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The map label for this gene is mdtG [H]

Identifier: 152975250

GI number: 152975250

Start: 1560454

End: 1561668

Strand: Direct

Name: mdtG [H]

Synonym: Bcer98_1455

Alternate gene names: 152975250

Gene position: 1560454-1561668 (Clockwise)

Preceding gene: 152975249

Following gene: 152975252

Centisome position: 38.18

GC content: 38.44

Gene sequence:

>1215_bases
ATGGCCAGCTGGAAAAGAAATTTAATGATTTGTTGGCTTGGTTGTTTTACCACTGCAGCCGGTATGAGTTTAGTAATTCC
TTTCCTATCCTTTTATATTGAGAAACTTGGCGTGACTGGAACTTCTAATATCGCACAGTGGTCAGGAATTGCATTTGGGG
TAACATTTTTAATGGGTGCCATTGTATCGCCTTTATGGGGGAAACTTGGTGATACACATGGACGAAAATTAATGCTTATT
CGTGCTAGTCTCGGTATGGCGATTATTATGACACTTATGGGATTTGTGACAAATGTGTATCAATTAGTTGCCCTTCGCTT
TTTAATGGGAGCGGTATCTGGTTTTCTTTCTACAGCAATGACATTTATTGCTGCAGAAACACCGAAAGAGCATTCTGGTT
GGGCGATTTCTACAATCTCAACTGGGGGGGTTAGTGGTTCCTTACTTGGACCAATGCTCGGTGGGTATTTATCAGAGTTA
ATTGGTATGAGATATGTATTTTTCGTAACAGGCGCTTTTTTATTTCTATCCTTTATTATTGTCTTTTTCTTTTTAAAGGA
AGAAAATCGTTCTGTTCAACCGAAAAAAGCACAACCGAAAAAAGTATGGACGATGGTTCCAGCAAAACATTTTATTATGA
GCTTATTTGTCGTTACATTTATGATTCAACTTGCAAATATGTCGATACAACCTATTATTACATTATATGTAAAGCATTTG
GCGGGGGCGCACACAGCGCATATTGAAACCATCGCGGGGGCTGTTATGTCCGCAACAGGCTTGGCTGTAATTTTAGCAGC
TCCTCGATTAGGACGTTTATCTGATCATATTGGTCCGCAAAAAACATTGATTGTAGCTTTGTTTGTTGCAGGGATTGTTT
TTATTCCACAAGCTTTTGTGACCTCTGCTTGGCAATTGTTAATTTTACGATTTCTTTTAGGAATTGCACAAGCTGGATTA
TTACCTTCTGTACAAACGCTACTAAAAAAACACACACCAAATCACATCACTGGCCGTATTTTTGGATATAATCAATCCTT
TCAATTTTTAGGAAATATGATTGGTCCCGTACTTGGAGGGCAGGTAGCCGCGCATGCTGGTTTCCAATATGTATTCTTTT
CAACTGCCGCGCTATTATTTATAGCTTGTATTTGGGTATATTTCCATAATAGACATGCAGAAGTGACAGGAAAAGAAGGA
TTGAAAGTTAGTTAA

Upstream 100 bases:

>100_bases
GAAATTTAACGAGAAAAGAAGACTTATGTAAGAGGAGCATATTGCTAAACTTTTCAAGGAAAAGGGTGTAGAATGGTTAT
CTAAGAAGGAAGGTGTGAAA

Downstream 100 bases:

>100_bases
CAAGGTGAATAAATATAAAGTGAAGCATAATTTATATAGTTTCAGTTTATAAGAATCGAATTTTAGGACATTATAAAAAG
CACATCACCATAAAAATGTG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEKLGVTGTSNIAQWSGIAFGVTFLMGAIVSPLWGKLGDTHGRKLMLI
RASLGMAIIMTLMGFVTNVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPMLGGYLSEL
IGMRYVFFVTGAFLFLSFIIVFFFLKEENRSVQPKKAQPKKVWTMVPAKHFIMSLFVVTFMIQLANMSIQPIITLYVKHL
AGAHTAHIETIAGAVMSATGLAVILAAPRLGRLSDHIGPQKTLIVALFVAGIVFIPQAFVTSAWQLLILRFLLGIAQAGL
LPSVQTLLKKHTPNHITGRIFGYNQSFQFLGNMIGPVLGGQVAAHAGFQYVFFSTAALLFIACIWVYFHNRHAEVTGKEG
LKVS

Sequences:

>Translated_404_residues
MASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEKLGVTGTSNIAQWSGIAFGVTFLMGAIVSPLWGKLGDTHGRKLMLI
RASLGMAIIMTLMGFVTNVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPMLGGYLSEL
IGMRYVFFVTGAFLFLSFIIVFFFLKEENRSVQPKKAQPKKVWTMVPAKHFIMSLFVVTFMIQLANMSIQPIITLYVKHL
AGAHTAHIETIAGAVMSATGLAVILAAPRLGRLSDHIGPQKTLIVALFVAGIVFIPQAFVTSAWQLLILRFLLGIAQAGL
LPSVQTLLKKHTPNHITGRIFGYNQSFQFLGNMIGPVLGGQVAAHAGFQYVFFSTAALLFIACIWVYFHNRHAEVTGKEG
LKVS
>Mature_403_residues
ASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEKLGVTGTSNIAQWSGIAFGVTFLMGAIVSPLWGKLGDTHGRKLMLIR
ASLGMAIIMTLMGFVTNVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPMLGGYLSELI
GMRYVFFVTGAFLFLSFIIVFFFLKEENRSVQPKKAQPKKVWTMVPAKHFIMSLFVVTFMIQLANMSIQPIITLYVKHLA
GAHTAHIETIAGAVMSATGLAVILAAPRLGRLSDHIGPQKTLIVALFVAGIVFIPQAFVTSAWQLLILRFLLGIAQAGLL
PSVQTLLKKHTPNHITGRIFGYNQSFQFLGNMIGPVLGGQVAAHAGFQYVFFSTAALLFIACIWVYFHNRHAEVTGKEGL
KVS

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Homo sapiens, GI217416366, Length=232, Percent_Identity=27.1551724137931, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787291, Length=394, Percent_Identity=47.9695431472081, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI87082404, Length=325, Percent_Identity=24.9230769230769, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319871, Length=152, Percent_Identity=27.6315789473684, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43909; Mature: 43778

Theoretical pI: Translated: 10.62; Mature: 10.62

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCC
>Mature Secondary Structure 
ASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEKLGVTGTSNIAQWSGIAFGVTFLMGA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
IVSPLWGKLGDTHGRKLMLIRASLGMAIIMTLMGFVTNVYQLVALRFLMGAVSGFLSTAM
HHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFIAAETPKEHSGWAISTISTGGVSGSLLGPMLGGYLSELIGMRYVFFVTGAFLFLSFII
HHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFFFLKEENRSVQPKKAQPKKVWTMVPAKHFIMSLFVVTFMIQLANMSIQPIITLYVKHL
HHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AGAHTAHIETIAGAVMSATGLAVILAAPRLGRLSDHIGPQKTLIVALFVAGIVFIPQAFV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
TSAWQLLILRFLLGIAQAGLLPSVQTLLKKHTPNHITGRIFGYNQSFQFLGNMIGPVLGG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCC
QVAAHAGFQYVFFSTAALLFIACIWVYFHNRHAEVTGKEGLKVS
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA