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The map label for this gene is yfnA [H]

Identifier: 152974341

GI number: 152974341

Start: 582043

End: 583458

Strand: Direct

Name: yfnA [H]

Synonym: Bcer98_0510

Alternate gene names: 152974341

Gene position: 582043-583458 (Clockwise)

Preceding gene: 152974340

Following gene: 152974342

Centisome position: 14.24

GC content: 37.85

Gene sequence:

>1416_bases
GTGGCCAACCTATTTAAAAAGAAATCCGTTACGCAATTGTTAGGGGAAAGTAAAAGTAAAACTTTAACGAAAACACTAGG
GGCATTTGACCTAACGATGCTAGGGATTGGTGCGATAATTGGTACAGGAGTACTTGTATTAACTGGATTAGTAGCAGCAA
GAGATGCTGGTCCAGCCGTTATTTTTTCATTTATGATTGCGGCTGTTGTTTGTGGATTCGCAGCATTATGTTATGCAGAA
GTTGCTTCGACTCTGCCTGTTTCAGGTAGTGTATACACATATTCGTATGCAACGATTGGTGAATTTATTGCCCATTTAAT
GGGATGGACATTGCTATCCGTATATGTAGTAACAACTGCTGCGGTAGCTGGTGGATGGACAGGTTACTTCCATAACTTAA
TAAGTGGATTTGGATTAGAAATTCCAAAGGAACTGTTAACGATTCCAGCGCAAGGCGGCATAGTGAATTTGCCAGCGGTG
GTTATCACTTTAGTACTGACTTGGTTATTATCGCGTGGTACAAAGGAAAGTAAACGTGTAAATAACGCAATGGTGTTAAT
AAAAATTGGCATTGTTGTTCTATTTATTGCTGTTGGTGTATTTTACGTAAAACCAGAAAATTGGGTACCGTTTGCACCAT
ATGGTTTAAGTGGAATCTTTGCTGGAGGAGCAGCAGTATTCTTTGCTTTCTTAGGATTTGATGCATTAGCAACTTCAGCA
GAAGAAGTGAAAAATCCACAACGTGATCTTCCAATCGGTATTATTGCCTCACTAATCATTTGTACAATCATTTATGTTGC
AGTTTGTCTTGTTATGACGGGCATGGTTTCTTATAAGGAATTAGATGTACCAGAAGCGATGGCTTATGTATTAGAAGTTG
TAGGACAAGATAAAGTGGCAGGTGTAATCGCAGTTGGAGCTGTAATTGGGATTATGGCTGTAATTTTCGCTTATATTTAT
GCGACAACGCGCGTATTTTTTGCAATGAGCCGTGACGGTTTATTGCCAGAATCTTTTGCGAAAATTAACAAAAAGACAGA
AGCACCAACATTTTCGACTTGGTTAACAGGAATTGGTAGTGCTTTAATTGCTGGATTTATTGATTTGAAAGAATTATCAA
ATTTAGCGAATATTGGAGCGTTATTAACATTTGCGATGGTAGGTGTATCGGTTATCATCCTTCGTAAAACACATCCGAAA
TTAGATCGTGGATTTAAGGTACCGCTTGTACCTCTTATACCGATCATTTCAATTGCATGTTGTTTATTCTTAATGGTGAA
CTTACCGTTAACAACGTGGATGTATTTCGGAGCATGGTTAGCAATTGGAGTTGGTGTATACTTTGTATATTCGAAAAAAC
ATAGTCATTTAAAAGAAGATGGAAGTTCGCAAGATAGTTTAGAAAAAGCTAACTAA

Upstream 100 bases:

>100_bases
AGCATTATACAAAATAATAATCGAACAATATTTCATACAACATGATAAGAGCTAAGAGTGAAGACCTCTTAGCTCTTATT
AGCAAAAGGGGGCATACATC

Downstream 100 bases:

>100_bases
AGGGATATAAAACATGTAAGCCTTGTGCGTCTAGGGAGCGTGCAAGGCTTTTTTGTGCAAATGAAGAGGACCTATGTTAT
TTTGTCGAGTTGTTATGTCG

Product: amino acid permease-associated region

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MANLFKKKSVTQLLGESKSKTLTKTLGAFDLTMLGIGAIIGTGVLVLTGLVAARDAGPAVIFSFMIAAVVCGFAALCYAE
VASTLPVSGSVYTYSYATIGEFIAHLMGWTLLSVYVVTTAAVAGGWTGYFHNLISGFGLEIPKELLTIPAQGGIVNLPAV
VITLVLTWLLSRGTKESKRVNNAMVLIKIGIVVLFIAVGVFYVKPENWVPFAPYGLSGIFAGGAAVFFAFLGFDALATSA
EEVKNPQRDLPIGIIASLIICTIIYVAVCLVMTGMVSYKELDVPEAMAYVLEVVGQDKVAGVIAVGAVIGIMAVIFAYIY
ATTRVFFAMSRDGLLPESFAKINKKTEAPTFSTWLTGIGSALIAGFIDLKELSNLANIGALLTFAMVGVSVIILRKTHPK
LDRGFKVPLVPLIPIISIACCLFLMVNLPLTTWMYFGAWLAIGVGVYFVYSKKHSHLKEDGSSQDSLEKAN

Sequences:

>Translated_471_residues
MANLFKKKSVTQLLGESKSKTLTKTLGAFDLTMLGIGAIIGTGVLVLTGLVAARDAGPAVIFSFMIAAVVCGFAALCYAE
VASTLPVSGSVYTYSYATIGEFIAHLMGWTLLSVYVVTTAAVAGGWTGYFHNLISGFGLEIPKELLTIPAQGGIVNLPAV
VITLVLTWLLSRGTKESKRVNNAMVLIKIGIVVLFIAVGVFYVKPENWVPFAPYGLSGIFAGGAAVFFAFLGFDALATSA
EEVKNPQRDLPIGIIASLIICTIIYVAVCLVMTGMVSYKELDVPEAMAYVLEVVGQDKVAGVIAVGAVIGIMAVIFAYIY
ATTRVFFAMSRDGLLPESFAKINKKTEAPTFSTWLTGIGSALIAGFIDLKELSNLANIGALLTFAMVGVSVIILRKTHPK
LDRGFKVPLVPLIPIISIACCLFLMVNLPLTTWMYFGAWLAIGVGVYFVYSKKHSHLKEDGSSQDSLEKAN
>Mature_470_residues
ANLFKKKSVTQLLGESKSKTLTKTLGAFDLTMLGIGAIIGTGVLVLTGLVAARDAGPAVIFSFMIAAVVCGFAALCYAEV
ASTLPVSGSVYTYSYATIGEFIAHLMGWTLLSVYVVTTAAVAGGWTGYFHNLISGFGLEIPKELLTIPAQGGIVNLPAVV
ITLVLTWLLSRGTKESKRVNNAMVLIKIGIVVLFIAVGVFYVKPENWVPFAPYGLSGIFAGGAAVFFAFLGFDALATSAE
EVKNPQRDLPIGIIASLIICTIIYVAVCLVMTGMVSYKELDVPEAMAYVLEVVGQDKVAGVIAVGAVIGIMAVIFAYIYA
TTRVFFAMSRDGLLPESFAKINKKTEAPTFSTWLTGIGSALIAGFIDLKELSNLANIGALLTFAMVGVSVIILRKTHPKL
DRGFKVPLVPLIPIISIACCLFLMVNLPLTTWMYFGAWLAIGVGVYFVYSKKHSHLKEDGSSQDSLEKAN

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of D-Alanine, D-Serine And Glycine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=431, Percent_Identity=35.4988399071926, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI258614003, Length=427, Percent_Identity=37.4707259953162, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI258614005, Length=427, Percent_Identity=37.2365339578454, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI258645169, Length=427, Percent_Identity=37.0023419203747, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI181337167, Length=389, Percent_Identity=35.73264781491, Blast_Score=225, Evalue=8e-59,
Organism=Homo sapiens, GI114326544, Length=433, Percent_Identity=34.1801385681293, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI114326550, Length=433, Percent_Identity=34.1801385681293, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI110347453, Length=404, Percent_Identity=35.3960396039604, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI186910308, Length=446, Percent_Identity=26.0089686098655, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI186910306, Length=446, Percent_Identity=26.0089686098655, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI186910304, Length=446, Percent_Identity=26.0089686098655, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI115648063, Length=435, Percent_Identity=26.2068965517241, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI115648022, Length=435, Percent_Identity=26.2068965517241, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI33286428, Length=465, Percent_Identity=26.8817204301075, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI7657683, Length=373, Percent_Identity=26.5415549597855, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI187423910, Length=453, Percent_Identity=23.841059602649, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI7657591, Length=453, Percent_Identity=23.841059602649, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI33286430, Length=242, Percent_Identity=29.3388429752066, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI71999149, Length=360, Percent_Identity=22.5, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1790653, Length=479, Percent_Identity=25.2609603340292, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87081708, Length=489, Percent_Identity=20.6543967280164, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081869, Length=473, Percent_Identity=25.369978858351, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788480, Length=446, Percent_Identity=23.9910313901345, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI87082023, Length=446, Percent_Identity=25.3363228699552, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1786694, Length=396, Percent_Identity=24.4949494949495, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789017, Length=403, Percent_Identity=22.5806451612903, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786302, Length=432, Percent_Identity=20.3703703703704, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI87082250, Length=431, Percent_Identity=23.4338747099768, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI2367353, Length=337, Percent_Identity=21.6617210682493, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786789, Length=365, Percent_Identity=20.2739726027397, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790584, Length=279, Percent_Identity=25.089605734767, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786908, Length=342, Percent_Identity=23.9766081871345, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI87081915, Length=422, Percent_Identity=21.563981042654, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=397, Percent_Identity=34.7607052896725, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI17533459, Length=414, Percent_Identity=34.0579710144928, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17531343, Length=411, Percent_Identity=31.3868613138686, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17540018, Length=432, Percent_Identity=25.2314814814815, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17568033, Length=443, Percent_Identity=23.7020316027088, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71982612, Length=400, Percent_Identity=22.75, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71982608, Length=409, Percent_Identity=22.7383863080685, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17537453, Length=387, Percent_Identity=23.2558139534884, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI32566699, Length=374, Percent_Identity=26.4705882352941, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193208714, Length=419, Percent_Identity=23.3890214797136, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32566695, Length=419, Percent_Identity=23.3890214797136, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666159, Length=411, Percent_Identity=38.9294403892944, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI221512776, Length=411, Percent_Identity=38.9294403892944, Blast_Score=278, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24668806, Length=420, Percent_Identity=34.5238095238095, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI21356285, Length=420, Percent_Identity=34.5238095238095, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24668802, Length=420, Percent_Identity=34.5238095238095, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24667468, Length=413, Percent_Identity=34.8668280871671, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI161077963, Length=403, Percent_Identity=35.9801488833747, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI281366235, Length=412, Percent_Identity=33.495145631068, Blast_Score=203, Evalue=3e-52,
Organism=Drosophila melanogaster, GI116007820, Length=412, Percent_Identity=33.495145631068, Blast_Score=203, Evalue=3e-52,
Organism=Drosophila melanogaster, GI116007818, Length=413, Percent_Identity=33.1719128329298, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI85725152, Length=413, Percent_Identity=33.1719128329298, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI21357367, Length=445, Percent_Identity=28.5393258426966, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI221331183, Length=422, Percent_Identity=26.7772511848341, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17647653, Length=422, Percent_Identity=26.7772511848341, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24664379, Length=422, Percent_Identity=26.7772511848341, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI45550968, Length=469, Percent_Identity=25.1599147121535, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921172, Length=469, Percent_Identity=25.1599147121535, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24651635, Length=400, Percent_Identity=25.25, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24651633, Length=400, Percent_Identity=25.25, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24641995, Length=400, Percent_Identity=24.5, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641993, Length=400, Percent_Identity=24.5, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50174; Mature: 50043

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHCCCCCCCHHCCCC
>Mature Secondary Structure 
ANLFKKKSVTQLLGESKSKTLTKTLGAFDLTMLGIGAIIGTGVLVLTGLVAARDAGPAV
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]