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The map label for this gene is ctaB1

Identifier: 152975226

GI number: 152975226

Start: 1526196

End: 1527113

Strand: Direct

Name: ctaB1

Synonym: Bcer98_1429

Alternate gene names: 152975226

Gene position: 1526196-1527113 (Clockwise)

Preceding gene: 152975224

Following gene: 152975228

Centisome position: 37.34

GC content: 33.55

Gene sequence:

>918_bases
ATGGGAAGGAAAAAAGAAGTAACAAATGCCCAAAGACAACGACCGGAAATTTTGGCTCAAACTATTAAAACTGGAATTAT
TAAATCCAATTTAGTGCCAATGTTTGCTGGATTGACACTCGCTTTATATAAATATAAAATAAGCCCGTTTGAAAAAATAC
CAGAGATTCTATTTGCTTTTATAGGTTCAATCTTAATAATAGGAGCAGCGGGGGCATTTAATAATTTATATGATCGTGAT
ATTGACTCTATTATGGAGAGAACAAAAAATAGACCAACTGTAACGGGAGATATAAGCCCGAAGACAGCACTATGGCTTGG
AATATTTATGACGATTTTTGGTTTAGTATTCCTTGCGCTAACGACATATTTAGCAGCAATACTAGGGTTTATAGGTTTAT
TTTTATATGTTGTACCATATACAATGTGGAGCAAAAGAAGAACCATTTACAACACAGAAATCGGAAGTGTTTCAGGAGCA
ATGCCGCCGCTTATCGGTTGGGCTGCTATATATCCGGATGTGACACATCCAGCTATTATCGGTCTTTTTATTATTATGAT
TATTTGGCAAATGCCTCATTTCTATGCAATAGCGATTCGTAAACATAAAGAGTATGAGGCTGCGAACGTTCCAATGCTTC
CAGTAGTGAAGGGAGTTAAAAGAACATATATACAAACAAATGTGTATTTAGTTATTTTAATTATCATAAGTATTCTTTTA
GGATCATTAAGTATCGGCCTTATGTTAGTATCGCTTCTATTAAGCATTTTATGGTTGGCCTTAAGTATTTATGGATATAA
AAAAATGGATTCAGAGAAATGGGCAAAATCATTGTTTATTTTCTCACTGTTCCATATGACAATTTTATTTTCCACAGTTA
TTATCTACTCTCTTGTAGGTATCTTTTTTGGAAGTTAA

Upstream 100 bases:

>100_bases
TTTAGATGGAGATTTCACTGCCCTAAAATAGTGGATAAAAAAGTAGGAATCATTTGTTCTATTGTAGTAAGATAATTTAA
TGGAAGGGAGAAAAGATATT

Downstream 100 bases:

>100_bases
TTTGTAAATAATAAAAAACAATTTCCACTATATAAAAGGGGAAATTGTTTTTTATTATATCAATATTGTTTTCTTACCTT
TTTAAATGATATGGAAAACA

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase 1; Heme O synthase 1

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MGRKKEVTNAQRQRPEILAQTIKTGIIKSNLVPMFAGLTLALYKYKISPFEKIPEILFAFIGSILIIGAAGAFNNLYDRD
IDSIMERTKNRPTVTGDISPKTALWLGIFMTIFGLVFLALTTYLAAILGFIGLFLYVVPYTMWSKRRTIYNTEIGSVSGA
MPPLIGWAAIYPDVTHPAIIGLFIIMIIWQMPHFYAIAIRKHKEYEAANVPMLPVVKGVKRTYIQTNVYLVILIIISILL
GSLSIGLMLVSLLLSILWLALSIYGYKKMDSEKWAKSLFIFSLFHMTILFSTVIIYSLVGIFFGS

Sequences:

>Translated_305_residues
MGRKKEVTNAQRQRPEILAQTIKTGIIKSNLVPMFAGLTLALYKYKISPFEKIPEILFAFIGSILIIGAAGAFNNLYDRD
IDSIMERTKNRPTVTGDISPKTALWLGIFMTIFGLVFLALTTYLAAILGFIGLFLYVVPYTMWSKRRTIYNTEIGSVSGA
MPPLIGWAAIYPDVTHPAIIGLFIIMIIWQMPHFYAIAIRKHKEYEAANVPMLPVVKGVKRTYIQTNVYLVILIIISILL
GSLSIGLMLVSLLLSILWLALSIYGYKKMDSEKWAKSLFIFSLFHMTILFSTVIIYSLVGIFFGS
>Mature_304_residues
GRKKEVTNAQRQRPEILAQTIKTGIIKSNLVPMFAGLTLALYKYKISPFEKIPEILFAFIGSILIIGAAGAFNNLYDRDI
DSIMERTKNRPTVTGDISPKTALWLGIFMTIFGLVFLALTTYLAAILGFIGLFLYVVPYTMWSKRRTIYNTEIGSVSGAM
PPLIGWAAIYPDVTHPAIIGLFIIMIIWQMPHFYAIAIRKHKEYEAANVPMLPVVKGVKRTYIQTNVYLVILIIISILLG
SLSIGLMLVSLLLSILWLALSIYGYKKMDSEKWAKSLFIFSLFHMTILFSTVIIYSLVGIFFGS

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=203, Percent_Identity=33.9901477832512, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786631, Length=274, Percent_Identity=39.051094890511, Blast_Score=178, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71998235, Length=236, Percent_Identity=31.3559322033898, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6325085, Length=170, Percent_Identity=34.7058823529412, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI19921064, Length=249, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX1_BACCN (A7GNP0)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001374743.1
- STRING:   A7GNP0
- EnsemblBacteria:   EBBACT00000038934
- GeneID:   5346250
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_1429
- eggNOG:   COG0109
- GeneTree:   EBGT00050000001177
- HOGENOM:   HBG656003
- OMA:   EPQLQHD
- ProtClustDB:   PRK04375
- BioCyc:   BCER315749:BCER98_1429-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 34266; Mature: 34135

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1e62d858)-; HASH(0x1f6d0a84)-; HASH(0x1f210a00)-; HASH(0x1f6d607c)-; HASH(0x1f1fec3c)-; HASH(0x1f6d0934)-; HASH(0x1f6f1a44)-; HASH(0x1ddf39dc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRKKEVTNAQRQRPEILAQTIKTGIIKSNLVPMFAGLTLALYKYKISPFEKIPEILFAF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
IGSILIIGAAGAFNNLYDRDIDSIMERTKNRPTVTGDISPKTALWLGIFMTIFGLVFLAL
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHH
TTYLAAILGFIGLFLYVVPYTMWSKRRTIYNTEIGSVSGAMPPLIGWAAIYPDVTHPAII
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHH
GLFIIMIIWQMPHFYAIAIRKHKEYEAANVPMLPVVKGVKRTYIQTNVYLVILIIISILL
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSLSIGLMLVSLLLSILWLALSIYGYKKMDSEKWAKSLFIFSLFHMTILFSTVIIYSLVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFFGS
HHHCH
>Mature Secondary Structure 
GRKKEVTNAQRQRPEILAQTIKTGIIKSNLVPMFAGLTLALYKYKISPFEKIPEILFAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH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HHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA