATCAAT
CATAGTGAGGAGAAAAGACA

Downstream 100 bases:

>100_bases
GAGGTTATGCCAATAATTGTTAGACAAGAACGTGAAGAAGAGTATAAAAAAACAGAAGAAGTTGTACAACAGGCATTTTT
ACATGAAGAGTTTAGCGATA

Product: DNA mismatch repair protein MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MNQMTFEKLQYNELKDIVKSYCVSGLGKRLLDQLEPSTNIKVVRNRLNETTEARAILDAEGHVPFLGISNIDNIMQKLEK
GMILEPSEFVSVSDFLRGCRKIKKFMLDKEFFAPMLAAYANSMSEFKSIEEEIQFCIKGNRVDSAASKELKRIRNQMDSV
EGKIKERLNKFLNSSANKKYIQEFFISKKDDRYTIPVKASYKNQVAGTIVAVSSKGSTVFIEPNTVTTLNVELASLRAEE
AMEEYQILATLSGMILENIYQIKINIELVSQYDLVFAKAKFSKQIGGIEPKLNDYGYIKLVHCKHPLLSGEVIPLNFEIG
QKYRSLIITGPNAGGKTIVLKTIGLLTLAAMSGFHIAGERETEIAVFEHIFVDIGDNQSIENALSTFSSHMKNLSEIMEV
SNNNTLLLFDEIGSGTEPNEGAALAISILEEFYHMGCITVATTHYGEIKRFSEMHSDFMNAAMQFHSETLEPMYQLLIGK
SGESNALWISRKMNVREHVLQRAKEYMENKEYRLEKLHEGKVRKPKIVKQAVEEAYAYKKGDRVRLLDDDEFGIIYREKD
NFSNVVVFSKERFIEVNSKRIALEVEAKELYPEGYDLDTLFVDYKERKMQHDIERGSKKALRNIQKEIRKNKG

Sequences:

>Translated_633_residues
MNQMTFEKLQYNELKDIVKSYCVSGLGKRLLDQLEPSTNIKVVRNRLNETTEARAILDAEGHVPFLGISNIDNIMQKLEK
GMILEPSEFVSVSDFLRGCRKIKKFMLDKEFFAPMLAAYANSMSEFKSIEEEIQFCIKGNRVDSAASKELKRIRNQMDSV
EGKIKERLNKFLNSSANKKYIQEFFISKKDDRYTIPVKASYKNQVAGTIVAVSSKGSTVFIEPNTVTTLNVELASLRAEE
AMEEYQILATLSGMILENIYQIKINIELVSQYDLVFAKAKFSKQIGGIEPKLNDYGYIKLVHCKHPLLSGEVIPLNFEIG
QKYRSLIITGPNAGGKTIVLKTIGLLTLAAMSGFHIAGERETEIAVFEHIFVDIGDNQSIENALSTFSSHMKNLSEIMEV
SNNNTLLLFDEIGSGTEPNEGAALAISILEEFYHMGCITVATTHYGEIKRFSEMHSDFMNAAMQFHSETLEPMYQLLIGK
SGESNALWISRKMNVREHVLQRAKEYMENKEYRLEKLHEGKVRKPKIVKQAVEEAYAYKKGDRVRLLDDDEFGIIYREKD
NFSNVVVFSKERFIEVNSKRIALEVEAKELYPEGYDLDTLFVDYKERKMQHDIERGSKKALRNIQKEIRKNKG
>Mature_633_residues
MNQMTFEKLQYNELKDIVKSYCVSGLGKRLLDQLEPSTNIKVVRNRLNETTEARAILDAEGHVPFLGISNIDNIMQKLEK
GMILEPSEFVSVSDFLRGCRKIKKFMLDKEFFAPMLAAYANSMSEFKSIEEEIQFCIKGNRVDSAASKELKRIRNQMDSV
EGKIKERLNKFLNSSANKKYIQEFFISKKDDRYTIPVKASYKNQVAGTIVAVSSKGSTVFIEPNTVTTLNVELASLRAEE
AMEEYQILATLSGMILENIYQIKINIELVSQYDLVFAKAKFSKQIGGIEPKLNDYGYIKLVHCKHPLLSGEVIPLNFEIG
QKYRSLIITGPNAGGKTIVLKTIGLLTLAAMSGFHIAGERETEIAVFEHIFVDIGDNQSIENALSTFSSHMKNLSEIMEV
SNNNTLLLFDEIGSGTEPNEGAALAISILEEFYHMGCITVATTHYGEIKRFSEMHSDFMNAAMQFHSETLEPMYQLLIGK
SGESNALWISRKMNVREHVLQRAKEYMENKEYRLEKLHEGKVRKPKIVKQAVEEAYAYKKGDRVRLLDDDEFGIIYREKD
NFSNVVVFSKERFIEVNSKRIALEVEAKELYPEGYDLDTLFVDYKERKMQHDIERGSKKALRNIQKEIRKNKG

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=275, Percent_Identity=24.7272727272727, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI36949366, Length=446, Percent_Identity=23.9910313901345, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI26638666, Length=226, Percent_Identity=31.858407079646, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI4505253, Length=226, Percent_Identity=31.858407079646, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI26638664, Length=226, Percent_Identity=30.9734513274336, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI262231786, Length=226, Percent_Identity=30.9734513274336, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4504191, Length=269, Percent_Identity=23.7918215613383, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4557761, Length=182, Percent_Identity=28.021978021978, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1789089, Length=334, Percent_Identity=23.9520958083832, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508445, Length=312, Percent_Identity=25, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17534743, Length=205, Percent_Identity=25.3658536585366, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539736, Length=218, Percent_Identity=23.394495412844, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17508447, Length=209, Percent_Identity=25.3588516746411, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319935, Length=319, Percent_Identity=26.6457680250784, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324482, Length=294, Percent_Identity=26.1904761904762, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320302, Length=271, Percent_Identity=22.8782287822878, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321109, Length=267, Percent_Identity=26.2172284644195, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321912, Length=250, Percent_Identity=23.2, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664545, Length=489, Percent_Identity=23.9263803680982, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24584320, Length=250, Percent_Identity=29.6, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 72219; Mature: 72219

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQMTFEKLQYNELKDIVKSYCVSGLGKRLLDQLEPSTNIKVVRNRLNETTEARAILDAE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHEEEECC
GHVPFLGISNIDNIMQKLEKGMILEPSEFVSVSDFLRGCRKIKKFMLDKEFFAPMLAAYA
CCCCEEECCCHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
NSMSEFKSIEEEIQFCIKGNRVDSAASKELKRIRNQMDSVEGKIKERLNKFLNSSANKKY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IQEFFISKKDDRYTIPVKASYKNQVAGTIVAVSSKGSTVFIEPNTVTTLNVELASLRAEE
HHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEEECCCEEEEEEHHHHHHHHHH
AMEEYQILATLSGMILENIYQIKINIELVSQYDLVFAKAKFSKQIGGIEPKLNDYGYIKL
HHHHHHHHHHHHHHHHCCEEEEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
VHCKHPLLSGEVIPLNFEIGQKYRSLIITGPNAGGKTIVLKTIGLLTLAAMSGFHIAGER
EEECCCCCCCCEEEEEHHHCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHCCCEECCCC
ETEIAVFEHIFVDIGDNQSIENALSTFSSHMKNLSEIMEVSNNNTLLLFDEIGSGTEPNE
CCHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
GAALAISILEEFYHMGCITVATTHYGEIKRFSEMHSDFMNAAMQFHSETLEPMYQLLIGK
CHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGESNALWISRKMNVREHVLQRAKEYMENKEYRLEKLHEGKVRKPKIVKQAVEEAYAYKK
CCCCCEEEEEECCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
GDRVRLLDDDEFGIIYREKDNFSNVVVFSKERFIEVNSKRIALEVEAKELYPEGYDLDTL
CCEEEEECCCCEEEEEEECCCCCCEEEEECCCEEEECCCEEEEEEEHHHHCCCCCCCCCE
FVDYKERKMQHDIERGSKKALRNIQKEIRKNKG
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQMTFEKLQYNELKDIVKSYCVSGLGKRLLDQLEPSTNIKVVRNRLNETTEARAILDAE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHEEEECC
GHVPFLGISNIDNIMQKLEKGMILEPSEFVSVSDFLRGCRKIKKFMLDKEFFAPMLAAYA
CCCCEEECCCHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
NSMSEFKSIEEEIQFCIKGNRVDSAASKELKRIRNQMDSVEGKIKERLNKFLNSSANKKY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IQEFFISKKDDRYTIPVKASYKNQVAGTIVAVSSKGSTVFIEPNTVTTLNVELASLRAEE
HHHHHCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEEECCCEEEEEEHHHHHHHHHH
AMEEYQILATLSGMILENIYQIKINIELVSQYDLVFAKAKFSKQIGGIEPKLNDYGYIKL
HHHHHHHHHHHHHHHHCCEEEEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
VHCKHPLLSGEVIPLNFEIGQKYRSLIITGPNAGGKTIVLKTIGLLTLAAMSGFHIAGER
EEECCCCCCCCEEEEEHHHCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHCCCEECCCC
ETEIAVFEHIFVDIGDNQSIENALSTFSSHMKNLSEIMEVSNNNTLLLFDEIGSGTEPNE
CCHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
GAALAISILEEFYHMGCITVATTHYGEIKRFSEMHSDFMNAAMQFHSETLEPMYQLLIGK
CHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGESNALWISRKMNVREHVLQRAKEYMENKEYRLEKLHEGKVRKPKIVKQAVEEAYAYKK
CCCCCEEEEEECCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
GDRVRLLDDDEFGIIYREKDNFSNVVVFSKERFIEVNSKRIALEVEAKELYPEGYDLDTL
CCEEEEECCCCEEEEEEECCCCCCEEEEECCCEEEECCCEEEEEEEHHHHCCCCCCCCCE
FVDYKERKMQHDIERGSKKALRNIQKEIRKNKG
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA