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The map label for this gene is serA [H]

Identifier: 152975827

GI number: 152975827

Start: 2187239

End: 2188411

Strand: Reverse

Name: serA [H]

Synonym: Bcer98_2085

Alternate gene names: 152975827

Gene position: 2188411-2187239 (Counterclockwise)

Preceding gene: 152975828

Following gene: 152975826

Centisome position: 53.55

GC content: 37.94

Gene sequence:

>1173_bases
ATGTTTCATATTCAAACATTGAATCAAATTGCCGAAAAAGGTTTACAAGTTTTTGCAGCAGAACGATATAACATCGGACA
AAGGATAGAGCATCCTGATGGAATTTTACTTCGCAGTTATTCTTTACATCAAGAAGAGCTTTCAAAGAACTTAAAGGCAA
TTGCAAGAGCCGGAGCGGGTGTAAATAATATTCCTATAGATCGATGCACAGAAAAAGGGATTGTTGTATTTAATACACCG
GGTGCAAATGCGAATGCAGTAAAAGAATTGATACTGGCAAGTTTCATTCTGTCTTCTCGAAATATTATAAATGGAGTTAG
TTGGACAAAGGGATTAGAGGGAAAAGAGATTCCTCAGCTTGTCGAAGCAGGAAAAAAACAGTTTGTTGGATCGGAAATCG
CCGGAAAACGATTAGGAGTGATTGGTCTTGGTGCAATCGGTGCACTTGTTGCGAATGATGCGCTATCTTTAGGAATGGAT
GTTGTCGGATATGACCCTTATATTTCAGTGGAAACGGCATGGCGTTTATCTACACATGTGCAAAGAGCGTTTAGCTTAGA
TGAAATTTTTGCGACTTGTGATTATATTACATTACATATTCCGCTTACAGAGCAAACGCGAGGAATCATTGGAGAACATG
CGGTTCGTATGATGAAAAAAGGTGTGCGTTTATTCAATTTTTCAAGAGGAGAGCTTGTTGATGAGACGGCCTTAGAAAAG
GCTTTAGAAGAAGAAACGATCAATCATTATATGACAGACTTTCCAAATGAGAATGTCATAAAGATGAAAAATGTAGTTGC
AACGCCACACCTTGGCGCTTCAACATATGAATCAGAAGAAAATTGCGCTGTTATGGCTGCGTGCCAATTGCGAGATTATT
TGGAAACAGGAAATATTCGGAATTCAGTTAACTATCCGAATGTAGAACTTCCGTATGTTGGAAAAAAACGGATTACGATT
ATGCATCAAAACGTTCCGAACATGGTTGGACAAATTACAGGGTGCTTAGCGGAGCATCATATTAACATTGCGGATATGAT
TAACCGTAGTAAAAACTCTTGGGCATATACAATGATTGATATTGATAATGGGATGGATGATAGAATGAAGGAAAATATTG
TTGAGAATATAAGGAGAATTACAGGTGTTGTAGCCGTTCGAATGATTGTATAA

Upstream 100 bases:

>100_bases
GCGTGCAAGTATTTATAATGCAATGCCGATAGAAGGGGTGAAAAAATTAGTAGCGTATATGAAGACCTTTGAGTTAGAGA
ATAGATAGGGGGATGAGGAT

Downstream 100 bases:

>100_bases
AGGGGAGAGGAAAATGGCGACAATTCGACCATTTCGGGCTATTCGTCCGGTGCAAAATAAGGCGGCGCAAGTTGCAGCTT
TACCATATGATGTATTAAAT

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MFHIQTLNQIAEKGLQVFAAERYNIGQRIEHPDGILLRSYSLHQEELSKNLKAIARAGAGVNNIPIDRCTEKGIVVFNTP
GANANAVKELILASFILSSRNIINGVSWTKGLEGKEIPQLVEAGKKQFVGSEIAGKRLGVIGLGAIGALVANDALSLGMD
VVGYDPYISVETAWRLSTHVQRAFSLDEIFATCDYITLHIPLTEQTRGIIGEHAVRMMKKGVRLFNFSRGELVDETALEK
ALEEETINHYMTDFPNENVIKMKNVVATPHLGASTYESEENCAVMAACQLRDYLETGNIRNSVNYPNVELPYVGKKRITI
MHQNVPNMVGQITGCLAEHHINIADMINRSKNSWAYTMIDIDNGMDDRMKENIVENIRRITGVVAVRMIV

Sequences:

>Translated_390_residues
MFHIQTLNQIAEKGLQVFAAERYNIGQRIEHPDGILLRSYSLHQEELSKNLKAIARAGAGVNNIPIDRCTEKGIVVFNTP
GANANAVKELILASFILSSRNIINGVSWTKGLEGKEIPQLVEAGKKQFVGSEIAGKRLGVIGLGAIGALVANDALSLGMD
VVGYDPYISVETAWRLSTHVQRAFSLDEIFATCDYITLHIPLTEQTRGIIGEHAVRMMKKGVRLFNFSRGELVDETALEK
ALEEETINHYMTDFPNENVIKMKNVVATPHLGASTYESEENCAVMAACQLRDYLETGNIRNSVNYPNVELPYVGKKRITI
MHQNVPNMVGQITGCLAEHHINIADMINRSKNSWAYTMIDIDNGMDDRMKENIVENIRRITGVVAVRMIV
>Mature_390_residues
MFHIQTLNQIAEKGLQVFAAERYNIGQRIEHPDGILLRSYSLHQEELSKNLKAIARAGAGVNNIPIDRCTEKGIVVFNTP
GANANAVKELILASFILSSRNIINGVSWTKGLEGKEIPQLVEAGKKQFVGSEIAGKRLGVIGLGAIGALVANDALSLGMD
VVGYDPYISVETAWRLSTHVQRAFSLDEIFATCDYITLHIPLTEQTRGIIGEHAVRMMKKGVRLFNFSRGELVDETALEK
ALEEETINHYMTDFPNENVIKMKNVVATPHLGASTYESEENCAVMAACQLRDYLETGNIRNSVNYPNVELPYVGKKRITI
MHQNVPNMVGQITGCLAEHHINIADMINRSKNSWAYTMIDIDNGMDDRMKENIVENIRRITGVVAVRMIV

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=309, Percent_Identity=33.6569579288026, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI61743967, Length=289, Percent_Identity=32.1799307958478, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4557497, Length=288, Percent_Identity=32.2916666666667, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI145580578, Length=286, Percent_Identity=29.3706293706294, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI4557499, Length=286, Percent_Identity=29.3706293706294, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI145580575, Length=285, Percent_Identity=29.4736842105263, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI6912396, Length=246, Percent_Identity=25.2032520325203, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1789279, Length=371, Percent_Identity=30.9973045822102, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87082289, Length=278, Percent_Identity=27.6978417266187, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1787645, Length=219, Percent_Identity=32.8767123287671, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=271, Percent_Identity=33.210332103321, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=271, Percent_Identity=28.7822878228782, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=371, Percent_Identity=28.8409703504043, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6322116, Length=395, Percent_Identity=27.5949367088608, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6324055, Length=279, Percent_Identity=23.6559139784946, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921140, Length=277, Percent_Identity=34.6570397111913, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646446, Length=279, Percent_Identity=30.8243727598566, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646448, Length=279, Percent_Identity=30.8243727598566, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646452, Length=279, Percent_Identity=30.8243727598566, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646450, Length=279, Percent_Identity=30.8243727598566, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI62472511, Length=279, Percent_Identity=30.8243727598566, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI45552429, Length=289, Percent_Identity=24.2214532871972, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24585514, Length=289, Percent_Identity=23.8754325259516, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI28574282, Length=289, Percent_Identity=23.8754325259516, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45551003, Length=289, Percent_Identity=23.8754325259516, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI28574284, Length=289, Percent_Identity=23.8754325259516, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574286, Length=255, Percent_Identity=24.7058823529412, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585516, Length=296, Percent_Identity=24.3243243243243, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28571528, Length=255, Percent_Identity=26.2745098039216, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 43278; Mature: 43278

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHIQTLNQIAEKGLQVFAAERYNIGQRIEHPDGILLRSYSLHQEELSKNLKAIARAGAG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCC
VNNIPIDRCTEKGIVVFNTPGANANAVKELILASFILSSRNIINGVSWTKGLEGKEIPQL
CCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHCCCCHHCCCCCCHHHHH
VEAGKKQFVGSEIAGKRLGVIGLGAIGALVANDALSLGMDVVGYDPYISVETAWRLSTHV
HHHHHHHHCCHHHCCCCCCEEEHHHHHHHHHHHHHHHCCEEECCCCEEEEHHHHHHHHHH
QRAFSLDEIFATCDYITLHIPLTEQTRGIIGEHAVRMMKKGVRLFNFSRGELVDETALEK
HHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHH
ALEEETINHYMTDFPNENVIKMKNVVATPHLGASTYESEENCAVMAACQLRDYLETGNIR
HHHHHHHHHHHHCCCCCCEEEHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
NSVNYPNVELPYVGKKRITIMHQNVPNMVGQITGCLAEHHINIADMINRSKNSWAYTMID
CCCCCCCEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEE
IDNGMDDRMKENIVENIRRITGVVAVRMIV
ECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFHIQTLNQIAEKGLQVFAAERYNIGQRIEHPDGILLRSYSLHQEELSKNLKAIARAGAG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCC
VNNIPIDRCTEKGIVVFNTPGANANAVKELILASFILSSRNIINGVSWTKGLEGKEIPQL
CCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHCCCCHHCCCCCCHHHHH
VEAGKKQFVGSEIAGKRLGVIGLGAIGALVANDALSLGMDVVGYDPYISVETAWRLSTHV
HHHHHHHHCCHHHCCCCCCEEEHHHHHHHHHHHHHHHCCEEECCCCEEEEHHHHHHHHHH
QRAFSLDEIFATCDYITLHIPLTEQTRGIIGEHAVRMMKKGVRLFNFSRGELVDETALEK
HHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHH
ALEEETINHYMTDFPNENVIKMKNVVATPHLGASTYESEENCAVMAACQLRDYLETGNIR
HHHHHHHHHHHHCCCCCCEEEHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
NSVNYPNVELPYVGKKRITIMHQNVPNMVGQITGCLAEHHINIADMINRSKNSWAYTMID
CCCCCCCEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEE
IDNGMDDRMKENIVENIRRITGVVAVRMIV
ECCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]