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The map label for this gene is hemH2 [H]

Identifier: 152974686

GI number: 152974686

Start: 990814

End: 991770

Strand: Direct

Name: hemH2 [H]

Synonym: Bcer98_0873

Alternate gene names: 152974686

Gene position: 990814-991770 (Clockwise)

Preceding gene: 152974685

Following gene: 152974687

Centisome position: 24.24

GC content: 36.05

Gene sequence:

>957_bases
ATGAAAAAGAAAATAGGTTTACTTGTAATGGCATATGGAACACCGGAATCGTTGGAGGATGTAGAAGCGTATTACACGCA
TATTCGACATGGTTGTAAACCATCTGCGGAAGCGCTTGAAGATTTAATTATGCGCTATAAAGCAATTGGTGGTATTTCAC
CACTTGCAAAAATTACAAAGGAACAAGCTCGTCAGTTAACTGCTTCATTGAATGAAAAATTTACAGATTATGAATTTGTT
TGTTACTTAGGATTGAAGCACATTGCTCCTTTTATTGAAGATGCAGTAGCAGATATGAAGCGTGAGGGGATCGAAAAGGC
AATTAGTATCGTATTAGCGCCCCATTATTCAACATTTAGTATTCAAGCATATAATGACCGTGCAATTCATGCTTCAAGAG
AAATAGGAGGTCCTGTCATTGAACCGATTGAACAGTGGTATGACGAGCCGAAATTTATTGCATACTGGGCAAATCAAATA
AAAGAAACATTTGGGAAAATTAAACATAAAGAAAAAGCGGTTGTCATTTTTTCAGCGCATAGTTTACCAGAAAAAATTAT
TGCTGCTGGTGATCCTTACGTAGAACAGCTCCAGCATACTGCAGATTTAATTGCAGCAGAAGCTGGCATTCCACATTATA
CAATTGGCTGGCAAAGTGCGGGGAATACAGGGGAGCCGTGGATTGGACCAGATGTGCAAGATTTAACGAGAGATTTGTAT
AAACAGAATGGTTATGAATCTTTTATATATTGTCCAGTAGGTTTTGTGGCAGAGCATTTAGAGGTTTTATATGACAATGA
TTATGAATGTAAAGTTGTGACGGATGAATTACGTGTTGCATACTTTAGACCAGCTATGCCAAACACGCAAGATGTATTTA
TTGATTGTTTAACTGAAATTGTTTCTAAAAAGGTAAACAAAATGATTGACAATAAGTTAATTTTGAATAATAATTAA

Upstream 100 bases:

>100_bases
TAGAATTATTATTTTGACATATTTATTATTGATTGATACACTTAGAAACAGATGTTCTTGAAAAAGATTCTCATTTATAA
AATTGAGGTGTAAACAAATA

Downstream 100 bases:

>100_bases
ATTATAATAATTTTAAATAAATAATAATTGTTAGTAATAAAGAGGAGGCTCTCTTGATGAATTTAAATAATCGCTTAACA
ACAAACCAAGGTGCTCCAGT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 2; Protoheme ferro-lyase 2 [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKKKIGLLVMAYGTPESLEDVEAYYTHIRHGCKPSAEALEDLIMRYKAIGGISPLAKITKEQARQLTASLNEKFTDYEFV
CYLGLKHIAPFIEDAVADMKREGIEKAISIVLAPHYSTFSIQAYNDRAIHASREIGGPVIEPIEQWYDEPKFIAYWANQI
KETFGKIKHKEKAVVIFSAHSLPEKIIAAGDPYVEQLQHTADLIAAEAGIPHYTIGWQSAGNTGEPWIGPDVQDLTRDLY
KQNGYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELRVAYFRPAMPNTQDVFIDCLTEIVSKKVNKMIDNKLILNNN

Sequences:

>Translated_318_residues
MKKKIGLLVMAYGTPESLEDVEAYYTHIRHGCKPSAEALEDLIMRYKAIGGISPLAKITKEQARQLTASLNEKFTDYEFV
CYLGLKHIAPFIEDAVADMKREGIEKAISIVLAPHYSTFSIQAYNDRAIHASREIGGPVIEPIEQWYDEPKFIAYWANQI
KETFGKIKHKEKAVVIFSAHSLPEKIIAAGDPYVEQLQHTADLIAAEAGIPHYTIGWQSAGNTGEPWIGPDVQDLTRDLY
KQNGYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELRVAYFRPAMPNTQDVFIDCLTEIVSKKVNKMIDNKLILNNN
>Mature_318_residues
MKKKIGLLVMAYGTPESLEDVEAYYTHIRHGCKPSAEALEDLIMRYKAIGGISPLAKITKEQARQLTASLNEKFTDYEFV
CYLGLKHIAPFIEDAVADMKREGIEKAISIVLAPHYSTFSIQAYNDRAIHASREIGGPVIEPIEQWYDEPKFIAYWANQI
KETFGKIKHKEKAVVIFSAHSLPEKIIAAGDPYVEQLQHTADLIAAEAGIPHYTIGWQSAGNTGEPWIGPDVQDLTRDLY
KQNGYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELRVAYFRPAMPNTQDVFIDCLTEIVSKKVNKMIDNKLILNNN

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=341, Percent_Identity=25.2199413489736, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI60499021, Length=341, Percent_Identity=25.2199413489736, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786681, Length=188, Percent_Identity=25.531914893617, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324750, Length=284, Percent_Identity=23.2394366197183, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17864156, Length=341, Percent_Identity=26.6862170087977, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45552018, Length=180, Percent_Identity=31.6666666666667, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=24.21875, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35953; Mature: 35953

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKIGLLVMAYGTPESLEDVEAYYTHIRHGCKPSAEALEDLIMRYKAIGGISPLAKITK
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
EQARQLTASLNEKFTDYEFVCYLGLKHIAPFIEDAVADMKREGIEKAISIVLAPHYSTFS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
IQAYNDRAIHASREIGGPVIEPIEQWYDEPKFIAYWANQIKETFGKIKHKEKAVVIFSAH
EEECCCCCEECHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECC
SLPEKIIAAGDPYVEQLQHTADLIAAEAGIPHYTIGWQSAGNTGEPWIGPDVQDLTRDLY
CCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHH
KQNGYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELRVAYFRPAMPNTQDVFIDCLTEI
HCCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEHHHHHHHEECCCCCCHHHHHHHHHHHH
VSKKVNKMIDNKLILNNN
HHHHHHHHHCCCEEECCC
>Mature Secondary Structure
MKKKIGLLVMAYGTPESLEDVEAYYTHIRHGCKPSAEALEDLIMRYKAIGGISPLAKITK
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
EQARQLTASLNEKFTDYEFVCYLGLKHIAPFIEDAVADMKREGIEKAISIVLAPHYSTFS
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
IQAYNDRAIHASREIGGPVIEPIEQWYDEPKFIAYWANQIKETFGKIKHKEKAVVIFSAH
EEECCCCCEECHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECC
SLPEKIIAAGDPYVEQLQHTADLIAAEAGIPHYTIGWQSAGNTGEPWIGPDVQDLTRDLY
CCCHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHH
KQNGYESFIYCPVGFVAEHLEVLYDNDYECKVVTDELRVAYFRPAMPNTQDVFIDCLTEI
HCCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEHHHHHHHEECCCCCCHHHHHHHHHHHH
VSKKVNKMIDNKLILNNN
HHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]