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The map label for this gene is lgrD [H]

Identifier: 152974204

GI number: 152974204

Start: 422965

End: 426549

Strand: Direct

Name: lgrD [H]

Synonym: Bcer98_0368

Alternate gene names: 152974204

Gene position: 422965-426549 (Clockwise)

Preceding gene: 152974203

Following gene: 152974205

Centisome position: 10.35

GC content: 34.34

Gene sequence:

>3585_bases
ATGGAAGCAGTATTAACAAATTCTTATAATGAAACAATCAAAGAGTCTCTAGAAAGAATAAACGGAAAAAGTAGAATTCC
TATGGATTTCCGAAATCTAGAGGGAGAAGTAGATACAAAAACAATATTGTTTCCAATAACAATTAATATGGTTGATCTGT
TAGGAGCAAGTATAATGTGGTTACATCATATTGCTAATGAGAAACATATAATTGTTTTGTATCATGAAAGGGAAAAACTA
TTTCCTATTGTGATTGAAATCTCTCCTTTCCTTTCTTATAAAAAGTTAAAAGAACAGATCGTTGAGCAAATAGGTCAAAT
TCAAGCGATGGATGAGACAGACATACAAGAATTACAAAAGCATGATAATCTATTTGGAATGGCACCTATTATTGTTGGTC
AAACATACTATCATTCACAGGAGAATGATATATTACAGTTTGTCCTTAATGAAGAGAAGCAAGGTGTAGAAGTGATATTT
AATGGTTTGATTTGGAAGGAAAAGACGATTGCTCGCTATATGAGGCAAATAGAGGGAGTATTCATACATGCCTTACAGAA
TAGAGATGAACACGTTGGGAATTTCCGAATTATTACAGATGAAGAGATAGCACTCTATAATGAGATAAATAACACGAAAG
CAACATATCCAGAAAAAAGCATTGTTGAGATGTTTTATAAAACGGTTAAGCAATTTCCGAATCGTATTGCATTATCTTCT
AAAGAAGGTGCTTTAACGTATCAAGAATTGAATCAAAGAAGTAATCAAATAGCTCACATGTTAATACAAAATGGTGTGCA
ACCAGGAGATTATGTGGGGATTTTTATGAAACGCAGTATCGACACAGTGATAAGTATATTAGCTGTGTTGAAGGCTAATG
CGGCATATGTTCCAATTGATCCAGATTATCCGGAGAGTAGAATTGAGTACATTATTCAAGATAGTAAAGCGAAAGTTATT
TTAACAAAAGAAACAGAGATTACATCTAAAGGTATTCAAGCAATCTCAATCTATGATAGTGAGAATTATTTGGTTAATGA
TGTGAAGCTTCCTATCAATTGTGATGATATAGCATATATGATTTATACATCAGGATCGACAGGGAATCCGAAAGGAACAA
TGTTAGCTCATCGAGGTGTTGTCAATCTATGTACTTGGATGCAACGACAGTATAAATTAACAGAAGAGGATGTATTTGCA
CAGTTTCCTTCATTTAGCTTTGATGCTTCTGTATGGGAATTATTTGCTGCTTTATTTTGCGGAGGCACCTTATATGTATT
ATTAGAAGAAGAACGCTTATCGGTAGAAGCATTTGCAAATGCAATCCATAGAGTAAAAGCAACTTCTATTTTAGCGTTAG
CAACAGTTTTTGTAAGACAAGTAGCAACCTATTTAGAAGATGAAGAGATATATAAGCTGAGTTCATTGAAACGGATTGCA
ATTGGAGGAGAGATGTTACCGATCGAGGTGATTAAATTATGGAGAGAAAGAATTGGAACAAATATTGAAATTCATAATGT
ATATGGACCGACAGAGTGTACAGTCGTAACAACAACTTACCCGATTCCGAGTCAGTTGGATGAGAACATTGTAAGTGTTC
CAATTGGTAAGCCGTGTGCAAATTATCAAATTATGATATTGGATGAGAATATGAGGCTTTGTCCAATTGGTGTACCTGGC
GAACTGCATATAGAATCAGTAGGACTAGCAAAAGGATATTTTAATAAACCGGAAAAAACAGTAGAAGCATTTGTTCCAAA
CCCATTCAACCCTATTGTTAATATATATAAAACTGGAGATATCGTTAGACTCTTAGAAGACGGGAATATTGAATTTTTAC
ATAGAAAAGATGATCAAGTGAAAATTAGAGGACACCGTATTGAGTTAGGAGAAATTCAAAATCAAATTTCTCAAAATTAT
AATGTAAAAGAAAATATTGTGTTTGCTAAGAAAAGTAAAGAAGGAAGTCAATATTTGATTGCTTTTTATACAACTTTAAC
AAAAAAAGAGATGCCAGAACTCATTTACAAATTACAAGAGCAGTTACCAGATTATATGATTCCGTCTAAGTTAATTTATA
TTGATGAACTACCGCTTACACCAAATAAGAAAATAGATGTTAAGAAACTAGGGCAACTAGAAGAAGAGTATGAGCCGACT
CGCCTACAAGAATATGTTGCACCATCTACTGAAGCAGAGAAGATTATCGCACAGGCTTGGACAGAAGTATTAGGAGTTTC
CAAAATTGGTGTACATGATGATTTCTTTACCATTGGTGGGCATTCATTAAAAGTATTACGTATTTTAACATTGTTAAAAG
AAGATTTTCCGCATTTAACAATTCAAGACTTCTTTAAGGAAAAGACAGTGTATAAGTTAGCGCGAATACAAAGGGAGTTA
ACCCTAGAAGAAAATGTATTTCATGAATATAAATGGATACATGAACCAGAGGCTATTCAGTATACGGAAGGAATAACTAA
TAACCGGATTTCCAATGTCTTTTTAACAGGAGCAACAGGTTATTTAGGATCACATATCCTATATGAATTATTGCAGCAAA
CCTCAGCTCATATTTATTGTTTAGTAAGACCTAAAAAAGATGTAGAGCAAAGAATTATGGAAACTTTAACAGGATATTTT
CATGATATTCCAAATGAAGCTCTGGCACGTATAACAGCTATTCCTGGTGACCTTGGTGAAGAATACTTTGGACTTAGTAA
GGAAGAGTTTATAGCGATACGTTCTAAAGTTGATACAGTCGTTCACTGCGGGGCAGACGTAAGACATTTTGGGGATGTAA
AGCAATTTGAAAATGTAAATATTCAAGGGACAAAGCGCATGCTTGCATTAGCCGATGAAGGAGCAGCATTCCATTTTATT
TCTACGATTAGTATTCCAATCGATTTAGCAGTAGAACAATGGGATATGTATAAAAAACGCGGTGATTTTGAGTATCATGT
AGAGTTAGAGAATGTGTATTCCAATAGTAAACTACAGGCAGAAAATCTTGTTCGTGAAGCAATGAGTCGTGGCATGAGAG
GGAATATTTATCGCGCTGGTAATTTAACATGCCATTCCGAAACGGGAGTATTTCAACAAAATATTGAAGGAAATGCATTT
TATCGCCTCATTAAAACGATGTTATTAATTGGACAAGCACCAAACGTGAAGTGGAAAGTGGACTTTGCTCCAATTGATTT
TGCAAGTAAATCAATTGTGACGTATATGCAAGATCCTCAAATTATAGGTGAAACATTGCATATTTGTCATCCAGATCCGA
TTGATTTTGTACATTTTGTGCAGTTAATGATAGAATGCGGGCATCATTTAGAAATTGTTCCTCTTTCGCAATATGTAGAT
TCAGGGTTACAGTTAGCGAAAGAGGATGAGGAGATAGCAGAATTGATTGCTTCACAAGTAGCTGGCGATGGAGCGCAGCA
GTCTGAATTTGTAATAGGTACAAAAAGAACAAATGAATGGATAAAGAAAAAGAAAATTGCAGTGCCAATAATTGACCAAC
AGTTTATTCAGAAGCTATTAGCACATGGAGAACAAGTGGGGTATTTTCCAAACGTAGAAAAATAA

Upstream 100 bases:

>100_bases
ATCTTTAAGTTGGCTTGCTCAAGAGTTACAAGAATTGATTGGTGAATTTAAAAGCGAATAGAGCATAAACAAGGTGTAGA
TGGTAAGGGAAGTGAATGAC

Downstream 100 bases:

>100_bases
CAGACAAGATGTACCATGCTTTTGTTTGTTCAATAAAATAAATCATGCTACAATGAAAACGAATTAAGGACCGGGGAGCC
AAGTGGCTGAGAGGATGTAA

Product: amino acid adenylation domain-containing protein

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-Leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent glycine adenylase; GlyA; Glycine activase; Linear gramicidin--PCP reductase [H]

Number of amino acids: Translated: 1194; Mature: 1194

Protein sequence:

>1194_residues
MEAVLTNSYNETIKESLERINGKSRIPMDFRNLEGEVDTKTILFPITINMVDLLGASIMWLHHIANEKHIIVLYHEREKL
FPIVIEISPFLSYKKLKEQIVEQIGQIQAMDETDIQELQKHDNLFGMAPIIVGQTYYHSQENDILQFVLNEEKQGVEVIF
NGLIWKEKTIARYMRQIEGVFIHALQNRDEHVGNFRIITDEEIALYNEINNTKATYPEKSIVEMFYKTVKQFPNRIALSS
KEGALTYQELNQRSNQIAHMLIQNGVQPGDYVGIFMKRSIDTVISILAVLKANAAYVPIDPDYPESRIEYIIQDSKAKVI
LTKETEITSKGIQAISIYDSENYLVNDVKLPINCDDIAYMIYTSGSTGNPKGTMLAHRGVVNLCTWMQRQYKLTEEDVFA
QFPSFSFDASVWELFAALFCGGTLYVLLEEERLSVEAFANAIHRVKATSILALATVFVRQVATYLEDEEIYKLSSLKRIA
IGGEMLPIEVIKLWRERIGTNIEIHNVYGPTECTVVTTTYPIPSQLDENIVSVPIGKPCANYQIMILDENMRLCPIGVPG
ELHIESVGLAKGYFNKPEKTVEAFVPNPFNPIVNIYKTGDIVRLLEDGNIEFLHRKDDQVKIRGHRIELGEIQNQISQNY
NVKENIVFAKKSKEGSQYLIAFYTTLTKKEMPELIYKLQEQLPDYMIPSKLIYIDELPLTPNKKIDVKKLGQLEEEYEPT
RLQEYVAPSTEAEKIIAQAWTEVLGVSKIGVHDDFFTIGGHSLKVLRILTLLKEDFPHLTIQDFFKEKTVYKLARIQREL
TLEENVFHEYKWIHEPEAIQYTEGITNNRISNVFLTGATGYLGSHILYELLQQTSAHIYCLVRPKKDVEQRIMETLTGYF
HDIPNEALARITAIPGDLGEEYFGLSKEEFIAIRSKVDTVVHCGADVRHFGDVKQFENVNIQGTKRMLALADEGAAFHFI
STISIPIDLAVEQWDMYKKRGDFEYHVELENVYSNSKLQAENLVREAMSRGMRGNIYRAGNLTCHSETGVFQQNIEGNAF
YRLIKTMLLIGQAPNVKWKVDFAPIDFASKSIVTYMQDPQIIGETLHICHPDPIDFVHFVQLMIECGHHLEIVPLSQYVD
SGLQLAKEDEEIAELIASQVAGDGAQQSEFVIGTKRTNEWIKKKKIAVPIIDQQFIQKLLAHGEQVGYFPNVEK

Sequences:

>Translated_1194_residues
MEAVLTNSYNETIKESLERINGKSRIPMDFRNLEGEVDTKTILFPITINMVDLLGASIMWLHHIANEKHIIVLYHEREKL
FPIVIEISPFLSYKKLKEQIVEQIGQIQAMDETDIQELQKHDNLFGMAPIIVGQTYYHSQENDILQFVLNEEKQGVEVIF
NGLIWKEKTIARYMRQIEGVFIHALQNRDEHVGNFRIITDEEIALYNEINNTKATYPEKSIVEMFYKTVKQFPNRIALSS
KEGALTYQELNQRSNQIAHMLIQNGVQPGDYVGIFMKRSIDTVISILAVLKANAAYVPIDPDYPESRIEYIIQDSKAKVI
LTKETEITSKGIQAISIYDSENYLVNDVKLPINCDDIAYMIYTSGSTGNPKGTMLAHRGVVNLCTWMQRQYKLTEEDVFA
QFPSFSFDASVWELFAALFCGGTLYVLLEEERLSVEAFANAIHRVKATSILALATVFVRQVATYLEDEEIYKLSSLKRIA
IGGEMLPIEVIKLWRERIGTNIEIHNVYGPTECTVVTTTYPIPSQLDENIVSVPIGKPCANYQIMILDENMRLCPIGVPG
ELHIESVGLAKGYFNKPEKTVEAFVPNPFNPIVNIYKTGDIVRLLEDGNIEFLHRKDDQVKIRGHRIELGEIQNQISQNY
NVKENIVFAKKSKEGSQYLIAFYTTLTKKEMPELIYKLQEQLPDYMIPSKLIYIDELPLTPNKKIDVKKLGQLEEEYEPT
RLQEYVAPSTEAEKIIAQAWTEVLGVSKIGVHDDFFTIGGHSLKVLRILTLLKEDFPHLTIQDFFKEKTVYKLARIQREL
TLEENVFHEYKWIHEPEAIQYTEGITNNRISNVFLTGATGYLGSHILYELLQQTSAHIYCLVRPKKDVEQRIMETLTGYF
HDIPNEALARITAIPGDLGEEYFGLSKEEFIAIRSKVDTVVHCGADVRHFGDVKQFENVNIQGTKRMLALADEGAAFHFI
STISIPIDLAVEQWDMYKKRGDFEYHVELENVYSNSKLQAENLVREAMSRGMRGNIYRAGNLTCHSETGVFQQNIEGNAF
YRLIKTMLLIGQAPNVKWKVDFAPIDFASKSIVTYMQDPQIIGETLHICHPDPIDFVHFVQLMIECGHHLEIVPLSQYVD
SGLQLAKEDEEIAELIASQVAGDGAQQSEFVIGTKRTNEWIKKKKIAVPIIDQQFIQKLLAHGEQVGYFPNVEK
>Mature_1194_residues
MEAVLTNSYNETIKESLERINGKSRIPMDFRNLEGEVDTKTILFPITINMVDLLGASIMWLHHIANEKHIIVLYHEREKL
FPIVIEISPFLSYKKLKEQIVEQIGQIQAMDETDIQELQKHDNLFGMAPIIVGQTYYHSQENDILQFVLNEEKQGVEVIF
NGLIWKEKTIARYMRQIEGVFIHALQNRDEHVGNFRIITDEEIALYNEINNTKATYPEKSIVEMFYKTVKQFPNRIALSS
KEGALTYQELNQRSNQIAHMLIQNGVQPGDYVGIFMKRSIDTVISILAVLKANAAYVPIDPDYPESRIEYIIQDSKAKVI
LTKETEITSKGIQAISIYDSENYLVNDVKLPINCDDIAYMIYTSGSTGNPKGTMLAHRGVVNLCTWMQRQYKLTEEDVFA
QFPSFSFDASVWELFAALFCGGTLYVLLEEERLSVEAFANAIHRVKATSILALATVFVRQVATYLEDEEIYKLSSLKRIA
IGGEMLPIEVIKLWRERIGTNIEIHNVYGPTECTVVTTTYPIPSQLDENIVSVPIGKPCANYQIMILDENMRLCPIGVPG
ELHIESVGLAKGYFNKPEKTVEAFVPNPFNPIVNIYKTGDIVRLLEDGNIEFLHRKDDQVKIRGHRIELGEIQNQISQNY
NVKENIVFAKKSKEGSQYLIAFYTTLTKKEMPELIYKLQEQLPDYMIPSKLIYIDELPLTPNKKIDVKKLGQLEEEYEPT
RLQEYVAPSTEAEKIIAQAWTEVLGVSKIGVHDDFFTIGGHSLKVLRILTLLKEDFPHLTIQDFFKEKTVYKLARIQREL
TLEENVFHEYKWIHEPEAIQYTEGITNNRISNVFLTGATGYLGSHILYELLQQTSAHIYCLVRPKKDVEQRIMETLTGYF
HDIPNEALARITAIPGDLGEEYFGLSKEEFIAIRSKVDTVVHCGADVRHFGDVKQFENVNIQGTKRMLALADEGAAFHFI
STISIPIDLAVEQWDMYKKRGDFEYHVELENVYSNSKLQAENLVREAMSRGMRGNIYRAGNLTCHSETGVFQQNIEGNAF
YRLIKTMLLIGQAPNVKWKVDFAPIDFASKSIVTYMQDPQIIGETLHICHPDPIDFVHFVQLMIECGHHLEIVPLSQYVD
SGLQLAKEDEEIAELIASQVAGDGAQQSEFVIGTKRTNEWIKKKKIAVPIIDQQFIQKLLAHGEQVGYFPNVEK

Specific function: Activates the 13th to the 16th (Trp, D-Leu, Trp and Gly) amino acids in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 14th (D-Leu) amino acid. It also catalyzes

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=427, Percent_Identity=29.2740046838407, Blast_Score=140, Evalue=9e-33,
Organism=Homo sapiens, GI38505220, Length=508, Percent_Identity=25.5905511811024, Blast_Score=130, Evalue=7e-30,
Organism=Homo sapiens, GI42544132, Length=520, Percent_Identity=23.6538461538462, Blast_Score=112, Evalue=2e-24,
Organism=Homo sapiens, GI156151445, Length=560, Percent_Identity=22.8571428571429, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI28416953, Length=547, Percent_Identity=22.1206581352834, Blast_Score=101, Evalue=4e-21,
Organism=Homo sapiens, GI157311624, Length=518, Percent_Identity=23.5521235521236, Blast_Score=96, Evalue=3e-19,
Organism=Homo sapiens, GI157311622, Length=518, Percent_Identity=23.5521235521236, Blast_Score=96, Evalue=3e-19,
Organism=Homo sapiens, GI122937307, Length=500, Percent_Identity=23, Blast_Score=94, Evalue=1e-18,
Organism=Homo sapiens, GI58082049, Length=518, Percent_Identity=23.3590733590734, Blast_Score=92, Evalue=3e-18,
Organism=Homo sapiens, GI115511026, Length=505, Percent_Identity=21.7821782178218, Blast_Score=91, Evalue=8e-18,
Organism=Homo sapiens, GI13375727, Length=543, Percent_Identity=21.1786372007366, Blast_Score=86, Evalue=2e-16,
Organism=Escherichia coli, GI1786801, Length=706, Percent_Identity=29.3201133144476, Blast_Score=313, Evalue=3e-86,
Organism=Escherichia coli, GI145693145, Length=527, Percent_Identity=23.5294117647059, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1788107, Length=549, Percent_Identity=24.2258652094718, Blast_Score=117, Evalue=5e-27,
Organism=Escherichia coli, GI1786810, Length=516, Percent_Identity=23.2558139534884, Blast_Score=98, Evalue=3e-21,
Organism=Escherichia coli, GI221142682, Length=516, Percent_Identity=23.4496124031008, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1789201, Length=375, Percent_Identity=24.8, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17556356, Length=542, Percent_Identity=29.7047970479705, Blast_Score=157, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17550940, Length=531, Percent_Identity=25.2354048964218, Blast_Score=127, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=482, Percent_Identity=24.6887966804979, Blast_Score=126, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17558820, Length=482, Percent_Identity=24.4813278008299, Blast_Score=117, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17531443, Length=492, Percent_Identity=22.7642276422764, Blast_Score=90, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17551278, Length=569, Percent_Identity=22.4956063268893, Blast_Score=90, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17560308, Length=531, Percent_Identity=22.5988700564972, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994703, Length=564, Percent_Identity=20.2127659574468, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994694, Length=564, Percent_Identity=20.2127659574468, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994690, Length=564, Percent_Identity=20.2127659574468, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560140, Length=476, Percent_Identity=21.0084033613445, Blast_Score=83, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI115534440, Length=609, Percent_Identity=20.1970443349754, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32564422, Length=445, Percent_Identity=21.7977528089888, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32564420, Length=445, Percent_Identity=21.7977528089888, Blast_Score=74, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17559526, Length=551, Percent_Identity=22.5045372050817, Blast_Score=71, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=1232, Percent_Identity=25.3246753246753, Blast_Score=321, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6319264, Length=530, Percent_Identity=23.5849056603774, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24648676, Length=607, Percent_Identity=27.0181219110379, Blast_Score=199, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24581924, Length=527, Percent_Identity=24.2884250474383, Blast_Score=100, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21355181, Length=530, Percent_Identity=23.2075471698113, Blast_Score=92, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656500, Length=507, Percent_Identity=22.879684418146, Blast_Score=90, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648260, Length=461, Percent_Identity=21.6919739696312, Blast_Score=74, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19920962, Length=147, Percent_Identity=35.3741496598639, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573762, Length=131, Percent_Identity=32.824427480916, Blast_Score=70, Evalue=8e-12,
Organism=Drosophila melanogaster, GI20129837, Length=130, Percent_Identity=33.0769230769231, Blast_Score=69, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24652250, Length=130, Percent_Identity=33.0769230769231, Blast_Score=69, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR013120
- InterPro:   IPR016040
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR010080 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF07993 NAD_binding_4; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 136402; Mature: 136402

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAVLTNSYNETIKESLERINGKSRIPMDFRNLEGEVDTKTILFPITINMVDLLGASIMW
CCCEECCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCEEEEEEEEHHHHHHHHHHHHH
LHHIANEKHIIVLYHEREKLFPIVIEISPFLSYKKLKEQIVEQIGQIQAMDETDIQELQK
HHHHCCCCEEEEEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHCEECCCHHHHHHHHH
HDNLFGMAPIIVGQTYYHSQENDILQFVLNEEKQGVEVIFNGLIWKEKTIARYMRQIEGV
HCCCCCCCHHHCCCHHCCCCCCHHHHHHHCCCCCCHHHHHHCHHCCHHHHHHHHHHHHHH
FIHALQNRDEHVGNFRIITDEEIALYNEINNTKATYPEKSIVEMFYKTVKQFPNRIALSS
HHHHHCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECC
KEGALTYQELNQRSNQIAHMLIQNGVQPGDYVGIFMKRSIDTVISILAVLKANAAYVPID
CCCCEEHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEECC
PDYPESRIEYIIQDSKAKVILTKETEITSKGIQAISIYDSENYLVNDVKLPINCDDIAYM
CCCCHHHHHHHEECCCEEEEEEECCHHHCCCCEEEEEEECCCEEEEEEEECCCCCCEEEE
IYTSGSTGNPKGTMLAHRGVVNLCTWMQRQYKLTEEDVFAQFPSFSFDASVWELFAALFC
EEECCCCCCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHC
GGTLYVLLEEERLSVEAFANAIHRVKATSILALATVFVRQVATYLEDEEIYKLSSLKRIA
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCEEEE
IGGEMLPIEVIKLWRERIGTNIEIHNVYGPTECTVVTTTYPIPSQLDENIVSVPIGKPCA
ECCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCHHHCCCEEECCCCCCCC
NYQIMILDENMRLCPIGVPGELHIESVGLAKGYFNKPEKTVEAFVPNPFNPIVNIYKTGD
CEEEEEEECCCEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCHHHHEEEECCC
IVRLLEDGNIEFLHRKDDQVKIRGHRIELGEIQNQISQNYNVKENIVFAKKSKEGSQYLI
EEEEEECCCEEEEECCCCEEEEEEEEEEHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEE
AFYTTLTKKEMPELIYKLQEQLPDYMIPSKLIYIDELPLTPNKKIDVKKLGQLEEEYEPT
EEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCHHHHCCCH
RLQEYVAPSTEAEKIIAQAWTEVLGVSKIGVHDDFFTIGGHSLKVLRILTLLKEDFPHLT
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCH
IQDFFKEKTVYKLARIQRELTLEENVFHEYKWIHEPEAIQYTEGITNNRISNVFLTGATG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEECCCH
YLGSHILYELLQQTSAHIYCLVRPKKDVEQRIMETLTGYFHDIPNEALARITAIPGDLGE
HHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCH
EYFGLSKEEFIAIRSKVDTVVHCGADVRHFGDVKQFENVNIQGTKRMLALADEGAAFHFI
HHHCCCHHHHHHHHHHHHHHEECCCCHHHHCCHHHHCCCCCCCCCEEEEEECCCCEEEEE
STISIPIDLAVEQWDMYKKRGDFEYHVELENVYSNSKLQAENLVREAMSRGMRGNIYRAG
EEEECCCEEHHHHHHHHHHCCCEEEEEEEHHHHCCCCCCHHHHHHHHHHCCCCCCEEECC
NLTCHSETGVFQQNIEGNAFYRLIKTMLLIGQAPNVKWKVDFAPIDFASKSIVTYMQDPQ
CEEEECCCCCHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHCCCH
IIGETLHICHPDPIDFVHFVQLMIECGHHLEIVPLSQYVDSGLQLAKEDEEIAELIASQV
HHHCHHEECCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHCCHHHHHCCHHHHHHHHHHHH
AGDGAQQSEFVIGTKRTNEWIKKKKIAVPIIDQQFIQKLLAHGEQVGYFPNVEK
CCCCCCCCCEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MEAVLTNSYNETIKESLERINGKSRIPMDFRNLEGEVDTKTILFPITINMVDLLGASIMW
CCCEECCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCEEEEEEEEHHHHHHHHHHHHH
LHHIANEKHIIVLYHEREKLFPIVIEISPFLSYKKLKEQIVEQIGQIQAMDETDIQELQK
HHHHCCCCEEEEEEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHCEECCCHHHHHHHHH
HDNLFGMAPIIVGQTYYHSQENDILQFVLNEEKQGVEVIFNGLIWKEKTIARYMRQIEGV
HCCCCCCCHHHCCCHHCCCCCCHHHHHHHCCCCCCHHHHHHCHHCCHHHHHHHHHHHHHH
FIHALQNRDEHVGNFRIITDEEIALYNEINNTKATYPEKSIVEMFYKTVKQFPNRIALSS
HHHHHCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECC
KEGALTYQELNQRSNQIAHMLIQNGVQPGDYVGIFMKRSIDTVISILAVLKANAAYVPID
CCCCEEHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCEEEECC
PDYPESRIEYIIQDSKAKVILTKETEITSKGIQAISIYDSENYLVNDVKLPINCDDIAYM
CCCCHHHHHHHEECCCEEEEEEECCHHHCCCCEEEEEEECCCEEEEEEEECCCCCCEEEE
IYTSGSTGNPKGTMLAHRGVVNLCTWMQRQYKLTEEDVFAQFPSFSFDASVWELFAALFC
EEECCCCCCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHC
GGTLYVLLEEERLSVEAFANAIHRVKATSILALATVFVRQVATYLEDEEIYKLSSLKRIA
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCEEEE
IGGEMLPIEVIKLWRERIGTNIEIHNVYGPTECTVVTTTYPIPSQLDENIVSVPIGKPCA
ECCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCHHHCCCEEECCCCCCCC
NYQIMILDENMRLCPIGVPGELHIESVGLAKGYFNKPEKTVEAFVPNPFNPIVNIYKTGD
CEEEEEEECCCEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCHHHHEEEECCC
IVRLLEDGNIEFLHRKDDQVKIRGHRIELGEIQNQISQNYNVKENIVFAKKSKEGSQYLI
EEEEEECCCEEEEECCCCEEEEEEEEEEHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEE
AFYTTLTKKEMPELIYKLQEQLPDYMIPSKLIYIDELPLTPNKKIDVKKLGQLEEEYEPT
EEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHCHHHHCCCH
RLQEYVAPSTEAEKIIAQAWTEVLGVSKIGVHDDFFTIGGHSLKVLRILTLLKEDFPHLT
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCH
IQDFFKEKTVYKLARIQRELTLEENVFHEYKWIHEPEAIQYTEGITNNRISNVFLTGATG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEECCCH
YLGSHILYELLQQTSAHIYCLVRPKKDVEQRIMETLTGYFHDIPNEALARITAIPGDLGE
HHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCH
EYFGLSKEEFIAIRSKVDTVVHCGADVRHFGDVKQFENVNIQGTKRMLALADEGAAFHFI
HHHCCCHHHHHHHHHHHHHHEECCCCHHHHCCHHHHCCCCCCCCCEEEEEECCCCEEEEE
STISIPIDLAVEQWDMYKKRGDFEYHVELENVYSNSKLQAENLVREAMSRGMRGNIYRAG
EEEECCCEEHHHHHHHHHHCCCEEEEEEEHHHHCCCCCCHHHHHHHHHHCCCCCCEEECC
NLTCHSETGVFQQNIEGNAFYRLIKTMLLIGQAPNVKWKVDFAPIDFASKSIVTYMQDPQ
CEEEECCCCCHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHCCCH
IIGETLHICHPDPIDFVHFVQLMIECGHHLEIVPLSQYVDSGLQLAKEDEEIAELIASQV
HHHCHHEECCCCCCCHHHHHHHHHHCCCCEEEEEHHHHHCCHHHHHCCHHHHHHHHHHHH
AGDGAQQSEFVIGTKRTNEWIKKKKIAVPIIDQQFIQKLLAHGEQVGYFPNVEK
CCCCCCCCCEEEEECCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA