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The map label for this gene is hom [H]

Identifier: 152975289

GI number: 152975289

Start: 1604462

End: 1605757

Strand: Direct

Name: hom [H]

Synonym: Bcer98_1496

Alternate gene names: 152975289

Gene position: 1604462-1605757 (Clockwise)

Preceding gene: 152975288

Following gene: 152975290

Centisome position: 39.26

GC content: 35.88

Gene sequence:

>1296_bases
ATGAATCGTGTTGTACATGTTGGAGTATTAGGACTAGGAACTGTTGGAAGTGGCGTCGTTCAAATTTTACAGGAACATGG
TAAGAAGATTGGTCTTGAGACAGGGAGTGAAGTGAAGGTAAAAACAGTTGTTGTGCGGGATTTAGAAAAAGAACGAGATG
TTTCTATCAAGGGAATTATTGTTACAAGAGAGGCCGAAGAACTTTTACATGATGCAGATATTGATATTGTTGTAGAGGTA
ATGGGCGGGATTCAAGAAGCAAAAGAGCATATTATAAAAGCGTTGCAATATAAGAAGCATGTTGTAACTGCTAATAAAGA
TTTGATGGCTGTACATGGAGCAGAATTACTACAACTTGCAAACGAGAATCATTGTGAGTTGCTTTATGAAGCGAGTGTAG
CAGGTGGAATTCCAATATTAAGAGGACTTGCTGACGGATTAGCTTCAGATCATATTGAAAAGATGATGGGAATTTTGAAT
GGAACAACAAATTATATTTTAACAAAGATGAGTCAAAATGGCTGGTCTTATGAAGAAGCGTTGCAAGAAGCAAAGAGGTT
AGGGTTTGCAGAATCAGATCCTACAGCAGATGTAGATGGGCTAGATGCAGCAAGAAAAGTAGCTATTCTTGCTAATTTAG
GATTTTCAATGAATGTGTCTTTAGATGAGGTCTATGTTCGCGGTATTCGGAATATTGAAAAAGAAGATTTGGAAATAGCA
GAAAAACTAGGGTTTACAATGAAACTGATTGGGAAAGCAGAAAGAGAAGGTTCAGCAATTCATTTAAGCGTTGCACCTAC
TTTATTGCCGAGCAAACATCCTCTGTCAAGTGTAAATAATGAGTTTAATGCTGTATACGTACATGGTCAAGCAGTTGGAG
AAGTCATGTTTTACGGACCGGGTGCAGGCAAGTTGCCGACAGGTTCTGCTGTAGTAAGTGATATTGTAGCTATTGTTAAA
AAAATGAACCAAGAGGTGCAAAATCAAGATGTATGTAAAGAAATGGAGCCATATGAATTAAAACAAGATAAAGATATTGT
TTCAAAATATTTCTTGCGTATTATATTACGTGATGAACCAGGGATGTTCCATAAAGTGACAGAATGTTTCGAGAATTGTT
CTGTTAGTTTCGAAGAAATTATACAATTACCAGTAAATAAAGAATTTGCAGAAATTGTAATTGTAACGCATCAAACTTCC
AAATATCAATTTTCACAAGTCTTACAGTTATTAGAGGATGTCGCAAGTGAAATAAAAAGTTACTACAGTATTGAGGAGGA
AAAACAATATGTATAA

Upstream 100 bases:

>100_bases
TGATGCTGGTTATATGTACGGAAAGAACCGCTAGCATGTATAGAAAGCAAATAAGAAAAGAACAGATTGTTTATTTTCAA
ATTTGAGAGGAGATTGAAAG

Downstream 100 bases:

>100_bases
AGGGTTATTAAAACAATATGCTTCTTATTTACCTGTGAGCCACAATACACCAGAGGTTAGTTTGATGGAGGGAAATACAC
CGCTTATTCCGCTTGAAAAT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNRVVHVGVLGLGTVGSGVVQILQEHGKKIGLETGSEVKVKTVVVRDLEKERDVSIKGIIVTREAEELLHDADIDIVVEV
MGGIQEAKEHIIKALQYKKHVVTANKDLMAVHGAELLQLANENHCELLYEASVAGGIPILRGLADGLASDHIEKMMGILN
GTTNYILTKMSQNGWSYEEALQEAKRLGFAESDPTADVDGLDAARKVAILANLGFSMNVSLDEVYVRGIRNIEKEDLEIA
EKLGFTMKLIGKAEREGSAIHLSVAPTLLPSKHPLSSVNNEFNAVYVHGQAVGEVMFYGPGAGKLPTGSAVVSDIVAIVK
KMNQEVQNQDVCKEMEPYELKQDKDIVSKYFLRIILRDEPGMFHKVTECFENCSVSFEEIIQLPVNKEFAEIVIVTHQTS
KYQFSQVLQLLEDVASEIKSYYSIEEEKQYV

Sequences:

>Translated_431_residues
MNRVVHVGVLGLGTVGSGVVQILQEHGKKIGLETGSEVKVKTVVVRDLEKERDVSIKGIIVTREAEELLHDADIDIVVEV
MGGIQEAKEHIIKALQYKKHVVTANKDLMAVHGAELLQLANENHCELLYEASVAGGIPILRGLADGLASDHIEKMMGILN
GTTNYILTKMSQNGWSYEEALQEAKRLGFAESDPTADVDGLDAARKVAILANLGFSMNVSLDEVYVRGIRNIEKEDLEIA
EKLGFTMKLIGKAEREGSAIHLSVAPTLLPSKHPLSSVNNEFNAVYVHGQAVGEVMFYGPGAGKLPTGSAVVSDIVAIVK
KMNQEVQNQDVCKEMEPYELKQDKDIVSKYFLRIILRDEPGMFHKVTECFENCSVSFEEIIQLPVNKEFAEIVIVTHQTS
KYQFSQVLQLLEDVASEIKSYYSIEEEKQYV
>Mature_431_residues
MNRVVHVGVLGLGTVGSGVVQILQEHGKKIGLETGSEVKVKTVVVRDLEKERDVSIKGIIVTREAEELLHDADIDIVVEV
MGGIQEAKEHIIKALQYKKHVVTANKDLMAVHGAELLQLANENHCELLYEASVAGGIPILRGLADGLASDHIEKMMGILN
GTTNYILTKMSQNGWSYEEALQEAKRLGFAESDPTADVDGLDAARKVAILANLGFSMNVSLDEVYVRGIRNIEKEDLEIA
EKLGFTMKLIGKAEREGSAIHLSVAPTLLPSKHPLSSVNNEFNAVYVHGQAVGEVMFYGPGAGKLPTGSAVVSDIVAIVK
KMNQEVQNQDVCKEMEPYELKQDKDIVSKYFLRIILRDEPGMFHKVTECFENCSVSFEEIIQLPVNKEFAEIVIVTHQTS
KYQFSQVLQLLEDVASEIKSYYSIEEEKQYV

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=251, Percent_Identity=27.0916334661355, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790376, Length=351, Percent_Identity=25.3561253561254, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=119, Percent_Identity=34.453781512605, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47606; Mature: 47606

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRVVHVGVLGLGTVGSGVVQILQEHGKKIGLETGSEVKVKTVVVRDLEKERDVSIKGII
CCCEEEEEEEECCCHHHHHHHHHHHHCCEECCCCCCCEEEEHHHHHHHHHHCCCEEEEEE
VTREAEELLHDADIDIVVEVMGGIQEAKEHIIKALQYKKHVVTANKDLMAVHGAELLQLA
EECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEHHHHHHHHHC
NENHCELLYEASVAGGIPILRGLADGLASDHIEKMMGILNGTTNYILTKMSQNGWSYEEA
CCCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCHHHH
LQEAKRLGFAESDPTADVDGLDAARKVAILANLGFSMNVSLDEVYVRGIRNIEKEDLEIA
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHEECCCEECCCHHHHHHHHHHCCCHHHHHHH
EKLGFTMKLIGKAEREGSAIHLSVAPTLLPSKHPLSSVNNEFNAVYVHGQAVGEVMFYGP
HHCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHCCCCCCEEEEECCEECEEEEECC
GAGKLPTGSAVVSDIVAIVKKMNQEVQNQDVCKEMEPYELKQDKDIVSKYFLRIILRDEP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
GMFHKVTECFENCSVSFEEIIQLPVNKEFAEIVIVTHQTSKYQFSQVLQLLEDVASEIKS
CHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
YYSIEEEKQYV
HHCCCHHCCCC
>Mature Secondary Structure
MNRVVHVGVLGLGTVGSGVVQILQEHGKKIGLETGSEVKVKTVVVRDLEKERDVSIKGII
CCCEEEEEEEECCCHHHHHHHHHHHHCCEECCCCCCCEEEEHHHHHHHHHHCCCEEEEEE
VTREAEELLHDADIDIVVEVMGGIQEAKEHIIKALQYKKHVVTANKDLMAVHGAELLQLA
EECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEHHHHHHHHHC
NENHCELLYEASVAGGIPILRGLADGLASDHIEKMMGILNGTTNYILTKMSQNGWSYEEA
CCCCCEEEEECHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCHHHH
LQEAKRLGFAESDPTADVDGLDAARKVAILANLGFSMNVSLDEVYVRGIRNIEKEDLEIA
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHEECCCEECCCHHHHHHHHHHCCCHHHHHHH
EKLGFTMKLIGKAEREGSAIHLSVAPTLLPSKHPLSSVNNEFNAVYVHGQAVGEVMFYGP
HHCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHCCCCCCEEEEECCEECEEEEECC
GAGKLPTGSAVVSDIVAIVKKMNQEVQNQDVCKEMEPYELKQDKDIVSKYFLRIILRDEP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
GMFHKVTECFENCSVSFEEIIQLPVNKEFAEIVIVTHQTSKYQFSQVLQLLEDVASEIKS
CHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHH
YYSIEEEKQYV
HHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]