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The map label for this gene is purC

Identifier: 152974111

GI number: 152974111

Start: 311333

End: 312052

Strand: Direct

Name: purC

Synonym: Bcer98_0270

Alternate gene names: 152974111

Gene position: 311333-312052 (Clockwise)

Preceding gene: 152974110

Following gene: 152974112

Centisome position: 7.62

GC content: 35.83

Gene sequence:

>720_bases
ATGCAAAAGCTAGAATTGCTGTATGAAGGTAAGGCAAAAAGAATATATCGTACAGAAGCAGCAGATATGGTTTGGATAGA
GTACAAAGATAGTGCTACTGCTTTCAATGGAGAGAAAAAAGCGACCATTACAGGAAAAGGTCGTTTGAACAATGAAATTA
CAACTTTTTTGTTCAGAAAGTTGCAAGAAGTGGGAATTGAAACACATTTTGTAAAGAAGCTATCAGATACAGAACAACTT
GTGAAAAAAGTAAGTATTATTCCATTAGAAGTTGTTACAAGAAACGTCATTGCAGGGAGCCTTTCCAAACGATTAGGAAT
GGAAGAGGGAATACCACTTGCCAAACCAATCGTAGAATTTTACTACAAAGATGATGATTTAGGAGATCCTCTTGTAACAG
AAGATCATATTCGTGTGTTAAACGCTGCAACATTAGAGCAGATAAGTACATTACGAGAAAAGGCTCTACGAATCAATCAA
GTTTTGATTGAGCATTTCGCAAGCTGTCGTGTAAGGTTAATAGATTTTAAATTAGAGTTTGGTATTACAGAGGAAGGCAA
GATTGTATTAGCGGATGAAATCTCACCAGATACTTGTCGTTTATGGGATGAAGAGAGCAATGAGAAATTTGATAAAGATG
TATTTCGCCGCGATTTAGGTAATTTAACCGAGGCATATGAAGAAATTTTAAAACGTTTAGGAGGGGCTTCACATGTATAA

Upstream 100 bases:

>100_bases
AACTAAGCAGAAAATTTTATATGGCACAGAATAGCGTTATTCTGTGCCATTCTTTATAAAAATATTATTCACATTTTTCA
AACTACAGGGGGCTTGCGAA

Downstream 100 bases:

>100_bases
AGTTAAGGTATATGTAACATTAAGAGAGAGTGTATTAGATCCACAAGGAACAGCAGTAAAAGGTGCTCTTCACAGCCTTT
CCTTTACAGAAGTACAAGAT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQKLELLYEGKAKRIYRTEAADMVWIEYKDSATAFNGEKKATITGKGRLNNEITTFLFRKLQEVGIETHFVKKLSDTEQL
VKKVSIIPLEVVTRNVIAGSLSKRLGMEEGIPLAKPIVEFYYKDDDLGDPLVTEDHIRVLNAATLEQISTLREKALRINQ
VLIEHFASCRVRLIDFKLEFGITEEGKIVLADEISPDTCRLWDEESNEKFDKDVFRRDLGNLTEAYEEILKRLGGASHV

Sequences:

>Translated_239_residues
MQKLELLYEGKAKRIYRTEAADMVWIEYKDSATAFNGEKKATITGKGRLNNEITTFLFRKLQEVGIETHFVKKLSDTEQL
VKKVSIIPLEVVTRNVIAGSLSKRLGMEEGIPLAKPIVEFYYKDDDLGDPLVTEDHIRVLNAATLEQISTLREKALRINQ
VLIEHFASCRVRLIDFKLEFGITEEGKIVLADEISPDTCRLWDEESNEKFDKDVFRRDLGNLTEAYEEILKRLGGASHV
>Mature_239_residues
MQKLELLYEGKAKRIYRTEAADMVWIEYKDSATAFNGEKKATITGKGRLNNEITTFLFRKLQEVGIETHFVKKLSDTEQL
VKKVSIIPLEVVTRNVIAGSLSKRLGMEEGIPLAKPIVEFYYKDDDLGDPLVTEDHIRVLNAATLEQISTLREKALRINQ
VLIEHFASCRVRLIDFKLEFGITEEGKIVLADEISPDTCRLWDEESNEKFDKDVFRRDLGNLTEAYEEILKRLGGASHV

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=236, Percent_Identity=33.0508474576271, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI5453539, Length=236, Percent_Identity=33.0508474576271, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI119220559, Length=243, Percent_Identity=31.6872427983539, Blast_Score=106, Evalue=1e-23,
Organism=Escherichia coli, GI1788820, Length=234, Percent_Identity=44.8717948717949, Blast_Score=206, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17531275, Length=233, Percent_Identity=38.6266094420601, Blast_Score=136, Evalue=9e-33,
Organism=Drosophila melanogaster, GI18860083, Length=237, Percent_Identity=33.7552742616034, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24583917, Length=247, Percent_Identity=29.5546558704453, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_BACCN (A7GKH5)

Other databases:

- EMBL:   CP000764
- RefSeq:   YP_001373628.1
- ProteinModelPortal:   A7GKH5
- SMR:   A7GKH5
- STRING:   A7GKH5
- EnsemblBacteria:   EBBACT00000037901
- GeneID:   5344698
- GenomeReviews:   CP000764_GR
- KEGG:   bcy:Bcer98_0270
- eggNOG:   COG0152
- GeneTree:   EBGT00050000000820
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BioCyc:   BCER315749:BCER98_0270-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 27320; Mature: 27320

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLELLYEGKAKRIYRTEAADMVWIEYKDSATAFNGEKKATITGKGRLNNEITTFLFRK
CCHHHHHHCCCCHHEEECCCCCEEEEEECCCCCEECCCCEEEEEECCCCCHHHHHHHHHH
LQEVGIETHFVKKLSDTEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGIPLAKPIVEF
HHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
YYKDDDLGDPLVTEDHIRVLNAATLEQISTLREKALRINQVLIEHFASCRVRLIDFKLEF
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEE
GITEEGKIVLADEISPDTCRLWDEESNEKFDKDVFRRDLGNLTEAYEEILKRLGGASHV
CCCCCCCEEEEECCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQKLELLYEGKAKRIYRTEAADMVWIEYKDSATAFNGEKKATITGKGRLNNEITTFLFRK
CCHHHHHHCCCCHHEEECCCCCEEEEEECCCCCEECCCCEEEEEECCCCCHHHHHHHHHH
LQEVGIETHFVKKLSDTEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGIPLAKPIVEF
HHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
YYKDDDLGDPLVTEDHIRVLNAATLEQISTLREKALRINQVLIEHFASCRVRLIDFKLEF
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEE
GITEEGKIVLADEISPDTCRLWDEESNEKFDKDVFRRDLGNLTEAYEEILKRLGGASHV
CCCCCCCEEEEECCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA