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The map label for this gene is hemZ [H]

Identifier: 152974529

GI number: 152974529

Start: 803604

End: 805091

Strand: Direct

Name: hemZ [H]

Synonym: Bcer98_0706

Alternate gene names: 152974529

Gene position: 803604-805091 (Clockwise)

Preceding gene: 152974528

Following gene: 152974530

Centisome position: 19.66

GC content: 36.22

Gene sequence:

>1488_bases
TTGTTAATTTCAATTAAAACGTTACAAGATGATCGTTTTTTACGTCCGCTACAACATATTAGTGGCTTGTTTTTTGAGGA
GAGTACGATAGGGTTTGAGAAAGAAGGGGCAAATCTTATTGTTGATATACAAATTGAAGGAAATGTAATGGCTTCTGCCT
GTTTAACAGACGTTGTGACAGGAAATGTATATAAGCAAACATTTTCTAAAGATTTATCTTCTTATGGAGTAGAAAAAGAA
CGTATGAAACAAGTGAAGCATGTTGTTTCCTATGTGTATCTTTCAGTTTTACAGCAACTAACTGGAATAAAACAGAGCTG
GGGAATTTTAACAGGGGTACGTCCAACAAAACTTCTTCATAAAATGCTACAAAGTGGTATGTCAAAAGAAGAGGCGCATA
AAGAACTTCGTGATAGTTATTTAATTGATGAAGAAAAGATTAAATTATTGCAGCGCATCGTCGATTGTCAATTATCAGTT
ATTCCTGATTTATATCGCTTAAAGGAAGAAGTAAGTATTTATATCGGTATTCCGTTTTGTCCAACGAAATGTGCGTATTG
TACGTTCCCGGCTTATGCGATTAACGGGCGCCAAGGCTCTGTTGATTCATTCTTAGGCGGTTTGCATTATGAAATTCGTG
AAATTGGTGCGTTCTTAAAGGAAAAGGGAATTAAAGTTACGACGATTTATTACGGCGGTGGTACACCGACAAGTATTACA
GCAGAAGAGATGGATATGTTGTATGAACAAATGTATGAATCCTTTCCAAATGTGGAAAATGTGCGTGAAGTAACGGTTGA
GGCAGGGCGTCCAGATACCATTACACCAGAAAAACTAGAAGTATTAAATAAATGGAATATTGACCGTATTAGCATTAATC
CGCAGTCGTACCATCAAGAAACGTTAAAGGCGATTGGGCGCCATCATACAGTAGAAGAGACAATTGAGAAGTATCATTTA
GCACGTAAAATGGGAATGAACAATATTAATATGGACTTAATTATTGGTCTTCCAGGTGAAGGGTTAGAAATCTTTCAGCA
TACGTTAGCTGAAACGGAAAAGTTAATGCCAGAATCATTAACTGTGCACACACTATCATTTAAACGTGCTTCTGAAATGA
CGCAAAATAAGCGCAAATATAAAGTTGCTGGTCGCGAAGAAATTACTGCGATGATGCATGAAGCAGAAGAGTGGACGAAA
AAACATAATTACGTACCATACTACTTATATCGTCAAAAAAATATTTTAGGCAACTTAGAGAATGTAGGGTATGCGATGCC
AACGCAAGAGAGCCTCTATAATATTGTAATTATGGAAGAAGTGCAGTCTATTATTGGTCTTGGTTGCGGTGCATCAAGTA
AATTTGTTCATCCGAAAACAGGAGCCATTACGTATTTTGCCAATCCGAAAGATCCAAAGTCATACAATGATGGCTATGTA
AAATATACAGAAGATAAGCTAAAGATTTTAGAAGAACTATTTTGTTAA

Upstream 100 bases:

>100_bases
TACATGGTTTACATAAAAAAGTAGTAAAATCTTCTATATTGACCTAAAAACGCCCTTCAAGTAAACTAAAGAGAGTTTAC
AAATGAAAAGGTGATAAGGG

Downstream 100 bases:

>100_bases
ACGAAAATAAGTCTGTCCTTTTGGATAGGCTCTTTTTTTGGTAGTGATGAGGTGGCGAATTTTGTCGTCTGATCGATATT
TCGTGTCGAATCGCCGATAT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MLISIKTLQDDRFLRPLQHISGLFFEESTIGFEKEGANLIVDIQIEGNVMASACLTDVVTGNVYKQTFSKDLSSYGVEKE
RMKQVKHVVSYVYLSVLQQLTGIKQSWGILTGVRPTKLLHKMLQSGMSKEEAHKELRDSYLIDEEKIKLLQRIVDCQLSV
IPDLYRLKEEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEIREIGAFLKEKGIKVTTIYYGGGTPTSIT
AEEMDMLYEQMYESFPNVENVREVTVEAGRPDTITPEKLEVLNKWNIDRISINPQSYHQETLKAIGRHHTVEETIEKYHL
ARKMGMNNINMDLIIGLPGEGLEIFQHTLAETEKLMPESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTK
KHNYVPYYLYRQKNILGNLENVGYAMPTQESLYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITYFANPKDPKSYNDGYV
KYTEDKLKILEELFC

Sequences:

>Translated_495_residues
MLISIKTLQDDRFLRPLQHISGLFFEESTIGFEKEGANLIVDIQIEGNVMASACLTDVVTGNVYKQTFSKDLSSYGVEKE
RMKQVKHVVSYVYLSVLQQLTGIKQSWGILTGVRPTKLLHKMLQSGMSKEEAHKELRDSYLIDEEKIKLLQRIVDCQLSV
IPDLYRLKEEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEIREIGAFLKEKGIKVTTIYYGGGTPTSIT
AEEMDMLYEQMYESFPNVENVREVTVEAGRPDTITPEKLEVLNKWNIDRISINPQSYHQETLKAIGRHHTVEETIEKYHL
ARKMGMNNINMDLIIGLPGEGLEIFQHTLAETEKLMPESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTK
KHNYVPYYLYRQKNILGNLENVGYAMPTQESLYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITYFANPKDPKSYNDGYV
KYTEDKLKILEELFC
>Mature_495_residues
MLISIKTLQDDRFLRPLQHISGLFFEESTIGFEKEGANLIVDIQIEGNVMASACLTDVVTGNVYKQTFSKDLSSYGVEKE
RMKQVKHVVSYVYLSVLQQLTGIKQSWGILTGVRPTKLLHKMLQSGMSKEEAHKELRDSYLIDEEKIKLLQRIVDCQLSV
IPDLYRLKEEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEIREIGAFLKEKGIKVTTIYYGGGTPTSIT
AEEMDMLYEQMYESFPNVENVREVTVEAGRPDTITPEKLEVLNKWNIDRISINPQSYHQETLKAIGRHHTVEETIEKYHL
ARKMGMNNINMDLIIGLPGEGLEIFQHTLAETEKLMPESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTK
KHNYVPYYLYRQKNILGNLENVGYAMPTQESLYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITYFANPKDPKSYNDGYV
KYTEDKLKILEELFC

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=228, Percent_Identity=24.5614035087719, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1789325, Length=319, Percent_Identity=26.6457680250784, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI87082341, Length=192, Percent_Identity=28.6458333333333, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 56505; Mature: 56505

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLISIKTLQDDRFLRPLQHISGLFFEESTIGFEKEGANLIVDIQIEGNVMASACLTDVVT
CEEEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHC
GNVYKQTFSKDLSSYGVEKERMKQVKHVVSYVYLSVLQQLTGIKQSWGILTGVRPTKLLH
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHCCCCHHHHHH
KMLQSGMSKEEAHKELRDSYLIDEEKIKLLQRIVDCQLSVIPDLYRLKEEVSIYIGIPFC
HHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCC
PTKCAYCTFPAYAINGRQGSVDSFLGGLHYEIREIGAFLKEKGIKVTTIYYGGGTPTSIT
CCCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCC
AEEMDMLYEQMYESFPNVENVREVTVEAGRPDTITPEKLEVLNKWNIDRISINPQSYHQE
HHHHHHHHHHHHHHCCCCCHHHHHHEECCCCCCCCHHHHHHHHCCCCCEEEECHHHHHHH
TLKAIGRHHTVEETIEKYHLARKMGMNNINMDLIIGLPGEGLEIFQHTLAETEKLMPESL
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCE
TVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTKKHNYVPYYLYRQKNILGNLE
EEEEEHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCHH
NVGYAMPTQESLYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITYFANPKDPKSYNDGYV
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCE
KYTEDKLKILEELFC
EECHHHHHHHHHHCC
>Mature Secondary Structure
MLISIKTLQDDRFLRPLQHISGLFFEESTIGFEKEGANLIVDIQIEGNVMASACLTDVVT
CEEEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHC
GNVYKQTFSKDLSSYGVEKERMKQVKHVVSYVYLSVLQQLTGIKQSWGILTGVRPTKLLH
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHCCCCHHHHHH
KMLQSGMSKEEAHKELRDSYLIDEEKIKLLQRIVDCQLSVIPDLYRLKEEVSIYIGIPFC
HHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCC
PTKCAYCTFPAYAINGRQGSVDSFLGGLHYEIREIGAFLKEKGIKVTTIYYGGGTPTSIT
CCCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCC
AEEMDMLYEQMYESFPNVENVREVTVEAGRPDTITPEKLEVLNKWNIDRISINPQSYHQE
HHHHHHHHHHHHHHCCCCCHHHHHHEECCCCCCCCHHHHHHHHCCCCCEEEECHHHHHHH
TLKAIGRHHTVEETIEKYHLARKMGMNNINMDLIIGLPGEGLEIFQHTLAETEKLMPESL
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCE
TVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTKKHNYVPYYLYRQKNILGNLE
EEEEEHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCHH
NVGYAMPTQESLYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITYFANPKDPKSYNDGYV
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCE
KYTEDKLKILEELFC
EECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10568751 [H]