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The map label for this gene is yvaE [H]

Identifier: 152974148

GI number: 152974148

Start: 352947

End: 353270

Strand: Direct

Name: yvaE [H]

Synonym: Bcer98_0307

Alternate gene names: 152974148

Gene position: 352947-353270 (Clockwise)

Preceding gene: 152974147

Following gene: 152974152

Centisome position: 8.64

GC content: 32.1

Gene sequence:

>324_bases
ATGATATATTGGTTATTACTACTCGTAACAATTATATTTGAAGTCGCTGGAACGGTCGCAATGAAGTTATCAAATGGTTT
AACGAAGTTTGTTCCAAGTGTATTCATCTTTGTATGTTATGGCATTTGTTTTAGCGTTTTTGCCATTGTTGTAAAAAAGA
TTCATTTAAGTATTGCTTACGCAATCTGGTCCGGTTTAGGCACATTATGTATTACAATCATTAGCTTTTGCTTTTTTAAA
GAACATATTAGCTTGTTTCAAGCGTTTTGCATTCTGTTCATTGTATTAGGTGTAATCGGATTAAAGGTTTCATCAGCAAC
ATAA

Upstream 100 bases:

>100_bases
ATATATTTCATTAGGATTATAATGCTAACAATCTTGTTTAGGAGAAGATAAAAATATATACTAGAATCTCTATAATCTAA
CAAAAAGATGAGGGATCTAG

Downstream 100 bases:

>100_bases
AAGCTGTCTTCCGATTTTTGGAAGACAGCTTTTATGTTGTATTAAAACGCCCAATTCCCTTTACGGAAGATAGGCTCATG
TTTCCCATCAGCTGTAATAC

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
MIYWLLLLVTIIFEVAGTVAMKLSNGLTKFVPSVFIFVCYGICFSVFAIVVKKIHLSIAYAIWSGLGTLCITIISFCFFK
EHISLFQAFCILFIVLGVIGLKVSSAT

Sequences:

>Translated_107_residues
MIYWLLLLVTIIFEVAGTVAMKLSNGLTKFVPSVFIFVCYGICFSVFAIVVKKIHLSIAYAIWSGLGTLCITIISFCFFK
EHISLFQAFCILFIVLGVIGLKVSSAT
>Mature_107_residues
MIYWLLLLVTIIFEVAGTVAMKLSNGLTKFVPSVFIFVCYGICFSVFAIVVKKIHLSIAYAIWSGLGTLCITIISFCFFK
EHISLFQAFCILFIVLGVIGLKVSSAT

Specific function: Multidrug Transporter. Confers Resistance To A Wide Range Of Toxic Compounds By Removing Them For The Cells. The Efflux Is Coupled To An Influx Of Protons. Probably Prevents The Incorporation Of Methyl VIologen Into Cells. Involved In Ethidium Bromide Ef

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=89, Percent_Identity=39.3258426966292, Blast_Score=64, Evalue=3e-12,
Organism=Escherichia coli, GI87082378, Length=102, Percent_Identity=28.4313725490196, Blast_Score=61, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11824; Mature: 11824

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYWLLLLVTIIFEVAGTVAMKLSNGLTKFVPSVFIFVCYGICFSVFAIVVKKIHLSIAY
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIWSGLGTLCITIISFCFFKEHISLFQAFCILFIVLGVIGLKVSSAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIYWLLLLVTIIFEVAGTVAMKLSNGLTKFVPSVFIFVCYGICFSVFAIVVKKIHLSIAY
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIWSGLGTLCITIISFCFFKEHISLFQAFCILFIVLGVIGLKVSSAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]