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The map label for this gene is lysA [H]

Identifier: 152974944

GI number: 152974944

Start: 1252512

End: 1253828

Strand: Direct

Name: lysA [H]

Synonym: Bcer98_1141

Alternate gene names: 152974944

Gene position: 1252512-1253828 (Clockwise)

Preceding gene: 152974943

Following gene: 152974945

Centisome position: 30.65

GC content: 39.71

Gene sequence:

>1317_bases
ATGTATTTACACGGCACGAGCCGGATTAATGAACAAGGACACTTAGAAATTGGAGGGTGCGATACAACGCAGTTGGCGAA
ACGATATGGGACACCGCTTTATGTATATGATGAAACTGCAATTAGGGAAAATTGTCGTGCGTTTCACCATGCTTTTCAAA
AAAGCGGGTTCTCTTATCAAGTAGCATATGCAAGTAAAGCGTTCTTGTGCATGGAGATGTGCCGAGTAGCATTAGAGGAA
AATATGTCTTTAGATGTTGTTTCGGGCGGGGAGTTATATACCGCTTTACAAGCAGGATTTCCAGCATCACGCATTCATTT
TCATGGGAATAATAAAACAGAAGAAGAAATGAGAATGGCGCTAGAAGCAAATATTGGATGTTTTGTAGTAGATAACTTTT
TTGAATTAGAAGTATTACATGATTTAGCGGAGCAGTATAAAAAAATGGTGAATATATTGATTCGTGTCACACCTGGTGTA
GAGGCGCATACACATGAATATATTACAACAGGCCAAGATGATTCGAAATTTGGTTTTGGTGTTTCAAACGGGCAAGCACT
GCACGCTATGGAACGTGCATTAGAAAAAACAAATTATAATGTGTTAGGTATACATTCGCATATTGGTTCGCAAATTTTTG
AAACAGCAGGTTTTATTCGTGCGATTGAAGTATTACATCATTTTTTAGAAGGAGTAAAAACAAAAACAGGTTATACAATT
TCGGTGCTGAATGTAGGGGGGGGATTTGGTATTCGTTATACGGAATCGGATACACCACTTACTCTTGAGGCGTATGTGCA
AGCTGTAACAGATGCGGTAAGAGAGCGATTTACAGCATGTGAGTATCCACTTCCGGAAATATGGATTGAACCTGGTCGCA
GTATTGTTGGTGATGCAGGAACAACAATTTATACAGTAGGCGCAATAAAAAATATTCCTGGTATTCGTAAATATGTTTCA
GTCGATGGGGGAATGACAGATAATTTAAGGCCTGCATTATATGGTGCACGCTATGAAGCGATGCTTGCAAACCGTGCAAA
TGTAGCAAACGAAGAAGTTGTCTCAATTGCAGGGAAATGTTGTGAGAGCGGAGATATGTTAATATGGGATGTTTATCTTC
CGCAAGTAGTCTCTTCAGATCTATTAGCGGTGTCTTGTACAGGTGCATACGGGTATTCTATGGCAAATAATTATAATCGG
ATTCGTAGGCCAGCCGTTGTATTTGCGAAAGATGGAACATCTCAAGTGGTAGTGGAGCGCGAGTCGTATGAAAATATAAT
TGGGAACGATCGCATACGTATAAAAGAGCTCGTTTAA

Upstream 100 bases:

>100_bases
GAAGAACTCCTACTGATTAAAGTTTTACTTTATCTAAAAGCGTGACAATGAATAGAAGATTGGGGTTATGAGTTTTAGAG
AAAATAAGGGAGGAATTTAC

Downstream 100 bases:

>100_bases
AATAAAAAGGAGTTGTTCAAAAGGGAACAATTCCTTTTTTAAATAAAAAAATATAAAATATATCGGAAAACTAGGATTGA
AAAAAATCAGAATTATGATA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MYLHGTSRINEQGHLEIGGCDTTQLAKRYGTPLYVYDETAIRENCRAFHHAFQKSGFSYQVAYASKAFLCMEMCRVALEE
NMSLDVVSGGELYTALQAGFPASRIHFHGNNKTEEEMRMALEANIGCFVVDNFFELEVLHDLAEQYKKMVNILIRVTPGV
EAHTHEYITTGQDDSKFGFGVSNGQALHAMERALEKTNYNVLGIHSHIGSQIFETAGFIRAIEVLHHFLEGVKTKTGYTI
SVLNVGGGFGIRYTESDTPLTLEAYVQAVTDAVRERFTACEYPLPEIWIEPGRSIVGDAGTTIYTVGAIKNIPGIRKYVS
VDGGMTDNLRPALYGARYEAMLANRANVANEEVVSIAGKCCESGDMLIWDVYLPQVVSSDLLAVSCTGAYGYSMANNYNR
IRRPAVVFAKDGTSQVVVERESYENIIGNDRIRIKELV

Sequences:

>Translated_438_residues
MYLHGTSRINEQGHLEIGGCDTTQLAKRYGTPLYVYDETAIRENCRAFHHAFQKSGFSYQVAYASKAFLCMEMCRVALEE
NMSLDVVSGGELYTALQAGFPASRIHFHGNNKTEEEMRMALEANIGCFVVDNFFELEVLHDLAEQYKKMVNILIRVTPGV
EAHTHEYITTGQDDSKFGFGVSNGQALHAMERALEKTNYNVLGIHSHIGSQIFETAGFIRAIEVLHHFLEGVKTKTGYTI
SVLNVGGGFGIRYTESDTPLTLEAYVQAVTDAVRERFTACEYPLPEIWIEPGRSIVGDAGTTIYTVGAIKNIPGIRKYVS
VDGGMTDNLRPALYGARYEAMLANRANVANEEVVSIAGKCCESGDMLIWDVYLPQVVSSDLLAVSCTGAYGYSMANNYNR
IRRPAVVFAKDGTSQVVVERESYENIIGNDRIRIKELV
>Mature_438_residues
MYLHGTSRINEQGHLEIGGCDTTQLAKRYGTPLYVYDETAIRENCRAFHHAFQKSGFSYQVAYASKAFLCMEMCRVALEE
NMSLDVVSGGELYTALQAGFPASRIHFHGNNKTEEEMRMALEANIGCFVVDNFFELEVLHDLAEQYKKMVNILIRVTPGV
EAHTHEYITTGQDDSKFGFGVSNGQALHAMERALEKTNYNVLGIHSHIGSQIFETAGFIRAIEVLHHFLEGVKTKTGYTI
SVLNVGGGFGIRYTESDTPLTLEAYVQAVTDAVRERFTACEYPLPEIWIEPGRSIVGDAGTTIYTVGAIKNIPGIRKYVS
VDGGMTDNLRPALYGARYEAMLANRANVANEEVVSIAGKCCESGDMLIWDVYLPQVVSSDLLAVSCTGAYGYSMANNYNR
IRRPAVVFAKDGTSQVVVERESYENIIGNDRIRIKELV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=417, Percent_Identity=29.0167865707434, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48577; Mature: 48577

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLHGTSRINEQGHLEIGGCDTTQLAKRYGTPLYVYDETAIRENCRAFHHAFQKSGFSYQ
CEECCCCCCCCCCCEEECCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCEEE
VAYASKAFLCMEMCRVALEENMSLDVVSGGELYTALQAGFPASRIHFHGNNKTEEEMRMA
EEHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHH
LEANIGCFVVDNFFELEVLHDLAEQYKKMVNILIRVTPGVEAHTHEYITTGQDDSKFGFG
HHCCCCEEEECCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCEEECCCCCCCCCCC
VSNGQALHAMERALEKTNYNVLGIHSHIGSQIFETAGFIRAIEVLHHFLEGVKTKTGYTI
CCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
SVLNVGGGFGIRYTESDTPLTLEAYVQAVTDAVRERFTACEYPLPEIWIEPGRSIVGDAG
EEEEECCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCEECCCC
TTIYTVGAIKNIPGIRKYVSVDGGMTDNLRPALYGARYEAMLANRANVANEEVVSIAGKC
CEEEEECCHHCCCCCHHEEEECCCCCCCCCHHHHCCHHHHHHHCCCCCCHHHHHHHHHHH
CESGDMLIWDVYLPQVVSSDLLAVSCTGAYGYSMANNYNRIRRPAVVFAKDGTSQVVVER
CCCCCEEEEEEHHHHHHCCCCEEEEECCCCCCHHHCCHHHHCCCEEEEEECCCCEEEEEH
ESYENIIGNDRIRIKELV
HHHHHHHCCCCEEEEECC
>Mature Secondary Structure
MYLHGTSRINEQGHLEIGGCDTTQLAKRYGTPLYVYDETAIRENCRAFHHAFQKSGFSYQ
CEECCCCCCCCCCCEEECCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHCCCEEE
VAYASKAFLCMEMCRVALEENMSLDVVSGGELYTALQAGFPASRIHFHGNNKTEEEMRMA
EEHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCEEEECCCCCCHHHHHHH
LEANIGCFVVDNFFELEVLHDLAEQYKKMVNILIRVTPGVEAHTHEYITTGQDDSKFGFG
HHCCCCEEEECCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCEEECCCCCCCCCCC
VSNGQALHAMERALEKTNYNVLGIHSHIGSQIFETAGFIRAIEVLHHFLEGVKTKTGYTI
CCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
SVLNVGGGFGIRYTESDTPLTLEAYVQAVTDAVRERFTACEYPLPEIWIEPGRSIVGDAG
EEEEECCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCEECCCC
TTIYTVGAIKNIPGIRKYVSVDGGMTDNLRPALYGARYEAMLANRANVANEEVVSIAGKC
CEEEEECCHHCCCCCHHEEEECCCCCCCCCHHHHCCHHHHHHHCCCCCCHHHHHHHHHHH
CESGDMLIWDVYLPQVVSSDLLAVSCTGAYGYSMANNYNRIRRPAVVFAKDGTSQVVVER
CCCCCEEEEEEHHHHHHCCCCEEEEECCCCCCHHHCCHHHHCCCEEEEEECCCCEEEEEH
ESYENIIGNDRIRIKELV
HHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]