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The map label for this gene is aceA [H]

Identifier: 152974667

GI number: 152974667

Start: 970890

End: 972167

Strand: Direct

Name: aceA [H]

Synonym: Bcer98_0854

Alternate gene names: 152974667

Gene position: 970890-972167 (Clockwise)

Preceding gene: 152974666

Following gene: 152974668

Centisome position: 23.76

GC content: 42.96

Gene sequence:

>1278_bases
ATGAAAAATGAAAGAGTTCAGCAATTGCAAGAGGATTGGGAATTAAATGCACGCTGGAAGGGGATTACGCGTCCTTATTC
TGCTGAAGATGTAATTCGTCTTCGCGGGTCAATTGATATTGAACATACATTGGCGCGCCGTGGTGCGGAGAAACTTTGGA
ACATGCTTCATACAGAAGACTACATTCATGCGCTGGGAGCGTTAACAGGTAACCAAGCGATGCAACAAGTAAAAGCGGGC
TTAAAAGCAATTTACTTAAGTGGTTGGCAAGTAGCAGCGGATGCGAATTTATCTGGTCATATGTATCCGGATCAAAGTTT
GTATCCGGTAAATAGTGTACCAGCTGTTGTAAAACGGATGAATCAAACGCTTCAGCGCGCAGATCAAATTCAGCATATGG
AAGGAAACGGAGGTATCGACTACTTCGTGCCGATTATTGCTGATGCTGAGGCCGGATTTGGCGGACAATTAAATGTATTT
GAATTAATGAAAAGTATGATTGAAGCAGGAGCAGCAGGTGTTCACTTCGAAGATCAATTATCTTCGGAAAAGAAATGCGG
ACATTTAGGCGGAAAGGTGTTATTACCAACACAAACAGCAGTGCGCAATTTAATTTCAGCACGGCTAGCGGCAGATGTAA
TGGGCGTATCGACAATCATTGTTGCAAGAACGGATGCGGATGCAGCAGATTTAATTACAAGCGATATCGATCCAGTCGAT
CGAAAGTTTATTACAGGAGAAAGAACGCCAGAAGGTTTTTACCGTACAAAAGCGGGGCTCGATCAAGCAATTGCGCGCGG
CTTAGCATATGCACCATATGCAGACCTTGTTTGGTGTGAAACATCTGAGCCAAATGTAGAAGATGCAAAGCGCTTTGCTG
AAGCGATTCATGAGAAGTATCCAGGGAAATTACTAGCTTATAACTGTTCGCCATCCTTTAACTGGAAACAAAAATTAGGT
GAAAAAACAATTGCAAACTTTCAAAAAGAAATTGCATCATACGGTTATAAATTCCAATTCGTAACGCTTGCTGGATTCCA
TTCCTTAAACTATAGCATGTTTGAATTAGCACGCGGTTATAAGGAGCGTGGCATGGCAGCATATTCTGAATTGCAACAAG
CAGAATTTGCTGCTGAACAATACGGCTACTCCGCAACGCGTCATCAGCGCGAAGTAGGAACGGGTTACTTTGATGAAGTC
GCGCAAGTTATTACAGGTGGTACATCTTCGACAACAGCGCTGAAAGGTTCTACGGAAGAGGCGCAGTTTACAAAATAA

Upstream 100 bases:

>100_bases
CGACAAAGTTATTTACTGATTTAGTGCGTAAGGATGAGTTTGAACCATTTTTAACATTACCTGGTTATGAAATTTTATAA
AAGAAAAGGGGATGGAAGAA

Downstream 100 bases:

>100_bases
GTGAGGGGACAGGTGTCGATACTAGGCGCCTGTTTTCTATTGAAAAAATTCTTTTTGTATATCTGTTTCGTTTTTTAGGG
TAATAGCTCTATTTTATAGA

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKNERVQQLQEDWELNARWKGITRPYSAEDVIRLRGSIDIEHTLARRGAEKLWNMLHTEDYIHALGALTGNQAMQQVKAG
LKAIYLSGWQVAADANLSGHMYPDQSLYPVNSVPAVVKRMNQTLQRADQIQHMEGNGGIDYFVPIIADAEAGFGGQLNVF
ELMKSMIEAGAAGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLISARLAADVMGVSTIIVARTDADAADLITSDIDPVD
RKFITGERTPEGFYRTKAGLDQAIARGLAYAPYADLVWCETSEPNVEDAKRFAEAIHEKYPGKLLAYNCSPSFNWKQKLG
EKTIANFQKEIASYGYKFQFVTLAGFHSLNYSMFELARGYKERGMAAYSELQQAEFAAEQYGYSATRHQREVGTGYFDEV
AQVITGGTSSTTALKGSTEEAQFTK

Sequences:

>Translated_425_residues
MKNERVQQLQEDWELNARWKGITRPYSAEDVIRLRGSIDIEHTLARRGAEKLWNMLHTEDYIHALGALTGNQAMQQVKAG
LKAIYLSGWQVAADANLSGHMYPDQSLYPVNSVPAVVKRMNQTLQRADQIQHMEGNGGIDYFVPIIADAEAGFGGQLNVF
ELMKSMIEAGAAGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLISARLAADVMGVSTIIVARTDADAADLITSDIDPVD
RKFITGERTPEGFYRTKAGLDQAIARGLAYAPYADLVWCETSEPNVEDAKRFAEAIHEKYPGKLLAYNCSPSFNWKQKLG
EKTIANFQKEIASYGYKFQFVTLAGFHSLNYSMFELARGYKERGMAAYSELQQAEFAAEQYGYSATRHQREVGTGYFDEV
AQVITGGTSSTTALKGSTEEAQFTK
>Mature_425_residues
MKNERVQQLQEDWELNARWKGITRPYSAEDVIRLRGSIDIEHTLARRGAEKLWNMLHTEDYIHALGALTGNQAMQQVKAG
LKAIYLSGWQVAADANLSGHMYPDQSLYPVNSVPAVVKRMNQTLQRADQIQHMEGNGGIDYFVPIIADAEAGFGGQLNVF
ELMKSMIEAGAAGVHFEDQLSSEKKCGHLGGKVLLPTQTAVRNLISARLAADVMGVSTIIVARTDADAADLITSDIDPVD
RKFITGERTPEGFYRTKAGLDQAIARGLAYAPYADLVWCETSEPNVEDAKRFAEAIHEKYPGKLLAYNCSPSFNWKQKLG
EKTIANFQKEIASYGYKFQFVTLAGFHSLNYSMFELARGYKERGMAAYSELQQAEFAAEQYGYSATRHQREVGTGYFDEV
AQVITGGTSSTTALKGSTEEAQFTK

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=432, Percent_Identity=66.6666666666667, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI1786525, Length=267, Percent_Identity=26.5917602996255, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17561814, Length=413, Percent_Identity=64.1646489104116, Blast_Score=559, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI71982926, Length=413, Percent_Identity=64.1646489104116, Blast_Score=558, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6320908, Length=289, Percent_Identity=38.4083044982699, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6325263, Length=251, Percent_Identity=39.4422310756972, Blast_Score=173, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 47055; Mature: 47055

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNERVQQLQEDWELNARWKGITRPYSAEDVIRLRGSIDIEHTLARRGAEKLWNMLHTED
CCCHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
YIHALGALTGNQAMQQVKAGLKAIYLSGWQVAADANLSGHMYPDQSLYPVNSVPAVVKRM
HHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
NQTLQRADQIQHMEGNGGIDYFVPIIADAEAGFGGQLNVFELMKSMIEAGAAGVHFEDQL
HHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHH
SSEKKCGHLGGKVLLPTQTAVRNLISARLAADVMGVSTIIVARTDADAADLITSDIDPVD
CCHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHCCCCHHH
RKFITGERTPEGFYRTKAGLDQAIARGLAYAPYADLVWCETSEPNVEDAKRFAEAIHEKY
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHC
PGKLLAYNCSPSFNWKQKLGEKTIANFQKEIASYGYKFQFVTLAGFHSLNYSMFELARGY
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHCCHHHHHHHHHH
KERGMAAYSELQQAEFAAEQYGYSATRHQREVGTGYFDEVAQVITGGTSSTTALKGSTEE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCC
AQFTK
CCCCC
>Mature Secondary Structure
MKNERVQQLQEDWELNARWKGITRPYSAEDVIRLRGSIDIEHTLARRGAEKLWNMLHTED
CCCHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
YIHALGALTGNQAMQQVKAGLKAIYLSGWQVAADANLSGHMYPDQSLYPVNSVPAVVKRM
HHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
NQTLQRADQIQHMEGNGGIDYFVPIIADAEAGFGGQLNVFELMKSMIEAGAAGVHFEDQL
HHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHH
SSEKKCGHLGGKVLLPTQTAVRNLISARLAADVMGVSTIIVARTDADAADLITSDIDPVD
CCHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHCCCCHHH
RKFITGERTPEGFYRTKAGLDQAIARGLAYAPYADLVWCETSEPNVEDAKRFAEAIHEKY
HHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHC
PGKLLAYNCSPSFNWKQKLGEKTIANFQKEIASYGYKFQFVTLAGFHSLNYSMFELARGY
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHCCHHHHHHHHHH
KERGMAAYSELQQAEFAAEQYGYSATRHQREVGTGYFDEVAQVITGGTSSTTALKGSTEE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCC
AQFTK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]