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The map label for this gene is ksgA [H]

Identifier: 152973889

GI number: 152973889

Start: 45333

End: 46211

Strand: Direct

Name: ksgA [H]

Synonym: Bcer98_0036

Alternate gene names: 152973889

Gene position: 45333-46211 (Clockwise)

Preceding gene: 152973888

Following gene: 152973890

Centisome position: 1.11

GC content: 35.72

Gene sequence:

>879_bases
ATGAAGGATATCGCAACGCCAAATCGTACAAAAGATATTGTTGAAAAGTACGGATTTTCATTTAAAAAAAGTTTGGGACA
AAATTTCCTAATTGATACAAATGTATTAAATCGCATTGTTGATTATGCAGAGATCGGCCCTAAAGGCGGAGCTATTGAAA
TTGGTCCTGGTATTGGAGCTTTAACAGAGCAATTAGCGAAACGTGCCAAAAAAGTAGTAGCTTTTGAAATTGATCAAAGA
CTATTACCCATTTTAGATGAGACGTTAGCCCCATATGATAATGTGACGATTATTAATAAAGATGTTTTAAAAGCAAATGT
GCACGAAGTATTTCAAGAACAATTCGAAGAAGGACAAGACGTAATGGTGGTAGCTAATTTACCATATTACGTGACAACGC
CAATTTTGTTCAAATTGCTTGAAGAAAAGCTCCCTGTTCGTGGGTTTGTAGTGATGATGCAAAAAGAGGTAGGAGATCGT
TTGGCTGCTAAGCCGGGAACAAAAGATTATGGTTCTTTATCCATTGCAATTCAATATTATACAGAAGTAGAGACAGTTAT
GACAGTTCCGCGTACGGTATTTGTTCCACAACCAAATGTGGATTCATCCGTTATTCGTCTTTTAAAACGTCCGAAGCCAA
TTGTAGAAGTAATAGACGAAAAGTTTTTCTTTGAGGTAGTACGAGCAAGCTTTGCACAACGCCGTAAAACATTAATGAAT
AATTTATCAAATAACTTAAATGATTTTCCGAAAGATAAAGAATTGTTAGAGCGAATTTTAACAGAGATAGGAATTGATCC
GAAACGTCGAGGTGAAACGTTATCCATTGAAGAATTTGCAATGTTAAGTAATGCGCTCGTTCCTCATAAGATGAAGTAA

Upstream 100 bases:

>100_bases
ATACAAATGCGAAGCAGTTACATAAACGGTTACAAATGTTTCAAGTTTCTAAGGAGGCATTTGCAACAGCTTATAAGCAA
GTATTACAGGAGGAAAAGAA

Downstream 100 bases:

>100_bases
AGTATGAATCAGTGTGGAGCGTTATCCTTCGCTGACTAGGAGCTCGCACTAACCAGCTACTATAAAATAGCGGATAAAAA
TTTAAATAAATAATAAAGGA

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKDIATPNRTKDIVEKYGFSFKKSLGQNFLIDTNVLNRIVDYAEIGPKGGAIEIGPGIGALTEQLAKRAKKVVAFEIDQR
LLPILDETLAPYDNVTIINKDVLKANVHEVFQEQFEEGQDVMVVANLPYYVTTPILFKLLEEKLPVRGFVVMMQKEVGDR
LAAKPGTKDYGSLSIAIQYYTEVETVMTVPRTVFVPQPNVDSSVIRLLKRPKPIVEVIDEKFFFEVVRASFAQRRKTLMN
NLSNNLNDFPKDKELLERILTEIGIDPKRRGETLSIEEFAMLSNALVPHKMK

Sequences:

>Translated_292_residues
MKDIATPNRTKDIVEKYGFSFKKSLGQNFLIDTNVLNRIVDYAEIGPKGGAIEIGPGIGALTEQLAKRAKKVVAFEIDQR
LLPILDETLAPYDNVTIINKDVLKANVHEVFQEQFEEGQDVMVVANLPYYVTTPILFKLLEEKLPVRGFVVMMQKEVGDR
LAAKPGTKDYGSLSIAIQYYTEVETVMTVPRTVFVPQPNVDSSVIRLLKRPKPIVEVIDEKFFFEVVRASFAQRRKTLMN
NLSNNLNDFPKDKELLERILTEIGIDPKRRGETLSIEEFAMLSNALVPHKMK
>Mature_292_residues
MKDIATPNRTKDIVEKYGFSFKKSLGQNFLIDTNVLNRIVDYAEIGPKGGAIEIGPGIGALTEQLAKRAKKVVAFEIDQR
LLPILDETLAPYDNVTIINKDVLKANVHEVFQEQFEEGQDVMVVANLPYYVTTPILFKLLEEKLPVRGFVVMMQKEVGDR
LAAKPGTKDYGSLSIAIQYYTEVETVMTVPRTVFVPQPNVDSSVIRLLKRPKPIVEVIDEKFFFEVVRASFAQRRKTLMN
NLSNNLNDFPKDKELLERILTEIGIDPKRRGETLSIEEFAMLSNALVPHKMK

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=224, Percent_Identity=35.7142857142857, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI156415992, Length=292, Percent_Identity=31.1643835616438, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1786236, Length=272, Percent_Identity=35.2941176470588, Blast_Score=157, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI25146882, Length=286, Percent_Identity=34.2657342657343, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25141369, Length=293, Percent_Identity=29.0102389078498, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324989, Length=224, Percent_Identity=33.4821428571429, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21358017, Length=237, Percent_Identity=36.2869198312236, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357273, Length=296, Percent_Identity=28.3783783783784, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 33072; Mature: 33072

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDIATPNRTKDIVEKYGFSFKKSLGQNFLIDTNVLNRIVDYAEIGPKGGAIEIGPGIGA
CCCCCCCCHHHHHHHHHCCHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCEEEECCCCHH
LTEQLAKRAKKVVAFEIDQRLLPILDETLAPYDNVTIINKDVLKANVHEVFQEQFEEGQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHCCCC
VMVVANLPYYVTTPILFKLLEEKLPVRGFVVMMQKEVGDRLAAKPGTKDYGSLSIAIQYY
EEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHH
TEVETVMTVPRTVFVPQPNVDSSVIRLLKRPKPIVEVIDEKFFFEVVRASFAQRRKTLMN
HHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLSNNLNDFPKDKELLERILTEIGIDPKRRGETLSIEEFAMLSNALVPHKMK
HHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKDIATPNRTKDIVEKYGFSFKKSLGQNFLIDTNVLNRIVDYAEIGPKGGAIEIGPGIGA
CCCCCCCCHHHHHHHHHCCHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCEEEECCCCHH
LTEQLAKRAKKVVAFEIDQRLLPILDETLAPYDNVTIINKDVLKANVHEVFQEQFEEGQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHCCCC
VMVVANLPYYVTTPILFKLLEEKLPVRGFVVMMQKEVGDRLAAKPGTKDYGSLSIAIQYY
EEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHH
TEVETVMTVPRTVFVPQPNVDSSVIRLLKRPKPIVEVIDEKFFFEVVRASFAQRRKTLMN
HHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLSNNLNDFPKDKELLERILTEIGIDPKRRGETLSIEEFAMLSNALVPHKMK
HHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA