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The map label for this gene is cadA [H]

Identifier: 152974343

GI number: 152974343

Start: 584368

End: 586725

Strand: Direct

Name: cadA [H]

Synonym: Bcer98_0512

Alternate gene names: 152974343

Gene position: 584368-586725 (Clockwise)

Preceding gene: 152974342

Following gene: 152974345

Centisome position: 14.3

GC content: 37.66

Gene sequence:

>2358_bases
ATGGCTGAGGCACTTGTGAAACGAAAACTTGTGTTGGAAGGATTGGATTGTGCGAATTGCGCTATGAAAATCGAAAAAGG
CATTGGAAATTTAGAAGGCGTATCGTCTTGTTCTGTCAATTTTGCAACGAAGACAATGGTTTTAGAGACAGAGAAAAATA
AAGAAGGCCATGTTGTTACGGAAGCAAAACAACTCGTTACGAAATTAGAACCGCACATTAAAGTACGGGAAGAACAAAAC
AAAAAAAGCGTAAAAGAAGTATTGGTATTAAATGGGTTAGATTGTGCAAATTGCGCATTAAAAATTGAAACGAATGTAAA
AGAAATGCCTGGTATTTCAACAGCTACAGTTGATTTCGTATCGAAAAAATTAAAAATAGAAGTTACGAATAAAAAAGAAC
TAGAAACAGTAGTAGCGAATGTAGAACATGTTGTTCATAAGTTAGAGCCAGATGTAAAAGTTGTTCGTGAGGGGAAAAAA
GAACATCATCATGATCATAGCCATGGAGAAGGAAATGTAAAGAAAATGATTGTACGCTTAGCGATAGGTGGGGGATTAAC
AGCAGCAGCGCTTGCAGGACTACCACAAGCAATGAGTATTTCTCTTTTCATCATCGCATATTTACTAATTGGTGGGGAAA
TCGTGTGGCGCGCGGTAAGAAATATAGCTCGCGGCCAAGTGTTTGATGAAAACTTTTTAATGGCTGTAGCAACGTTAGGT
GCATTTGCGATTGGTGAATATCCTGAAGCAGTTGCAGTTATGCTTTTCTACCAAGTAGGTGAATTGTTCCAAAGTATTGC
AGTAAATCGTTCCCGTAAATCAATTACTTCATTAATGGATATTCGTCCTGAATATGCAAACGTTAAAGTCGGAAATGAAA
CAAAACAAGTCTCACCAGAAGACGTACAAATTGGTGATTATATTATTGTGAAACCAGGTGAGAAAGTACCGTTAGATGGG
AAAGTAATTGAAGGAACATCAATGGTAGATACTTCAGCATTAACGGGTGAATCTGTACCGCGAGAAGTAGAAGTTGGGAA
TGAAGTATTAAGCGGTTTCGTAAACCAAAATGGTGTATTAACCATTGAGGTAACGAAAGAGTTTGAGGAATCAACAGTAT
CTAAAATTTTAGATTTGGTACAAAATGCAAGTAGCCGTAAAGCACCAACAGAAAATTTCATTACAAAATTTGCTCGCTAC
TATACGCCTGTTGTCGTGATTACAGCAGCTGTATTGGCATTTATTCCACCTCTTATTTTAGAGGGAGCTACATTCTCAGA
GTGGATTTATCGTGCGTTAGTATTTCTTGTTATTTCTTGTCCATGTGCATTAGTCGTATCCATTCCGCTCGGATTCTTCG
GTGGCATTGGCGGCGCATCTAAAAGTGGTATTTTAGTGAAAGGAAGTAACTATTTAGAAGCATTAAATGATGTACAACAT
ATTGTTTTTGACAAAACAGGAACATTGACAAAAGGTGTTTTTAAAGTAACAAAAATGGAGCCAGCTGGCACGACTACGAA
AGAGGAACTTCTTGAATATGCAGCATTCGCAGAAGTATATTCAAATCATCCAATTGCGCAATCCATTCGAAATGCGTATA
GAAAGTCAGTTGATGAAAAAAATATTGAGGATTATAACGAAATTTCTGGTCATGGTACAGTAGTAAAAGTAAATGGAAAA
GAAATTTTTGCCGGTAACGCAAAATTAATGAAAAAAGAAAATATTGAATTCCAGCAGCCAGAAACGGTAGGGACACTTGT
TCATGTTGCTGTTGACGGAAGATATGCTGGGTATATTGTAATTTCAGATGAAGTAAAAGAAGATTCAAAACAAGCGATTC
AGAAATTAAAAGAGCTCGGTATTAAGAAAACAGTTATGCTAACAGGTGATGCCAAACGGATTGGAGAAGCTGTTGGAAAA
GAGCTTGGATTAGATGAAGTACATGCGGAACTATTACCAGAGCAAAAAGTAGAAGAAATTGAAAAAATTGCTGTGGCAAA
ACAGTCGAAAGAAAAAGTTGCTTTCGTTGGTGATGGTATTAATGACACACCAGTATTAGCGAGAGCGGATGTTGGGATTG
CGATGGGGGGTTTAGGATCTGATGCAGCGATTGAAGCGGCAGACATTGTCATTATGACAGATGAACCTTCTAAAATCGCA
ACGGCTATAAAAATTGCCAAACGTACGCGTAGCGTTGTGTGGCAAAATATTATTTTTGCGCTTGGTGTAAAAGGTCTTGT
GTTACTACTCGGGGCATTTGGAATTGCAACCATGTGGGAAGCTGTCTTCTCTGATGTCGGTGTTACATTAATTGCTGTAT
TAAATGCAATGCGTGCGCTTAGAGTAAAAAATTTATAA

Upstream 100 bases:

>100_bases
TTATTCATTAGCTGACCATCATGTAATCGGTATTTTTGAACAAGCATTCGAACACGTAAATGAGGAAGATTAAAAAGAAA
AAGCGCAAGGAGGGAGAAAA

Downstream 100 bases:

>100_bases
AGTAAAAAGAGGAGTGAAGAAAACTCCTCTTTTTACTTTTGGATATTTTTTGTAATTTGTTCCCTTACAGTTTGAATATA
CTTCATTTTATGATTCCAAC

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 785; Mature: 784

Protein sequence:

>785_residues
MAEALVKRKLVLEGLDCANCAMKIEKGIGNLEGVSSCSVNFATKTMVLETEKNKEGHVVTEAKQLVTKLEPHIKVREEQN
KKSVKEVLVLNGLDCANCALKIETNVKEMPGISTATVDFVSKKLKIEVTNKKELETVVANVEHVVHKLEPDVKVVREGKK
EHHHDHSHGEGNVKKMIVRLAIGGGLTAAALAGLPQAMSISLFIIAYLLIGGEIVWRAVRNIARGQVFDENFLMAVATLG
AFAIGEYPEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPEYANVKVGNETKQVSPEDVQIGDYIIVKPGEKVPLDG
KVIEGTSMVDTSALTGESVPREVEVGNEVLSGFVNQNGVLTIEVTKEFEESTVSKILDLVQNASSRKAPTENFITKFARY
YTPVVVITAAVLAFIPPLILEGATFSEWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGILVKGSNYLEALNDVQH
IVFDKTGTLTKGVFKVTKMEPAGTTTKEELLEYAAFAEVYSNHPIAQSIRNAYRKSVDEKNIEDYNEISGHGTVVKVNGK
EIFAGNAKLMKKENIEFQQPETVGTLVHVAVDGRYAGYIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKRIGEAVGK
ELGLDEVHAELLPEQKVEEIEKIAVAKQSKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPSKIA
TAIKIAKRTRSVVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLIAVLNAMRALRVKNL

Sequences:

>Translated_785_residues
MAEALVKRKLVLEGLDCANCAMKIEKGIGNLEGVSSCSVNFATKTMVLETEKNKEGHVVTEAKQLVTKLEPHIKVREEQN
KKSVKEVLVLNGLDCANCALKIETNVKEMPGISTATVDFVSKKLKIEVTNKKELETVVANVEHVVHKLEPDVKVVREGKK
EHHHDHSHGEGNVKKMIVRLAIGGGLTAAALAGLPQAMSISLFIIAYLLIGGEIVWRAVRNIARGQVFDENFLMAVATLG
AFAIGEYPEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPEYANVKVGNETKQVSPEDVQIGDYIIVKPGEKVPLDG
KVIEGTSMVDTSALTGESVPREVEVGNEVLSGFVNQNGVLTIEVTKEFEESTVSKILDLVQNASSRKAPTENFITKFARY
YTPVVVITAAVLAFIPPLILEGATFSEWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGILVKGSNYLEALNDVQH
IVFDKTGTLTKGVFKVTKMEPAGTTTKEELLEYAAFAEVYSNHPIAQSIRNAYRKSVDEKNIEDYNEISGHGTVVKVNGK
EIFAGNAKLMKKENIEFQQPETVGTLVHVAVDGRYAGYIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKRIGEAVGK
ELGLDEVHAELLPEQKVEEIEKIAVAKQSKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPSKIA
TAIKIAKRTRSVVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLIAVLNAMRALRVKNL
>Mature_784_residues
AEALVKRKLVLEGLDCANCAMKIEKGIGNLEGVSSCSVNFATKTMVLETEKNKEGHVVTEAKQLVTKLEPHIKVREEQNK
KSVKEVLVLNGLDCANCALKIETNVKEMPGISTATVDFVSKKLKIEVTNKKELETVVANVEHVVHKLEPDVKVVREGKKE
HHHDHSHGEGNVKKMIVRLAIGGGLTAAALAGLPQAMSISLFIIAYLLIGGEIVWRAVRNIARGQVFDENFLMAVATLGA
FAIGEYPEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPEYANVKVGNETKQVSPEDVQIGDYIIVKPGEKVPLDGK
VIEGTSMVDTSALTGESVPREVEVGNEVLSGFVNQNGVLTIEVTKEFEESTVSKILDLVQNASSRKAPTENFITKFARYY
TPVVVITAAVLAFIPPLILEGATFSEWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGILVKGSNYLEALNDVQHI
VFDKTGTLTKGVFKVTKMEPAGTTTKEELLEYAAFAEVYSNHPIAQSIRNAYRKSVDEKNIEDYNEISGHGTVVKVNGKE
IFAGNAKLMKKENIEFQQPETVGTLVHVAVDGRYAGYIVISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKRIGEAVGKE
LGLDEVHAELLPEQKVEEIEKIAVAKQSKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPSKIAT
AIKIAKRTRSVVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLIAVLNAMRALRVKNL

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=867, Percent_Identity=26.1822376009227, Blast_Score=266, Evalue=6e-71,
Organism=Homo sapiens, GI55743073, Length=548, Percent_Identity=28.6496350364964, Blast_Score=221, Evalue=3e-57,
Organism=Homo sapiens, GI115529486, Length=895, Percent_Identity=24.9162011173184, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI118498343, Length=157, Percent_Identity=30.5732484076433, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1789879, Length=700, Percent_Identity=35, Blast_Score=364, Evalue=1e-101,
Organism=Escherichia coli, GI1786691, Length=853, Percent_Identity=26.6119577960141, Blast_Score=269, Evalue=6e-73,
Organism=Escherichia coli, GI1786914, Length=505, Percent_Identity=28.5148514851485, Blast_Score=151, Evalue=2e-37,
Organism=Escherichia coli, GI2367363, Length=584, Percent_Identity=22.7739726027397, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17556548, Length=879, Percent_Identity=27.1899886234357, Blast_Score=220, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71997269, Length=174, Percent_Identity=28.735632183908, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71997275, Length=167, Percent_Identity=29.3413173652695, Blast_Score=67, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71997262, Length=167, Percent_Identity=29.3413173652695, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=561, Percent_Identity=30.8377896613191, Blast_Score=228, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6319772, Length=605, Percent_Identity=26.1157024793388, Blast_Score=176, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6325221, Length=584, Percent_Identity=24.1438356164384, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321430, Length=577, Percent_Identity=23.3968804159445, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6321271, Length=194, Percent_Identity=28.3505154639175, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221329854, Length=603, Percent_Identity=26.6998341625207, Blast_Score=167, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24668708, Length=157, Percent_Identity=28.6624203821656, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281366617, Length=157, Percent_Identity=28.6624203821656, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24668704, Length=157, Percent_Identity=28.6624203821656, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI161085803, Length=157, Percent_Identity=28.6624203821656, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24668696, Length=157, Percent_Identity=28.6624203821656, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI281366676, Length=260, Percent_Identity=26.1538461538462, Blast_Score=69, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 85049; Mature: 84918

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEALVKRKLVLEGLDCANCAMKIEKGIGNLEGVSSCSVNFATKTMVLETEKNKEGHVVT
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCEEH
EAKQLVTKLEPHIKVREEQNKKSVKEVLVLNGLDCANCALKIETNVKEMPGISTATVDFV
HHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCCHHCCEEEEECCHHHCCCCCHHHHHHH
SKKLKIEVTNKKELETVVANVEHVVHKLEPDVKVVREGKKEHHHDHSHGEGNVKKMIVRL
CCEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHCCCCCCCCCHHHHHHHHH
AIGGGLTAAALAGLPQAMSISLFIIAYLLIGGEIVWRAVRNIARGQVFDENFLMAVATLG
HHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AFAIGEYPEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPEYANVKVGNETKQVSPE
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCC
DVQIGDYIIVKPGEKVPLDGKVIEGTSMVDTSALTGESVPREVEVGNEVLSGFVNQNGVL
CEEECCEEEECCCCCCCCCCEEECCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHCCCCEE
TIEVTKEFEESTVSKILDLVQNASSRKAPTENFITKFARYYTPVVVITAAVLAFIPPLIL
EEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGATFSEWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGILVKGSNYLEALNDVQH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHH
IVFDKTGTLTKGVFKVTKMEPAGTTTKEELLEYAAFAEVYSNHPIAQSIRNAYRKSVDEK
HHHCCCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
NIEDYNEISGHGTVVKVNGKEIFAGNAKLMKKENIEFQQPETVGTLVHVAVDGRYAGYIV
CCCHHHHCCCCCEEEEECCCEEEECCHHHHHHCCCCCCCCCHHCEEEEEEECCCEEEEEE
ISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKRIGEAVGKELGLDEVHAELLPEQKVEEI
EECHHCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHCCHHHHHHH
EKIAVAKQSKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPSKIA
HHHHHHHCCCCCEEEEECCCCCCCEEEECCCCEEECCCCCCCEEEEEEEEEECCCCHHHH
TAIKIAKRTRSVVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLIAVLNAMRAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVKNL
HHCCC
>Mature Secondary Structure 
AEALVKRKLVLEGLDCANCAMKIEKGIGNLEGVSSCSVNFATKTMVLETEKNKEGHVVT
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCEEH
EAKQLVTKLEPHIKVREEQNKKSVKEVLVLNGLDCANCALKIETNVKEMPGISTATVDFV
HHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCCHHCCEEEEECCHHHCCCCCHHHHHHH
SKKLKIEVTNKKELETVVANVEHVVHKLEPDVKVVREGKKEHHHDHSHGEGNVKKMIVRL
CCEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHCCCCCCCCCHHHHHHHHH
AIGGGLTAAALAGLPQAMSISLFIIAYLLIGGEIVWRAVRNIARGQVFDENFLMAVATLG
HHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AFAIGEYPEAVAVMLFYQVGELFQSIAVNRSRKSITSLMDIRPEYANVKVGNETKQVSPE
HHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCC
DVQIGDYIIVKPGEKVPLDGKVIEGTSMVDTSALTGESVPREVEVGNEVLSGFVNQNGVL
CEEECCEEEECCCCCCCCCCEEECCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHCCCCEE
TIEVTKEFEESTVSKILDLVQNASSRKAPTENFITKFARYYTPVVVITAAVLAFIPPLIL
EEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGATFSEWIYRALVFLVISCPCALVVSIPLGFFGGIGGASKSGILVKGSNYLEALNDVQH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHH
IVFDKTGTLTKGVFKVTKMEPAGTTTKEELLEYAAFAEVYSNHPIAQSIRNAYRKSVDEK
HHHCCCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
NIEDYNEISGHGTVVKVNGKEIFAGNAKLMKKENIEFQQPETVGTLVHVAVDGRYAGYIV
CCCHHHHCCCCCEEEEECCCEEEECCHHHHHHCCCCCCCCCHHCEEEEEEECCCEEEEEE
ISDEVKEDSKQAIQKLKELGIKKTVMLTGDAKRIGEAVGKELGLDEVHAELLPEQKVEEI
EECHHCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHCCHHHHHHH
EKIAVAKQSKEKVAFVGDGINDTPVLARADVGIAMGGLGSDAAIEAADIVIMTDEPSKIA
HHHHHHHCCCCCEEEEECCCCCCCEEEECCCCEEECCCCCCCEEEEEEEEEECCCCHHHH
TAIKIAKRTRSVVWQNIIFALGVKGLVLLLGAFGIATMWEAVFSDVGVTLIAVLNAMRAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVKNL
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]