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The map label for this gene is panC

Identifier: 152975063

GI number: 152975063

Start: 1370613

End: 1371461

Strand: Direct

Name: panC

Synonym: Bcer98_1263

Alternate gene names: 152975063

Gene position: 1370613-1371461 (Clockwise)

Preceding gene: 152975062

Following gene: 152975064

Centisome position: 33.54

GC content: 38.87

Gene sequence:

>849_bases
ATGAAAGTGATAACAACAGTGAAGGACATGCAACAAATTGCAGGCGAACTTCGGGCAAGTGGTAAAGAGATTGGGTTTGT
TCCAACAATGGGATATTTACATGAAGGACATGCAACTTTATTGCGCCAGGCCAAAAAAGAAAATGACATTGTCATTTTAA
GTGTATTTGTGAATCCGTTACAGTTTGGACCAGATGAAGATTTCGATCGTTATCCAAGGGATATAAAGCGAGATGAAAGA
GTGGCAAAAGAAGCGGGCGTTGACTACTTATTTTATCCGAGTGTAGACGAAATGTATCCAGCAGAACAAACAACAAAAAT
AGAGGTTGTAAAACGTACAAATGTTTTATGTGGGAAAAGACGACCGGTTCATTTTGCAGGTGTTGCGACGGTGTTGATGA
AACTGTTTCATATTACAATGCCAACTCGTGCTTATTTCGGAATGAAAGATGCACAGCAAGTAGCAGTTGTTGAAGGGATT
GTCAGTGACTTTCATATCCCAGTTACAATTGTACCAGTTGAGATTGTTAGGGAAGCAGACGGGTTGGCGAAAAGCTCCCG
CAACGTATATTTATCGGAGCAAGAACGTAAGGAAGCACCACATTTATACCGCAGCTTATGTATAGCAAAACAGAAAATAG
AAGAGGGGGAGCGTCATCCACGAAACATTACCACAGTTGTAAAAGAATACATTGAAGCAAATACAAACGGTATAGTTGAT
TATGTAGATATATATGCATATCCAGCTTTAACGCCACTAGAAATCATCAAAGGCAGAATAATTTTAGCAATTGCAGTTCA
GTTCAAGAATGCGCGATTAATTGACAATATAACATTAACGGTTCAATAA

Upstream 100 bases:

>100_bases
AATATGTGGCTGAAGTAAAAACAAGACAATTTCCAGAAGATCAATATTCATTTACGATGAAAGAAGAAGAGTATGTAGCT
TTATATGGAGGAAAACAGGG

Downstream 100 bases:

>100_bases
GGGGGAGACATCCATGTTTCGTACAATGATGAGAGCAAAGTTACATCGTGCAACTGTAACAGAAGCTAATTTAAATTATG
TTGGAAGTATTACAATTGAT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MKVITTVKDMQQIAGELRASGKEIGFVPTMGYLHEGHATLLRQAKKENDIVILSVFVNPLQFGPDEDFDRYPRDIKRDER
VAKEAGVDYLFYPSVDEMYPAEQTTKIEVVKRTNVLCGKRRPVHFAGVATVLMKLFHITMPTRAYFGMKDAQQVAVVEGI
VSDFHIPVTIVPVEIVREADGLAKSSRNVYLSEQERKEAPHLYRSLCIAKQKIEEGERHPRNITTVVKEYIEANTNGIVD
YVDIYAYPALTPLEIIKGRIILAIAVQFKNARLIDNITLTVQ

Sequences:

>Translated_282_residues
MKVITTVKDMQQIAGELRASGKEIGFVPTMGYLHEGHATLLRQAKKENDIVILSVFVNPLQFGPDEDFDRYPRDIKRDER
VAKEAGVDYLFYPSVDEMYPAEQTTKIEVVKRTNVLCGKRRPVHFAGVATVLMKLFHITMPTRAYFGMKDAQQVAVVEGI
VSDFHIPVTIVPVEIVREADGLAKSSRNVYLSEQERKEAPHLYRSLCIAKQKIEEGERHPRNITTVVKEYIEANTNGIVD
YVDIYAYPALTPLEIIKGRIILAIAVQFKNARLIDNITLTVQ
>Mature_282_residues
MKVITTVKDMQQIAGELRASGKEIGFVPTMGYLHEGHATLLRQAKKENDIVILSVFVNPLQFGPDEDFDRYPRDIKRDER
VAKEAGVDYLFYPSVDEMYPAEQTTKIEVVKRTNVLCGKRRPVHFAGVATVLMKLFHITMPTRAYFGMKDAQQVAVVEGI
VSDFHIPVTIVPVEIVREADGLAKSSRNVYLSEQERKEAPHLYRSLCIAKQKIEEGERHPRNITTVVKEYIEANTNGIVD
YVDIYAYPALTPLEIIKGRIILAIAVQFKNARLIDNITLTVQ

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=279, Percent_Identity=40.5017921146953, Blast_Score=200, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6322046, Length=310, Percent_Identity=37.741935483871, Blast_Score=174, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_BACCN (A7GN77)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001374580.1
- ProteinModelPortal:   A7GN77
- SMR:   A7GN77
- STRING:   A7GN77
- EnsemblBacteria:   EBBACT00000037569
- GeneID:   5346025
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_1263
- eggNOG:   COG0414
- GeneTree:   EBGT00050000001451
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- ProtClustDB:   PRK00380
- BioCyc:   BCER315749:BCER98_1263-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31930; Mature: 31930

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVITTVKDMQQIAGELRASGKEIGFVPTMGYLHEGHATLLRQAKKENDIVILSVFVNPL
CCEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHCCCCEEEEEEEECHH
QFGPDEDFDRYPRDIKRDERVAKEAGVDYLFYPSVDEMYPAEQTTKIEVVKRTNVLCGKR
CCCCCCCHHHCCHHHHHHHHHHHHHCCCEEECCCHHHHCCCCCCCEEEEEECCCHHCCCC
RPVHFAGVATVLMKLFHITMPTRAYFGMKDAQQVAVVEGIVSDFHIPVTIVPVEIVREAD
CCEEHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHH
GLAKSSRNVYLSEQERKEAPHLYRSLCIAKQKIEEGERHPRNITTVVKEYIEANTNGIVD
HHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEE
YVDIYAYPALTPLEIIKGRIILAIAVQFKNARLIDNITLTVQ
HHHHHHCCCCCHHHHHCCCEEEEEEEEECCCEEEEEEEEEEC
>Mature Secondary Structure
MKVITTVKDMQQIAGELRASGKEIGFVPTMGYLHEGHATLLRQAKKENDIVILSVFVNPL
CCEEHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCHHHHHHHHHCCCCEEEEEEEECHH
QFGPDEDFDRYPRDIKRDERVAKEAGVDYLFYPSVDEMYPAEQTTKIEVVKRTNVLCGKR
CCCCCCCHHHCCHHHHHHHHHHHHHCCCEEECCCHHHHCCCCCCCEEEEEECCCHHCCCC
RPVHFAGVATVLMKLFHITMPTRAYFGMKDAQQVAVVEGIVSDFHIPVTIVPVEIVREAD
CCEEHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHH
GLAKSSRNVYLSEQERKEAPHLYRSLCIAKQKIEEGERHPRNITTVVKEYIEANTNGIVD
HHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEE
YVDIYAYPALTPLEIIKGRIILAIAVQFKNARLIDNITLTVQ
HHHHHHCCCCCHHHHHCCCEEEEEEEEECCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA