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The map label for this gene is mtaD

Identifier: 152975255

GI number: 152975255

Start: 1565274

End: 1566581

Strand: Direct

Name: mtaD

Synonym: Bcer98_1460

Alternate gene names: 152975255

Gene position: 1565274-1566581 (Clockwise)

Preceding gene: 152975254

Following gene: 152975256

Centisome position: 38.3

GC content: 38.0

Gene sequence:

>1308_bases
TTGAAAACAGCTTATGTAAGCGCTACAATTGTGACGCTTAATGAACAAAATGAAGTATTTGAAAATGGATATATTATTGT
AGAGGATCATACGATTATAGAAGTGCAACATGGAGATTTTTTTAAACACGATCAAGTGGATGAGGTCGTTGATTTAAAAG
GAAAATGGTTATTACCAGGTCTTGTGAATACACATACTCATATTGTAATGAGTCTTTTGCGCGGTATCGGGGATGATATG
TTATTACAACCGTGGCTTGAAACGAGAATTTGGCCTCTTGAACGTCAATTCACTCCAGAGCTTGCCGTTGCGAGTACAGA
ACTTGGTTTGTTAGAAATGGTGAAAAGTGGGACAACAACCTTTTCGGATATGTTTAACCCAATTGGTATCGACCAAGATG
CGATTATGGAAACGGTTCGTAATAGTGGAATGCGTGCAGCGGTTTCAAGAACTTTATTTAGTTTTGGTACAAAAGAAGAT
GAGAAAAAAGCAATTCAAGAAGCAGAGAAATATGTGAAACGATATTATCGTGAACATGATATGTTAACAACGATGGTTGC
ACCTCATAGTCCATATACATGTTCTACAGAAATGTTAGAGGAGTGTGCAAGAATTGCAATGGAAAACAATACGATGGTTC
ATATTCATCTTTCAGAAACAGAGCGCGAAGTACAAGATATTGAAAAGCAGTATGGGAAACGCCCTGTAGAATATATCGAG
AGCTGCGGTTTATTTAAGAGACCGACAGTCATTGCGCATGGTGTTGTGCTCAATGAAAATGAGCGCACTTTCTTAGCTGA
ACATGATGTGCGTGTAGCGCATAATCCAAATAGTAATTTAAAGCTTGGGTCTGGAATTGCAAATGTGAAAGCAATGCTAG
AAGCGGGTATTAAAGTAGGGATTGCAACTGATAGCGTGGCATCTAACAATAATTTAGATATGTTTGAAGAAATGCGCATT
GCAACTTTATTACAAAAAGGAATTCATCAAGATGCAACTGCATTACCAGTTGAAACGGCTCTTTCACTCGCAACAAAAGG
AGCAGCAGAAGTAATTGGGATGAAACAGACAGGTTCTATTGAAAGAGGAAAGTGTGCGGATTTTATTACGATTGATCCAG
CAAAAAAACCTCACTTGCAACCAGCTGAAGAAGTATTATCCCATCTTGTTTATGCAGCAAGTGGAAAAGATGTGTCTGAT
GTTGTCATCAATGGAAAACAAATTATGTGGAACGGCGAGTGCAAAACATTAGATGAAGAGAGAATCATTTTTGAGGCTAG
ACGTTATAAGCATGGTTTGCAAATGTAA

Upstream 100 bases:

>100_bases
TACAAGAAACTTTTGACTCTTTAAAATGATTAAGTTACTATAATAGTAGTAACCAATTGAGGTAGAATTATATTTTAAAG
AATCGAGAGGGGAAATATTT

Downstream 100 bases:

>100_bases
TTCGTATAAGAATGCTATTTTTTCGTGAAATCGAAAAAATAGCATTTTTAAATTGATAAGCGGATAAAGATTCATGGAGG
TGTAACACTTTTTCAGTAAA

Product: chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKTAYVSATIVTLNEQNEVFENGYIIVEDHTIIEVQHGDFFKHDQVDEVVDLKGKWLLPGLVNTHTHIVMSLLRGIGDDM
LLQPWLETRIWPLERQFTPELAVASTELGLLEMVKSGTTTFSDMFNPIGIDQDAIMETVRNSGMRAAVSRTLFSFGTKED
EKKAIQEAEKYVKRYYREHDMLTTMVAPHSPYTCSTEMLEECARIAMENNTMVHIHLSETEREVQDIEKQYGKRPVEYIE
SCGLFKRPTVIAHGVVLNENERTFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRI
ATLLQKGIHQDATALPVETALSLATKGAAEVIGMKQTGSIERGKCADFITIDPAKKPHLQPAEEVLSHLVYAASGKDVSD
VVINGKQIMWNGECKTLDEERIIFEARRYKHGLQM

Sequences:

>Translated_435_residues
MKTAYVSATIVTLNEQNEVFENGYIIVEDHTIIEVQHGDFFKHDQVDEVVDLKGKWLLPGLVNTHTHIVMSLLRGIGDDM
LLQPWLETRIWPLERQFTPELAVASTELGLLEMVKSGTTTFSDMFNPIGIDQDAIMETVRNSGMRAAVSRTLFSFGTKED
EKKAIQEAEKYVKRYYREHDMLTTMVAPHSPYTCSTEMLEECARIAMENNTMVHIHLSETEREVQDIEKQYGKRPVEYIE
SCGLFKRPTVIAHGVVLNENERTFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRI
ATLLQKGIHQDATALPVETALSLATKGAAEVIGMKQTGSIERGKCADFITIDPAKKPHLQPAEEVLSHLVYAASGKDVSD
VVINGKQIMWNGECKTLDEERIIFEARRYKHGLQM
>Mature_435_residues
MKTAYVSATIVTLNEQNEVFENGYIIVEDHTIIEVQHGDFFKHDQVDEVVDLKGKWLLPGLVNTHTHIVMSLLRGIGDDM
LLQPWLETRIWPLERQFTPELAVASTELGLLEMVKSGTTTFSDMFNPIGIDQDAIMETVRNSGMRAAVSRTLFSFGTKED
EKKAIQEAEKYVKRYYREHDMLTTMVAPHSPYTCSTEMLEECARIAMENNTMVHIHLSETEREVQDIEKQYGKRPVEYIE
SCGLFKRPTVIAHGVVLNENERTFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRI
ATLLQKGIHQDATALPVETALSLATKGAAEVIGMKQTGSIERGKCADFITIDPAKKPHLQPAEEVLSHLVYAASGKDVSD
VVINGKQIMWNGECKTLDEERIIFEARRYKHGLQM

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=381, Percent_Identity=26.7716535433071, Blast_Score=131, Evalue=2e-30,
Organism=Escherichia coli, GI1789249, Length=369, Percent_Identity=26.5582655826558, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87082177, Length=425, Percent_Identity=24.4705882352941, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17540282, Length=387, Percent_Identity=25.8397932816537, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319963, Length=413, Percent_Identity=25.181598062954, Blast_Score=116, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24643849, Length=446, Percent_Identity=26.0089686098655, Blast_Score=128, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_BACCN (A7GNR9)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001374772.1
- ProteinModelPortal:   A7GNR9
- STRING:   A7GNR9
- EnsemblBacteria:   EBBACT00000039424
- GeneID:   5346017
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_1460
- eggNOG:   COG0402
- GeneTree:   EBGT00050000003455
- HOGENOM:   HBG668170
- OMA:   CPVERLW
- ProtClustDB:   PRK15493
- BioCyc:   BCER315749:BCER98_1460-MONOMER
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 48772; Mature: 48772

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: BINDING 94-94 BINDING 150-150 BINDING 189-189 BINDING 219-219 BINDING 304-304

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAYVSATIVTLNEQNEVFENGYIIVEDHTIIEVQHGDFFKHDQVDEVVDLKGKWLLPG
CCCEEEEEEEEEECCCCHHHHCCEEEEECCEEEEEECCCCCCCCCHHHHHHCCCCEECCC
LVNTHTHIVMSLLRGIGDDMLLQPWLETRIWPLERQFTPELAVASTELGLLEMVKSGTTT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
FSDMFNPIGIDQDAIMETVRNSGMRAAVSRTLFSFGTKEDEKKAIQEAEKYVKRYYREHD
HHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
MLTTMVAPHSPYTCSTEMLEECARIAMENNTMVHIHLSETEREVQDIEKQYGKRPVEYIE
HHEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHH
SCGLFKRPTVIAHGVVLNENERTFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVG
HCCCCCCCCEEEECEEEECCCCEEEEECCEEEEECCCCCCEECCCHHHHHHHHHCCCEEE
IATDSVASNNNLDMFEEMRIATLLQKGIHQDATALPVETALSLATKGAAEVIGMKQTGSI
EECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHCCCCCCCCC
ERGKCADFITIDPAKKPHLQPAEEVLSHLVYAASGKDVSDVVINGKQIMWNGECKTLDEE
CCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHEEECCEEEEECCCCCCCCHH
RIIFEARRYKHGLQM
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTAYVSATIVTLNEQNEVFENGYIIVEDHTIIEVQHGDFFKHDQVDEVVDLKGKWLLPG
CCCEEEEEEEEEECCCCHHHHCCEEEEECCEEEEEECCCCCCCCCHHHHHHCCCCEECCC
LVNTHTHIVMSLLRGIGDDMLLQPWLETRIWPLERQFTPELAVASTELGLLEMVKSGTTT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
FSDMFNPIGIDQDAIMETVRNSGMRAAVSRTLFSFGTKEDEKKAIQEAEKYVKRYYREHD
HHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
MLTTMVAPHSPYTCSTEMLEECARIAMENNTMVHIHLSETEREVQDIEKQYGKRPVEYIE
HHEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHH
SCGLFKRPTVIAHGVVLNENERTFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVG
HCCCCCCCCEEEECEEEECCCCEEEEECCEEEEECCCCCCEECCCHHHHHHHHHCCCEEE
IATDSVASNNNLDMFEEMRIATLLQKGIHQDATALPVETALSLATKGAAEVIGMKQTGSI
EECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHCCCCCCCCC
ERGKCADFITIDPAKKPHLQPAEEVLSHLVYAASGKDVSDVVINGKQIMWNGECKTLDEE
CCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHEEECCEEEEECCCCCCCCHH
RIIFEARRYKHGLQM
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA