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The map label for this gene is kbl [C]

Identifier: 152974361

GI number: 152974361

Start: 608335

End: 609525

Strand: Direct

Name: kbl [C]

Synonym: Bcer98_0533

Alternate gene names: 152974361

Gene position: 608335-609525 (Clockwise)

Preceding gene: 152974359

Following gene: 152974362

Centisome position: 14.88

GC content: 36.52

Gene sequence:

>1191_bases
ATGTCTAGTAAAACACTTGCAAAATTTTTAGAAGAAAATTTAGAAGATTTGAAAGCAAAGGGACTTTATAACGTAATTGA
TCCGCTAGAAAGTCCAAATGGACCAATGATTACAATTGGCGGGAAAGAATATATTAACTTATCTTCAAATAACTATCTTG
GCTTAGCAACAGATAATCGTCTGCAAGAAGCGGCAATTGGTGCAATCCATAAGTATGGTGTTGGTGCGGGGGCAGTTCGC
ACGATTAACGGTACACTTGACTTGCATATCAAATTAGAAGAAACAATTGCAAAGTTTAAACATACAGAAGCAGCGATTGC
ATATCAATCAGGATTTAACTGTAACATGGCAGCAATTTCAGCTGTAATGGATAAACATGATGCTATTCTTTCTGATGAGT
TAAACCATGCATCTATTATTGATGGATCTCGTTTATCAAAAGCAAAAATAATCGTTTATAAACATTCTGATATGGAAGAT
TTACGCAAAAAAGCAATCGAAGCCAAAGAATCAGGGCTTTACAACAAATTAATGGTTATTACAGATGGTGTTTTCTCAAT
GGATGGTGATATTGCAAAATTACCAGAAATCGTTAAAATCGCTGAAGAATTAGATTTAATGACATATGTAGATGATGCAC
ATGGTTCAGGAGTGCTCGGAAAAGGTGCAGGTACTGTTAAGCATTTCGGTCTTTCAGATAAAGTAGATTTCCAAATTGGT
ACACTATCAAAAGCAATTGGGGTAATTGGTGGATATGTAGCAGGGAAGCAAAACTTAATCGATTGGTTAAAAGTGCGTTC
ACGCCCATTCTTATTTTCTACAGCTTTAACACCAGCTGATGCGGCGGCTTGCAAGAAATCTATCGAGATTTTAATGGAAA
GTACGGAGCTGCATGATCGTTTATGGGAAAATGGTCGCTATTTAAAACAAGGGTTAAAAGATCTTGGCTTTAATATTGGG
GACAGTGAAACGCCAATTACACCATGTATTATTGGTGATGAAGTGTTAACGCAAGAGTTCAGTAAACGTTTAAATGAAGA
AGGTGTATATGCAAAATCTATCGTGTTCCCAACTGTACCAAGAGGAACAGGGCGTGTTCGTAATATGCCAACAGCAGCTC
ATACGAAAGAAATGCTTGATGAAGCAATTCGTACGTATGAAAAAGTAGGAAAAGAAATGGGGATTATTTAA

Upstream 100 bases:

>100_bases
TTTTTCTATAATAAGATTAAAAAACGTGTTAAGCTAATAGAGGGAGTATTGGCATTATTGAGATAATAATCCGCTTACAT
GAATGATGGGAGGCTTCACA

Downstream 100 bases:

>100_bases
CACTTTTACATCTTTTGAAAGCTTGCAAATGAGGAGTGGGGAAAATGAAAAAAATTTTAGTAACCGGTTCTTTAGGGCAA
ATTGGTTCTGAACTTGTCAT

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase 1; 7-keto-8-amino-pelargonic acid synthase 1; 7-KAP synthase 1; KAPA synthase 1; 8-amino-7-ketopelargonate synthase 1; Alpha-oxoamine synthase 1; L-alanine--pimeloyl-CoA ligase 1 [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSSKTLAKFLEENLEDLKAKGLYNVIDPLESPNGPMITIGGKEYINLSSNNYLGLATDNRLQEAAIGAIHKYGVGAGAVR
TINGTLDLHIKLEETIAKFKHTEAAIAYQSGFNCNMAAISAVMDKHDAILSDELNHASIIDGSRLSKAKIIVYKHSDMED
LRKKAIEAKESGLYNKLMVITDGVFSMDGDIAKLPEIVKIAEELDLMTYVDDAHGSGVLGKGAGTVKHFGLSDKVDFQIG
TLSKAIGVIGGYVAGKQNLIDWLKVRSRPFLFSTALTPADAAACKKSIEILMESTELHDRLWENGRYLKQGLKDLGFNIG
DSETPITPCIIGDEVLTQEFSKRLNEEGVYAKSIVFPTVPRGTGRVRNMPTAAHTKEMLDEAIRTYEKVGKEMGII

Sequences:

>Translated_396_residues
MSSKTLAKFLEENLEDLKAKGLYNVIDPLESPNGPMITIGGKEYINLSSNNYLGLATDNRLQEAAIGAIHKYGVGAGAVR
TINGTLDLHIKLEETIAKFKHTEAAIAYQSGFNCNMAAISAVMDKHDAILSDELNHASIIDGSRLSKAKIIVYKHSDMED
LRKKAIEAKESGLYNKLMVITDGVFSMDGDIAKLPEIVKIAEELDLMTYVDDAHGSGVLGKGAGTVKHFGLSDKVDFQIG
TLSKAIGVIGGYVAGKQNLIDWLKVRSRPFLFSTALTPADAAACKKSIEILMESTELHDRLWENGRYLKQGLKDLGFNIG
DSETPITPCIIGDEVLTQEFSKRLNEEGVYAKSIVFPTVPRGTGRVRNMPTAAHTKEMLDEAIRTYEKVGKEMGII
>Mature_395_residues
SSKTLAKFLEENLEDLKAKGLYNVIDPLESPNGPMITIGGKEYINLSSNNYLGLATDNRLQEAAIGAIHKYGVGAGAVRT
INGTLDLHIKLEETIAKFKHTEAAIAYQSGFNCNMAAISAVMDKHDAILSDELNHASIIDGSRLSKAKIIVYKHSDMEDL
RKKAIEAKESGLYNKLMVITDGVFSMDGDIAKLPEIVKIAEELDLMTYVDDAHGSGVLGKGAGTVKHFGLSDKVDFQIGT
LSKAIGVIGGYVAGKQNLIDWLKVRSRPFLFSTALTPADAAACKKSIEILMESTELHDRLWENGRYLKQGLKDLGFNIGD
SETPITPCIIGDEVLTQEFSKRLNEEGVYAKSIVFPTVPRGTGRVRNMPTAAHTKEMLDEAIRTYEKVGKEMGII

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=395, Percent_Identity=36.2025316455696, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI284448556, Length=354, Percent_Identity=37.2881355932203, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI4758668, Length=362, Percent_Identity=36.7403314917127, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI119220554, Length=419, Percent_Identity=31.0262529832936, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI83977442, Length=353, Percent_Identity=30.3116147308782, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI83977444, Length=353, Percent_Identity=30.3116147308782, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI83977440, Length=353, Percent_Identity=30.3116147308782, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI4502025, Length=365, Percent_Identity=32.3287671232877, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI40316939, Length=365, Percent_Identity=32.3287671232877, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI5454084, Length=314, Percent_Identity=30.5732484076433, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1790046, Length=390, Percent_Identity=40, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI1786993, Length=357, Percent_Identity=32.4929971988796, Blast_Score=185, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI71994529, Length=393, Percent_Identity=37.9134860050891, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=32.520325203252, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=32.8729281767956, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17560914, Length=362, Percent_Identity=32.8729281767956, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI71982625, Length=304, Percent_Identity=28.6184210526316, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71982617, Length=304, Percent_Identity=28.6184210526316, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320267, Length=377, Percent_Identity=32.0954907161804, Blast_Score=196, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6320438, Length=373, Percent_Identity=31.3672922252011, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323954, Length=259, Percent_Identity=28.957528957529, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24662918, Length=395, Percent_Identity=37.9746835443038, Blast_Score=272, Evalue=2e-73,
Organism=Drosophila melanogaster, GI17137420, Length=348, Percent_Identity=34.1954022988506, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17136286, Length=368, Percent_Identity=30.4347826086957, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24653280, Length=311, Percent_Identity=29.2604501607717, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24653276, Length=311, Percent_Identity=29.2604501607717, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24653278, Length=311, Percent_Identity=29.2604501607717, Blast_Score=151, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43208; Mature: 43077

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKTLAKFLEENLEDLKAKGLYNVIDPLESPNGPMITIGGKEYINLSSNNYLGLATDNR
CCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEECCCEEEEECCCCEEEECCCCH
LQEAAIGAIHKYGVGAGAVRTINGTLDLHIKLEETIAKFKHTEAAIAYQSGFNCNMAAIS
HHHHHHHHHHHHCCCCCCEEEECCEEEEEEEEHHHHHHHHHHHHHEEECCCCCCCHHHHH
AVMDKHDAILSDELNHASIIDGSRLSKAKIIVYKHSDMEDLRKKAIEAKESGLYNKLMVI
HHHHHHHHHHHCCCCCCEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHEEEEE
TDGVFSMDGDIAKLPEIVKIAEELDLMTYVDDAHGSGVLGKGAGTVKHFGLSDKVDFQIG
ECCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCCCCCEECCCCCCCCEEHH
TLSKAIGVIGGYVAGKQNLIDWLKVRSRPFLFSTALTPADAAACKKSIEILMESTELHDR
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LWENGRYLKQGLKDLGFNIGDSETPITPCIIGDEVLTQEFSKRLNEEGVYAKSIVFPTVP
HHHCCHHHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCEEEEEECCCCC
RGTGRVRNMPTAAHTKEMLDEAIRTYEKVGKEMGII
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSKTLAKFLEENLEDLKAKGLYNVIDPLESPNGPMITIGGKEYINLSSNNYLGLATDNR
CHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCEEEECCCEEEEECCCCEEEECCCCH
LQEAAIGAIHKYGVGAGAVRTINGTLDLHIKLEETIAKFKHTEAAIAYQSGFNCNMAAIS
HHHHHHHHHHHHCCCCCCEEEECCEEEEEEEEHHHHHHHHHHHHHEEECCCCCCCHHHHH
AVMDKHDAILSDELNHASIIDGSRLSKAKIIVYKHSDMEDLRKKAIEAKESGLYNKLMVI
HHHHHHHHHHHCCCCCCEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCHHEEEEE
TDGVFSMDGDIAKLPEIVKIAEELDLMTYVDDAHGSGVLGKGAGTVKHFGLSDKVDFQIG
ECCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCCCCCEECCCCCCCCEEHH
TLSKAIGVIGGYVAGKQNLIDWLKVRSRPFLFSTALTPADAAACKKSIEILMESTELHDR
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LWENGRYLKQGLKDLGFNIGDSETPITPCIIGDEVLTQEFSKRLNEEGVYAKSIVFPTVP
HHHCCHHHHHHHHHHCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCEEEEEECCCCC
RGTGRVRNMPTAAHTKEMLDEAIRTYEKVGKEMGII
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]